Human herpesvirus 6 infection after allogeneic stem cell transplantation: Incidence, outcome, and factors associated with HHV-6 reactivation

Transplantation

Volumn 95, Issue 10, 2013, Pages 1292-1298

  Jeulin, Helene ^a,b   Agrinier, Nelly ^c   Guery, Matthieu ^a   Salmon, Alexandra ^d   Clément, Laurence ^d   Bordigoni, Pierre ^b,d   Venard, Véronique ^a,b  

^a CHU NANCY BRABOIS   (France)

^b UNIVERSITÉ DE LORRAINE   (France)

^c UNIVERSITY HOSPITAL OF NANCY   (France)

^d HÔPITAL D ENFANTS   (France)

Author keywords

Diagnosis; Hematopoietic stem cell transplantation; Human herpesvirus 6; Integration; Risk factor

Indexed keywords

CIDOFOVIR; CYCLOSPORIN; FOSCARNET; GANCICLOVIR; METHOTREXATE; STEROID;

ACUTE GRAFT VERSUS HOST DISEASE; ADOLESCENT; ADULT; AGE DISTRIBUTION; ALLOGENEIC STEM CELL TRANSPLANTATION; ARTICLE; CHILD; CHRONIC GRAFT VERSUS HOST DISEASE; CYTOMEGALOVIRUS INFECTION; CYTOPENIA; ENGRAFTMENT; FEMALE; FEVER; HERPES VIRUS INFECTION; HUMAN; HUMAN HERPESVIRUS 6; INCIDENCE; MAJOR CLINICAL STUDY; MALE; MIXED INFECTION; MORTALITY; PRIORITY JOURNAL; PROGNOSIS; RASH; RISK FACTOR; SCHOOL CHILD; SEX DETERMINATION; TREATMENT OUTCOME; VIRUS ENCEPHALITIS; VIRUS LOAD; VIRUS REACTIVATION;

ADULT; DNA, VIRAL; FEMALE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HERPESVIRUS 6, HUMAN; HUMANS; INCIDENCE; MALE; PROGNOSIS; ROSEOLOVIRUS INFECTIONS; TRANSPLANTATION, HOMOLOGOUS; VIRAL LOAD; VIRUS ACTIVATION;

EID: 84878528595     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e318289958b     Document Type: Article

References (34)

