In vivo visualization of amyloid deposits in the heart with 11C-PIB and PET

Journal of Nuclear Medicine

Volumn 54, Issue 2, 2013, Pages 213-220

  Antoni, Gunnar ^a,b   Lubberink, Mark ^a,b   Estrada, Sergio ^a   Axelsson, Jan ^c   Carlson, Kristina ^b   Lindsjö, Lars ^b   Kero, Tanja ^a,b   Långström, Bengt ^a,d,e   Granstam, Sven Olof ^a   Rosengren, Sara ^b   Vedin, Ola ^a   Wassberg, Cecilia ^a,b   Wikström, Gerhard ^a   Westermark, Per ^a,f   Sörensen, Jens ^a,b  

^a UPPSALA UNIVERSITY   (Sweden)

^b UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^c UMEÅ UNIVERSITY   (Sweden)

^d IMPERIAL COLLEGE LONDON   (United Kingdom)

^e UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^f UPPSALA UNIVERSITY   (Sweden)

Author keywords

11C acetate; 11C PIB; Amyloid; Myocardial blood flow; PET imaging; Systemic amyloidosis; Transthyretin

Indexed keywords

CARBON N METHYL 2 (4' METHYLAMINOPHENYL) 6 HYDROXYBENZOTHIAZOLE C 11; IMMUNOGLOBULIN LIGHT CHAIN; PREALBUMIN; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CARDIAC IMAGING; CLINICAL ARTICLE; CLINICAL EVALUATION; COMPUTER ASSISTED EMISSION TOMOGRAPHY; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; DISEASE CLASSIFICATION; FEMALE; FOLLOW UP; HEART AMYLOIDOSIS; HEART PERFUSION; HUMAN; IMAGE ANALYSIS; IN VITRO STUDY; IN VIVO STUDY; MALE; NON INVASIVE PROCEDURE; PATIENT ASSESSMENT; PRIORITY JOURNAL; RADIATION EXPOSURE; RADIOISOTOPE DIAGNOSIS; RADIOISOTOPE DISTRIBUTION;

AGED; AMYLOID; AMYLOIDOSIS; BENZOTHIAZOLES; CARBON ISOTOPES; CASE-CONTROL STUDIES; FEMALE; HEART; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MALE; MIDDLE AGED; MYOCARDIUM; NUCLEAR MEDICINE; POSITRON-EMISSION TOMOGRAPHY; PREALBUMIN; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84873554741     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.111.102053     Document Type: Article

References (28)

