Protein kinase B phosphorylation correlates with vascular endothelial growth factor A and microvessel density in gastric adenocarcinoma

Journal of International Medical Research

Volumn 40, Issue 6, 2012, Pages 2124-2134

  Zhou, X D ^a   Chen, H X ^b   Guan, R N ^a   Lei, Y P ^a   Shu, X ^a   Zhu, Y ^a   Lv, N H ^a  

^a Department of Gastroenterology ^*  (China)

^b NANCHANG UNIVERSITY   (China)

Author keywords

Angiogenesis; Gastric adenocarcinoma; Microvessel density; Protein kinase B; Vascular endothelial growth factor A

Indexed keywords

CD34 ANTIGEN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; VASCULOTROPIN A;

ADULT; AGED; ANGIOGENESIS; ARTICLE; CELL DENSITY; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; MICROVASCULATURE; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STOMACH ADENOCARCINOMA; STOMACH MUCOSA; UPREGULATION; WESTERN BLOTTING;

EID: 84872246733     PISSN: 03000605     EISSN: 14732300     Source Type: Journal    
DOI: 10.1177/030006051204000610     Document Type: Article

References (39)

1. Parkin DM, Pisani P, Ferlay J, et al: Estimates of the worldwide incidence of 25 major cancers in 1990. Int J Cancer 1999; 80: 827-841.
2. Hundahl SA, Phillips JL, Menck HR: The National Cancer Data Base Report on poor survival of U.S. gastric carcinoma patients treated with gastrectomy: Fifth Edition American Joint Committee on Cancer staging, proximal disease, and the different disease hypothesis. Cancer 2000; 88: 921-932.
3. Leung DW, Cachianes G, Kuang WJ, et al: Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 1989; 246: 1306-1309.
4. Konno H, Ohta M, Baba M, et al: The role of circulating IL-8 and VEGF protein in the progression of gastric cancer. Cancer Sci 2003; 94: 735-740.
5. Ding S, Li C, Lin S, et al: Distinct roles of VEGFA and VEGF-C in tumour metastasis of gastric carcinoma. Oncol Rep 2007; 17: 369-375.
6. Manning BD, Cantley LC: AKT/PKB signaling: navigating downstream. Cell 2007; 129: 1261-1274.
7. Jiang B, Liu L: PI3K/PTEN signaling in tumorigenesis and angiogenesis. Biochim Biophys Acta 2008; 1784: 150-158.
8. Bellacosa A, Testa JR, Staal SP, et al: A retroviral oncogne, Akt, encoding a serine-threonine kinase containing as SH2-like region. Science 1991; 254: 274-277.
9. Carnero A: The PKB/AKT pathway in cancer. Curr Pharm Des 2010; 16: 34-44.
10. Tsutsui S, Matsuyama A, Yamamoto M, et al: The Akt expression correlates with the VEGF-A and -C expression as well as the microvessel and lymphatic vessel density in breast cancer. Oncol Rep 2010; 23: 621-630.
11. Wen YG, Wang Q, Zhou CZ, et al: Mutation analysis of tumor suppressor gene PTEN in patients with gastric carcinomas and its impact on PI3K/AKT pathway. Oncol Rep 2010; 24: 89-95.
12. Yu HG, Ai YW, Yu LL, et al: Phosphoinositide 3- kinase/Akt pathway plays an important role in chemoresistance of gastric cancer cells against etoposide and doxorubicin induced cell death. Int J Cancer 2008; 122: 433-443.
13. Li W, Tan D, Zhang Z, et al: Activation of AktmTOR- p70S6K pathway in angiogenesis in hepatocellular carcinoma. Oncol Rep 2008; 20: 713-719.
14. Fang J, Xia C, Cao Z, et al: Apigenin inhibits VEGF and HIF-1 expression via PI3K/AKT/p70S6K1 and HDM2/p53 pathways. FASEB J 2005; 19: 342-353.
15. He L, Wu Y, Lin L, et al: Hispidulin, a small flavonoid molecule, suppresses the angiogenesis and growth of human pancreatic cancer by targeting vascular endothelial growth factor receptor 2-mediated PI3K/Akt/mTOR signaling pathway. Cancer Sci 2011; 102: 219-225.
16. Sliva D, Jedinak A, Kawasaki J, et al: Phellinus linteus suppresses growth, angiogenesis and invasive behaviour of breast cancer cells through the inhibition of AKT signalling. Br J Cancer 2008; 98: 1348-1356.
17. Silva SR, Bowen KA, Rychahou PG, et al: VEGFR- 2 expression in carcinoid cancer cells and its role in tumor growth and metastasis. Int J Cancer 2011; 128: 1045-1056.
