Low expression of Mfn2 is associated with mitochondrial damage and apoptosis in the placental villi of early unexplained miscarriage

Placenta

Volumn 34, Issue 7, 2013, Pages 613-618

  Pang, W ^a   Zhang, Y ^b   Zhao, N ^a   Darwiche, S S ^c   Fu, X ^a   Xiang, W ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Miscarriage; Mitochondria; Mitofusin 2; Placental villous

Indexed keywords

MITOFUSIN 2; PROTEIN BAX; PROTEIN BCL 2;

ADULT; APOPTOSIS; ARTICLE; CELL DAMAGE; CELL STRUCTURE; CLINICAL ARTICLE; CONTROLLED STUDY; EMBRYO DEVELOPMENT; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; MITOCHONDRION; NICK END LABELING; PLACENTA; PREGNANCY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPONTANEOUS ABORTION; TRANSMISSION ELECTRON MICROSCOPY; TROPHOBLAST; WESTERN BLOTTING;

ABORTION, SPONTANEOUS; ADENOSINE TRIPHOSPHATE; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CHORIONIC VILLI; FEMALE; GTP PHOSPHOHYDROLASES; HUMANS; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; PREGNANCY; PROTO-ONCOGENE PROTEINS C-BCL-2; TROPHOBLASTS;

EID: 84878617178     PISSN: 01434004     EISSN: 15323102     Source Type: Journal    
DOI: 10.1016/j.placenta.2013.03.013     Document Type: Article

References (36)

