Community-acquired Legionella Pneumonia in the intensive care unit: Impact on survival of combined antibiotic therapy

Medicina Intensiva

Volumn 37, Issue 5, 2013, Pages 320-326

  Rello, J ^a,b,c   Gattarello, S ^a   Souto, J ^a   Sole Violan, J ^b,d   Valles, J ^b,e   Peredo, R ^e   Zaragoza, R ^f   Vidaur, L ^b,g   Parra, A ^h   Roig, J ⁱ   Almirall, J ^j   Alonso, R ^k   Alvarez, B ^l   Alvarez Lerma, F ^m   Badia, J R ⁿ   Barcenilla, F ^o   Bassetti, M ^p   Blanquer, J ^q   Blasco, M A ^f   Bobillo, F ^r   Bodi, M ^h   Borges, M ^s   Bouza, E ^t   Broch, M J ^u   Carrasco, N ^v   Catalan, M ^w   de la Torre, V ^x   Diaz, E ^h   Doblas, A ^y   Fierro, J ^z   Garcia, F ^aa   Garnacho, J ^ab   Herranz, M A ^ac   Huertos, M J ^ad   Jimenez, J ^ab   Jorda, R ^ae   Koulentis, D ^af   Lopez, D ^ag   Lopez Cambra, M J ^ah   Lopez Pueyo, M J ^ai   Lores, A ^aj   Lucena, F ^ak   Luque, P ^al   Maiez, R ^aj   Maravi, E ^am   Margarit, A ^an   Martin, A ^ao   Masdeu, G ^ap   Mendia, A ^aq   Mesalles, E ^ar   Pereira, J ^as   Poulakou, G ^at   Renedo, F ^au   Ricard, J M ^av   Robles, J C ^aw   Rocha, L ^ax   Sierra, R ^ay   Sirvent, J M ^az   Sole, J ^d   Suberviola, B ^ba   Torres, A ⁿ   more..

^a HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

^c UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^d HOSPITAL UNIVERSITARIO DE GRAN CANARIA DR NEGRÍN   (Spain)

^e HOSPITAL DE SABADELL   (Spain)

^f HOSPITAL UNIVERSITARIO DR PESET   (Spain)

^g HOSPITAL DONOSTIA   (Spain)

^h HOSPITAL UNIVERSITARI JOAN XXIII   (Spain)

ⁱ HOSPITAL NOSTRA SENYORA DE MERITXELL   (Andorra)

^j Mataro Hospital   (Spain)

^k HOSPITAL UNIVERSITARIO CENTRAL DE ASTURIAS   (Spain)

^l HOSPITAL GENERAL UNIVERSITARIO DE ALICANTE   (Spain)

^m HOSPITAL DEL MAR   (Spain)

ⁿ HOSPITAL CLÍNIC   (Spain)

^o HOSPITAL ARNAU DE VILANOVA   (Spain)

^p UNIVERSITY OF GENOA   (Italy)

^q Hospital Clinic   (Spain)

^r HOSPITAL CLÍNICO UNIVERSITARIO DE VALLADOLID   (Spain)

^s HOSPITAL SON LLÀTZER   (Spain)

^t HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

^u HOSPITAL DE SAGUNTO   (Spain)

^v HOSPITAL UNIVERSITARIO DE LA PRINCESA   (Spain)

^w HOSPITAL UNIVERSITARIO 12 DE OCTUBRE   (Spain)

^x HOSPITAL UNIVERSITARIO VIRGEN DE LA VICTORIA   (Spain)

^y HOSPITAL JUAN RAMÓN JIMÉNEZ   (Spain)

^z Poniente Hospital   (Spain)

^aa HOSPITAL GENERAL UNIVERSITARIO DE ALBACETE   (Spain)

^ab HOSPITAL UNIVERSITARIO VIRGEN DEL ROCÍO   (Spain)

^ac HOSPITAL UNIVERSITARIO RÍO HORTEGA   (Spain)

^ad HOSPITAL UNIVERSITARIO DE PUERTO REAL   (Spain)

^ae HOSPITAL UNIVERSITARIO SON ESPASES   (Spain)

