메뉴 건너뛰기




Volumn 30, Issue 6, 2013, Pages 447-458

Decitabine: A review of its use in older patients with acute myeloid leukaemia

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; ANTIBIOTIC AGENT; ANTIFUNGAL AGENT; CYTARABINE; INFUSION FLUID;

EID: 84878628126     PISSN: 1170229X     EISSN: 11791969     Source Type: Journal    
DOI: 10.1007/s40266-013-0084-x     Document Type: Review
Times cited : (17)

References (60)
  • 1
    • 80051976690 scopus 로고    scopus 로고
    • Acute myeloid leukaemia: Optimal management of acute myeloid leukaemia and recent developments
    • 21861539 10.2165/11593060-000000000-00000 1:CAS:528:DC%2BC3MXhsVKhu7zK
    • Villela L, Bolanos-Meade J. Acute myeloid leukaemia: optimal management of acute myeloid leukaemia and recent developments. Drugs. 2011;71(2):1537-50.
    • (2011) Drugs , vol.71 , Issue.2 , pp. 1537-1550
    • Villela, L.1    Bolanos-Meade, J.2
  • 2
    • 70349256226 scopus 로고    scopus 로고
    • The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: Rationale and important changes
    • 19357394 10.1182/blood-2009-03-209262 1:CAS:528:DC%2BD1MXps1eit70%3D
    • Vardiman JW, Thiele J, Arber DA, et al. The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes. Blood. 2009;114(5):937-51.
    • (2009) Blood , vol.114 , Issue.5 , pp. 937-951
    • Vardiman, J.W.1    Thiele, J.2    Arber, D.A.3
  • 3
    • 79952945610 scopus 로고    scopus 로고
    • National Cancer Institute Accessed 20 Dec 2012
    • National Cancer Institute. SEER stat fact sheets: acute myeloid leukemia. 2012. http://seer.cancer.gov/statfacts/html/amyl.html. Accessed 20 Dec 2012.
    • (2012) SEER Stat Fact Sheets: Acute Myeloid Leukemia
  • 4
    • 77954317788 scopus 로고    scopus 로고
    • Acute myeloblastic leukaemias and myelodysplastic syndromes in adult patients: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
    • 20555069 10.1093/annonc/mdq179
    • Fey MF, Dreyling M. Acute myeloblastic leukaemias and myelodysplastic syndromes in adult patients: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2010;21(Suppl. 5):v158-61.
    • (2010) Ann Oncol , vol.21 , Issue.SUPPL.. 5
    • Fey, M.F.1    Dreyling, M.2
  • 5
    • 77449159028 scopus 로고    scopus 로고
    • Diagnosis and management of acute myeloid leukemia in adults: Recommendations from an international expert panel, on behalf of the European LeukemiaNet
    • 19880497 10.1182/blood-2009-07-235358
    • Dohner H, Estey EH, Amadori S, et al. Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet. Blood. 2010;115(3):453-74.
    • (2010) Blood , vol.115 , Issue.3 , pp. 453-474
    • Dohner, H.1    Estey, E.H.2    Amadori, S.3
  • 6
    • 79951535539 scopus 로고    scopus 로고
    • Acute myeloid leukaemia in the elderly: A review
    • 21314823 10.1111/j.1365-2141.2010.08470.x
    • Pollyea DA, Kohrt HE, Medeiros BC. Acute myeloid leukaemia in the elderly: a review. Br J Haematol. 2011;152(5):524-42.
    • (2011) Br J Haematol , vol.152 , Issue.5 , pp. 524-542
    • Pollyea, D.A.1    Kohrt, H.E.2    Medeiros, B.C.3
  • 8
    • 33646404606 scopus 로고    scopus 로고
    • Age and acute myeloid leukemia
    • 16455952 10.1182/blood-2005-09-3724 1:CAS:528:DC%2BD28Xkt1GitL8%3D
    • Appelbaum FR, Gundacker H, Head DR, et al. Age and acute myeloid leukemia. Blood. 2006;107(9):3481-5.
    • (2006) Blood , vol.107 , Issue.9 , pp. 3481-3485
    • Appelbaum, F.R.1    Gundacker, H.2    Head, D.R.3
  • 9
    • 0037158110 scopus 로고    scopus 로고
    • The outcomes and costs of acute myeloid leukemia among the elderly
    • 12123403 10.1001/archinte.162.14.1597
    • Menzin J, Lang K, Earle CC, et al. The outcomes and costs of acute myeloid leukemia among the elderly. Arch Intern Med. 2002;162(14):1597-603.
