Potentially relevant incidental findings on research whole-body MRI in the general adult population: Frequencies and management

European Radiology

Volumn 23, Issue 3, 2013, Pages 816-826

  Hegenscheid, Katrin ^a   Seipel, Rebecca ^a   Schmidt, Carsten O ^a   Völzke, Henry ^a   Kühn, Jens Peter ^a   Biffar, Reiner ^a   Kroemer, Heyo K ^a   Hosten, Norbert ^a   Puls, Ralf ^a  

^a UNIVERSITY MEDICINE GREIFSWALD   (Germany)

Author keywords

Incidental findings; Magnetic resonance imaging; Management; Prevalence; Whole body

Indexed keywords

CONTRAST MEDIUM;

ABDOMINAL AORTA ANEURYSM; ABDOMINAL WALL HERNIA; ACOUSTIC NEURINOMA; ADRENAL CORTEX ADENOMA; ADULT; AGED; ANGIOMYOLIPOMA; ARACHNOID CYST; ARTICLE; BONE CYST; BONE EDEMA; BONE LESION; BONE METASTASIS; BRAIN EDEMA; BRAIN HEMORRHAGE; BRAIN INFARCTION; BRAIN TUMOR; BREAST LESION; CARDIOVASCULAR MAGNETIC RESONANCE; CAROTID ARTERY OBSTRUCTION; CAVERNOUS HEMANGIOMA; CERVICAL LYMPHADENOPATHY; CHOLESTASIS; CHRONIC CHOLECYSTITIS; CHRONIC PANCREATITIS; COHORT ANALYSIS; CONTRAST ENHANCEMENT; DIAGNOSTIC ACCURACY; EDEMA; ENCHONDROMA; FEMALE; FEMUR NECK FRACTURE; FIBROUS DYSPLASIA; FRACTURE; GASTROINTESTINAL TUMOR; GLIOMA; GOITER; HEART FAILURE; HEMOCHROMATOSIS; HUMAN; HYPOPHYSIS ADENOMA; HYPOPHYSIS CYST; HYPOPHYSIS DISEASE; ILEUS; INCIDENTAL FINDING; INTRACRANIAL ANEURYSM; KIDNEY CYST; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LIVER HEMANGIOMA; LIVER INJURY; LOBAR PNEUMONIA; LUNG NODULE; LYMPHADENOPATHY; MAGNETIC RESONANCE ANGIOGRAPHY; MAGNETIC RESONANCE MAMMOGRAPHY; MAJOR CLINICAL STUDY; MALE; MAMMOGRAPHY; MENINGIOMA; NODULAR HYPERPLASIA; NORMOTENSIVE HYDROCEPHALUS; NUCLEAR MAGNETIC RESONANCE IMAGING; OVARY CYST; PATIENT REFERRAL; PERICARDIAL EFFUSION; PICTURE ARCHIVING AND COMMUNICATION SYSTEM; PLASMACYTOMA; PLEURA EFFUSION; PNEUMONIA; PNEUMOPERITONEUM; PNEUMOTHORAX; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROSTATE HYPERTROPHY; RESIDENT; SPINAL CORD DISEASE; SPINE TUMOR; SPLENOMEGALY; SUBDURAL HEMATOMA; URINARY TRACT OBSTRUCTION; UTERUS CANCER; VERTEBRAL CANAL STENOSIS; WHOLE BODY MRI;

EID: 84878611510     PISSN: 09387994     EISSN: 14321084     Source Type: Journal    
DOI: 10.1007/s00330-012-2636-6     Document Type: Article

References (46)