18. Heeg S, Hirt N, Queisser A, et al: EGFR overexpression induces activation of telomerase via PI3K/AKT-mediated phosphorylation and transcriptional regulation through Hif1-alpha in a cellular model of oral-esophageal carcinogenesis. Cancer Sci 2011; 102: 351-360.
19. Sobin LH, Wittekind C (eds): TNM Classification of Malignant Tumors (UICC), 5th edn. Hoboken: Wiley-Blackwell, 1997.
20. Weidner N, Semple JP, Welch WR, et al: Tumor angiogenesis and metastases-correlation in invasive breast carcinoma. N Engl J Med 1991; 324: 1-8.
21. Delli Carpini J, Karam AK, Montgomery L: Vascular endothelial growth factor and its relationship to the prognosis and treatment of breast, ovarian, and cervical cancer. Angiogenesis 2010; 13: 43-58.
22. Huang C, Huang R, Chang W, et al: The expression and clinical significance of pSTAT3, VEGF and VEGF-C in pancreatic adenocarcinoma. Neoplasma 2012; 59: 52-61.
23. Vidal O, Metges JP, Elizalde I, et al: High preoperative serum vascular endothelial growth factor levels predict poor clinical outcome after curative resection of gastric cancer. Br J Surg 2009; 96: 1443-1451.
24. Carmeliet P: Angiogenesis in health and disease. Nat Med 2003; 9: 653-660.
25. Yancopoulos GD, Davis S, Gale NW, et al: Vascular-specific growth factors and blood vessel formation. Nature 2000; 407: 242-248.
26. Nissen LJ, Cao R, Hedlund EM, et al: Angiogenic factors FGF2 and PDGF-BB synergistically promote murine tumor neovascularization and metastasis. J Clin Invest 2007; 117: 2766-2777.
27. Cao Y: Opinion: emerging mechanisms of tumour lymphangiogenesis and lymphatic metastasis. Nat Rev Cancer 2005; 5: 735-743.
28. Kondo K, Kaneko T, Baba M, et al: VEGF-C and VEGF-A synergistically enhance lymph node metastasis of gastric cancer. Biol Pharm Bull 2007; 30: 633-637.
29. Miyamoto N, Yamamoto H, Taniguchi H, et al: Differential expression of angiogenesis-related genes in human gastric cancers with and those without high-frequency microsatellite instability. Cancer Lett 2007; 254: 42-53.
30. Lee SJ, Kim JG, Sohn SK, et al: No association of vascular endothelial growth factor-A (VEGF-A) and VEGF-C expression with survival in patients with gastric cancer. Cancer Res Treat 2009; 41: 218-223.
31. Zhao HC, Qin R, Chen XX, et al: Microvessel density is a prognostic marker of human gastric cancer. World J Gastroenterol 2006; 12: 7598-7603.
32. Saito H, Osaki T, Murakami D, et al: Prediction of sites of recurrence in gastric carcinoma using immunohistochemical parameters. J Surg Oncol 2007; 95: 123-128.
33. Kolev Y, Uetake H, Iida S, et al: Prognostic significance of VEGF expression in correlation with COX-2, microvessel density, and clinicopathological characteristics in human gastric carcinoma. Ann Surg Oncol 2007; 14: 2738-2747.
34. Suzuki S, Dobashi Y, Hatakeyama Y, et al: Clinicopathological significance of plateletderived growth factor (PDGF)-B and vascular endothelial growth factor-A expression, PDGF receptor-β phosphorylation, and microvessel density in gastric cancer. BMC Cancer 2010; 10: 659.
35. Nikiteas NI, Tzanakis N, Theodoropoulos G, et al: Vascular endothelial growth factor and endoglin (CD-105) in gastric cancer. Gastric Cancer 2007; 10: 12-17.
36. Yang S, Zhao Z, Wu R, et al: Expression and biological relationship of vascular endothelial growth factor-A and matrix metalloproteinase- 9 in gastric carcinoma. J Int Med Res 2011; 39: 2076-2085.
37. Johnsen JI, Segerström L, Orrego A, et al: Inhibitors of mammalian target of rapamycin downregulate MYCN protein expression and inhibit neuroblastoma growth in vitro and in vivo. Oncogene 2008; 27: 2910-2922.
38. Gao N, Nester RA, Sarkar MA: 4-Hydroxy estradiol but not 2-hydroxy estradiol induces expression of hypoxia-inducible factor 1α and vascular endothelial growth factor A through phosphatidylinositol 3-kinase/Akt/FRAP pathway in OVCAR-3 and A2780-CP70 human ovarian carcinoma cells. Toxicol Appl Pharmacol 2004; 196: 124-135.
39. Villaume K, Blanc M, Gouysse G, et al: VEGF secretion by neuroendocrine tumor cells is inhibited by octreotide and by inhibitors of the PI3K/AKT/mTOR pathway. Neuroendocrinology 2010; 91: 268-278.