Interobserver variability and the effect of education in the histopathological diagnosis of differentiated vulvar intraepithelial neoplasia

Modern Pathology

Volumn 26, Issue 6, 2013, Pages 874-880

  Van Den Einden, Loes C G ^a   De Hullu, Joanne A ^a   Massuger, Leon F A G ^a   Grefte, Johanna M M ^a,d   Bult, Peter ^a   Wiersma, Anne ^b   Van Engen Van Grunsven, Adriana C H ^a   Sturm, Bart ^a   Bosch, Steven L ^a   Hollema, Harry ^c   Bulten, Johan ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b RIJNSTATE HOSPITAL   (Netherlands)

^c UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^d GELRE HOSPITALS   (Netherlands)

Author keywords

Interobserver agreement; VIN; vulvar carcinoma

Indexed keywords

ARTICLE; DIFFERENTIATED VULVAR INTRAEPITHELIAL NEOPLASM; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; KAPPA STATISTICS; LICHEN SCLEROSUS ET ATROPHICUS; MITOSIS; PRIORITY JOURNAL; SQUAMOUS CELL CARCINOMA; TISSUE CULTURE; TUMOR DIAGNOSIS; VULVA TUMOR;

EID: 84878543184     PISSN: 08933952     EISSN: 15300285     Source Type: Journal    
DOI: 10.1038/modpathol.2012.235     Document Type: Article

References (23)

1. van der Avoort IA, Shirango H, Hoevenaars BM, et al. Vulvar squamous cell carcinoma is a multifactorial disease following two separate and independent pathways. Int J Gynecol Pathol 2006;25:22-29.
2. Maclean AB. Vulval cancer: prevention and screening. Best Pract Res Clin Obstet Gynaecol 2006;20:379-395.
3. Eva LJ, Ganesan R, Chan KK, et al. Differentiated-type vulval intraepithelial neoplasia has a high-risk association with vulval squamous cell carcinoma. Int J Gynecol Cancer 2009;19:741-744.
4. van de Nieuwenhof HP, Bulten J, Hollema H, et al. Differentiated vulvar intraepithelial neoplasia is often found in lesions, previously diagnosed as lichen sclerosus, which have progressed to vulvar squamous cell carcinoma. Mod Pathol 2011;24:297-305.
5. Kokka F, Singh N, Faruqi A, et al. Is differentiated vulval intraepithelial neoplasia the precursor lesion of human papillomavirus-negative vulval squamous cell carcinoma Int J Gynecol Cancer 2011;21:1297-1305.
6. Sideri M, Jones RW, Wilkinson EJ, et al. Squamous vulvar intraepithelial neoplasia: 2004 modified terminology, ISSVD Vulvar Oncology Subcommittee. J Reprod Med 2005;50:807-810.
7. Preti M, Van Seters M, Sideri M, et al. Squamous vulvar intraepithelial neoplasia. Clin Obstet Gynecol 2005;48:845-861.
8. Darragh TM, Colgan TJ, Cox JT, et al. The lower anogenital squamous terminology standardization project for HPV-associated lesions: background and consensus recommendations from the College of American Pathologists and the American Society for Colposcopy and Cervical Pathology. Arch Pathol Lab Med 2012;136:1266-1297.
9. van de Nieuwenhof HP, van der Avoort IA, de Hullu JA. Review of squamous premalignant vulvar lesions. Crit Rev Oncol Hematol 2008;68:131-156.
10. Wilkinson EJ. Premalignant and malignant tumors of the vulva, In: Kurman RJ, Ellenson LH, Ronnett BM(eds) Blaustein's Pathology of the Female Genital Tract, 6th edn. Springer: New York; 2011, pp 55-103.
11. Hart WR. Vulvar intraepithelial neoplasia: historical aspects and current status. Int J Gynecol Pathol 2001;20:16-30.
12. McCluggage WG. Recent developments in vulvovaginal pathology. Histopathology 2009;54:156-173.
13. Scurry J, Campion M, Scurry B, et al. Pathologic audit of 164 consecutive cases of vulvar intraepithelial neoplasia. Int J Gynecol Pathol 2006;25:176-181.
14. Scurry J, Wilkinson EJ. Review of terminology of precursors of vulvar squamous cell carcinoma. J Low Genit Tract Dis 2006;10:161-169.
15. Mulvany NJ, Allen DG. Differentiated intraepithelial neoplasia of the vulva. Int J Gynecol Pathol 2008;27:125-135.
16. Koch GG, Landis JR, Freeman JL, et al. A general methodology for the analysis of experiments with repeated measurement of categorical data. Biometrics 1977;33:133-158.
17. Yang B, Hart WR. Vulvar intraepithelial neoplasia of the simplex (differentiated) type: a clinicopathologic study including analysis of HPV and p53 expression. Am J Surg Pathol 2000;24:429-441.
18. Fox H, Wells M. Recent advances in the pathology of the vulva. Histopathology 2003;42:209-216.
19. Preti M, Mezzetti M, Robertson C, et al. Inter-observer variation in histopathological diagnosis and grading of vulvar intraepithelial neoplasia: results of an European collaborative study. Int J Obstetrics Gynaecol 2000;107:594-599.
20. Trimble CLD-W M, Wilkinson EJ, Zaino RJ, et al. Reproducibility of the histopathological classification of vulvar squamous carcinoma and intraepithelial neoplasia. J Low Genit Tract Dis 1999;3: 98-103.
21. van Beurden M, de Craen AJ, de Vet HC, et al. The contribution of MIB 1 in the accurate grading of vulvar intraepithelial neoplasia. J Clin Pathol 1999;52: 820-824.
22. Hoevenaars BM, van der Avoort IA, de Wilde PC, et al. A panel of p16(INK4A), MIB1 and p53 proteins can distinguish between the 2 pathways leading to vulvar squamous cell carcinoma. Int J Cancer 2008;123: 2767-2773.
23. van der Avoort IA, van der Laak JA, Paffen A, et al. MIB1 expression in basal cell layer: a diagnostic tool to identify premalignancies of the vulva. Mod Pathol 2007;20:770-778.