IFN-γ induces lipogenesis in mouse mesangial cells via the JAK2/STAT1 pathway

American Journal of Physiology - Cell Physiology

Volumn 304, Issue 8, 2013, Pages

  Hao, Jun ^a   Zhang, Yu Jun ^a,b   Lv, Xin ^a   Xu, Ning ^a   Liu, Qin Juan ^a   Zhao, Song ^a   Feng, Xiao Juan ^a   Xing, Ling Ling ^a   Kang, Peng Peng ^a   Li, Gui Ying ^a   Liu, Shu Xia ^a  

^a HEBEI MEDICAL UNIVERSITY   (China)

^b Law College Shijiazhuang   (China)

Author keywords

HMGB1; IFN ; JAK2 STAT1; Lipid deposition; SREBP 1

Indexed keywords

FATTY ACID SYNTHASE; GAMMA INTERFERON; HIGH MOBILITY GROUP B1 PROTEIN; JANUS KINASE 2; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; STAT1 PROTEIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRIACYLGLYCEROL;

ARTICLE; DRUG MECHANISM; LIPID STORAGE; LIPOGENESIS; MESANGIUM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING;

ANIMALS; CELL LINE; HMGB1 PROTEIN; INTERFERON-GAMMA; JANUS KINASE 2; LIPOGENESIS; MESANGIAL CELLS; MICE; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR;

EID: 84878631286     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00352.2012     Document Type: Article

References (29)

