The combination of catechin and epicatechin gallate from fructus crataegi potentiates β-lactam antibiotics against Methicillin-Resistant Staphylococcus aureus (MRSA) in vitro and in vivo

International Journal of Molecular Sciences

Volumn 14, Issue 1, 2013, Pages 1802-1821

  Qin, Rongxin ^a   Xiao, Kangkang ^a   Li, Bin ^a   Jiang, Weiwei ^a   Peng, Wei ^a   Zheng, Jiang ^a   Zhou, Hong ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

( ) epicatechin gallate; Drug accumulation; Fructus crataegi; MRSA; Synergistic effect

Indexed keywords

AMPICILLIN; BETA LACTAM ANTIBIOTIC; CATECHIN; CEFAZOLIN; CEFEPIME; CILASTATIN PLUS IMIPENEM; CRATAEGUS EXTRACT; DAUNORUBICIN; EPICATECHIN GALLATE; EPIGALLOCATECHIN; LINEZOLID; MESSENGER RNA; METICILLIN; MONOMER; OXACILLIN; SULTAMICILLIN; TEICOPLANIN; VANCOMYCIN; ANTIINFECTIVE AGENT;

ABCA GENE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL GENE; BACTERIAL INFECTION; BACTERIAL LOAD; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; CRATAEGUS; DOWN REGULATION; DRUG ACCUMULATION; DRUG HALF LIFE; DRUG ISOLATION; DRUG POTENTIATION; DRUG SCREENING; FRUIT; GENE EXPRESSION REGULATION; IN VITRO STUDY; IN VIVO STUDY; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; NORA GENE; NORC GENE; SEPSIS; ANALOGS AND DERIVATIVES; ANIMAL; CHEMISTRY; DRUG COMBINATION; STAPHYLOCOCCAL INFECTIONS;

BACTERIA (MICROORGANISMS); CRATAEGUS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MUS; ROSACEAE;

ANIMALS; ANTI-BACTERIAL AGENTS; CATECHIN; CRATAEGUS; DRUG THERAPY, COMBINATION; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICE; OXACILLIN; SEPSIS; STAPHYLOCOCCAL INFECTIONS;

EID: 84878632744     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms14011802     Document Type: Article

References (37)