1. Salahuddin SZ, Ablashi DV, Markham PD, et al. Isolation of a new virus, HBLV, in patients with lymphoproliferative disorders. Science 1986; 234: 596.
2. Bhattarakosol P, Pancharoen C, Mekmullica J. Seroprevalence of antihuman herpes virus-6 IgG antibody in children of Bangkok, Thailand. Southeast Asian J Trop Med Public Health 2001; 32: 143.
3. Yamanishi K, Okuno T, Shiraki K, et al. Identification of human herpesvirus-6 as a causal agent for exanthem subitum. Lancet 1988; 1: 1065.
4. Radonić A, Oswald O, Thulke S, et al. Infections with human herpesvirus 6 variant B delay platelet engraftment after allogeneic haematopoietic stem cell transplantation. Br J Haematol 2005; 131: 480.
5. Betts BC, Young J-AH, Ustun C, et al. Human herpesvirus 6 infection after hematopoietic cell transplantation: is routine surveillance necessary? Biol Blood Marrow Transplant 2011; 17: 1562.
6. Jaskula E, Dlubek D, Sedzimirska M, et al. Reactivations of cytomegalovirus, human herpes virus 6, and Epstein-Barr virus differ with respect to risk factors and clinical outcome after hematopoietic stem cell transplantation. Transplant Proc 2010; 42: 3273.
7. Singh N, Carrigan DR. Human herpesvirus-6 in transplantation: an emerging pathogen. Ann Intern Med 1996; 124: 1065.
8. Drobyski WR, Knox KK, Majewski D, et al. Brief report: fatal encephalitis due to variant B human herpesvirus-6 infection in a bone marrowYtransplant recipient. N Engl J Med 1994; 330: 1356.
9. Ljungman P, Singh N. Human herpesvirus-6 infection in solid organ and stem cell transplant recipients. J Clin Virol 2006; 37(Suppl 1): S87.
10. de Pagter PJA, Schuurman R, Visscher H, et al. Human herpes virus 6 plasma DNA positivity after hematopoietic stem cell transplantation in children: an important risk factor for clinical outcome. Biol Blood Marrow Transplant 2008; 14: 831.
11. Leong HN, Tuke PW, Tedder RS, et al. The prevalence of chromosomally integrated human herpesvirus 6 genomes in the blood of UK blood donors. Blood 2007; 51: 45.
12. Tanaka-Taya K, Sashihara J, Kurahashi H, et al. Human herpesvirus 6 (HHV-6) is transmitted from parent to child in an integrated form and characterization of cases with chromosomally integrated HHV-6 DNA. J Med Virol 2004; 73: 465.
13. Potenza L, Barozzi P, Masetti M, et al. Prevalence of human herpesvirus-6 chromosomal integration (CIHHV-6) in Italian solid organ and allogeneic stem cell transplant patients. Am J Transplant 2009; 9: 1690.
14. Gautheret-Dejean A, Henquell C, Mousnier F, et al. Different expression of human herpesvirus-6 (HHV-6) load in whole blood may have a significant impact on the diagnosis of active infection. J Clin Virol 2009; 46: 33.
15. Gautheret-Dejean A, Manichanh C, Thien-Ah-Koon F, et al. Development of a real-time polymerase chain reaction assay for the diagnosis of human herpesvirus-6 infection and application to bone marrow transplant patients. J Virol Methods 2002; 100: 27.
16. Jeulin H, Gue'ry M, Cle'ment L, et al. Chromosomally integrated HHV- 6: slow decrease of HHV-6 viral load after hematopoietic stem-cell transplantation. Transplantation 2009; 88: 1142.
17. Jeulin H, Salmon A, Gautheret-Dejean A, et al. Contribution of human herpesvirus 6 (HHV-6) viral load in whole blood and serum to investigate integrated HHV-6 transmission after haematopoietic stem cell transplantation. J Clin Virol 2009; 45: 43.
18. Hentrich M, Oruzio D, Ja?ger G, et al. Impact of human herpesvirus-6 after haematopoietic stem cell transplantation. Br J Haematol 2005; 128: 66.
19. Zerr DM. Human herpesvirus-6: a clinical update. Herpes 2006; 13: 20.
20. Kadakia MP, Rybka WB, Stewart JA, et al. Human herpesvirus 6: infection and disease following autologous and allogeneic bone marrow transplantation. Blood 1996; 87: 534.
21. Yoshikawa T, Morooka M, Suga S, et al. Five cases of thrombocytopenia induced by primary human herpesvirus 6 infection. Acta Paediatr Jpn 1998; 40: 278.
22. Hubacek P, Muzikova K, Hrdlickova A, et al. Prevalence of HHV-6 integrated chromosomally among children treated for acute lymphoblastic or myeloid leukemia in the Czech Republic. J Med Virol 2009; 263: 258.
23. Clark DA, Nacheva EP, Leong HN, et al. Transmission of integrated human herpesvirus 6 through stem cell transplantation: implications for laboratory diagnosis. J Infect Dis 2006; 193: 912.
24. Hubacek P, Virgili A, Ward KN, et al. HHV-6 DNA throughout the tissues of two stem cell transplant patients with chromosomally integrated HHV-6 and fatal CMV pneumonitis. Br J Haematol 2009; 145: 394.
25. Hubacek P, Hyncicova K, Muzikova K, et al. Disappearance of preexisting high HHV-6 DNA load in blood after allogeneic SCT. Bone Marrow Transplant 2007; 40: 805.
26. Scho?nberger S, Meisel R, Adams O, et al. Prospective, comprehensive, and effective viral monitoring in children undergoing allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 2010; 16: 1428.
27. Imbert-Marcille BM, Tang XW, Lepelletier D, et al. Human herpesvirus 6 infection after autologous or allogeneic stem cell transplantation: a single-center prospective longitudinal study of 92 patients. Clin Infect Dis 2000; 31: 881.
28. Sashihara J, Tanaka-Taya K, Tanaka S, et al. High incidence of human herpesvirus 6 infection with a high viral load in cord blood stem cell transplant recipients. Blood 2002; 100: 2005.
29. Yamane A, Mori T, Suzuki S, et al. Risk factors for developing human herpesvirus 6 (HHV-6) reactivation after allogeneic hematopoietic stem cell transplantation and its association with central nervous system disorders. Biol Blood Marrow Transplant 2007; 13: 100.
30. Scheurer ME, Pritchett JC, Amirian ES, et al. HHV-6 encephalitis in umbilical cord blood transplantation: a systematic review and meta-analysis. Bone Marrow Transplant 2013; 48: 574.
31. Savolainen H, Lautenschlager I, Piiparinen H, et al. Human herpesvirus-6 and -7 in pediatric stem cell transplantation. Pediatr Blood Cancer 2005; 45: 820.
32. Wang F, Yao K, Yin Q-Z, et al. Human herpesvirus-6Yspecific interleukin 10Yproducing CD4+ T cells suppress the CD4+ T-cell response in infected individuals. Microbiol Immunol 2006; 50: 787.
33. Peduzzi P, Concato J, Kemper E, et al. A simulation study of the number of events per variable in logistic regression analysis. J Clin Epidemiol 1996; 49: 1373.
34. Pichereau C, Desseaux K, Janin A, et al. The complex relationship between human herpesvirus 6 and acute graft-versus-host disease. Biol Blood Marrow Transplant 2012; 18: 141.