Multiple serotonergic paths to antidepressant efficacy

Journal of Neurophysiology

Volumn 109, Issue 9, 2013, Pages 2245-2249

  Lutz, Pierre Eric ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

Depression; Neurogenesis; Selective serotonin reuptake inhibitor; Serotonin receptor

Indexed keywords

1 (4 AMINO 5 CHLORO 2 METHOXYPHENYL) 3 (1 BUTYL 4 PIPERIDINYL) 1 PROPANONE; ANTIDEPRESSANT AGENT; BW 723 C86; FLUOXETINE; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; SEROTONIN UPTAKE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; DEPRESSION; DRUG EFFICACY; HUMAN; NONHUMAN; PRIORITY JOURNAL; TREATMENT RESPONSE;

DEPRESSION; NEUROGENESIS; SELECTIVE SEROTONIN REUPTAKE INHIBITOR; SEROTONIN RECEPTOR;

ANIMALS; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; DEPRESSION; DEPRESSIVE DISORDER; HUMANS; RECEPTORS, SEROTONIN; SEROTONERGIC NEURONS; SEROTONIN AGENTS; SEROTONIN UPTAKE INHIBITORS;

EID: 84878481079     PISSN: 00223077     EISSN: 15221598     Source Type: Journal    
DOI: 10.1152/jn.01093.2012     Document Type: Article

References (21)

1. Albert PR. Transcriptional regulation of the 5-HT1A receptor: implications for mental illness. Philos Trans R Soc Lond B Biol Sci 367: 2402-2415, 2012.
2. Bjork K, Svenningsson P. Modulation of monoamine receptors by adaptor proteins and lipid rafts: role in some effects of centrally acting drugs and therapeutic agents. Annu Rev Pharmacol Toxicol 51: 211-242, 2011.
3. Blier P, de Montigny C. Current advances and trends in the treatment of depression. Trends Pharmacol Sci 15: 220-226, 1994.
4. Celada P, Puig MV, Casanovas JM, Guillazo G, Artigas F. Control of dorsal raphe serotonergic neurons by the medial prefrontal cortex: involvement of serotonin-1A, GABA(A), and glutamate receptors. J Neurosci 21: 9917-9929, 2001.
5. Diaz SL, Doly S, Narboux-Neme N, Fernandez S, Mazot P, Banas SM, Boutourlinsky K, Moutkine I, Belmer A, Roumier A, Maroteaux L. 5-HT(2B) receptors are required for serotonin-selective antidepressant actions. Mol Psych 17: 154-163, 2012.
6. Doly S, Valjent E, Setola V, Callebert J, Herve D, Launay JM, Maroteaux L. Serotonin 5-HT2B receptors are required for 3,4-methylenedioxymeth amphetamine-induced hyperlocomotion and 5-HT release in vivo and in vitro. J Neurosci 28: 2933-2940, 2008.
7. Egeland M, Warner-Schmidt J, Greengard P, Svenningsson P. Neurogenic effects of fluoxetine are attenuated in p11 (S100A10) knockout mice. Biol Psychol 67: 1048-1056, 2010.
8. Hannon J, Hoyer D. Molecular biology of 5-HT receptors. Behav Brain Res 195: 198-213, 2008.
9. Hutcheson JD, Setola V, Roth BL, Merryman WD. Serotonin receptors and heart valve disease-it was meant 2B. Pharmacol Ther 132: 146-157, 2011.
10. Lemonde S, Turecki G, Bakish D, Du L, Hrdina PD, Bown CD, Sequeira A, Kushwaha N, Morris SJ, Basak A, Ou XM, Albert PR. Impaired repression at a 5-hydroxytryptamine 1A receptor gene polymorphism associated with major depression and suicide. J Neurosci 23: 8788-8799, 2003.
11. Lucas G, Compan V, Charnay Y, Neve RL, Nestler EJ, Bockaert J, Barrot M, Debonnel G. Frontocortical 5-HT4 receptors exert positive feedback on serotonergic activity: viral transfections, subacute and chronic treatments with 5-HT4 agonists. Biol Psychol 57: 918-925, 2005.
12. Lucas G, Rymar VV, Du J, Mnie-Filali O, Bisgaard C, Manta S, Lambas-Senas L, Wiborg O, Haddjeri N, Pineyro G, Sadikot AF, Debonnel G. Serotonin(4) (5-HT(4)) receptor agonists are putative antidepressants with a rapid onset of action. Neuron 55: 712-725, 2007.
13. McDevitt RA, Neumaier JF. Regulation of dorsal raphe nucleus function by serotonin autoreceptors: a behavioral perspective. J Chem Neuroanat 41: 234-246, 2011.
14. Mnie-Filali O, Faure C, Lambas-Senas L, Mansari ME, Belblidia H, Gondard E, Etievant A, Scarna H, Didier A, Berod A, Blier P, Haddjeri N. Pharmacological blockade of 5-HT(7) receptors as a putative fast acting antidepressant strategy. Neuropsychopharmacology 36: 1275-1288, 2011.
15. Richardson-Jones JW, Craige CP, Guiard BP, Stephen A, Metzger KL, Kung HF, Gardier AM, Dranovsky A, David DJ, Beck SG, Hen R, Leonardo ED. 5-HT1A autoreceptor levels determine vulnerability to stress and response to antidepressants. Neuron 65: 40-52, 2010.
16. Richardson-Jones JW, Craige CP, Nguyen TH, Kung HF, Gardier AM, Dranovsky A, David DJ, Guiard BP, Beck SG, Hen R, Leonardo ED. Serotonin-1A autoreceptors are necessary and sufficient for the normal formation of circuits underlying innate anxiety. J Neurosci 31: 6008-6018, 2011.
17. Santarelli L, Saxe M, Gross C, Surget A, Battaglia F, Dulawa S, Weisstaub N, Lee J, Duman R, Arancio O, Belzung C, Hen R. Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science 301: 805-809, 2003.
18. Schmidt EF, Warner-Schmidt JL, Otopalik BG, Pickett SB, Greengard P, Heintz N. Identification of the cortical neurons that mediate antidepressant responses. Cell 149: 1152-1163, 2012.
19. Svenningsson P, Chergui K, Rachleff I, Flajolet M, Zhang X, El Yacoubi M, Vaugeois JM, Nomikos GG, Greengard P. Alterations in 5-HT1B receptor function by p11 in depression-like states. Science 311: 77-80, 2006.
20. Svenningsson P, Tzavara ET, Qi H, Carruthers R, Witkin JM, Nomikos GG, Greengard P. Biochemical and behavioral evidence for antidepressant-like effects of 5-HT6 receptor stimulation. J Neurosci 27: 4201-4209, 2007.
21. Warner-Schmidt JL, Flajolet M, Maller A, Chen EY, Qi H, Svenningsson P, Greengard P. Role of p11 in cellular and behavioral effects of 5-HT4 receptor stimulation. J Neurosci 29: 1937-1946, 2009.