1. Moellering, R.C., Jr. MRSA: The first half century. J. Antimicrob. Chemother. 2012, 67, 4-11.
2. Livermore, D.M. Antibiotic resistance in Staphylococci. Int. J. Antimicrob. Agents 2000, 16, S3-S10.
3. Pantosti, A.; Sanchinim, A.; Monaco, M. Mechanisms of antibiotic resistance in Staphylococcus aureus. Future Microbiol. 2007, 2, 323-334.
4. Li, X.Z.; Nikaido, H. Efflux-Mediated drug resistance in bacteria: An update. Drugs 2009, 69, 1555-1623.
5. Poole, K. Efflux pumps as antimicrobial resistance mechanisms. Ann. Med. 2007, 39, 162-176.
6. Taylor, P.W.; Stapleton, P.D.; Paul, L.J. New ways to treat bacterial infections. Drug Discov. Today 2002, 7, 1086-1091.
7. Kondo, K.; Takaishi, Y.; Shibata, H.; Higuti, T. ILSMRs (intensifier of β-lactam-susceptibility in methicillin-resistant Staphylococcus aureus) from Tara [Caesalpinia spinosa (Molina) Kuntze]. Phytomedicine 2006, 13, 209-212.
8. Liu, I.X.; Durham, D.G.; Richards, R.M. Baicalin synergy with beta-lactam antibiotics against methicillin-resistant Staphylococcus aureus and other beta-lactam-resistant strains of S. aureus. J. Pharm. Pharmacol. 2000, 52, 361-366.
9. Nicolson, K.; Evans, G.; O'Toole, P.W. Potentiation of methicillin activity against methicillin-resistant Staphylococcus aureus by diterpenes. FEMS Microbiol. Lett. 1999, 179, 233-239.
10. Shiota, S.; Shimizu, M.; Mizusima. T.; Ito, H.; Hatano, T.; Yoshida, T.; Tsuchiya, T. Restoration of effectiveness of beta-lactams on methicillin-resistant Staphylococcus aureus by tellimagrandin I from rose red. FEMS Microbiol. Lett. 2000, 185, 135-138.
11. Shimizu, M.; Shiota, S.; Mizushima, T.; Ito, H.; Hatano, T.; Yoshida, T.; Tsuchiya, T. Marked potentiation of activity of beta-lactams against methicillin-resistant Staphylococcus aureus by corilagin. Antimicrob. Agents Chemother. 2001, 45, 3198-3201.
12. Eid, C.N.; Halligan, N.G.; Nicas, T.I.; Mullen, D.L.; Butler, T.F.; Loncharich, R.J.; Paschal, J.W.; Schofield, C.J.; Westwood, N.J.; Cheng, L. Tripeptide LY301621 and its diastereomers as methicillin potentiators against methicillin resistant Staphylococcus aureus. J. Antibiot. (Tokyo) 1997, 50, 283-285.
13. Hu, Z.Q.; Zhao, W.H.; Asano, N.; Yoda, Y.; Hara, Y.; Shimamura, T. Epigallocatechin gallate synergistically enhances the activity of carbapenems against methicillin-resistant Staphylococcus aureus. Antimicrob. Agents Chemother. 2002, 46, 558-560.
14. Shiota, S.; Shimizu, M.; Mizushima, T.; Ito, H.; Hatano, T.; Yoshida, T.; Tsuchiya, T. Marked reduction in the minimum inhibitory concentration (MIC) of beta-lactams in methicillin-resistant Staphylococcus aureus produced by epicatechin gallate, an ingredient of green tea (Camellia sinensis). Biol. Pharm. Bull. 1999, 22, 1388-1390.
15. Stapleton, P.D.; Shah, S.; Anderson, J.C.; Hara, Y.; Hamilton-Miller, J.M.; Taylor, P.W. Modulation of beta-lactam resistance in Staphylococcus aureus by catechins and gallates. Int. J. Antimicrob. Agents 2004, 23, 462-467.
16. Taylor, P.W.; Hamilton-Miller, J.M.; Stapleton, P.D. Antimicrobial properties of green tea catechins. Food Sci. Technol. Bull. 2005, 2, 71-81.
17. Pittler, M.H.; Schmidt, K.; Ernst, E. Hawthorn extract for treating chronic heart failure: Meta-Analysis of randomized trials. Am. J. Med. 2003, 114, 665-674.
18. Schüssler, M.; Hölzl, J.; Fricke, U. Myocardial effects of flavonoids from Crataegus species. Arzneimittel-Forschung 1995, 45, 842-845.
19. Schwinger, R.H.; Pietsch, M.; Frank, K.; Brixius, K. Crataegus. special extract WS 1442 increases force of contraction in human myocardium cAMP-independently. J. Cardiovasc. Pharmacol. 2000, 35, 700-707.
20. Quettier-Deleu, C.; Voiselle, G.; Fruchart, J.C.; Duriez, P.; Teissier, E.; Bailleul, F.; Vasseur, J.; Trotin, F. Hawthorn extracts inhibit LDL oxidation. Pharmazie 2003, 58, 577-581.
