Muscle metaboreflex-induced coronary vasoconstriction limits ventricular contractility during dynamic exercise in heart failure

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 304, Issue 7, 2013, Pages

  Coutsos, Matthew ^a   Sala Mercado, Javier A ^a   Ichinose, Masashi ^a,b,c   Li, ZhenHua ^a,d   Dawe, Elizabeth J ^a   O'Leary, Donal S ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b KOBE UNIVERSITY   (Japan)

^c MEIJI UNIVERSITY   (Japan)

^d SHANDONG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

PRAZOSIN;

ADRENERGIC RECEPTOR BLOCKING; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; CORONARY ARTERY CONSTRICTION; CORONARY BLOOD VESSEL; CORONARY VASCULAR CONDUCTANCE; DYNAMIC EXERCISE; EXPERIMENTAL DOG; HEART FAILURE; HEART HEMODYNAMICS; HEART LEFT VENTRICLE PRESSURE; HEART OUTPUT; HEART PACING; HEART PERFORMANCE; HEART VENTRICLE CONTRACTILITY; HEART VENTRICLE FUNCTION; MUSCLE METABOREFLEX; MUSCLE REFLEX; NONHUMAN; PRIORITY JOURNAL;

EID: 84878586469     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00879.2012     Document Type: Article

References (70)

