A Binding-Site Barrier Affects Imaging Efficiency of High Affinity Amyloid-Reactive Peptide Radiotracers In Vivo

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Wall, Jonathan S ^a   Williams, Angela ^a   Richey, Tina ^a   Stuckey, Alan ^a   Huang, Ying ^a   Wooliver, Craig ^a   Macy, Sallie ^a   Heidel, Eric ^a   Gupta, Neil ^a   Lee, Angela ^a   Rader, Brianna ^a   Martin, Emily B ^a   Kennel, Stephen J ^a  

^a UNIVERSITY OF TENNESSEE GRADUATE SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID A PROTEIN; ARGININE; HEPARIN; IODINE 123; IODINE 125; LYSINE; P5 PEPTIDE; P5R PEPTIDE; PEPTIDE DERIVATIVE; TRACER; UNCLASSIFIED DRUG;

ALPHA HELIX; AMYLOIDOSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BINDING AFFINITY; BINDING SITE; CIRCULAR DICHROISM; COMPUTER ASSISTED TOMOGRAPHY; COMPUTER TOMOGRAPHY SCANNER; CONTROLLED STUDY; EX VIVO STUDY; IN VIVO STUDY; ISOTOPE LABELING; MOUSE; NONHUMAN; PEPTIDE SYNTHESIS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN SECONDARY STRUCTURE; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY;

AMINO ACID SEQUENCE; AMYLOID; ANIMALS; BINDING SITES; HEPARIN; IMMOBILIZED PROTEINS; MICE; MODELS, MOLECULAR; MOLECULAR IMAGING; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; RADIOACTIVE TRACERS; SPLEEN; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON; TOMOGRAPHY, X-RAY COMPUTED;

MURINAE; MUS;

EID: 84878637733     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0066181     Document Type: Article

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