    • (2002) Arch Intern Med , vol.162 , Issue.14 , pp. 1597-1603
    • Menzin, J.1    Lang, K.2    Earle, C.C.3
  • 10
    • 84861441484 scopus 로고    scopus 로고
    • Azacitidine: A review of its use in the management of myelodysplastic syndromes/acute myeloid leukaemia
    • 22571445 10.2165/11209430-000000000-00000 1:CAS:528:DC%2BC38XhtVOmu7vN
    • Keating GM. Azacitidine: a review of its use in the management of myelodysplastic syndromes/acute myeloid leukaemia. Drugs. 2012;72(8):1111-36.
    • (2012) Drugs , vol.72 , Issue.8 , pp. 1111-1136
    • Keating, G.M.1
  • 11
    • 84869220154 scopus 로고    scopus 로고
    • The role of decitabine for the treatment of acute myeloid leukemia
    • 23115225 10.1345/aph.1R151 1:CAS:528:DC%2BC38XhvVKrtLvL
    • Ganetsky A. The role of decitabine for the treatment of acute myeloid leukemia. Ann Pharmacother. 2012;46(11):1511-7.
    • (2012) Ann Pharmacother , vol.46 , Issue.11 , pp. 1511-1517
    • Ganetsky, A.1
  • 12
    • 0023270085 scopus 로고
    • Hypermethylation of the 5' region of the calcitonin gene is a property of human lymphoid and acute myeloid malignancies
    • 3607279 1:CAS:528:DyaL2sXlvFajurY%3D
    • Baylin SB, Fearon ER, Vogelstein B, et al. Hypermethylation of the 5' region of the calcitonin gene is a property of human lymphoid and acute myeloid malignancies. Blood. 1987;70(2):412-7.
    • (1987) Blood , vol.70 , Issue.2 , pp. 412-417
    • Baylin, S.B.1    Fearon, E.R.2    Vogelstein, B.3
  • 13
    • 84856720426 scopus 로고    scopus 로고
    • CpG methylation patterns and decitabine treatment response in acute myeloid leukemia cells and normal hematopoietic precursors
    • 21836612 10.1038/leu.2011.207 1:CAS:528:DC%2BC38XitFGgtbs%3D
    • Negrotto S, Ng KP, Jankowska AM, et al. CpG methylation patterns and decitabine treatment response in acute myeloid leukemia cells and normal hematopoietic precursors. Leukemia. 2012;26(2):244-54.
    • (2012) Leukemia , vol.26 , Issue.2 , pp. 244-254
    • Negrotto, S.1    Ng, K.P.2    Jankowska, A.M.3
  • 14
    • 0000929806 scopus 로고
    • Synthesis of 2'-deoxy-d-ribofuranosyl-5-azacytosine
    • 1:CAS:528:DyaF2cXkvFals70%3D
    • Pliml J, Sorm K. Synthesis of 2'-deoxy-d-ribofuranosyl-5-azacytosine. Coll Czeck Chem Commun. 1964;29:2576-7.
    • (1964) Coll Czeck Chem Commun , vol.29 , pp. 2576-2577
    • Pliml, J.1    Sorm, K.2
  • 15
    • 33744928876 scopus 로고    scopus 로고
    • Decitabine: In myelodysplastic syndromes
    • 16740014 10.2165/00003495-200666070-00011 1:CAS:528:DC%2BD28Xnt1Cmtbw%3D
    • McKeage K, Croom KF. Decitabine: in myelodysplastic syndromes. Drugs. 2006;66(7):951-8.
    • (2006) Drugs , vol.66 , Issue.7 , pp. 951-958
    • McKeage, K.1    Croom, K.F.2
  • 16
    • 84901253654 scopus 로고    scopus 로고
    • European Medicines Agency Accessed 8 Feb 2013
    • European Medicines Agency. Dacogen (decitabine): summary of product characteristics. 2012. http://www.ema.europa.eu/docs/en-GB/document-library/ EPAR-Product-Information/human/002221/WC500133569.pdf. Accessed 8 Feb 2013.
    • (2012) Dacogen (Decitabine): Summary of Product Characteristics
  • 17
    • 77749302093 scopus 로고    scopus 로고
    • A comparison of azacitidine and decitabine activities in acute myeloid leukemia cell lines
    • 2 Feb 2010. doi: 10.1371/journal.pone.0009001
    • Hollenbach PW, Nguyen AN, Brady H, et al. A comparison of azacitidine and decitabine activities in acute myeloid leukemia cell lines. PLoS ONE. 2 Feb 2010. doi: 10.1371/journal.pone.0009001.
    • PLoS ONE.