1. Adreani CM, Kaufman MP. Effect of arterial occlusion on responses of group III and IV afferents to dynamic exercise. J Appl Physiol 84: 1827-1833, 1998.
2. Ansorge EJ, Augustyniak RA, Perinot RL, Hammond RL, Kim JK, Sala-Mercado JA, Rodriguez J, Rossi NF, O'Leary DS. Altered muscle metaboreflex control of coronary blood flow and ventricular function in heart failure. Am J Physiol Heart Circ Physiol 288: H1381-H1388, 2005.
3. Ansorge EJ, Shah SH, Augustyniak R, Rossi NF, Collins HL, O'Leary DS. Muscle metaboreflex control of coronary blood flow. Am J Physiol Heart Circ Physiol 283: H526-H532, 2002.
4. Aronow WS, Lurie M, Turbow M, Whittaker K, Van CS, Hughes D. Effect of prazosin vs placebo on chronic left ventricular heart failure. Circulation 59: 344-350, 1979.
5. Augustyniak RA, Collins HL, Ansorge EJ, Rossi NF, O'Leary DS. Severe exercise alters the strength and mechanisms of the muscle metaboreflex. Am J Physiol Heart Circ Physiol 280: H1645-H1652, 2001.
6. Awan NA, Miller RR, DeMaria AN, Maxwell KS, Neumann A, Mason DT. Efficacy of ambulatory systemic vasodilator therapy with oral prazosin in chronic refractory heart failure. Concomitant relief of pulmonary congestion and elevation of pump output demonstrated by improvements in symptomatology, exercise tolerance, hemodynamics and echocardiography. Circulation 56: 346-354, 1977.
7. Calderone A, Bouvier M, Li K, Juneau C, De Champlain J, Rouleau JL. Dysfunction of the beta and alpha adrenergic systems in a model of congestive heart failure. Circ Res 69: 332-343, 1991.
8. Canetti M, Akhter MW, Lerman A, Karaalp IS, Zell JA, Singh H, Mehra A, Elkayam U. Evaluation of myocardial blood flow reserve in patients with chronic congestive heart failure due to idiopathic dilated cardiomyopathy. Am J Cardiol 92: 1246-1249, 2003.
9. Cohn JN, Archibald DG, Ziesche S, Franciosa JA, Harston WE, Tristani FE, Dunkman WB, Jacobs W, Francis GS, Flohr KH. Effect of vasodilator therapy on mortality in chronic congestive heart failure. Results of a Veterans Administration Cooperative Study. N Engl J Med 314: 1547-1552, 1986.
10. Collins HL, Augustyniak RA, Ansorge EJ, O'Leary DS. Carotid baroreflex pressor responses at rest and during exercise:cardiac output vs. regional vasoconstriction. Am J Physiol Heart Circ Physiol 280: H642-H648, 2001.
11. Colucci WS, Wynne J, Holman BL, Braunwald E. Long-term therapy of heart failure with prazosin: a randomized double blind trial. Am J Cardiol 45: 337-344, 1980.
12. Coutsos M, Sala-Mercado JA, Ichinose M, Li Z, Dawe EJ, O'Leary DS. Muscle metaboreflex-induced coronary vasoconstriction functionally limits increases in ventricular contractility. J Appl Physiol 109: 271-278, 2010.
13. Crisafulli A, Salis E, Tocco F, Melis F, Milia R, Pittau G, Caria MA, Solinas R, Meloni L, Pagliaro P, Concu A. Impaired central hemodynamic response and exaggerated vasoconstriction during muscle metaboreflex acti-vation in heart failure patients. Am J Physiol Heart Circ Physiol 292: H2988-H2996, 2007.
14. Crisafulli A, Scott AC, Wensel R, Davos CH, Francis DP, Pagliaro P, Coats AJS, Concu A, Piepoli MF. Muscle metaboreflex-induced increases in stroke volume. Med Sci Sports Exerc 35: 221-228, 2003.
15. Crisafulli A, Salis E, Pittau G, Lorrai L, Tocco F, Melis F, Pagliaro P, Concu A. Modulation of cardiac contractility by muscle metaboreflex following efforts of different intensities in humans. Am J Physiol Heart Circ Physiol 291: H3035-H3042, 2006.
16. Eisenhofer G, Friberg P, Rundqvist B, Quyyumi AA, Lambert G, Kaye DM, Kopin IJ, Goldstein DS, Esler MD. Cardiac sympathetic nerve function in congestive heart failure. Circulation 93: 1667-1676, 1996.
17. Elkayam U, LeJemtel TH, Mathur M, Ribner HS, Frishman WH, Strom J, Sonnenblick EH. Marked early attenuation of hemodynamic effects of oral prazosin therapy in chronic congestive heart failure. Am J Cardiol 44: 540-545, 1979.
18. Feigl EO. Coronary Physiology. Physiol Rev 63: 1-205, 1983.
19. Fincke R, Hochman JS, Lowe AM, Menon V, Slater JN, Webb JG, LeJemtel TH, Cotter G. Cardiac power is the strongest hemodynamic correlate of mortality in cardiogenic shock: a report from the SHOCK trial registry. J Am Coll Cardiol 44: 340-348, 2004.
20. Fletcher L, Thomas D. Congestive heart failure: understanding the pathophysiology and management. J Am Acad Nurse Pract 13: 249-257, 2001.
21. Glower DD, Spratt JA, Snow ND, Kabas JS, Davis JW, Olsen CO, Tyson GS, Sabiston DC Jr, Rankin JS. Linearity of the Frank-Starling relationship in the intact heart: the concept of preload recruitable stroke work. Circulation 71: 994-1009, 1985.
22. Goldman SA, Johnson LL, Escala E, Cannon PJ, Weiss MB. Improved exercise ejection fraction with long-term prazosin therapy in patients with heart failure. Am J Med 68: 36-42, 1980.
