Physicians' responses to computerized drug-drug interaction alerts for outpatients

Computer Methods and Programs in Biomedicine

Volumn 111, Issue 1, 2013, Pages 17-25

  Yeh, Min Li ^a,b   Chang, Ying Jui ^b,c,d   Wang, Po Yen ^d   Li, Yu Chuan ^d   Hsu, Chien Yeh ^d  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b ORIENTAL INSTITUTE OF TECHNOLOGY   (Taiwan)

^c FAR EASTERN MEMORIAL HOSPITAL   (Taiwan)

^d TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Alert system; Drug drug interactions; Override; Patient safety

Indexed keywords

ADVERSE DRUG REACTIONS; ALERT SYSTEMS; COMPUTERIZED PHYSICIAN ORDER ENTRY SYSTEMS; DRUG-DRUG INTERACTIONS; LEARNING CURVE EFFECT; MEDICATION ERRORS; OVERRIDE; PATIENT SAFETY;

COMPUTER SOFTWARE; JAVA PROGRAMMING LANGUAGE;

DRUG INTERACTIONS;

AMIODARONE; ANTACID AGENT; ANTICOAGULANT AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CORTICOSTEROID; DIGOXIN; HYDANTOIN; IRON SALT; LEVODOPA; PARACETAMOL; PYRIDOXINE; QUINOLONE DERIVATIVE; SEROTONIN UPTAKE INHIBITOR; THEOPHYLLINE; VALPROIC ACID;

ARTICLE; COMPUTER PROGRAM; COMPUTER SYSTEM; COMPUTERIZED DRUG INTERACTION ALERT SYSTEM; COMPUTERIZED PROVIDER ORDER ENTRY; DATA BASE; GENERAL PRACTITIONER; GYNECOLOGIST; HUMAN; INFORMATION SYSTEM; PATIENT SAFETY; PEDIATRICS; PHARMACIST; PHYSICIAN; PRESCRIPTION; PSYCHIATRIST;

AMBULATORY CARE; DATABASES, FACTUAL; DRUG INTERACTIONS; DRUG-RELATED SIDE EFFECTS AND ADVERSE REACTIONS; HUMANS; MEDICAL ORDER ENTRY SYSTEMS; PHYSICIANS; SOFTWARE;

EID: 84878483722     PISSN: 01692607     EISSN: 18727565     Source Type: Journal    
DOI: 10.1016/j.cmpb.2013.02.006     Document Type: Article

References (34)