1. Hofman A, Breteler M, van Duijn C et al (2007) The Rotterdam Study: objectives and design update. Eur J Epidemiol 22:819-829
2. Turkbey E, McClelland R, Kronmal R et al (2010) The impact of obesity on the left ventricle: the Multi-Ethnic Study of Atherosclerosis (MESA). JACC Cardiovasc Imaging 3:266-274
3. Jefferson A, Himali J, Beiser A et al (2010) Cardiac index is associated with brain aging: the Framingham Heart Study. Circulation 122:690-697
4. Qiu C, Cotch MF, Sigurdsson S et al (2010) Cerebral microbleeds, retinopathy, and dementia: the AGES-Reykjavik Study. Neurology 75:2221-2228
5. Booth TC, Jackson A, Wardlaw JM, Taylor SA, Waldman AD (2010) Incidental findings found in "healthy" volunteers during imaging performed for research: current legal and ethical implications. Br J Radiol 83:456-465
6. Vernooij M, Ikram M, Tanghe H et al (2007) Incidental findings on brain MRI in the general population. N Engl J Med 357:1821-1828
7. Yue N, Elster A, Jungreis C, O'Leary D, Poirier V (1997) Clinically serious abnormalities found incidentally at MR imaging of the brain: data from the Cardiovascular Health Study. Radiology 202:41-46
8. Katzman G, Dagher A, Patronas N (1999) Incidental findings on brain magnetic resonance imaging from 1000 asymptomatic volunteers. JAMA 282:36-39
9. Wolf SM, Lawrenz FP, Nelson CA et al (2008) Managing incidental findings in human subjects research: analysis and recommendations. J Law Med Ethics 36:211
10. Illes J, Kirschen MP, Edwards E et al (2008) Practical approaches to incidental findings in brain imaging research. Neurology 70:384-390
11. Booth TC, Waldman AD, Wardlaw JM, Taylor SA, Jackson A (2011) Management of incidental findings during imaging research in "healthy" volunteers: current UK practice. Br J Radiol 85:11-21
12. Fenchel M, Requardt M, Tomaschko K et al (2005) Whole-body MR angiography using a novel 32-receiving-channel MR system with surface coil technology: first clinical experience. J Magn Reson Imaging 21:596-603
13. Schmidt G, Baur-Melnyk A, Herzog P (2005) High-resolution whole-body magnetic resonance image tumor staging with the use of parallel imaging versus dual-modality positron emission tomography-computed tomography: experience on a 32-channel system. Invest Radiol 40:743-753
14. Ladd SC (2009) Whole-body MRI as a screening tool? Eur J Radiol 70:452-462
15. Thomson V, Pialat J-B, Gay F et al (2008) Whole-body MRI for metastases screening: a preliminary study using 3D VIBE sequences with automatic subtraction between noncontrast and contrast enhanced images. Am J Clin Oncol 31:285-292
16. Völzke H, Alte D, Schmidt CO et al (2011) Cohort profile: the study of health in Pomerania. Int J Epidemiol 40:294-307
17. Hegenscheid K, Kühn JP, Völzke H, Biffar R, Hosten N, Puls R (2009) Whole-body magnetic resonance imaging of healthy volunteers: pilot study results from the population-based SHIP study. Rofo 181:748-759
18. Bosniak MA (1991) Difficulties in classifying cystic lesions of the kidney. Urol Radiol 13:91-93
19. American College of Radiology (2003) Breast Imaging-Reporting and Data System (BI-RADS) MRI atlas, 1st edn. American College of Radiology, Reston
20. Gluecker TM, Johnson CD, Wilson LA et al (2003) Extracolonic findings at CT colonography: evaluation of prevalence and cost in a screening population. Gastroenterology 124:911-916
21. Kim DH, Pickhardt PJ, Taylor AJ et al (2007) CT colonography versus colonoscopy for the detection of advanced neoplasia. N Engl J Med 357:1403-1412
22. Pickhardt P, Choi J, Hwang I et al (2003) Computed tomographic virtual colonoscopy to screen for colorectal neoplasia in asymptomatic adults. N Engl J Med 349:2191-2200
23. Yee J, Kumar NN, Godara S et al (2005) Extracolonic abnormalities discovered incidentally at CT colonography in a male population. Radiology 236:519-526