23. Gorman MW, Tune JD, Richmond KN, Feigl EO. Feedforward sympathetic coronary vasodilation in exercising dogs. J Appl Physiol 89: 1892-1902, 2000.
24. Gorman MW, Tune JD, Richmond KN, Feigl EO. Quantitative analysis of feedforward sympathetic coronary vasodilation in exercising dogs. J Appl Physiol 89: 1903-1911, 2000.
25. Gwathmey JK, Copelas L, MacKinnon R, Schoen FJ, Feldman MD, Grossman W, Morgan JP. Abnormal intracellular calcium handling in myocardium from patients with end-stage heart failure. Circ Res 61: 70-76, 1987.
26. Gwirtz PA, Overn SP, Mass HJ, Jones CE. α1-Adrenergic constriction limits coronary flow and cardiac function in running dogs. Am J Physiol Heart Circ Physiol 250: H1117-H1126, 1986.
27. Gwirtz PA, Stone HL. Coronary blood flow changes following activation of adrenergic receptors in the conscious dog. Am J Physiol Heart Circ Physiol 243: H13-H19, 1982.
28. Hammond RL, Augustyniak RA, Rossi NF, Churchill PC, Lapanowski K, O'Leary DS. Heart failure alters the strength and mechanisms of the muscle metaboreflex. Am J Physiol Heart Circ Physiol 278: H818-H828, 2000.
29. Hammond RL, Augustyniak RA, Rossi NF, Lapanowski K, Dunbar JC, O'Leary DS. Alteration of humoral and peripheral vascular responses during graded exercise in heart failure. J Appl Physiol 90: 55-61, 2001.
30. Huang AH, Feigl EO. Adrenergic coronary vasoconstriction helps maintain uniform transmural blood flow distribution during exercise. Circ Res 62: 286-298, 1988.
31. Kajstura J, Zhang X, Liu Y, Szoke E, Cheng W, Olivetti G, Hintze TH, Anversa P. The cellular basis of pacing-induced dilated cardiomyopathy: myocyte cell loss and myocyte cellular reactive hypertrophy. Circulation 92: 2306-2317, 1995.
32. Karunanithi MK, Michniewicz J, Copeland SE, Feneley MP. Right ventricular preload recruitable stroke work, end-systolic pressure volume, and dP/dtmax-end-diastolic volume relations compared as indexes of right ventricular contractile performance in conscious dogs. Circ Res 70: 1169-1179, 1992.
33. Kass DA, Maughan WL, Guo ZM, Kono A, Sunagawa K, Sagawa K. Comparative influence of load versus inotropic states on indexes of ventricular contractility-experimental and theoretical-analysis based on pressure-volume relationships. Circulation 76: 1422-1436, 1987.
34. Kaufman MP, Rybicki KJ. Discharge properties of group III and IV muscle afferents: their responses to mechanical and metabolic stimuli. Circ Res 61: I60-I65, 1987.
35. Khouri EM, Gregg DE, Rayford CR. Effect of exercise on cardiac output, left coronary flow and myocardial metabolism in the unanesthetized dog. Circ Res 17: 427-437, 1965.
36. Kim JK, Sala-Mercado JA, Rodriguez J, Scislo TJ, O'Leary DS. Arterial baroreflex alters strength and mechanisms of muscle metaboreflex during dynamic exercise. Am J Physiol Heart Circ Physiol 288: H1374-H1380, 2005.
37. LaPrad SL, Augustyniak RA, Hammond RL, O'Leary DS. Does gender influence the strength and mechanisms of the muscle metaboreflex during dynamic exercise in dogs? Am J Physiol Regul Integr Comp Physiol 276: R1203-R1208, 1999.
38. Leimbach WN Jr, Wallin BG, Victor RG, Aylward PE, Sundlof G, Mark AL. Direct evidence from intraneural recordings for increased central sympathetic outflow in patients with heart failure. Circulation 73: 913-919, 1986.
39. Little WC, Cheng CP, Mumma M, Igarashi Y, Vinten-Johansen J, Johnston WE. Comparison of measures of left ventricular contractile performance derived from pressure-volume loops in conscious dogs. Circulation 80: 1378-1387, 1989.
40. MacLean DA, Imadojemu VA, Sinoway LI. Interstitial pH, K, lactate, and phosphate determined with MSNA during exercise in humans. Am J Physiol Regul Integr Comp Physiol 278: R563-R571, 2000.
41. Markham RV Jr, Corbett JR, Gilmore A, Pettinger WA, Firth BG. Efficacy of prazosin in the management of chronic congestive heart failure: a 6-month randomized, double-blind, placebo-controlled study. Am J Cardiol 51: 1346-1352, 1983.
42. Mendoza DD, Cooper HA, Panza JA. Cardiac power output predicts mortality across a broad spectrum of patients with acute cardiac disease. Am Heart J 153: 366-370, 2007.
43. Mettauer B, Rouleau JL, Bichet D, Kortas C, Manzini C, Tremblay G, Chatterjee K. Differential long-term intrarenal and neurohormonal effects of captopril and prazosin in patients with chronic congestive heart failure: importance of initial plasma renin activity. Circulation 73: 492-502, 1986.
44. Mittelstadt SW, Bell LB, O'Hagan KP, Clifford PS. Muscle chemoreflex alters vascular conductance in nonischemic exercising skeletal muscle. J Appl Physiol 77: 2761-2766, 1994.
45. Momen A, Gahremanpour A, Mansoor A, Kunselman A, Blaha C, Pae W, Leuenberger UA, Sinoway LI. Vasoconstriction seen in coronary bypass grafts during handgrip in humans. J Appl Physiol 102: 735-739, 2007.
46. Mundhenke M, Schwartzkopff B, Kostering M, Deska U, Klein RM, Strauer BE. Endogenous plasma endothelin concentrations and coronary circulation in patients with mild dilated cardiomyopathy. Heart 81: 278-284, 1999.