^af KAT HOSPITAL   (Greece)

^ag Fundacion Gimenez Diaz   (Spain)

^ah HOSPITAL GENERAL DE SEGOVIA   (Spain)

^ai HOSPITAL UNIVERSITARIO DE BURGOS   (Spain)

^aj HOSPITAL UNIVERSITARI DE BELLVITGE   (Spain)

^ak HOSPITAL UNIVERSITARIO DE VALME   (Spain)

^al HOSPITAL CLÍNICO UNIVERSITARIO LOZANO BLESA   (Spain)

^am Universidad Pública de Navarra   (Spain)

^an Virgen Meritxell Hospital   (Andorra)

^ao HOSPITAL TXAGORRITXU   (Spain)

^ap HOSPITAL VERGE DE LA CINTA   (Spain)

^aq Hospital Nuestra Senora de Aranzazu   (Spain)

^ar HOSPITAL UNIVERSITARI GERMANS TRIAS I PUJOL   (Spain)

^as HOSPITAL DE SÃO JOÃO   (Portugal)

^at NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS   (Greece)

^au Hospital de Leon   (Mexico)

^av Rotger Clinic   (Spain)

^aw HOSPITAL UNIVERSITARIO REINA SOFÍA   (Spain)

^ax HOSPITAL JUAN CANALEJO   (Spain)

^ay HOSPITAL UNIVERSITARIO PUERTA DEL MAR   (Spain)

^az HOSPITAL JOSEP TRUETA   (Spain)

^ba HOSPITAL UNIVERSITARIO MARQUÉS DE VALDECILLA   (Spain)

more..

Author keywords

Combined antibiotic therapy; Legionella pneumophila; Legionnaires' disease; Severe community acquired pneumonia

Indexed keywords

ANTIBIOTIC AGENT; CLARITHROMYCIN; LEVOFLOXACIN; RIFAMPICIN;

ADULT; AGED; ANTIBIOTIC THERAPY; ARTICLE; ARTIFICIAL VENTILATION; CLINICAL ARTICLE; COMBINATION CHEMOTHERAPY; COMMUNITY ACQUIRED PNEUMONIA; CONTROLLED STUDY; DISEASE COURSE; DISEASE SEVERITY; FEMALE; HUMAN; INTENSIVE CARE UNIT; LEGIONNAIRE DISEASE; MALE; MONOTHERAPY; MORTALITY; MULTICENTER STUDY; PRESCRIPTION; PROSPECTIVE STUDY; SHOCK; SURVIVAL;

ANTI-BACTERIAL AGENTS; COMMUNITY-ACQUIRED INFECTIONS; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; INTENSIVE CARE UNITS; LEGIONNAIRES' DISEASE; MALE; MIDDLE AGED; PNEUMONIA, BACTERIAL; PROSPECTIVE STUDIES; SURVIVAL RATE;

EID: 84878625248     PISSN: 02105691     EISSN: 15786749     Source Type: Journal    
DOI: 10.1016/j.medin.2012.05.010     Document Type: Article

References (40)

