New insights into the pathogenesis and treatment of peritoneal fibrosis: A potential role of Wnt/β-catenin induced epithelial to mesenchymal transition and stem cells for therapy

Medical Hypotheses

Volumn 81, Issue 1, 2013, Pages 97-100

  Zhang, Fan ^a   Liu, Hong ^a   Liu, Fuyou ^a   Peng, Youming ^a   Chen, Meichu ^a   Liu, Yinghong ^a   Chen, Guochun ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN;

ARTICLE; CELL DIFFERENTIATION; CELL STRUCTURE; CELL TRANSFORMATION; EMBRYO DEVELOPMENT; EPITHELIAL MESENCHYMAL TRANSITION; EPITHELIUM CELL; GENE EXPRESSION; HUMAN; MESENCHYMAL STEM CELL; MESENCHYME CELL; PATHOGENESIS; PERITONEAL FIBROSIS; STEM CELL TRANSPLANTATION; WNT SIGNALING PATHWAY;

BETA CATENIN; EPITHELIAL-MESENCHYMAL TRANSITION; HUMANS; PERITONEAL FIBROSIS; STEM CELLS; WNT PROTEINS;

EID: 84878598342     PISSN: 03069877     EISSN: 15322777     Source Type: Journal    
DOI: 10.1016/j.mehy.2013.03.036     Document Type: Article

References (37)

