Development of a nanofluidic preconcentrator with precise sample positioning and multi-channel preconcentration

Microfluidics and Nanofluidics

Volumn 14, Issue 3-4, 2013, Pages 645-655

  Sung, Kung Bin ^a   Liao, Ke Pan ^a   Liu, Yen Lin ^a   Tian, Wei Cheng ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Electrical resistive circuit model; Multi channel preconcentration; Nanofluidic preconcentrator; Precise sample positioning

Indexed keywords

ELECTRIC NETWORK PARAMETERS; MICROCHANNELS; PROTEINS;

ELECTROKINETIC TRAPPING; HIGHLY SENSITIVE DETECTIONS; MULTIPLE MICROCHANNELS; PRE-CONCENTRATION; PRE-CONCENTRATION CAPABILITIES; PRE-CONCENTRATOR; PRECISE SAMPLE POSITIONING; RESISTIVE CIRCUITS;

NANOFLUIDICS;

EID: 84878584974     PISSN: 16134982     EISSN: 16134990     Source Type: Journal    
DOI: 10.1007/s10404-012-1084-6     Document Type: Article

References (22)

1. Atalay YT, Verboven P, Vermeir S, Vergauwe N, Nicolaï B, Lammertyn J (2009) Modeling and optimization of a multi-enzyme electrokinetically driven multiplexed microchip for simultaneous detection of sugars. Microfluid Nanofluid 7:393-406
2. Bard AJ, Faulkner LR (2001) Electrochemical methods, fundamentals and applications. Wiley, New York
3. Berli CLA (2008) Equivalent circuit modeling of electrokinetically driven analytical microsystems. Microfluid Nanofluid 4:391-399
4. Chatterjee AN, Cannon DM Jr, Gatimu EN, Sweedler JV, Aluru NR, Bohn PW (2005) Modeling and simulation of ionic currents in three-dimensional microfluidic devices with nanofluidic interconnects. J Nanopart Res 7:507-516
5. Dittrich PS, Tachikawa K, Manz A (2006) Micro total analysis systems latest advancements and trends. Anal Chem 78:3887-3907
6. Hughes BT, Berg JM, James DL, Ibraguimov A, Liu S, Temkin H (2008) One-dimensional axial simulation of electric double layer overlap effects in devices combining micro- and nanochannels. Microfluid Nanofluid 5:761-774
7. Johnson AM, Sadoway DR, Cima MJ, Langer R (2005) Design and testing of an impedance-based sensor for monitoring drug delivery. J Electrochem Soc 152:H6-H11
8. Kim SM, Burns MA, Hasselbrink EF (2006) Electrokinetic protein preconcentration using a simple glass/poly(dimethylsiloxane) microfluidic chip. Anal Chem 78:4779-4785
9. Kim SJ, Wang Y-C, Lee JH, Jang H, Han J (2007) Concentration polarization and nonlinear electrokinetic flow near a nanofluidic channel. Phys Rev Lett 99(044501):1-4
10. Laurell T, Nilsson J, Jensen K, Harrison DJ, Kutter JP (2004) Micro total analysis systems. The Royal Society of Chemistry, Cambridge
11. Lee JH, Han J (2010) Concentration-enhanced rapid detection of human chorionic gonadotropin as a tumor marker using a nanofluidic preconcentrator. Microfluid Nanofluid 9:973-979
12. Lee JH, Chung S, Kim SJ, Han J (2007) Poly(dimethylsiloxane)-based protein preconcentration using a nanogap generated by junction gap breakdown. Anal Chem 79:6868-6873
13. Lee JH, Song YA, Han J (2008) Multiplexed proteomic sample preconcentration device using surface-patterned ion-selective membrane. Lab Chip 8:596-601
14. Leinweber FC, Tallark U (2004) Nonequilibrium electrokinetic effects in beds of ion-permselective particles. Langmuir 20:11637-11648
15. Liao K-P, Sung K-B (2008) Highly sensitive immunosensor using a nanofluidic preconcentrator. In: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
16. Liao K-P, Sung KB, Tian W-C (2011) Precise sample positioning for multipoint immunoassay using nanofluidic preconcentrator. In: International Solid-State Sensors, Actuators and Microsystems Conference
17. Manz A, Graber N, Widmer HM (1990) Miniaturized total chemical analysis systems: a novel concept for chemical sensing. Sens Actuators, B 1:244-248
18. Pennathur S, Santiago JG (2005) Electrokinetic transport in nanochannels 1 theory. Anal Chem 77:6772-6781
19. Pu Q, Yun J, Temkin H, Liu S (2004) Ion-enrichment and ion-depletion effect of nanochannel structures. Nano Lett 4:1099-1103
20. Qiao R, Aluru NR (2002) A compact model for electroosmotic flows in microfluidic devices. J Micromech Microeng 12:625-635
21. Wang Y-C, Han J (2008) Pre-binding dynamic range and sensitivity enhancement for immuno-sensors using nanofluidic preconcentrator. Lab Chip 8:392-394
22. Wang Y-C, Stevens AL, Han J (2005) Million-fold preconcentration of proteins and peptides by nanofluidic filter. Anal Chem 77:4293-4299