CCL18 activates fibroblast-like synoviocytes in patients with rheumatoid arthritis

Journal of Rheumatology

Volumn 40, Issue 6, 2013, Pages 1026-1028

  Takayasu, Aiko ^a   Miyabe, Yoshishige ^a   Yokoyama, Waka ^a   Kaneko, Kayoko ^a   Fukuda, Shin ^a   Miyasaka, Nobuyuki ^a   Miyabe, Chie ^a,b   Kubota, Tetsuo ^a   Nanki, Toshihiro ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b TOKYO MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; CCL18 CHEMOKINE; CD68 ANTIGEN; CHEMOKINE; CYCLIC CITRULLINATED PEPTIDE ANTIBODY; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; PHOSPHATIDYLINOSITOL TRANSFER MEMBRANE ASSOCIATED PHOSPHATIDYLINOSITOL TRANSFER PROTEIN 3; RECEPTOR PROTEIN; RHEUMATOID FACTOR; STROMELYSIN; UNCLASSIFIED DRUG; VON WILLEBRAND FACTOR;

ADULT; AGED; CELL ACTIVATION; CELL PROLIFERATION; CLINICAL ARTICLE; CYTOKINE PRODUCTION; CYTOKINE RELEASE; CYTOKINE RESPONSE; DISEASE COURSE; DOSE RESPONSE; ENDOTHELIUM CELL; FIBROBLAST LIKE SYNOVIOCYTE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE; IN VITRO STUDY; JOINT SURGERY; LETTER; MACROPHAGE; OSTEOARTHRITIS; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RHEUMATOID ARTHRITIS; SYNOVIOCYTE; SYNOVIUM; WESTERN BLOTTING;

AGED; AGED, 80 AND OVER; ARTHRITIS, RHEUMATOID; CHEMOKINES, CC; HUMANS; MACROPHAGES; MIDDLE AGED; OSTEOARTHRITIS; SYNOVIAL MEMBRANE;

EID: 84878649141     PISSN: 0315162X     EISSN: 14992752     Source Type: Journal    
DOI: 10.3899/jrheum.121412     Document Type: Letter

References (10)

1. Muller-Ladner U, Ospelt C, Gay S, Distler O, Pap T. Cells of the synovium in rheumatoid arthritis. Synovial fibroblasts. Arthritis Res Ther 2007;9:223.
2. Schutyser E, Struyf S, Wuyts A, Put W, Geboes K, Grillet B, et al. Selective induction of CCL18/PARC by staphylococcal enterotoxins in mononuclear cells and enhanced levels in septic and rheumatoid arthritis. Eur J Immunol 2001;31:3755-62.
3. Radstake TR, van der Voort R, ten Brummelhuis M, de Waal Malefijt M, Looman M, Figdor CG, et al. Increased expression of CCL18, CCL19, and CCL17 by dendritic cells from patients with rheumatoid arthritis, and regulation by Fc gamma receptors. Ann Rheum Dis 2005;64:359-67.
4. Chen J, Yao Y, Gong C, Yu F, Su S, Chen J, et al. CCL18 from tumor-associated macrophages promotes breast cancer metastasis via PITPNM3. Cancer Cell 2011;19:541-55.
5. Nanki T, Nagasaka K, Hayashida K, Saita Y, Miyasaka N. Chemokines regulate IL-6 and IL-8 production by fibroblast-like synoviocytes from patients with rheumatoid arthritis. J Immunol 2001;167:5381-5.
6. van der Voort R, Kramer M, Lindhout E, Torensma R, Eleveld D, van Lieshout AW, et al. Novel monoclonal antibodies detect elevated levels of the chemokine CCL18/DC-CK1 in serum and body fluids in pathological conditions. J Leukoc Biol 2005; 77:739-47.
7. van Lieshout AW, Fransen J, Flendrie M, Eijsbouts AM, van den Hoogen FH, van Riel PL, et al. Circulating levels of the chemokine CCL18 but not CXCL16 are elevated and correlate with disease activity in rheumatoid arthritis. Ann Rheum Dis 2007;66:1334-8.
8. Hayashida K, Nanki T, Girschick H, Yavuz S, Ochi T, Lipsky PE. Synovial stromal cells from rheumatoid arthritis patients attract monocytes by producing MCP-1 and IL-8. Arthritis Res 2001;3:118-26.
9. Ainola MM, Mandelin JA, Liljestrom MP, Li TF, Hukkanen MV, Konttinen YT. Pannus invasion and cartilage degradation in rheumatoid arthritis: Involvement of MMP-3 and interleukin-1 beta. Clin Exp Rheumatol 2005;23:644-50.
10. Schutyser E, Richmond A, Van Damme J. Involvement of CC chemokine ligand 18 (CCL18) in normal and pathological processes. J Leukoc Biol 2005;78:14-26.