    • Hollenbach, P.W.1    Nguyen, A.N.2    Brady, H.3
  • 18
    • 84866551964 scopus 로고    scopus 로고
    • Genome-wide methylation profiling in decitabine-treated patients with acute myeloid leukemia
    • 22786882 10.1182/blood-2012-05-429175 1:CAS:528:DC%2BC38XhsVKiu73L
    • Yan P, Frankhouser D, Murphy M, et al. Genome-wide methylation profiling in decitabine-treated patients with acute myeloid leukemia. Blood. 2012;120(12):2466-74.
    • (2012) Blood , vol.120 , Issue.12 , pp. 2466-2474
    • Yan, P.1    Frankhouser, D.2    Murphy, M.3
  • 19
    • 84868593424 scopus 로고    scopus 로고
    • The DNA demethylating agent decitabine activates the TRAIL pathway and induces apoptosis in acute myeloid leukemia
    • 23046813 10.1016/j.bbadis.2012.10.001 1:CAS:528:DC%2BC38Xhslymsb7E
    • Soncini M, Santoro F, Gutierrez A, et al. The DNA demethylating agent decitabine activates the TRAIL pathway and induces apoptosis in acute myeloid leukemia. Biochim Biophys Acta. 2013;1832(1):114-20.
    • (2013) Biochim Biophys Acta , vol.1832 , Issue.1 , pp. 114-120
    • Soncini, M.1    Santoro, F.2    Gutierrez, A.3
  • 20
    • 84863337757 scopus 로고    scopus 로고
    • Transient low doses of DNA-demethylating agents exert durable antitumor effects on hematological and epithelial tumor cells
    • 22439938 10.1016/j.ccr.2011.12.029 1:CAS:528:DC%2BC38Xkt1ygt7o%3D
    • Tsai HC, Li H, Van Neste L, et al. Transient low doses of DNA-demethylating agents exert durable antitumor effects on hematological and epithelial tumor cells. Cancer Cell. 2012;21(3):430-46.
    • (2012) Cancer Cell , vol.21 , Issue.3 , pp. 430-446
    • Tsai, H.C.1    Li, H.2    Van Neste, L.3
  • 21
    • 84876444289 scopus 로고    scopus 로고
    • Genomic impact of transient low-dose decitabine treatment on primary AML cells
    • Klco JM, Spencer DH, Lamprecht TL, et al. Genomic impact of transient low-dose decitabine treatment on primary AML cells. Blood. 2013;121(9):1633-43.
    • (2013) Blood , vol.121 , Issue.9 , pp. 1633-1643
    • Klco, J.M.1    Spencer, D.H.2    Lamprecht, T.L.3
  • 22
    • 77955170877 scopus 로고    scopus 로고
    • Therapy with azanucleosides for myelodysplastic syndromes
    • 20551943 10.1038/nrclinonc.2010.87 1:CAS:528:DC%2BC3cXpsVCltr4%3D
    • Quintas-Cardama A, Santos FP, Garcia-Manero G. Therapy with azanucleosides for myelodysplastic syndromes. Nat Rev Clin Oncol. 2010;7(8):433-44.
    • (2010) Nat Rev Clin Oncol , vol.7 , Issue.8 , pp. 433-444
    • Quintas-Cardama, A.1    Santos, F.P.2    Garcia-Manero, G.3
  • 23
    • 67349200930 scopus 로고    scopus 로고
    • The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells
    • 19194470 10.1038/leu.2008.397 1:CAS:528:DC%2BD1MXntFygtLo%3D
    • Flotho C, Claus R, Batz C, et al. The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells. Leukemia. 2009;23(6):1019-28.
    • (2009) Leukemia , vol.23 , Issue.6 , pp. 1019-1028
    • Flotho, C.1    Claus, R.2    Batz, C.3
  • 24
    • 80052775248 scopus 로고    scopus 로고
    • Transformation-dependent silencing of tumor-selective apoptosis-inducing TRAIL by DNA hypermethylation is antagonized by decitabine
    • 21697397 10.1158/1535-7163.MCT-11-0140 1:CAS:528:DC%2BC3MXhtFCjurjE
    • Lund P, Kotova I, Kedinger V, et al. Transformation-dependent silencing of tumor-selective apoptosis-inducing TRAIL by DNA hypermethylation is antagonized by decitabine. Mol Cancer Ther. 2011;10(9):1611-23.