1. Lazarou J., Pomeranz B.H., Corey P.N. Incidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studies. Journal of American Medical Association 1998, 279:1200-1205.
2. Kohn L.T., Corrigan J., Donaldson M.S. To Err is Human: Building a Safer Health System 2000, National Academy Press, Washington, DC.
3. Great Britain Department of Health An Organisation with a Memory: Report of an Expert Group on Learning from Adverse Events in the NHS 2000, Stationery Office, London.
4. Bates D.W., Cullen D.J., Laird N., Petersen L.A., Small S.D., Servi D., Laffel G., Sweitzer B.J., Shea B.F., Hallisey R., Vliet M.V., Nemeskal R., Leape L.L., Servi D., Laird N., Bates D., Hojnowski-Diaz P., Petersen L.A., Petrycki S., Vliet M.V., Cotugno M., Patterson H., Shea B.F., Hickey M., Kleefield S., Cooper J., Cullen D.J., Kinneally E., Nemeskal R., Sweitzer B.J., Small S.D., Demonaco H.J., Clapp M.D., Hallisey R., Gallivan T., Ives J., Porter K., Thompson B.T., Laffel G., Hackman J.R., Edmondson A. Incidence of adverse drug events and potential adverse drug events. Implications for prevention. ADE Prevention Study Group. Journal of American Medical Association 1995, 274:29-34.
5. Guedon-Moreau L., Ducrocq D., Duc M.F., Quieureux Y., L'Hote C., Deligne J., Caron J. Absolute contraindications in relation to potential drug interactions in outpatient prescriptions: analysis of the first five million prescriptions in 1999. European Journal of Clinical Pharmacology 2003, 59:689-695.
6. Gandhi T.K., Weingart S.N., Borus J., Seger A.C., Peterson J., Burdick E., Seger D.L., Shu K., Federico F., Leape L.L., Bates D.W. Adverse drug events in ambulatory care. New England Journal of Medicine 2003, 348:1556-1564.
7. Impicciatore P., Choonara I., Clarkson A., Provasi D., Pandolfini C., Bonati M. Incidence of adverse drug reactions in paediatric in/out-patients: a systematic review and meta-analysis of prospective studies. British Journal of Clinical Pharmacology 2001, 52:77-83.
8. Lin M.S., Chang N.C., Yang K.Y.H., Chen Y.H. The potential drug-drug interactions in an ambulatory prescription data in Taiwan. The 20th International Conference on Pharmacoepidemiology and Therapeutic Risk Management, Bordeaux, France 2004, pp. 36.
9. Glassman P.A., Simon B., Belperio P., Lanto A. Improving recognition of drug interactions: benefits and barriers to using automated drug alerts. Medical Care 2002, 40:1161-1171.
10. Chang Y.J., Yeh M.L., Li Y.C., Hsu C.Y., Yen Y.T., Wang P.Y., Chu T.W. Potential drug interactions in dermatologic outpatient prescriptions-experience from nationwide population-based study in Taiwan. Dermatologica Sinica 2011, 29:81-85.
11. Davidson K.W., Kahn A., Price R.D. Reduction of adverse drug reactions by computerized drug interaction screening. Journal of Family Practice 1987, 25:371-375.
12. Murff H.J., Patel V.L., Hripcsak G., Bates D.W. Detecting adverse events for patient safety research: a review of current methodologies. Journal of Biomedical Informatics 2003, 36:131-143.
13. Bates D.W., Gawande A.A. Improving safety with information technology. New England Journal of Medicine 2003, 348:2526-2534.
14. Hsieh T.C., Kuperman G.J., Jaggi T., Hojnowski-Diaz P., Fiskio J., Williams D.H., Bates D.W., Gandhi T.K. Characteristics and consequences of drug allergy alert overrides in a computerized physician order entry system. Journal of the American Medical Informatics Association 2004, 11:482-491.
15. Weingart S.N., Toth M., Sands D.Z., Aronson M.D., Davis R.B., Phillips R.S. Physicians' decisions to override computerized drug alerts in primary care. Archives of Internal Medicine 2003, 163:2625-2631.
16. D.S Tatro, Drug Interaction Facts 2001. Facts & Comparisons, St. Louis, MO, 2001.
17. D.S. Tatro, Significance rating, in: Drug Interaction Facts 2001. Facts & Comparisons, St. Louis, MO, 2001, pp. xiv-xv.
18. Van Der Sijs H., Aarts J., Vulto A., Berg M. Overriding of drug safety alerts in computerized physician order entry. Journal of the American Medical Informatics Association 2006, 13:138-147.
19. Glassman P.A., Belperio P., Simon B., Lanto A., Lee M. Exposure to automated drug alerts over time: effects on clinicians' knowledge and perceptions. Medical Care 2006, 44:250-256.
20. Grizzle A.J., Mahmood M.H., Ko Y., Murphy J.E., Armstrong E.P., Skrepnek G.H., Jones W.N., Schepers G.P., Nichol W.P., Houranieh A., Dare D.C., Hoey C.T., Malone D.C. Reasons provided by prescribers when overriding drug-drug interaction alerts. American Journal of Managed Care 2007, 13:573-578.
21. Sittig D.F., Krall M., Kaalaas-Sittig J., Ash J.S. Emotional aspects of computer-based provider order entry: a qualitative study. Journal of the American Medical Informatics Association 2005, 12:561-567.
22. Long A.J., Chang P., Li Y.C., Chiu W.T. The use of a CPOE log for the analysis of physicians' behavior when responding to drug-duplication reminders. International Journal of Medical Informatics 2008, 77:499-506.
23. Magnus D., Rodgers S., Avery A.J. GPs' views on computerized drug interaction alerts: questionnaire survey. Journal of Clinical Pharmacy and Therapeutics 2002, 27:377-382.
24. Isaac T., Weissman J.S., Davis R.B., Massagli M., Cyrulik A., Sands D.Z., Weingart S.N. Overrides of medication alerts in ambulatory care. Archives of Internal Medicine 2009, 169:305-311.
25. Heeringa M., Beurskens R., Schouten W., Verduijn M.M. Elevated plasma levels of clozapine after concomitant use of fluvoxamine. Pharmacy World & Science 1999, 21:243-244.
26. Olesen O.V., Linnet K. Fluvoxamine-clozapine drug interaction: inhibition in vitro of five cytochrome P450 isoforms involved in clozapine metabolism. Journal of Clinical Psychopharmacology 2000, 20:35-42.
27. Lu M.L., Lane H.Y., Chen K.P., Jann M.W., Su M.H., Chang W.H. Fluvoxamine reduces the clozapine dosage needed in refractory schizophrenic patients. Journal of Clinical Psychiatry 2000, 61:594-599.
28. D.S. Tatro, Iron Salts and Antacids, in: Drug Interaction Facts 2003, Facts & Comparisons, St. Louis, Mo., 2003, pp. 753.
29. D.S. Tatro, Acetaminophen and Hydantoins, in: Drug Interaction Facts 2003, Facts & Comparisons, St. Louis, Mo., 2003, pp. 8.
30. D.S. Tatro, Beta Blockers and Serotonin Reuptake Inhibitors, in: Drug Interaction Facts 2003, Facts & Comparisons, St. Louis, Mo., 2003, pp. 262.
31. D.S. Tatro, Quinolones and Antacids, in: Drug Interaction Facts 2003, Facts & Comparisons, St. Louis, Mo., 2003, pp. 1100.
32. Bates D.W. CPOE and clinical decision support in hospitals: getting the benefits: comment on "Unintended effects of a computerized physician order entry nearly hard-stop alert to prevent a drug interaction" Archives of Internal Medicine 2010, 170:1583-1584.
33. Smithburger P.L., Buckley M.S., Bejian S., Burenheide K., Kane-Gill S.L. A critical evaluation of clinical decision support for the detection of drug-drug interactions. Expert Opinion on Drug Safety 2011, 10:871-882.
34. Tey H.L., Tian E.L., Tan A.W. Drug interactions in dermatological practice. Clinical and Experimental Dermatology 2008, 33:541-550.