24. Zalis ME, Barish MA, Choi JR et al (2005) CT colonography reporting and data system: a consensus proposal. Radiology 236:3-9
25. Illes J, Kirschen M, Karetsky K, Kelly M, Saha A, Desmond J, Raffin T, Glover G, Atlas S (2004) Discovery and disclosure of incidental findings in neuroimaging research. J Magn Reson Imaging 20:743-747
26. Illes J, Kirschen M, Edwards E et al (2006) Ethics. Incidental findings in brain imaging research. Science 311:783-784
27. Kim B, Illes J, Kaplan R, Reiss A, Atlas S (2002) Incidental findings on pediatric MR images of the brain. AJNR Am J Neuroradiol 23:1674-1677
28. Kumra S, Ashtari M, Britt Anderson B et al (2006) Ethical and practical considerations in the management of incidental findings in pediatric MRI studies. J Am Acad Child Adolesc Psychiatry 45:1000-1006
29. Furtado CD, Aguirre DA, Sirlin CB et al (2005) Whole-body CT screening: spectrum of findings and recommendations in 1192 patients. Radiology 237:385-394
30. Morin SHX, Cobbold JFL, Lim AKP et al (2009) Incidental findings in healthy control research subjects using whole-body MRI. Eur J Radiol 72:529-533
31. Schmidt GP, Schoenberg SO, Schmid R et al (2007) Screening for bone metastases: whole-body MRI using a 32-channel system versus dual-modality PET-CT. Eur Radiol 17:939-949
32. Regier M, Schwarz D, Henes FO (2011) Diffusion-weighted MR-imaging for the detection of pulmonary nodules at 1.5 Tesla: intraindividual comparison with multidetector computed tomography. J Med Imaging Radiat Oncol 55:266-274
33. Ladd S, Debatin J, Stang A et al (2007) Whole-body MR vascular screening detects unsuspected concomitant vascular disease in coronary heart disease patients. Eur Radiol 17:1035-1045
34. Jhaveri KS, Wong F, Ghai S, Haider MA (2006) Comparison of CT histogram analysis and chemical shift MRI in the characterization of indeterminate adrenal nodules. AJR Am J Roentgenol 187:1303-1308
35. Kuhl C (2007) The current status of breast MR imaging. Part I. Choice of technique, image interpretation, diagnostic accuracy, and transfer to clinical practice. Radiology 244:356-378
36. Kuhl CK, Mielcareck P, Klaschik S et al (1999) Dynamic breast MR imaging: are signal intensity time course data useful for differential diagnosis of enhancing lesions? Radiology 211:101-110
37. Runge VM (2000) Safety of approved MR contrast media for intravenous injection. J Magn Reson Imaging 12:205-213
38. Council of Europe Steering Committee on Bioethics (2004) Additional protocol to the convention on human rights and biomedicine concerning biomedical research. Council of Europe Steering Committee on Bioethics, Strasbourg. Available via http://conventions.coe.int. Accessed 20 April 2012
39. Sweeney JP, Thornhill JA, Graiger R, McDermott TE, Butler MR (1996) Incidentally detected renal cell carcinoma: pathological features, survival trends and implications for treatment. Br J Urol 78:351-353
40. Kleinschmidt A (2007) Incidental neuroimaging findings: lessons from brain research in volunteers. Curr Opin Neurol 20:387-389
41. Royal JM, Peterson BS (2008) The risks and benefits of searching for incidental findings in MRI research scans. J Law Med Ethics 36:305-314, 212
42. Orme N, Fletcher J, Siddiki H et al (2010) Incidental findings in imaging research: evaluating incidence, benefit, and burden. Arch Intern Med 170:1525-1532
43. Kirschen M, Jaworska A, Illes J (2006) Subjects' expectations in neuroimaging research. J Magn Reson Imaging 23:205-209
44. Quaid KA (1993) Psychological and ethical considerations in screening for disease. Am J Cardiol 72:64D-67D
45. Clayton EW (2008) Incidental findings in genetics research using archived DNA. J Law Med Ethics 36:212
46. Clayton EW (2003) Ethical, legal, and social implications of genomic medicine. N Engl J Med 349:562-569