    • (2011) Mol Cancer Ther , vol.10 , Issue.9 , pp. 1611-1623
    • Lund, P.1    Kotova, I.2    Kedinger, V.3
  • 25
    • 0021160287 scopus 로고
    • 5-Aza-2'-deoxycytidine induces terminal differentiation of leukemic blasts from patients with acute myeloid leukemias
    • 6206904 1:CAS:528:DyaL2cXmtVCjs78%3D
    • Pinto A, Attadia V, Fusco A, et al. 5-Aza-2'-deoxycytidine induces terminal differentiation of leukemic blasts from patients with acute myeloid leukemias. Blood. 1984;64(4):922-9.
    • (1984) Blood , vol.64 , Issue.4 , pp. 922-929
    • Pinto, A.1    Attadia, V.2    Fusco, A.3
  • 26
    • 21844466446 scopus 로고    scopus 로고
    • Pharmacology of 5-aza-2'-deoxycytidine (decitabine)
    • 16015507 10.1053/j.seminhematol.2005.05.002 1:CAS:528: DC%2BD2MXpsFekt7c%3D
    • Momparler RL. Pharmacology of 5-aza-2'-deoxycytidine (decitabine). Semin Hematol. 2005;42(Suppl. 2):S9-16.
    • (2005) Semin Hematol , vol.42 , Issue.SUPPL.. 2
    • Momparler, R.L.1
  • 27
    • 0035132573 scopus 로고    scopus 로고
    • Induction of MAGE-3 expression in lung and esophageal cancer cells
    • 11216765 10.1016/S0003-4975(00)02421-8 1:STN:280:DC%2BD3M7kvFyitw%3D%3D
    • Weiser TS, Ohnmacht GA, Guo ZS, et al. Induction of MAGE-3 expression in lung and esophageal cancer cells. Ann Thorac Surg. 2001;71(1):295-301.
    • (2001) Ann Thorac Surg , vol.71 , Issue.1 , pp. 295-301
    • Weiser, T.S.1    Ohnmacht, G.A.2    Guo, Z.S.3
  • 28
    • 0038142344 scopus 로고    scopus 로고
    • 5-Aza-2'-deoxycytidine (decitabine) treatment of hematopoietic malignancies: A multimechanism therapeutic approach?
    • 12756166 10.1182/blood-2002-11-3458 1:CAS:528:DC%2BD3sXktFKgs70%3D
    • Sigalotti L, Altomonte M, Colizzi F, et al. 5-Aza-2'-deoxycytidine (decitabine) treatment of hematopoietic malignancies: a multimechanism therapeutic approach? Blood. 2003;101(11):4644-6.
    • (2003) Blood , vol.101 , Issue.11 , pp. 4644-4646
    • Sigalotti, L.1    Altomonte, M.2    Colizzi, F.3
  • 29
    • 60249094793 scopus 로고    scopus 로고
    • Mechanisms of resistance to 5-aza-2'-deoxycytidine in human cancer cell lines
    • 18931345 10.1182/blood-2008-02-140038 1:CAS:528:DC%2BD1MXht1Wnsb8%3D
    • Qin T, Jelinek J, Si J, et al. Mechanisms of resistance to 5-aza-2'-deoxycytidine in human cancer cell lines. Blood. 2009;113(3):659-67.
    • (2009) Blood , vol.113 , Issue.3 , pp. 659-667
    • Qin, T.1    Jelinek, J.2    Si, J.3
  • 30
    • 0017749468 scopus 로고
    • Incorporation of a potent antileukemic agent, 5-aza-2'-deoxycytidine, into DNA of cells from leukemic mice
    • 71199 1:CAS:528:DyaE1cXhsF2jsg%3D%3D
    • Vesely J, Cihak A. Incorporation of a potent antileukemic agent, 5-aza-2'-deoxycytidine, into DNA of cells from leukemic mice. Cancer Res. 1977;37(10):3684-9.
    • (1977) Cancer Res , vol.37 , Issue.10 , pp. 3684-3689
    • Vesely, J.1    Cihak, A.2
  • 31
    • 0022870355 scopus 로고
    • Antagonism of 5-aza-2'-deoxycytidine antileukemic activity by concomitant treatment with cytarabine
    • 2431776 1:CAS:528:DyaL2sXht1emtw%3D%3D
    • Colombo T, Rossi C, D'Incalci M. Antagonism of 5-aza-2'-deoxycytidine antileukemic activity by concomitant treatment with cytarabine. Cancer Treat Rep. 1986;70(12):1451-3.
