Design, synthesis and evaluation of antimicrobial activity of N-terminal modified Leucocin A analogues

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 13, 2013, Pages 3715-3722

  Bodapati, Krishna Chaitanya ^a   Soudy, Rania ^a   Etayash, Hashem ^a   Stiles, Michael ^b   Kaur, Kamaljit ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b CanBiocin Inc   (Canada)

Author keywords

Antimicrobial activity; Antimicrobial peptide; Class IIa bacteriocins; Leucocin A (LeuA); Native chemical ligation; Solid phase peptide synthesis; Solution conformation; Structure activity relationships

Indexed keywords

ANTIINFECTIVE AGENT; LEUCOCIN A DERIVATIVE; UNCLASSIFIED DRUG; BACTERIOCIN; LEUCOCIN A-UAL 187;

AMINO TERMINAL SEQUENCE; ANTIMICROBIAL ACTIVITY; ARTICLE; CARBOXY TERMINAL SEQUENCE; CARNOBACTERIUM; CARNOBACTERIUM DIVERGENS; CIRCULAR DICHROISM; CONFORMATION; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; LISTERIA MONOCYTOGENES; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR DYNAMICS; NONHUMAN; STRUCTURE ACTIVITY RELATION; AMINO ACID SEQUENCE; CARNOBACTERIACEAE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; HUMAN; LISTERIOSIS; MOLECULAR GENETICS; PROTEIN SECONDARY STRUCTURE; STRUCTURAL HOMOLOGY; SYNTHESIS;

BACTERIA (MICROORGANISMS);

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; BACTERIOCINS; CARNOBACTERIACEAE; HUMANS; LISTERIA MONOCYTOGENES; LISTERIOSIS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, SECONDARY; STRUCTURAL HOMOLOGY, PROTEIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84878544428     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.04.045     Document Type: Article

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