47. O'Leary DS, Augustyniak RA. Muscle metaboreflex increases ventricular performance in conscious dogs. Am J Physiol Heart Circ Physiol 275: H220-H224, 1998.
48. O'Leary DS, Augustyniak RA, Ansorge EJ, Collins HL. Muscle metaboreflex improves O2 delivery to ischemic active skeletal muscle. Am J Physiol Heart Circ Physiol 276: H1399-H1403, 1999.
49. O'Leary DS, Sala-Mercado JA, Augustyniak RA, Hammond RL, Rossi NF, Ansorge EJ. Impaired muscle metaboreflex-induced increases in ventricular function in heart failure. Am J Physiol Heart Circ Physiol 287: H2612-H2618, 2004.
50. O'Leary DS, Sala-Mercado JA, Hammond RL, Ansorge EJ, Kim JK, Rodriguez J, Fano D, Ichinose M. Muscle metaboreflex-induced increases in cardiac sympathetic activity vasoconstrict the coronary vasculature. J Appl Physiol 103: 190-194, 2007.
51. O'Leary DS, Sheriff DD. Is the muscle metaboreflex important in control of blood flow to ischemic active skeletal muscle in dogs? Am J Physiol Heart Circ Physiol 268: H980-H986, 1995.
52. O'Leary DS. Altered reflex cardiovascular control during exercise in heart failure: animal studies. Exp Physiol 91: 73-77, 2006.
53. Ogoh S, Fadel PJ, Nissen P, Jans O, Selmer C, Secher NH, Raven PB. Baroreflex-mediated changes in cardiac output and vascular conductance in response to alterations in carotid sinus pressure during exercise in humans. J Physiol 550: 317-324, 2003.
54. Olivier NB, Stephenson RB. Characterization of baroreflex impairment in conscious dogs with pacing-induced heart failure. Am J Physiol Regul Integr Comp Physiol 265: R1132-R1140, 1993.
55. Rotto DM, Kaufman MP. Effect of metabolic products of muscular contraction on discharge of group III and IV afferents. J Appl Physiol 64: 2306-2313, 1988.
56. Rowell LB, Savage MV, Chambers J, Blackmon JR. Cardiovascular responses to graded reductions in leg perfusion in exercising humans. Am J Physiol Heart Circ Physiol 261: H1545-H1553, 1991.
57. Rubin SA, Chatterjee K, Gelberg HJ, Ports TA, Brundage BH, Parmley WW. Paradox of improved exercise but not resting hemodynamics with short-term prazosin in chronic heart failure. Am J Cardiol 43: 810-815, 1979.
58. Sala-Mercado JA, Ichinose M, Hammond RL, Ichinose TK, Pallante M, Stephenson LW, O'Leary DS, Iellamo F. Muscle metaboreflex attenuates spontaneous heart rate baroreflex sensitivity during dynamic exercise. Am J Physiol Heart Circ Physiol 292: H2867-H2873, 2007.
59. Sala-Mercado JA, Hammond RL, Kim JK, Rossi NF, Stephenson LW, O'Leary DS. Muscle metaboreflex control of ventricular contractility during dynamic exercise. Am J Physiol Heart Circ Physiol 290: H751-H757, 2006.
60. Schaper J, Froede R, Hein S, Buck A, Hashizume H, Speiser B, Friedl A, Bleese N. Impairment of the myocardial ultrastructure and changes of the cytoskeleton in dilated cardiomyopathy. Circulation 83: 504-514, 1991.
61. Sheriff DD, Wyss CR, Rowell LB, Scher AM. Does inadequate oxygen delivery trigger pressor response to muscle hypoperfusion during exercise? Am J Physiol Heart Circ Physiol 253: H1199-H1207, 1987.
62. Sinoway LI, Rea RF, Mosher TJ, Smith MB, Mark AL. Hydrogen ion concentration is not the sole determinant of muscle metaboreceptor responses in humans. J Clin Invest 89: 1875-1884, 1992.
63. Sinoway LI, Smith MB, Enders B, Leuenberger U, Dzwonczyk T, Gray K, Whisler S, Moore RL. Role of diprotonated phosphate in evoking muscle reflex responses in cats and humans. Am J Physiol Heart Circ Physiol 267: H770-H778, 1994.
64. Sinoway LI, Wroblewski KJ, Prophet SA, Ettinger SM, Gray KS, Whisler SK, Miller G, Moore RL. Glycogen depletion-induced lactate reductions attenuate reflex responses in exercising humans. Am J Physiol Heart Circ Physiol 263: H1499-H1505, 1992.
65. Spinale FG, Fulbright BM, Mukherjee R, Tanaka R, Hu J, Crawford FA, Zile MR. Relation between ventricular and myocyte function with tachycardia-induced cardiomyopathy. Circ Res 71: 174-187, 1992.
66. Spinale FG, Hendrick DA, Crawford FA, Smith AC, Hamada Y, Carabello BA. Chronic supraventricular tachycardia causes ventricular dysfunction and subendocardial injury. Am J Physiol Heart Circ Physiol 259: H218-H229, 1990.
67. Tune JD, Gorman MW, Feigl EO. Matching coronary blood flow to myocardial oxygen consumption. J Appl Physiol 97: 404-415, 2004.
68. Tune JD, Richmond KN, Gorman MW, Feigl EO. Control of coronary blood flow during exercise. Exp Biol Med 227: 238-250, 2002.
69. Victor RG, Bertocci LA, Pryor SL, Nunnally RL. Sympathetic nerve discharge is coupled to muscle cell pH during exercise in humans. J Clin Invest 82: 1301-1305, 1988.
70. Wyss CR, Ardell JL, Scher AM, Rowell LB. Cardiovascular responses to graded reductions in hindlimb perfusion in exercising dogs. Am J Physiol Heart Circ Physiol 245: H481-H486, 1983.