    • (1986) Cancer Treat Rep , vol.70 , Issue.12 , pp. 1451-1453
    • Colombo, T.1    Rossi, C.2    D'Incalci, M.3
  • 32
    • 0024240504 scopus 로고
    • Comparison of the antileukaemic activity of 5 aza-2-deoxycytidine and arabinofuranosyl-cytosine in rats with myelocytic leukaemia
    • 2465015 10.1038/bjc.1988.298 1:CAS:528:DyaL1MXhtVOktrg%3D
    • Richel DJ, Colly LP, Lurvink E, et al. Comparison of the antileukaemic activity of 5 aza-2-deoxycytidine and arabinofuranosyl-cytosine in rats with myelocytic leukaemia. Br J Cancer. 1988;58(6):730-3.
    • (1988) Br J Cancer , vol.58 , Issue.6 , pp. 730-733
    • Richel, D.J.1    Colly, L.P.2    Lurvink, E.3
  • 33
    • 84860772157 scopus 로고    scopus 로고
    • DNMT3A mutations and response to the hypomethylating agent decitabine in acute myeloid leukemia
    • 22124213 10.1038/leu.2011.342 1:CAS:528:DC%2BC38XmvFemsL0%3D
    • Metzeler KH, Walker A, Geyer S, et al. DNMT3A mutations and response to the hypomethylating agent decitabine in acute myeloid leukemia. Leukemia. 2012;26(5):1106-7.
    • (2012) Leukemia , vol.26 , Issue.5 , pp. 1106-1107
    • Metzeler, K.H.1    Walker, A.2    Geyer, S.3
  • 34
    • 77952140672 scopus 로고    scopus 로고
    • Clinical response and miR-29b predictive significance in older AML patients treated with a 10-day schedule of decitabine
    • 20368434 10.1073/pnas.1002650107 1:CAS:528:DC%2BC3cXlsFWhsbk%3D
    • Blum W, Garzon R, Klisovic RB, et al. Clinical response and miR-29b predictive significance in older AML patients treated with a 10-day schedule of decitabine. Proc Natl Acad Sci USA. 2010;107(16):7473-8.
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.16 , pp. 7473-7478
    • Blum, W.1    Garzon, R.2    Klisovic, R.B.3
  • 35
    • 84869095050 scopus 로고    scopus 로고
    • A randomized study of decitabine versus conventional care for maintenance therapy in patients with acute myeloid leukemia in complete remission
    • 22665218 10.1038/leu.2012.153 1:CAS:528:DC%2BC38Xhs1Giur%2FN
    • Boumber Y, Kantarjian H, Jorgensen J, et al. A randomized study of decitabine versus conventional care for maintenance therapy in patients with acute myeloid leukemia in complete remission. Leukemia. 2012;26(11):2428-31.
    • (2012) Leukemia , vol.26 , Issue.11 , pp. 2428-2431
    • Boumber, Y.1    Kantarjian, H.2    Jorgensen, J.3
  • 36
    • 84857747740 scopus 로고    scopus 로고
    • A multicenter phase II trial of decitabine as first-line treatment for older patients with acute myeloid leukemia judged unfit for induction chemotherapy
    • 22058219 10.3324/haematol.2011.048231
    • Lubbert M, Ruter BH, Claus R, et al. A multicenter phase II trial of decitabine as first-line treatment for older patients with acute myeloid leukemia judged unfit for induction chemotherapy. Haematologica. 2012;97(3):393-401.
    • (2012) Haematologica , vol.97 , Issue.3 , pp. 393-401
    • Lubbert, M.1    Ruter, B.H.2    Claus, R.3
  • 37
    • 34548529948 scopus 로고    scopus 로고
    • Phase i study of decitabine alone or in combination with valproic acid in acute myeloid leukemia
    • 17679729 10.1200/JCO.2006.09.4169 1:CAS:528:DC%2BD2sXhtFanu7zF
    • Blum W, Klisovic RB, Hackanson B, et al. Phase I study of decitabine alone or in combination with valproic acid in acute myeloid leukemia. J Clin Oncol. 2007;25(25):3884-91.
    • (2007) J Clin Oncol , vol.25 , Issue.25 , pp. 3884-3891
    • Blum, W.1    Klisovic, R.B.2    Hackanson, B.3
  • 38
    • 84864063679 scopus 로고    scopus 로고
    • Multicenter, randomized, open-label, phase III trial of decitabine versus patient choice, with physician advice, of either supportive care or low-dose cytarabine for the treatment of older patients with newly diagnosed acute myeloid leukemia
    • 22689805 10.1200/JCO.2011.38.9429 1:CAS:528:DC%2BC38Xht1ygsr%2FI
    • Kantarjian HM, Thomas XG, Dmoszynska A, et al. Multicenter, randomized, open-label, phase III trial of decitabine versus patient choice, with physician advice, of either supportive care or low-dose cytarabine for the treatment of older patients with newly diagnosed acute myeloid leukemia. J Clin Oncol. 2012;30(21):2670-7.