1. Mandell L.A., Wunderink R.G., Anzueto A., Barlett J.G., Douglas Campbell G., Dean N.C., et al. Infectious Diseases Society of America/American Thoracic Society Consensus Guidelines on the Management of Community-Acquired Pneumonia in Adults. DSA/ATS Guidelines for CAP in adults. Clin Infect Dis 2007, 44:27-72.
2. Pneumonia Guidelines Committee of BTS Standards of Care Committee. Thorax 2007, 56:1-64. British Thoracic Society guidelines for the management of community-acquired pneumonia in adults.
3. Mandell L.A., Marrie T.J., Grossman R.F., Chow A.W., Hyland R.H. Canadian guidelines for the initial management of community-acquired pneumonia: an evidence-based update by the Canadian Infectious Society and the Canadian Thoracic Society. Clin Infect Dis 2000, 31:383-421. the Canadian Community-Acquired Pneumonia Working Group.
4. SEPAR Working Group on Community-Acquired Pneumonia, Tuberculosis and Respiratory Infections (TIR) Assembly. Arch Bronconeumol 2005, 41:272-289. Guidelines for the diagnosis, treatment of community-acquired, pneumonia., Spanish Society of Pulmonology, Thoracic Surgery.
5. Stout J.E., Yu V.L. Legionellosis. N Engl J Med 1997, 337:682-687.
6. Diederen B.M. Legionella spp. and Legionnaires' disease. J Infect 2008, 56:1-12.
7. Roig J., Sabria M., Pedro-Botet M.L. Legionella spp.: community-acquired and nosocomial infections. Curr Opin Infect Dis 2003, 16:145-151.
8. Cunha B.A. Atypical pneumonias: current clinical concepts focusing on Legionnaires' disease. Curr Opin Pulm Med 2008, 14:183-194.
9. Edelstein P.H., Meyer R.D. Legionnaires'disease. A review. Chest 1984, 85:114-120.
10. Neil K., Berkelman R. Increasing incidence of legionellosis in the United States, 1990-2005: changing epidemiologic trends. Clin Infect Dis 2008, 47:591-599.
11. Cunha B.A. Severe Legionella pneumonia: rapid presumptive clinical diagnosis with Winthrop - University Hospital's weighted point score system (modified). Heart Lung 2008, 37:311-320.
12. Hinojosa J., Hinojosa C., González E., Almaráz A., Martín S., Zapatero A. Adequacy of the admission and care provided to the patients with community-acquired pneumonia. Rev Clin Esp 2011, 211:179-186.
13. Martin-Loeches I., Lisboa T., Rodriguez A., Putensen C., Annane D., Garnacho-Montero J., et al. Combination antibiotic therapy with macrolides improves survival in intubated patients with community-acquired pneumonia. Intensive Care Med 2010, 36:612-620.
14. Roig J., Rello J Legionnaires' disease: a rational approach to therapy. J Antimicrob Chemother 2003, 51:1119-1129.
15. Bartlett J.G. Is activity against " atypical" pathogens necessary in the treatment protocols for community-acquired pneumonia? Issues with combination therapy. Clin Infect Dis 2008, 47:232-236.
16. Falco V., Molina I., Juste C., Crespo M., Almirante B., Pigrau C., et al. Tratamiento de la neumonia por Legionella pneumophila. Macrolidos o quinolones?. Enferm Infecc Microbiol Clin 2006, 24:360-364.
17. Dournon E., Mayaud C., Wolff M., Schlemmer B., Samuel D., Sollet J.P., et al. Comparison of three antibiotic regimens in severe Legionnaires' disease. J Antimicrob Chemother 1990, 26:129-139.
18. Hubbard R.B., Mathur R.M., MacFarlane J.T. Severe community-acquired Legionella pneumonia: treatment, complications and outcome. Q J Med 1993, 86:327-332.
19. Tkatch L.S., Kusne S., Irish W.D., Krystofiak S., Wing E. Epidemiology of legionella pneumonia and factors associated with legionella-related mortality at a tertiary care center. Clin Infect Dis 1998, 27:1479-1486.
20. El-Ebiary M., Sarmiento X., Torres A., Nogué S., Mesalles E., Bodí M., et al. Prognostic factors of severe Legionella pneumonia requiring admission to ICU. Am J Respir Crit Care Med 1997, 156:1467-1472.
21. Gacouin A., Le Tulzo Y., Lavoue S., Camus C., Hoff J., Bassen R., et al. Severe pneumonia due to Legionella pneumophila: prognostic factors, impact of delayed appropriate antimicrobial therapy. Intensive Care Med 2002, 28:686-691.
