Repair of bone defect by using vascular bundle implantation combined with Runx II gene-transfected adipose-derived stem cells and a biodegradable matrix

Cell and Tissue Research

Volumn 352, Issue 3, 2013, Pages 561-571

  Han, Dong ^a   Li, Jianjun ^b  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Adipose derived stem cells; Gene therapy tissue engineered bone; Rabbit (New Zealand); Runx II; Vascularization

Indexed keywords

ADENOVIRUS VECTOR; COLLAGEN TYPE 1; POLYCAPROLACTONE; POLYLACTIC ACID; TRANSCRIPTION FACTOR RUNX2; VASCULOTROPIN;

ADIPOSE DERIVED STEM CELL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIODEGRADABLE IMPLANT; BIOMECHANICS; BONE DEFECT; BONE DEVELOPMENT; BONE MASS; BONE RADIOGRAPHY; BONE REMODELING; BONE STRENGTH; BONE TRANSPLANTATION; CONTROLLED STUDY; FEMALE; GENETIC TRANSFECTION; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; MICROANGIOGRAPHY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RABBIT; RADIUS; SCANNING ELECTRON MICROSCOPY; STEM CELL GENE THERAPY; TISSUE ENGINEERING; TREATMENT OUTCOME; VASCULARIZATION;

ADIPOSE TISSUE; ANIMALS; BIOCOMPATIBLE MATERIALS; BIOMECHANICAL PHENOMENA; BLOOD VESSELS; CELL SURVIVAL; COLLAGEN TYPE I; CORE BINDING FACTOR ALPHA 1 SUBUNIT; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MICROVESSELS; OSTEOGENESIS; RABBITS; RADIUS; STEM CELL TRANSPLANTATION; STEM CELLS; TISSUE ENGINEERING; TISSUE SCAFFOLDS; TRANSFECTION; VASCULAR ENDOTHELIAL GROWTH FACTOR A; WOUND HEALING;

ADENOVIRIDAE; ORYCTOLAGUS CUNICULUS;

EID: 84878531067     PISSN: 0302766X     EISSN: 14320878     Source Type: Journal    
DOI: 10.1007/s00441-013-1595-9     Document Type: Article

References (29)