    • (2012) J Clin Oncol , vol.30 , Issue.21 , pp. 2670-2677
    • Kantarjian, H.M.1    Thomas, X.G.2    Dmoszynska, A.3
  • 39
    • 77449149374 scopus 로고    scopus 로고
    • Multicenter, phase II study of decitabine for the first-line treatment of older patients with acute myeloid leukemia
    • 20026803 10.1200/JCO.2009.23.9178 1:CAS:528:DC%2BC3cXisVGgtLY%3D
    • Cashen AF, Schiller GJ, O'Donnell MR, et al. Multicenter, phase II study of decitabine for the first-line treatment of older patients with acute myeloid leukemia. J Clin Oncol. 2010;28(4):556-61.
    • (2010) J Clin Oncol , vol.28 , Issue.4 , pp. 556-561
    • Cashen, A.F.1    Schiller, G.J.2    O'Donnell, M.R.3
  • 40
    • 84973869862 scopus 로고    scopus 로고
    • European Medicines Agency Accessed 12 Feb 2013
    • European Medicines Agency. Dacogen: European public assessment report. 2012. http://www.ema.europa.eu/docs/en-GB/document-library/EPAR-Public- assessment-report/human/002221/WC500133571.pdf. Accessed 12 Feb 2013.
    • Dacogen: European public assessment report. 2012
  • 41
    • 1542753559 scopus 로고    scopus 로고
    • Revised recommendations of the international working group for diagnosis, standardization of response criteria, treatment outcomes, and reporting standards for therapeutic trials in acute myeloid leukemia
    • 14673054 10.1200/JCO.2003.04.036
    • Cheson BD, Bennett JM, Kopecky KJ, et al. Revised recommendations of the international working group for diagnosis, standardization of response criteria, treatment outcomes, and reporting standards for therapeutic trials in acute myeloid leukemia. J Clin Oncol. 2003;21(24):4642-9.
    • (2003) J Clin Oncol , vol.21 , Issue.24 , pp. 4642-4649
    • Cheson, B.D.1    Bennett, J.M.2    Kopecky, K.J.3
  • 42
    • 85081780454 scopus 로고    scopus 로고
    • A post hoc landmark analysis of survival probabilities in a multinational phase III trial of decitabine in older patients with newly diagnosed acute myeloid leukemia [abstract no. 3623]
    • Atlanta, GA; 8-11 Dec 2012
    • Thomas X, Arthur C, Delaunay J, et al. A post hoc landmark analysis of survival probabilities in a multinational phase III trial of decitabine in older patients with newly diagnosed acute myeloid leukemia [abstract no. 3623]. 54th American Society of Hematology Annual Meeting and Exposition, Atlanta, GA; 8-11 Dec 2012.
    • 54th American Society of Hematology Annual Meeting and Exposition
    • Thomas, X.1    Arthur, C.2    Delaunay, J.3
  • 43
    • 85081785611 scopus 로고    scopus 로고
    • Multivariate and subgroup analyses of a multinational phase III trial of decitabine in older patients with newly diagnosed acute myeloid leukemia [abstract no. 3618]
    • Atlanta, GA; 8-11 Dec 2012
    • Mayer J, Arthur C, Delaunay J, et al. Multivariate and subgroup analyses of a multinational phase III trial of decitabine in older patients with newly diagnosed acute myeloid leukemia [abstract no. 3618]. 54th American Society of Hematology Annual Meeting and Exposition, Atlanta, GA; 8-11 Dec 2012.
    • 54th American Society of Hematology Annual Meeting and Exposition
    • Mayer, J.1    Arthur, C.2    Delaunay, J.3
  • 44
    • 85081777926 scopus 로고    scopus 로고
    • Decitabine reduces transfusion dependence in older patients with acute myeloid leukaemia: Results from a post-hoc analysis of a randomised phase III trial
    • 10.1016/j.jval.2012.08.2161
    • Dass RN, Howes A, Spencer M, et al. Decitabine reduces transfusion dependence in older patients with acute myeloid leukaemia: results from a post-hoc analysis of a randomised phase III trial. Value Health. 2012;15(7):A431.
    • (2012) Value Health , vol.15 , Issue.7 , pp. 431
    • Dass, R.N.1    Howes, A.2    Spencer, M.3
  • 45
    • 33750148809 scopus 로고    scopus 로고
    • Guidelines on the management of acute myeloid leukaemia in adults
    • 17054678 10.1111/j.1365-2141.2006.06314.x 1:STN:280: DC%2BD28nivVOltQ%3D%3D
    • Milligan DW, Grimwade D, Cullis JO, et al. Guidelines on the management of acute myeloid leukaemia in adults. Br J Haematol. 2006;135(4):450-74.