1. Margetts P.J., Bonniaud P. Basic mechanisms and clinical implications of peritoneal fibrosis. Perit Dial Int 2003, 23:530-541.
2. Selgas R., Bajo A., Jimenez-Heffernan J.A., et al. Epithelial-to-mesenchymal transition of the mesothelial cell - its role in the response of the peritoneum to dialysis. Nephrol Dial Transpl 2006, 21(Suppl. 2):i2-i7.
3. Liu Y. Epithelial to mesenchymal transition in renal fibrogenesis: pathologic significance, molecular mechanism, and therapeutic intervention. J Am Soc Nephrol 2004, 15:1-12.
4. Vincent-Salomon A., Thiery J.P. Host microenvironment in breast cancer development: epithelial-mesenchymal transition in breast cancer development. Breast Cancer Res 2003, 5:101-106.
5. Chilosi M., Poletti V., Zamo A., et al. Aberrant Wnt/beta-catenin pathway activation in idiopathic pulmonary fibrosis. Am J Pathol 2003, 162:1495-1502.
6. Iwano M., Plieth D., Danoff T.M., Xue C., Okada H., Neilson E.G. Evidence that fibroblasts derive from epithelium during tissue fibrosis. J Clin Invest 2002, 110:341-350.
7. Yanez-Mo M., Lara-Pezzi E., Selgas R., et al. Peritoneal dialysis and epithelial-to-mesenchymal transition of mesothelial cells. N Engl J Med 2003, 348:403-413.
8. Jimenez-Heffernan J.A., Aguilera A., Aroeira L.S., et al. Immunohistochemical characterization of fibroblast subpopulations in normal peritoneal tissue and in peritoneal dialysis-induced fibrosis. Virchows Arch 2004, 444:247-256.
9. Lv Z.D., Na D., Ma X.Y., Zhao C., Zhao W.J., Xu H.M. Human peritoneal mesothelial cell transformation into myofibroblasts in response to TGF-ss1 in vitro. Int J Mol Med 2011, 27:187-193.
10. Liu Q., Mao H., Nie J., et al. Transforming growth factor {beta}1 induces epithelial-mesenchymal transition by activating the JNK-Smad3 pathway in rat peritoneal mesothelial cells. Perit Dial Int 2008, 28(Suppl. 3):S88-S95.
11. Margetts P.J., Bonniaud P., Liu L., et al. Transient overexpression of TGF-{beta}1 induces epithelial mesenchymal transition in the rodent peritoneum. J Am Soc Nephrol 2005, 16:425-436.
12. Del P.G., Jimenez-Heffernan J.A., Bajo M.A., et al. Epithelial-to-mesenchymal transition of mesothelial cells is an early event during peritoneal dialysis and is associated with high peritoneal transport. Kidney Int Suppl 2008, S26-S33.
13. Liu Y. New insights into epithelial-mesenchymal transition in kidney fibrosis. J Am Soc Nephrol 2010, 21:212-222.
14. Konigshoff M., Eickelberg O. WNT signaling in lung disease: a failure or a regeneration signal?. Am J Respir Cell Mol Biol 2010, 42:21-31.
15. Hwang I., Seo E.Y., Ha H. Wnt/beta-catenin signaling: a novel target for therapeutic intervention of fibrotic kidney disease. Arch Pharm Res 2009, 32:1653-1662.
16. Huang H., He X. Wnt/beta-catenin signaling: new (and old) players and new insights. Curr Opin Cell Biol 2008, 20:119-125.
17. Orford K., Crockett C., Jensen J.P., Weissman A.M., Byers S.W. Serine phosphorylation-regulated ubiquitination and degradation of beta-catenin. J Biol Chem 1997, 272:24735-24738.
18. Blavier L., Lazaryev A., Shi X.H., Dorey F.J., Shackleford G.M., DeClerck Y.A. Stromelysin-1 (MMP-3) is a target and a regulator of Wnt1-induced epithelial-mesenchymal transition (EMT). Cancer Biol Ther 2010, 10:198-208.
19. Brabletz T., Jung A., Dag S., Hlubek F., Kirchner T. Beta-catenin regulates the expression of the matrix metalloproteinase-7 in human colorectal cancer. Am J Pathol 1999, 155:1033-1038.
20. Eger A., Stockinger A., Schaffhauser B., Beug H., Foisner R. Epithelial mesenchymal transition by c-Fos estrogen receptor activation involves nuclear translocation of beta-catenin and upregulation of beta-catenin/lymphoid enhancer binding factor-1 transcriptional activity. J Cell Biol 2000, 148:173-188.
21. Villar J., Cabrera N.E., Valladares F., et al. Activation of the Wnt/beta-catenin signaling pathway by mechanical ventilation is associated with ventilator-induced pulmonary fibrosis in healthy lungs. PLoS One 2011, 6:e23914.
22. He W., Dai C., Li Y., Zeng G., Monga S.P., Liu Y. Wnt/beta-catenin signaling promotes renal interstitial fibrosis. J Am Soc Nephrol 2009, 20:765-776.
23. Doble B.W., Woodgett J.R. Role of glycogen synthase kinase-3 in cell fate and epithelial-mesenchymal transitions. Cell Tissue Organ 2007, 185:73-84.
24. Jiang Y.G., Luo Y., He D.L., et al. Role of Wnt/beta-catenin signaling pathway in epithelial-mesenchymal transition of human prostate cancer induced by hypoxia-inducible factor-1alpha. Int J Urol 2007, 14:1034-1039.
25. Fan M., Liu F., Yang Y., Ye Y., Huang G. Phosphorylation of glycogen synthase kinase-3beta induces epithelial mesenchymal transition in human peritoneal mesothelial cells. Zhong Nan Da Xue Xue Bao Yi Xue Ban 2010, 35:329-334.
26. Surendran K., Schiavi S., Hruska K.A. Wnt-dependent beta-catenin signaling is activated after unilateral ureteral obstruction, and recombinant secreted frizzled-related protein 4 alters the progression of renal fibrosis. J Am Soc Nephrol 2005, 16:2373-2384.
27. Lam A.P., Gottardi C.J. Beta-catenin signaling: a novel mediator of fibrosis and potential therapeutic target. Curr Opin Rheumatol 2011, 23:562-567.
28. Zhao J.H., Luo Y., Jiang Y.G., He D.L., Wu C.T. Knockdown of beta-catenin through shRNA cause a reversal of EMT and metastatic phenotypes induced by HIF-1alpha. Cancer Invest 2011, 29:377-382.
29. Tzouvelekis A., Koliakos G., Ntolios P., et al. Stem cell therapy for idiopathic pulmonary fibrosis: a protocol proposal. J Transl Med 2011, 9:182.
30. Li L., Zhang Y., Li Y., et al. Mesenchymal stem cell transplantation attenuates cardiac fibrosis associated with isoproterenol-induced global heart failure. Transpl Int 2008, 21:1181-1189.
31. Rabani V., Shahsavani M., Gharavi M., Piryaei A., Azhdari Z., Baharvand H. Mesenchymal stem cell infusion therapy in a carbon tetrachloride-induced liver fibrosis model affects matrix metalloproteinase expression. Cell Biol Int 2010, 34:601-605.
32. Barry F.P., Murphy J.M. Mesenchymal stem cells: clinical applications and biological characterization. Int J Biochem Cell Biol 2004, 36:568-584.
33. Lagasse E., Connors H., Al-Dhalimy M., et al. Purified hematopoietic stem cells can differentiate into hepatocytes in vivo. Nat Med 2000, 6:1229-1234.
34. Kuo T.K., Hung S.P., Chuang C.H., et al. Stem cell therapy for liver disease: parameters governing the success of using bone marrow mesenchymal stem cells. Gastroenterology 2008, 134(2111-2121):2121.
35. Burchfield J.S., Dimmeler S. Role of paracrine factors in stem and progenitor cell mediated cardiac repair and tissue fibrosis. Fibrogene Tissue Repair 2008, 1:4.
36. Mirotsou M., Zhang Z., Deb A., et al. Secreted frizzled related protein 2 (Sfrp2) is the key Akt-mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair. Proc Natl Acad Sci U S A 2007, 104:1643-1648.
37. Wang N., Li Q., Zhang L., et al. Mesenchymal stem cells attenuate peritoneal injury through secretion of TSG-6. PLoS One 2012, 7:e43768.