22. Bodí M., Rodríguez A., Solé-Violán J., Gilavert M.C., Garnacho J., Blanquer J., et al. Community-Acquired Pneumonia Intensive Care Units (CAPUCI) Study Investigators. Antibiotic prescription for community-acquired pneumonia in the intensive care unit: impact of adherence to Infectious Diseases Society of America Guidelines on survival. Clin Infect Dis 2005, 41:1709-1716.
23. Rello J., Quintana E., Ausina V., Net A., Prats G. A three-year study of severe community-acquired pneumonia with emphasis on outcome. Chest 1993, 103:232-235.
24. Rello J., Bodi M., Mariscal D., Navarro M., Diaz E., Gallego M., et al. Microbiological testing and outcome of patients with severe community-acquired pneumonia. Chest 2003, 123:174-180.
25. Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease (COPD) and asthma. Am Rev Respir Dis 1987, 136:225-244. American Thoracic Society.
26. Ewig S., Ruiz M., Mensa J.M., Marcos M.A., Martinez J.A., Arancibia F., et al. Severe community-acquired pneumonia: assessment of severity criteria. Am J Respir Crit Care Med 1998, 158:1102-1108.
27. Yu V.L., Plouffe J.P., Pastoris M.C., Stout J.E., Schousboe M., Widmer A., et al. Distribution of Legionella species and serogroups isolated by culture in patients with sporadic community-acquired legionellosis: an international collaborative survey. J Infect Dis 2002, 186:127-128.
28. von Baum H., Ewig S., Marre R., Suttorp N., Gonschior S., Welte T., et al. Community-acquired Legionella pneumonia: new insights from the German competence network for community acquired pneumonia. Clin Infect Dis 2008, 46:1356-1364. Competence Network for Community Acquired Pneumonia Study Group.
29. Rodríguez A., Mendia A., Sirvent J.M., Barcenilla F., de la Torre-Prados M.V., Solé-Violán J., et al. Combination antibiotic therapy improves survival in patients with community-acquired pneumonia and shock. Crit Care Med 2007, 35:1493-1498.
30. Baddour L.M., Yu V.L., Klugman K.P., Feldman C., Ortqvist A., Rello J., et al. Combination antibiotic therapy lowers mortality among severely ill patients with pneumococcal bacteremia. Am J Respir Crit Care Med 2004, 15:440-444. the International Pneumococcal Study Group.
31. Jacobson K.L., Miceli M.H., Tarrand J.J., Kontoyiannis D.P. Legionella pneumonia in cancer patients. Medicine (Baltimore) 2008, 87:152-159.
32. Roig J., Arnau J.M., Vallano A., Rello J. New developments in therapeutic agents for Legionnaires' disease. Anti-Infect Agents Med Chem 2007, 6:228-242.
33. Vergis E.N., Indorf A., File T.M., Phillips J., Bates J., Tan J., et al. Azithromycin vs cefuroxime plus erythromicin for empirical treatment of community-acquired pneumonia in hospitalized patients: a prospective, randomized, multicenter trial. Arch Intern Med 2000, 160:1294-1300.
34. Plouffe J.F., Breiman R.F., Fields B.S., Herbert M., Inverso J., Knirsch C., et al. Azithromycin in the treatment of Legionella pneumonia requiring hospitalization. Clin Infect Dis 2003, 37:1475-1480.
35. Sabria M., Pedro-Botet M.L., Gómez J., Roig J., Vilaseca B., Sopena N., et al. Fluoroquinolones vs macrolides in the treatment of Legionnaires disease. Chest 2005, 128:1401-1405.
36. Grau S., Antonio J.M., Ribes E., Salvadó M., Garcés J.M., Garau J. Impact of rifampicin addition to clarithromycin in Legionella pneumophila pneumonia. Int J Antimicrob Agents 2006, 28:249-252.
37. Yu V.L., Greenberg R.N., Zadelkis N., Stout J.E., Khashab M.M., Olson W.H., et al. Levofloxacin efficacy in the treatment of community-acquired legionellosis. Chest 2004, 125:2135-2139.
38. Pedro-Botet M.L., Yu V.L. Legionella: macrolides or quinolones?. Clin Microbiol Infect 2006, 12:25-30.
39. Edelstein P.H. Rifampin resistance of Legionella pneumophila is not increased during therapy for experimental Legionnaires' disease: study of rifampin resistance using a guinea pig model of Legionnaires disease. Antimicrob Agents Chemother 1991, 35:5-9.
40. Edelstein P.H., Calarco K., Yasui V.K. Antimicrobial therapy of experimentally induced Legionnaires' disease in guinea pigs. Am Rev Respir Dis 1984, 130:849-856.