    • (2006) Br J Haematol , vol.135 , Issue.4 , pp. 450-474
    • Milligan, D.W.1    Grimwade, D.2    Cullis, J.O.3
  • 46
    • 84867026521 scopus 로고    scopus 로고
    • Acute myeloid leukemia in older adults
    • 22791510 10.1007/s12185-012-1137-3
    • Yanada M, Naoe T. Acute myeloid leukemia in older adults. Int J Hematol. 2012;96(2):186-93.
    • (2012) Int J Hematol , vol.96 , Issue.2 , pp. 186-193
    • Yanada, M.1    Naoe, T.2
  • 47
    • 42049097308 scopus 로고    scopus 로고
    • Activity of decitabine in patients with myelodysplastic syndrome previously treated with azacitidine
    • 18398735 10.1080/10428190701882146 1:CAS:528:DC%2BD1cXksFaru7Y%3D
    • Borthakur G, Ahdab SE, Ravandi F, et al. Activity of decitabine in patients with myelodysplastic syndrome previously treated with azacitidine. Leuk Lymphoma. 2008;49(4):690-5.
    • (2008) Leuk Lymphoma , vol.49 , Issue.4 , pp. 690-695
    • Borthakur, G.1    Ahdab, S.E.2    Ravandi, F.3
  • 49
    • 85081783844 scopus 로고    scopus 로고
    • ® in acute myeloid leukemia [media release]. 10 Feb 2012
    • ® in acute myeloid leukemia [media release]. 10 Feb 2012. http://www.eisai.com/pdf/others/e20120210.pdf.
  • 50
    • 73149099172 scopus 로고    scopus 로고
    • Superior outcome with hypomethylating therapy in patients with acute myeloid leukemia and high-risk myelodysplastic syndrome and chromosome 5 and 7 abnormalities
    • 19795507 10.1002/cncr.24661 1:CAS:528:DC%2BC3cXjt1Wluw%3D%3D
    • Ravandi F, Issa JP, Garcia-Manero G, et al. Superior outcome with hypomethylating therapy in patients with acute myeloid leukemia and high-risk myelodysplastic syndrome and chromosome 5 and 7 abnormalities. Cancer. 2009;115:5746-51.
    • (2009) Cancer , vol.115 , pp. 5746-5751
    • Ravandi, F.1    Issa, J.P.2    Garcia-Manero, G.3
  • 51
    • 84857633196 scopus 로고    scopus 로고
    • Combination strategies in myelodysplastic syndromes
    • 22218883 10.1007/s12185-011-0987-4
    • Ornstein MC, Sekeres MA. Combination strategies in myelodysplastic syndromes. Int J Hematol. 2012;95(1):26-33.
    • (2012) Int J Hematol , vol.95 , Issue.1 , pp. 26-33
    • Ornstein, M.C.1    Sekeres, M.A.2
  • 52
    • 33750530675 scopus 로고    scopus 로고
    • Phase 1/2 study of the combination of 5-aza-2'-deoxycytidine with valproic acid in patients with leukemia
    • 16882711 10.1182/blood-2006-03-009142 1:CAS:528:DC%2BD28Xht1ahs7fK
    • Garcia-Manero G, Kantarjian HM, Sanchez-Gonzalez B, et al. Phase 1/2 study of the combination of 5-aza-2'-deoxycytidine with valproic acid in patients with leukemia. Blood. 2006;108(10):3271-9.
    • (2006) Blood , vol.108 , Issue.10 , pp. 3271-3279
    • Garcia-Manero, G.1    Kantarjian, H.M.2    Sanchez-Gonzalez, B.3
  • 53
    • 84862726260 scopus 로고    scopus 로고
    • Clinical and pharmacodynamic activity of bortezomib and decitabine in acute myeloid leukemia
    • 22566605 10.1182/blood-2012-03-413898 1:CAS:528:DC%2BC38XhtVGns7vK
    • Blum W, Schwind S, Tarighat SS, et al. Clinical and pharmacodynamic activity of bortezomib and decitabine in acute myeloid leukemia. Blood. 2012;119(25):6025-31.
