Efficacy, safety, and medication errors associated with the use of inhaled epoprostenol for adults with acute respiratory distress syndrome: A pilot study;Eficacia, seguridad y errores en medicación asociados con el uso de epoprostenol inhalados en adultos con síndrome de dificultad respiratoria aguda: Un estudio piloto

Annals of Pharmacotherapy

Volumn 47, Issue 6, 2013, Pages 790-796

  Dunkley, Kisha A ^a   Louzon, Patricia R ^b   Lee, Jinjoo ^b   Vu, Steve ^b  

^a JOHNS HOPKINS HOSPITAL   (United States)

^b FLORIDA HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROSTACYCLIN;

ADULT; ADULT RESPIRATORY DISTRESS SYNDROME; ARTERIAL OXYGEN TENSION; ARTICLE; CLINICAL ARTICLE; DEMOGRAPHY; DIZZINESS; DRUG EFFICACY; DRUG INDUCED HEADACHE; DRUG SAFETY; DRUG USE; HUMAN; HYPOTENSION; MEDICAL RECORD REVIEW; MEDICATION ERROR; NAUSEA; OBSERVATIONAL STUDY; OXYGENATION; PILOT STUDY; POSITIVE END EXPIRATORY PRESSURE; PRIORITY JOURNAL; RETROSPECTIVE STUDY; TREATMENT DURATION; VOMITING;

ADMINISTRATION, INHALATION; ADULT; AGED; FEMALE; HUMANS; HYPOTENSION; MALE; MEDICATION ERRORS; MIDDLE AGED; PILOT PROJECTS; RETROSPECTIVE STUDIES; SURVIVAL ANALYSIS;

EID: 84878517266     PISSN: 10600280     EISSN: None     Source Type: Journal    
DOI: 10.1345/aph.1R540     Document Type: Article

References (24)

1. Bernard GR, Artigas A, Brigham KL, et al. The American-European consensus conference on ARDS: definitions, mechanisms, relevant outcomes and clinical trial coordination. Am J Respir Crit Care Med 1994; 149:818-824.
2. Domenighetti G, Stricker H, Waldispuehl B. Nebulized prostacyclin (PGI2) in acute respiratory distress syndrome: impact of primary (pulmonary injury) and secondary (extrapulmonary injury) disease on gas exchange response. Crit Care Med 2001;29:57-62. doi: 10.1097/00003246-200101000-00015
3. Camamo JM, McCoy RH, Erstad BL. Retrospective evaluation of inhaled prostaglandins in patients with acute respiratory distress syndrome. Pharmacotherapy 2005;25:184-190. doi: 10.1592/phco.25.2.184.56952
4. Lubnow M, Luchner A, Philipp A, et al. Combination of high frequency oscillatory ventilation and interventional lung assist in severe acute respiratory distress syndrome. J Crit Care 2010;25:436-444. doi: 10.1016/j.jcrc.2009.11.004
5. Frutos-Vivar F, Nin N, Esteban A. Epidemiology of acute lung injury and acute respiratory distress syndrome. Curr Opin Crit Care 2004;10:1-6. doi: 10.1097/00075198-200402000-00001
6. Frutos-Vivar F, Ferguson ND, Esteban A. Epidemiology of acute lung injury and acute respiratory distress syndrome. Semin Respir Crit Care Med 2006;27:327-336. doi: 10.1055/s-2006-948287
7. Vane JR, Botting RM. Pharmacodynamic profile of prostacyclin. Am J Cardiol 1995;75:3A-10A. doi: 10.1016/S0002-9149(99)80377-4
8. Walmrath D, Schneider T, Schermuly R, et al. Direct comparison of inhaled nitric oxide and aerosolized prostacyclin in acute respiratory distress syndrome. Am J Respir Crit Care Med 1996;153:991-996.
9. Van Heerden P V, Barden A, Michalopoulos N, et al. Dose-response to inhaled aerosolized prostacyclin for hypoxemia due to ARDS. Chest 2000; 117:819-827.
10. Dahlem P, Aalderen WM, Neef M, et al. Randomized controlled trial of aerosolized prostacyclin therapy in children with acute lung injury. Crit Care Med 2004;32:1055-1060. doi: 10.1097/01.CCM.0000120055.52377.BF
11. Kingman MS, Tankersley MA, Lombardi S, et al. Prostacyclin administration errors in pulmonary arterial hypertension patients admitted to hospitals in the United States: a national survey. J Heart Lung Transplant 2010;29:841-846. doi: 10.1016/j.healun.2010.03.008
12. Package insert. Epoprostenol sodium for injection (Flolan). Research Triangle Park, NC: GlaxoSmithKline, April 2011.
13. van Heerden PV, Blythe D, Webb SAR. Inhaled aerosolized prostacyclin and nitric oxide as selective pulmonary vasodilators in ARDS-a pilot study. Anaesth Intensive Care 1996;24:564-568.
14. McMillen JC, Burke CF, Dhingra A, et al. Use of inhaled epoprostenol in patients with H1N1 influenza-associated acute respiratory distress syndrome: a case series. Ann Pharmacother 2011;45:e26. doi: 10.1345/aph.1P585
15. Walmrath D, Schneider T, Pilch J, et al. Aerosolised prostacyclin in adult respiratory distress syndrome. Lancet 1993;42:961-962. doi: 10.1016/0140-6736(93)92004-D
16. De Wet CJ, Affleck DG, Jacobsohn E, et al. Inhaled prostacyclin is safe, effective, and affordable in patients with pulmonary hypertension, right heart dysfunction, and refractory hypoxemia after cardiothoracic surgery. J Thorac Cardiovasc Surg 2004;127:1058-1067. doi: 10.1016/j.jtcvs2003.11.035
17. Siobal MS, Hess DR. Are inhaled vasodilators useful in acute lung injury and acute respiratory distress syndrome? Respir Care 2010;55:144-157.
18. Zwissler B, Kemming G, Habler O, et al. Inhaled prostacyclin (PGI2) versus inhaled nitric oxide in adult respiratory distress syndrome. Am J Respir Crit Care Med 1996;154:1671-1677.
19. Derdak S, Mehta S, Stewart TE, et al. High-frequency oscillatory ventilation for acute respiratory distress syndrome in adults: a randomized, controlled trial. Am J Respir Crit Care Med 2002;166:801-808. doi: 10.1164/rccm.2108052
20. Sedeek KA, Takeuchi M, Suchodolski K, et al. Determinants of tidal volume during high-frequency oscillation. Crit Care Med 2003;31:227-231.
21. Buckley MS, Feldman JP. Inhaled epoprostenol for the treatment of pulmonary arterial hypertension in critically ill adults. Pharmacotherapy 2010;30:728-740. doi: 10.1592/phco.30.7.7
22. Meyer J, Theilmeier G, Aken HV, et al. Inhaled prostaglandin E1 for the treatment of acute lung injury in severe multiple organ failure. Anesth Analg 1998;86:753-758.
23. Haraldsson A, Kieler-Jensen N, Nathorst-Westfelt U, Bergh CH, Ricksten SE. Comparison of inhaled nitric oxide and inhaled aerosolized prostacyclin in the evaluation of heart transplant candidates with elevated pulmonary vascular resistance. Chest 1998;114:780-786. doi: 10.1378/chest.114.3.780
24. Hache M, Denault AY, Belisle S, et al. Inhaled prostacyclin (PGI2) is an effective addition to the treatment of pulmonary hypertension and hypoxia in the operating room and intensive care unit. Can J Anaesth 2001;48: 924-929. doi: 10.1007/BF03017361