Preventing the autophagic survival response by inhibition of calpain enhances the cytotoxic activity of bortezomib in vitro and in vivo

Cancer Chemotherapy and Pharmacology

Volumn 71, Issue 6, 2013, Pages 1567-1576

  Escalante, Aluvia M ^a   McGrath, Ryan T ^a   Karolak, Matthew R ^a   Dorr, Robert T ^a   Lynch, Ronald M ^a   Landowski, Terry H ^a  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

Autophagy; Bortezomib; Calpain; Myeloma; Nelfinavir

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; BORTEZOMIB; CALPAIN; HUMAN IMMUNODEFICIENCY VIRUS PROTEINASE INHIBITOR; LIPOCORTIN 5; NELFINAVIR; PROTEASOME; SMALL INTERFERING RNA; TRYPAN BLUE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; AUTOPHAGY; CANCER RESISTANCE; CELL ASSAY; CELL DEATH; CELL GROWTH; CELL PROTECTION; CELL SURVIVAL; CONTROLLED STUDY; DRUG CYTOTOXICITY; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; GENE SILENCING; GROWTH INHIBITION; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IMMUNOFLUORESCENCE TEST; IN VITRO STUDY; IN VIVO STUDY; MOUSE; MYELOMA; NONHUMAN; PRIORITY JOURNAL; SCID MOUSE; TUMOR MODEL; TUMOR REGRESSION; TUMOR XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; AUTOPHAGY; BORONIC ACIDS; CALPAIN; CELL LINE, TUMOR; CELL SURVIVAL; DRUG SYNERGISM; HIV PROTEASE INHIBITORS; HUMANS; MICE; MICE, SCID; MULTIPLE MYELOMA; NELFINAVIR; PYRAZINES; RNA, SMALL INTERFERING; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84878658221     PISSN: 03445704     EISSN: 14320843     Source Type: Journal    
DOI: 10.1007/s00280-013-2156-3     Document Type: Article

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