Development of Microfabricated Capillary Array Electrophoresis Chip and Direct Observation of Dynamics of DNA Molecules Migrating in Microchannels

IEEJ Transactions on Sensors and Micromachines

Volumn 119, Issue 10, 1999, Pages 460-463

  Ueda, Masanori ^a   Baba, Yoshinobu ^a   Tabata, Osamu ^b  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b RITSUMEIKAN UNIVERSITY   (Japan)

Author keywords

capillary array electrophoresis; DNA analysis; laser induced fluorescence detection; LIGA process; microfabrication

Indexed keywords

EID: 84878505738     PISSN: 13418939     EISSN: 13475525     Source Type: Journal    
DOI: 10.1541/ieejsmas.119.460     Document Type: Article

References (9)

1. Y. Baba: Analysis of Disease-Causing Genes and DNA Based Drugs by Capillary Electrophoresis: Towards DNA Diagnosis and Gene Therapy for Human Diseases, J. Chromatogr., 687, 271-302 (1996).
2. F. Collins, A. Partinos, E. Jordan, A. Chakravarti, R. Gesteland, L. Walters, and the Mmbers of the DOE and NIH planning groups: New Goals for the U. S. Human Genome Project: 1998-2003, Science, 282, 682-689 (1998).
3. A. Manz, D. J. Harrison, E. Verpoorte, E., and H. M. Widmer: Planar chips technology for miniaturization of separation systems: A developing perspective in chemical monitoring, Adv. Chromatogr., 33, 1-66 (1993).
4. C. L. Colyer, T. Tang, N. Chiem, and D. J. Harrison: Clinical potential of microchip capillary electrophoresis systems, Electrophoresis, 18, 1733-1741 (1997).
5. C. S. Effenhauser, G. J. M. Bruin, and A. Paulus; Integrated chip-based capillary electrophoresis, Electrophoresis, 18, 2203-2213 (1997).
6. Y. Baba, Integrated Microfabricated Device Technologies: Advances in Genomic, Drug Discovery, and Clinical Diagnostic Applications, M. H. Heller and A. Guttman (Editors), Marcel Dekker Publisher, 1999.
7. Y. Baba and O. Tabata: Novel Microfabricated Capillary Array Electrophoresis Chip Fabricated by Synchrotron Radiation and Direct Observation of Dynamics of DNA Molecules Migrating in Microchannels, MESA, 1998, 331-334.
8. M. Ueda, H. Oana, Y. Baba, M. Doi, and K. Yoshikawa: Electrophoresis of Long DNA Molecules in Linear Polyacrylamide Solution, Biophys. Chem., 71, 113-123 (1998).
9. M. Ueda and Y. Baba: Imaging of DNA Molecule during Electrophoresis, Bioimaging, 7, 31-37 (1998).