    • (2012) Blood , vol.119 , Issue.25 , pp. 6025-6031
    • Blum, W.1    Schwind, S.2    Tarighat, S.S.3
  • 54
    • 80051801919 scopus 로고    scopus 로고
    • Combination decitabine, arsenic trioxide, and ascorbic acid for the treatment of myelodysplastic syndrome and acute myeloid leukemia: A phase i study
    • 21815182 10.1002/ajh.22092 1:CAS:528:DC%2BC3MXhtVaksLjM
    • Welch JS, Klco JM, Gao F, et al. Combination decitabine, arsenic trioxide, and ascorbic acid for the treatment of myelodysplastic syndrome and acute myeloid leukemia: a phase I study. Am J Hematol. 2011;86(9):796-800.
    • (2011) Am J Hematol , vol.86 , Issue.9 , pp. 796-800
    • Welch, J.S.1    Klco, J.M.2    Gao, F.3
  • 55
    • 85081781576 scopus 로고    scopus 로고
    • Phase 2 study of decitabine in combination with tretinoin in myelodysplastic syndromes and acute myelogenous leukemia: Interim results [abstract no. 3815]
    • Atlanta, GA; 8-11 Dec 2012
    • Klimek V, Dolezal EK, Juric JG, et al. Phase 2 study of decitabine in combination with tretinoin in myelodysplastic syndromes and acute myelogenous leukemia: interim results [abstract no. 3815]. 54th American Society of Hematology Annual Meeting and Exposition, Atlanta, GA; 8-11 Dec 2012.
    • 54th American Society of Hematology Annual Meeting and Exposition
    • Klimek, V.1    Dolezal, E.K.2    Juric, J.G.3
  • 56
    • 85081785894 scopus 로고    scopus 로고
    • Decitabine and gemtuzumab ozogamicin in acute myelogenous leukemia and high-risk myelodysplastic syndrome [abstract no. 3619]
    • Atlanta, GA; 8-11 Dec 2012
    • Daver N, Kantarjian HM, Garcia-Manero G, et al. Decitabine and gemtuzumab ozogamicin in acute myelogenous leukemia and high-risk myelodysplastic syndrome [abstract no. 3619]. 54th American Society of Hematology Annual Meeting and Exposition, Atlanta, GA; 8-11 Dec 2012.
    • 54th American Society of Hematology Annual Meeting and Exposition
    • Daver, N.1    Kantarjian, H.M.2    Garcia-Manero, G.3
  • 57
    • 84879783893 scopus 로고    scopus 로고
    • Decitabine in patients with newly diagnosed and relapsed acute myeloid leukemia
    • 7 Feb 2013. doi: 10.3109/10428194.2012.762093
    • Ritchie EK, Feldman EJ, Christos PJ, et al. Decitabine in patients with newly diagnosed and relapsed acute myeloid leukemia. Leuk Lymphoma. 7 Feb 2013. doi: 10.3109/10428194.2012.762093.
    • Leuk Lymphoma
    • Ritchie, E.K.1    Feldman, E.J.2    Christos, P.J.3
  • 58
    • 84877081295 scopus 로고    scopus 로고
    • Decitabine in patients with relapsed acute myeloid leukemia (AML) after allogeneic stem cell transplantation (allo-SCT)
    • Ganguly S, Amin M, Divine C, et al. Decitabine in patients with relapsed acute myeloid leukemia (AML) after allogeneic stem cell transplantation (allo-SCT). Ann Hematol. 2013;92(4):549-50.
    • (2013) Ann Hematol , vol.92 , Issue.4 , pp. 549-550
    • Ganguly, S.1    Amin, M.2    Divine, C.3
  • 59
    • 70749131024 scopus 로고    scopus 로고
    • Non-intensive treatment with low-dose 5-aza-2'-deoxycytidine prior to allogeneic blood SCT of older MDS/AML patients
    • 19363531 10.1038/bmt.2009.64 1:STN:280:DC%2BD1MjltVKjuw%3D%3D
    • Lubbert M, Bertz H, Ruter B, et al. Non-intensive treatment with low-dose 5-aza-2'-deoxycytidine prior to allogeneic blood SCT of older MDS/AML patients. Bone Marrow Transplant. 2009;44:585-8.
    • (2009) Bone Marrow Transplant , vol.44 , pp. 585-588
    • Lubbert, M.1    Bertz, H.2    Ruter, B.3
  • 60
    • 53549124697 scopus 로고    scopus 로고
    • Decitabine as "bridge therapy" to a MUD transplant in relapsed AML postautologous stem cell transplantation
    • 18767131 10.1002/ajh.21267
    • Ustun C, Kalla A, Farrow S, et al. Decitabine as "bridge therapy" to a MUD transplant in relapsed AML postautologous stem cell transplantation. Am J Hematol. 2008;83(10):825-7.
    • (2008) Am J Hematol , vol.83 , Issue.10 , pp. 825-827
    • Ustun, C.1    Kalla, A.2    Farrow, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.