1. C.R. Gracia, M.D. Sammel, J. Chittams, A.C. Hummel, A. Shaunik, and K.T. Barnhart Risk factors for spontaneous abortion in early symptomatic first-trimester pregnancies Obstet Gynecol 106 2005 993 999
2. R. Dumollard, M. Duchen, and J. Carroll The role of mitochondrial function in the oocyte and embryo Curr Top Dev Biol 77 2007 21 49
3. K. Handschuh, J. Guibourdenche, V. Tsatsaris, M. Guesnon, I. Laurendeau, and D. Evain-Brion Human chorionic gonadotropin expression in human trophoblasts from early placenta: comparative study between villous and extravillous trophoblastic cells Placenta 28 2007 175 184
4. O.M. De Brito, and L. Scorrano Mitofusin-2 regulates mitochondrial and endoplasmic reticulum morphology and tethering: the role of Ras Mitochondrion 9 2009 222 226
5. K.H. Chen, J. Tang, and D.L. Ma Cloning and expression of a novel cDNA related to hypertension Chin Med J 111 1998 384 386
6. S. Pich, D. Bach, P. Briones, M. Liesa, M. Camps, and X. Testar The Charcot-Marie-Tooth type 2A gene product, Mfn2, up-regulates fuel oxidation through expression of OXPHOS system Hum Mol Genet 14 2005 1405 1415
7. K.H. Chen, X. Guo, D. Ma, Y. Guo, Q. Li, and D. Yang Dysregulation of HSG triggers vascular proliferative disorders Nat Cell Biol 6 2004 872 883
8. Y. Zhang, L. Jiang, W. Hu, Q. Zheng, and W. Xiang Mitochondrial dysfunction during in vitro hepatocyte steatosis is reversed by omega-3 fatty acid-induced up-regulation of mitofusin 2 Metabolism 60 2011 767 775
9. H. Chen, S.A. Detmer, A.J. Ewald, E.E. Griffin, S.E. Fraser, and D.C. Chan Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development J Cell Biol 160 2003 189 200
10. H. Chen, J.M. McCaffery, and D.C. Chan Mitochondrial fusion protects against neurodegeneration in the cerebellum Cell 130 2007 548 562
11. G.J. Jiang, L. Pan, X.Y. Huang, M. Han, J.K. Wen, and F.Z. Sun Expression of HSG is essential for mouse blastocyst formation Biochem Biophys Res Commun 335 2005 351 355
12. W.P. Xiang, Z.N. Wen, W.J. Pang, L. Hu, C.L. Xiong, and Y. Zhang CR16 forms a complex with N-WASP in the human testes Cell Tissue Res 344 2011 519 526
13. J.T. Wilcox, J.K. Lai, E. Semple, B.A. Brisson, C. Gartley, and J.N. Armstrong Synaptically-competent neurons derived from canine embryonic stem cells by lineage selection with EGF and Noggin PLoS One 6 2011 19768
14. 2 levels J Biol Chem 286 2011 17649 17657
15. H. Chen, and D.C. Chan Mitochondrial dynamics - fusion, fission, movement, and mitophagy - in neurodegenerative diseases Hum Mol Genet 18 2009 169 176
16. C. García-Pérez, T.G. Schneider, G. Hajnoczky, and G. Csordás Alignment of sarcoplasmic reticulum-mitochondrial junctions with mitochondrial contact points Am J Physiol Heart Circ Physiol 301 2011 1907 1915
17. C. Fischer, S. Trajanoski, L. Papić, C. Windpassinger, G. Bernert, and M. Freilinger SNP array-based whole genome homozygosity mapping as the first step to a molecular diagnosis in patients with Charcot-Marie-Tooth disease J Neurol 259 2011 515 523
18. J. Baets, T. Deconinck, and E. De Vriendt Genetic spectrum of hereditary neuropathies with onset in the first year of life Brain 134 2011 2664 2676
19. M. Kawalec, K. Kotruchow, A. Kochański, and B. Zablocka Mitofusin 2 as a crucial peripheral nervous system protein and a common regulator of cell metabolism Postepy Biochem 57 2011 215 221
20. J.I. Bang, D.W. Bae, H.S. Lee, G.K. Deb, and M.O. Kim Proteomic analysis of placentas from cloned cat embryos identifies a set of differentially expressed proteins related to oxidative damage, senescence and apoptosis Proteomics 11 2011 4454 4467
21. A.N. Sharp, A.E. Heazell, I.P. Crocker, and G. Mor Placental apoptosis in health and disease Am J Reprod Immunol 64 2010 159 169
22. I.K. Prusac, S. Zekic Tomas, and D. Roje Apoptosis, proliferation and Fas ligand expression in placental trophoblast from pregnancies complicated by HELLP syndrome or pre-eclampsia Acta Obstet Gynecol Scand 90 2011 1157 1163
23. A.E. Heazell, A.N. Sharp, P.N. Baker, and I.P. Crocker Intra-uterine growth restriction is associated with increased apoptosis and altered expression of proteins in the p53 pathway in villous trophoblast Apoptosis 16 2011 135 144
24. Y. Tsujimoto, and S. Shimizu Bcl-2 family: life-or-death switch FEBS Lett 466 2000 6 10
25. S. Nagata Apoptosis by death factor Cell 88 1997 355 365
26. S. Ishioka, Y. Ezaka, K. Umemura, T. Hayashi, T. Endo, and T. Saito Proteomic analysis of mechanisms of hypoxia-induced apoptosis in trophoblastic cells Int J Med Sci 4 2007 36 44
27. J. Bereiter-Hahn Behavior of mitochondria in the living cell Int Rev Cytol 122 1990 1 63
28. D.C. Chan Mitochondrial fusion and fission in mammals Annu Rev Cell Dev Biol 22 2006 79 99
29. Benard Giovanni, and Karbowski Mariusz Mitochondrial fusion and division: regulation and role in cell viability Semin Cell Dev Biol 20 2009 365 374
30. C. Merkwirth, and T. Langer Mitofusin 2 builds a bridge between ER and mitochondria Cell 35 2008 1165 1167
31. P. May-Panloup, M.F. Chrétien, Y. Malthièry, and P. Reynier Mitochondria and reproduction Med Sci 20 2004 779 783
32. H.K. Au, T.S. Yeh, S.H. Kao, C.R. Tzeng, and R.H. Hsieh Abnormal mitochondrial structure in human unfertilized oocytes and arrested embryos Ann N Y Acad Sci 1042 2005 177 185
33. S.M. Seyedhassani, M. Houshmand, S.M. Kalantar, G. Modabber, and A. Aflatoonian No mitochondrial DNA deletions but more D-loop point mutations in repeated pregnancy loss J Assist Reprod Genet 27 2010 641 648
34. A.B. Knott, and E. Bossy-Wetzel Impairing the mitochondrial fission and fusion balance: a new mechanism of neurodegeneration Ann N Y Acad Sci 1147 2008 283 292
35. M.V. Zamaraeva, R.Z. Sabirov, E. Maeno, Y. Ando-Akatsuka, S.V. Bessonova, and Y. Okada Cells die with increased cytosolic ATP during apoptosis: a bioluminescence study with intracellular luciferase Cell Death Differ 12 2005 1390 1397
36. Tsujimoto Yoshihide Apoptosis and necrosis: intracellular ATP level as a determinant for cell death modes Cell Death Differ 4 1997 429 434