1. Merlini G, Westermark P. The systemic amyloidoses: clearer understanding of the molecular mechanisms offers hope for more effective therapies. J Intern Med. 2004;255:159-178.
2. Sipe JD, Benson MD, Buxbaum JN, et al. Amyloid fibril protein nomenclature: 2010 recommendations from the nomenclature committee of the International Society of Amyloidosis. Amyloid. 2012;19:167-170.
3. Brambilla D, Souguir H, Nicolas J, et al. Colloidal properties of biodegradable nanoparticles influence interaction with amyloid-beta peptide. J Biotechnol. 2010;156:338-340.
4. Liu D, Niemann M, Hu K, et al. Echocardiographic evaluation of systolic and diastolic function in patients with cardiac amyloidosis. Am J Cardiol. 2011;108: 591-598.
5. Syed IS, Glockner JF, Feng D, et al. Role of cardiac magnetic resonance imaging in the detection of cardiac amyloidosis. JACC Cardiovasc Imaging. 2010;3:155-164.
6. Hawkins PN, Richardson S, Vigushin DM, et al. Serum amyloid P component scintigraphy and turnover studies for diagnosis and quantitative monitoring of AA amyloidosis in juvenile rheumatoid arthritis. Arthritis Rheum. 1993;36:842-851.
7. 123I-labeled serum amyloid P component scintigraphy in patients with amyloidosis. Am J Med. 2006;119:355 e315-324.
8. Knuuti J, Sipola P. Is it time for cardiac innervation imaging? Q J Nucl Med Mol Imaging. 2005;49:97-105.
9. Aprile C, Marinone G, Saponaro R, Bonino C, Merlini G. Cardiac and pleuropulmonary AL amyloid imaging with technetium-99m labelled aprotinin. Eur J Nucl Med. 1995;22:1393-1401.
10. 99mTc-aprotinin scintigraphy in amyloidosis. Eur J Haematol. 2007;79:494-500.
11. 99mTc-DPD scintigraphy in transthyretinrelated familial amyloidotic polyneuropathy. Eur J Nucl Med Mol Imaging. 2002;29:376-379.
12. Wall JS, Kennel SJ, Stuckey AC, et al. Radioimmunodetection of amyloid deposits in patients with AL amyloidosis. Blood. 2010;116:2241-2244.
13. Klunk WE, Engler H, Nordberg A, et al. Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B. Ann Neurol. 2004;55:306-319.
14. Gertz MA, Comenzo R, Falk RH, et al. Definition of organ involvement and treatment response in immunoglobulin light chain amyloidosis (AL): a consensus opinion from the 10th International Symposium on Amyloid and Amyloidosis, Tours, France, 18-22 April 2004. Am J Hematol. 2005;79:319-328.
15. Ihse E, Suhr OB, Hellman U, Westermark P. Variation in amount of wild-type transthyretin in different fibril and tissue types in ATTR amyloidosis. J Mol Med (Berl). 2011;89:171-180.
16. Westermark GT, Sletten K, Westermark P. Alkali-degradation of amyloid: an ancient method useful for making monoclonal antibodies against amyloid fibril proteins. Scand J Immunol. 2009;70:535-540.
17. Westermark P, Davey E, Lindbom K, Enqvist S. Subcutaneous fat tissue for diagnosis and studies of systemic amyloidosis. Acta Histochem. 2006;108:209-213.
18. Buck A, Wolpers HG, Hutchins GD, et al. Effect of carbon-11-acetate recirculation on estimates of myocardial oxygen consumption by PET. J Nucl Med. 1991;32:1950-1957.
19. 11C]acetate for measuring myocardial blood flow: Studies in normal subjects and patients with hypertrophic cardiomyopathy. J Nucl Cardiol. 2010;17:264-275.
20. 11C]acetate as a quantitative perfusion tracer in myocardial PET. J Nucl Med. 2001;42:1174-1182.
21. 15O-water and PET using the basis function method. J Nucl Med. 2005;46:1219-1224.
22. Harms HJ, Knaapen P, de Haan S, Halbmeijer R, Lammertsma AA, Lubberink M. Automatic generation of absolute myocardial blood flow images using [15O]H2O and a clinical PET/CT scanner. Eur J Nucl Med Mol Imaging. 2011;38:930-939.
23. 15O-water and positron emission tomography. Mol Imaging Biol. 2005;7:273-285.
24. Cerqueira MD, Weissman NJ, Dilsizian V, et al. Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart: a statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association. Int J Cardiovasc Imaging. 2002;18:539-542.
25. Cornwell GG 3rd, Murdoch WL, Kyle RA, Westermark P, Pitkanen P. Frequency and distribution of senile cardiovascular amyloid. A clinicopathologic correlation. Am J Med. 1983;75:618-623.
26. 11C]hydroxyephedrine studies [abstract]. J Nucl Med. 2011;52(suppl 1):254.
27. 15O and dynamic positron-emission tomography: strategy for quantification in relation to the partial-volume effect. Circulation. 1988;78:104-115.
28. Tsai SB, Seldin DC, Wu H, O'Hara C, Ruberg FL, Sanchorawala V. Myocardial infarction with "clean coronaries" caused by amyloid light-chain AL amyloidosis: a case report and literature review. Amyloid. 2011;18:160-164.