1. Arora V, Verma J, Marwah V, Kumar A, Anand D, Das N. Cytokine imbalance in systemic lupus erythematosus: a study on northern Indian subjects. Lupus 21: 596-603, 2012.
2. Bennemann K, Galm O, Wilop S, Schubert C, Bruemmendorf TH, Jost E. Epigenetic dysregulation of secreted frizzled-related proteins in myeloproliferative neoplasms complements the JAK2V617F-mutation. Clin Epigenetics 4: 12, 2012.
3. Borba EF, Bonfa E. Dyslipoproteinemias in systemic lupus erythematosus: influence of disease, activity, and anticardiolipin antibodies. Lupus 6: 533-539, 1997.
4. Cambi GE, Lucchese G, Djeokeng MM, Modesti A, Fiaschi T, Fag-gian G, Sani G, Modesti PA. Impaired JAK2-induced activation of STAT3 in failing human myocytes. Mol Biosyst 8: 2351-2359, 2012.
5. Czura CJ, Yang H, Tracey KJ. High mobility group box-1 as a therapeutic target downstream of tumor necrosis factor. J Infect Dis 187, Suppl 2: S391-396, 2003.
6. Darnell JE Jr. STATs and gene regulation. Science 277: 1630-1635, 1997.
7. de Carvalho JF, Bonfa E, Borba EF. Systemic lupus erythematosus and lupus dyslipoproteinemia. Autoimmun Rev 7: 246-250, 2008.
8. Feng X, Hao J, Liu Q, Yang L, Lv X, Zhang Y, Xing L, Xu N, Liu S. HMGB1 mediates IFN-gamma-induced cell proliferation in MMC cells through regulation of cyclin Dl/CDK4/pl6 pathway. J. Cell Biochem 113: 2009-2019, 2012.
9. Hao J, Liu SX, Zhao S, Liu QJ, Liu W, Duan HJ. High-fat diet causes increased serum insulin and glucose which synergistically lead to renal tubular lipid deposition and extracellular matrix accumulation. Br J Nutr 107: 74-85, 2012.
10. Hao J, Zhu L, Zhao S, Liu S, Liu Q, Duan H. PTEN ameliorates high glucose-induced lipid deposits through regulating SREBP-1/FASN/ACC pathway in renal proximal tubular cells. Exp Cell Res 317: 1629-1639, 2011.
11. Hua X, Su J, Svenungsson E, Jensen-Urstad K, Angelin B, Bävenholm P, Frostegärd J. Dyslipidaemia and lipoprotein pattern in systemic lupus erythematosus (SLE) and SLE-related cardiovascular disease. Scand J Rheumatol 38: 184-189, 2009.
12. Johnson HM, Noon-Song E, Ahmed CM. Controlling nuclear Jaks and Stats for specific gene activation by Ifn gamma and other cytokines: a possible steroid-like connection. J. Clin Cell Immunol 2: pii: 1000112, OhKI.
13. Kim JH, Kim SJ, Lee IS, Lee MS, Uematsu S, Akira S, Oh KI. Bacterial endotoxin induces the release of high mobility group box 1 via the IFN-beta signaling pathway. J Immunol 182: 2458-2466, 2009.
14. Kondo S, Yoshizawa N, Oshima S, Takeuchi A, Kubota T, Oshikawa Y, Oda T, Akashi Y, Suzuki Y, Simizu E. The effect of abnormal lipid metabolism to glomerular injury. Nihon Jinzo Gakkai Shi 33: 659-664, 1991.
15. Kuniyasu H, Yano S, Sasaki T, Sasahira T, Sone S, Ohmori H. Colon cancer cell-derived high mobility group 1/amphoterin induces growth inhibition and apoptosis in macrophages. Am J Pathol 166: 751-760, 2005.
16. Kutty RK, Nagineni CN, Samuel W, Vijayasarathy C, Hooks JJ, Redmond TM. Inflammatory cytokines regulate microRNA-155 expression in human retinal pigment epithelial cells by activating JAK/STAT pathway. Biochem Biophys Res Commun 402: 390-395, 2010.
17. Najima Y, Yahagi N, Takeuchi Y, Matsuzaka T, Sekiya M, Nakagawa Y, Amemiya-Kudo M, Okazaki H, Okazaki S, Tamura Y, Iizuka Y, Ohashi K, Harada K, Gotoda T, Nagai R, Kadowaki T, Ishibashi S, Yamada N, Osuga J, Shimano H. High mobility group protein-Bl interacts with sterol regulatory element-binding proteins to enhance their DNA binding. J. Biol Chem 280: 27523-27532, 2005.
18. Perry D, Sang A, Yin Y, Zheng YY, Morel L. Muiine models of systemic lupus erythematosus. J Biomed Biotechnol 2011: 271694, 2011.
19. Pisetsky DS, Erlandsson-Harris H, Andersson U. High-mobility group box protein 1 (HMGB1): an alarmin mediating the pathogenesis of rheumatic disease. Arthritis Res Ther 10: 209, 2008.
20. Schindler C, Levy DE, Decker T. JAK-STAT signaling: from interferons to cytokines. J Biol Chem 282: 20059-20063, 2007.
21. Schindler C, Strehlow I. Cytokines and STAT signaling. Adv Pharmacol 47: 113-174, 2000.
22. Segal R, Dayan M, Globerson A, Habut B, Shearer GM, Mozes E. Effect of aging on cytokine production in normal and experimental systemic lupus erythematosus afflicted mice. Mech Ageing Dev 96: 47-58, 1997.
23. Sheu ML, Chao KF, Sung YJ, Lin WW, Lin-Shiau SY, Liu SH. Activation of phosphoinositide 3-kinase in response to inflammation and nitric oxide leads to the upregulation of cyclooxygenase-2 expression and subsequent cell proliferation in mesangial cells. Cell Signal 17: 975-998, 2005.
24. Sun L, Halaihel N, Weiping, W, Rogers T, Levi M. Role of sterol regulatory element-binding protein 1 in regulation of renal lipid metabolism and glomemlosclerosis in diabetes mellitus. J Biol Chem 277: 18919-18927, 2002.
25. Svenungsson E, Gunnarsson I, Fei GZ, Lundberg IE, Klareskog L, Frostegärd J. Elevated triglycerides and low levels of high-density lipoprotein as markers of disease activity in association with upregulation of the tumor necrosis factor alpha/tumor necrosis factor receptor system in systemic lupus erythematosus. Arthritis Rheum 48: 2533-2540, 2003.
26. Telles R, Lanna C, Ferreira G, Ribeiro A. Metabolic syndrome in patients with systemic lupus erythematosus: association with traditional risk factors for coronary heart disease and lupus characteristics. Lupus 19: 803-809, 2010.
27. Winter N, Meyer A, Richter A, Krisponeit D, Bullerdiek J. Elevated levels of HMGB1 in cancerous and inflammatory effusions. Anticancer Res 29: 5013-5017, 2009.
28. Xing Q, Wang B, Su H, Cui J, Li J. Elevated Thl7 cells are accompanied by FoxP3+ Treg cells decrease in patients with lupus nephritis. Rheumatol Int 32: 949-958, 2012.
29. Yoshizaki A, Komura K, Iwata Y, Ogawa F, Hara T, Muroi E, Takenaka M, Shimizu K, Hasegawa M, Fujimoto M, Sato S. Clinical significance of serum HMGB-1 and sRAGE levels in systemic sclerosis: association with disease severity. J. Clin Immunol 29: 180-189, 2009.