21. Tadić, V.M.; Dobrić, S.; Marković, G.M.; Dordević, S.M.; Arsić, I.A.; Menković, N.R.; Stević, T. Anti-Inflammatory, gastroprotective, free-radical-scavenging, and antimicrobial activities of hawthorn berries ethanol extract. J. Agric. Food Chem. 2008, 56, 7700-7709.
22. Liuji, C.; Xianqiang, Y.; Mingxiang, J. Research progress on pharmacokinetics of tea catechins. Cha Ye Ke Xue 2001, 21, 11-16.
23. Schmitz, F.J.; Fluit, A.C.; Lückefahr, M.; Engler, B.; Hofmann, B.; Verhoef, J.; Heinz, H.P.; Hadding, U.; Jones, M.E. The effect of reserpine, an inhibitor of multidrug efflux pumps, on the in vitro activities of ciprofloxacin, sparfloxacin and moxifloxacin against clinical isolates of Staphylococcus aureus. J. Antimicrob. Chemother. 1998, 42, 807-810.
24. Gibbons, S.; Udo, E.E. The effect of reserpine, a modulator of multidrug efflux pumps, on the in vitro activity of tetracycline against clinical isolates of methicillin resistant Staphylococcus aureus (MRSA) possessing the tet(K) determinant. Phytother Res. 2000, 14, 139-140.
25. Chang, Q.; Zuo, Y.; Harrison, F.; Chow, M.S. Hawthorn-An overview of chemical, pharmacological and clinical studies. J. Clin. Pharmacol. 2002, 42, 605-612.
26. Hamilton-Miller, J.M.; Shah, S. Activity of the tea component epicatechin gallate and analogues against methicillin-resistant Staphylococcus aureus. J. Antimicrob. Chemother. 2000, 46, 852-853.
27. Zhao, W.H.; Hu, Z.Q.; Okubo, S.; Hara, Y.; Shimamura, T. Mechanism of synergy between epigallocatechin gallate and β-lactams against methicillin-resistant Staphylococcus aureus. Antimicrob. Agents Chemother. 2001, 45, 1737-1742.
28. Stapleton, P.D.; Shah, S.; Hara, Y.; Taylor, P.W. Potentiation of catechin gallate-mediated sensitization of Staphylococcus aureus to oxacillin by nongalloylated catechins. Antimicrob. Agents Chemother. 2006, 50, 752-755.
29. Qidong, Y.; Guoqiang, L. Chiral Drugs: Research and Evaluation; Chemical Industry Press: Beijing, China, 2011.
30. Stapleton, P.D.; Shah, S.; Ehlert, K.; Hara, Y.; Taylor, P.W. The beta-lactam-resistance modifier (-)-epicatechin gallate alters the architecture of the cell wall of Staphylococcus aureus. Microbiology 2007, 153, 2093-2103.
31. Bernal, P.; Lemaire, S.; Pinho, M.G.; Mobashery, S.; Hinds, J.; Taylor, P.W. Insertion of epicatechin gallate into the cytoplasmic membrane of methicillin-resistant Staphylococcus aureus disrupts penicillin-binding protein (PBP) 2a-mediated beta-lactam resistance by delocalizing PBP2. J. Biol. Chem. 2010, 285, 24055-24065.
32. Kosmidis, C.; Schindler, B.D.; Jacinto, P.L.; Patel, D.; Bains, K.; Seo, S.M.; Kaatz, G.W. Expression of multidrug resistance efflux pump genes in clinical and environmental isolates of Staphylococcus aureus. Int. J. Antimicrob. Agents 2012, 40, 204-209.
33. Truong-Bolduc, Q.C.; Hooper, D.C. The transcriptional regulators NorG and MgrA modulate resistance to both quinolones and beta-lactams in Staphylococcus aureus. J. Bacteriol. 2007, 189, 2996-3005.
34. DeMarco, C.E.; Cushing, L.A.; Frempong-Manso, E.; Seo, S.M.; Jaravaza, T.A.; Kaatz, G.W. Efflux-Related resistance to norfloxacin, dyes, and biocides in bloodstream isolates of Staphylococcus aureus. Antimicrob. Agents Chemother. 2007, 51, 3235-3239.
35. Gibbons, S.; Moser, E.; Kaatz, G.W. Catechin gallates inhibit multidrug resistance (MDR) in Staphylococcus aureus. Planta. Med. 2004, 70, 1240-1242.
36. Odds, F.C. Synergy, antagonism, and what the chequerboard puts between them. J. Antimicrob. Chemother. 2003, 52, 1.
37. Hou, Z.; Meng, J.R.; Zhao, J.R.; Hu, B.Q.; Liu, J.; Yan, X.J.; Jia, M.; Luo, X.X. Inhibition of beta-lactamase-mediated oxacillin resistance in Staphylococcus aureus by a deoxyribozyme. Acta Pharmacol. Sin. 2007, 28, 1775-1782.