1. An C, Cheng Y, Yuan Q, Li J (2010) IGF-1 and BMP-2 induces differentiation of adipose-derived mesenchymal stem cells into chondrocytes-like cells. Ann Biomed Eng 38:1647-1654
2. Beier JP, Horch RE, Hess A, Arkudas A, Heinrich J, Loew J et al (2010) Axial vascularization of a large volume calcium phosphate ceramic bone substitute in the sheep AV loop model. J Tissue Eng Regen Med 4:216-223
3. Carano RAD, Filvaroff EH (2003) Angiogenesis and bone repair. Drug Discov Today 8:980-989
4. Dai KR, Xu XL, Tang TT, Zhu ZA, Yu CF, Lou JR et al (2005) Repairing of goat tibial bone defects with BMP-2 gene-modified tissue-engineered bone. Calcif Tissue Int 77:55-61
5. Divakov MG (1991) Revascularization of avascular spongy bone and head of the femur in transplantation of vascular bundle (an experimental and clinical study). Acta Chir Plast 33:114-125
6. Dragoo JL, Samimi B, Zhu M, Hame SL, Thomas BJ, Lieberman JR et al (2003) Tissue-engineered cartilage and bone using stem cells from human infrapatellar fat pads. J Bone Joint Surg Br 85:740-747
7. Ducy P, Zhang R, Geoffroy V, Ridall AL, Karsenty G (1997) Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell 89:747-754
8. Eweida AM, Nabawi AS, Elhammady HA, Marei MK, Khalil MR, Shawky MS et al (2012) Axially vascularized bone substitutes: a systematic review of literature and presentation of a novel model. Arch Orthop Trauma Surg 132:1353-1362
9. Follmar KE, Prichard HL, DeCroos FC, Wang HT, Levin LS, Klitzman B et al (2007) Combined bone allograft and adipose-derived stem cell autograft in a rabbit model. Ann Plast Surg 58:561-565
10. Fröhlich M, Grayson WL, Wan LQ, Marolt D, Drobnic M, Vunjak-Novakovic G et al (2008) Tissue engineered bone grafts: biological requirements, tissue culture and clinical relevance. Curr Stem Cell Res Ther 3:254-264
11. Justesen J, Pedersen SB, Stenderup K, Kassem M (2004) Subcutaneous adipocytes can differentiate into bone-forming cells in vitro and in vivo. Tissue Eng 10:381-391
12. Komori T, Yagi H, Nomura S, Yamaguchi A, Sasaki K, Deguchi K, Shimizu Y et al (1997) Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell 89:755-764
13. Kruyt MC, De Bruijn J, Veenhof M, Oner FC, Van Blitterswijk CA, Verbout AJ, Dhert WJ (2003) Application and limitations of chloromethyl- benzamidodialkylcarbocyanine for tracing cells used in bone tissue engineering. Tissue Eng 9:105-115
14. Laschke MW, Harder Y, Amon M, Martin I, Farhadi J, Ring A et al (2006) Angiogenesis in tissue engineering:breathing life into constructed tissue substitutes. Tissue Eng 12:2093-2104
15. Li J, Zhao Q, Wang E, Zhang C, Wang G, Yuan Q (2012) Dynamic compression of rabbit adipose-derived stem cells transfected with insulin-like growth factor 1 in chitosan/gelatin scaffolds induces chondrogenesis and matrix biosynthesis. J Cell Physiol 227:2003-2012
16. Miranville A, Heeschen C, Sengenès C, Curat CA, Busse R, Bouloumié A (2004) Improvement of postnatal neovascularization by human adipose tissue-derived stem cells. Circulation 110:349-355
17. Mizuno H, Zuk PA, Zhu M, Lorenz HP, Benhaim P, Hedrick MH (2002) Myogenic differentiation by human processed lipoaspirate cells. Plast Reconstr Surg 109:199-209
18. Nakasa T, Ishida O, Sunagawa T, Nakamae A, Yasunaga Y, Agung M et al (2005) Prefabrication of vascularized bone graft using a combination of fibroblast growth factor-2 and vascular bundle implantation into a novel interconnected porous calcium hydroxyapatite ceramic. J Biomed Mater Res A 75:350-355
19. Nguyen LH, Annabi N, Nikkhah M, Bae H, Binan L, Park S, Kang Y, Yang Y, Khademhosseini A (2012) Vascularized bone tissue engineering: approaches for potential improvement. Tissue Eng Part B Rev 18:363-382
20. Nikolić DK, Jovanović Z, Turković G, Vulović R, Mladenović M (2002) Supracondylar missile fractures of the femur. Injury 33:161-166
21. Ozyurek A, Leblebicioglu G, Bilgili H, Kurum B, Gedikoglu G, Atasever T et al (2008) Effects of vascular bundle implantation on autograft, fresh-frozen allograft, and xenograft incorporation in a rabbit model. Orthopedics 31:135
22. Rodriguez AM, Elabd C, Amri EZ, Ailhaud G, Dani C (2002) Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell 13:4279-4295
23. Safak T, Akyürek M, Ozcan G, Keçik A, Aydin M (2000) Osteocutaneous flap prefabrication based on the principle of vascular induction: an experimental and clinical study. Plast Reconstr Surg 105:1304-1313
24. Winter A, Breit S, Parsch D, Benz K, Steck E, Hauner H et al (2003) Cartilage-like gene expression in differentiated human stem cell spheroids: a comparison of bone marrow-derived and adipose tissue-derived stromal cells. Arthritis Rheum 48:418-429
25. Yang M, Ma QJ, Dang GT, Ma K, Chen P, Zhou CY (2005) In vitro and in vivo induction of bone formation based on ex vivo gene therapy using rat adipose-derived adult stem cells expressing BMP-7. Cytotherapy 7:273-281
26. Zelzer E, Glotzer DJ, Hartmann C, Thomas D, Fukai N, Soker S et al (2001) Tissue specific regulation of VEGF expression during bone development requires Cbfa1/Runx2. Mech Dev 106:97-106
27. Zhang X, Yang M, Lin L, Chen P, Ma KT, Zhou CY et al (2006) Runx2 overexpression enhances osteoblastic differentiation and mineralization in adipose-derived stem cells in vitro and in vivo. Calcif Tissue Int 79:169-178
28. Zhao M, Zhou J, Li X, Fang T, Dai W, Yin W, Dong J (2011) Repair of bone defect with vascularized tissue engineered bone graft seeded with mesenchymal stem cells in rabbits. Microsurgery 31:130-137
29. Zuk PA, Zhu M, Mizuno H, Huang J, Futrell JW, Katz AJ et al (2001) Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng 7:211-228