메뉴 건너뛰기




Volumn 110, Issue 22, 2013, Pages 9042-9047

PI3Ka activates integrin α4ß1 to establish a metastatic niche in lymph nodes

Author keywords

[No Author keywords available]

Indexed keywords

INTEGRIN; INTEGRIN ALPHA 4 BETA 1; PHOSPHATIDYLINOSITOL 3 KINASE; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1; VERY LATE ACTIVATION ANTIGEN 4;

EID: 84878468603     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1219603110     Document Type: Article
Times cited : (79)

References (33)
  • 1
    • 63049090100 scopus 로고    scopus 로고
    • Metastasis: From dissemination to organspecific colonization
    • Nguyen DX, Bos PD, Massagué J (2009) Metastasis: From dissemination to organspecific colonization. Nat Rev Cancer 9(4):274-284.
    • (2009) Nat Rev Cancer , vol.9 , Issue.4 , pp. 274-284
    • Nguyen, D.X.1    Bos, P.D.2    Massagué, J.3
  • 3
    • 63049104211 scopus 로고    scopus 로고
    • Microenvironmental regulation of metastasis
    • Joyce JA, Pollard JW (2009) Microenvironmental regulation of metastasis. Nat Rev Cancer 9(4):239-252.
    • (2009) Nat Rev Cancer , vol.9 , Issue.4 , pp. 239-252
    • Joyce, J.A.1    Pollard, J.W.2
  • 4
    • 0035122537 scopus 로고    scopus 로고
    • Induction of tumor lymphangiogenesis by vegf-c promotes breast cancer metastasis
    • Skobe M, et al. (2001) Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis. Nat Med 7(2):192-198.
    • (2001) Nat Med , vol.7 , Issue.2 , pp. 192-198
    • Skobe, M.1
  • 5
    • 33745168981 scopus 로고    scopus 로고
    • Clinical patterns of metastasis
    • Leong SP, et al. (2006) Clinical patterns of metastasis. Cancer Metastasis Rev 25(2):221-232.
    • (2006) Cancer Metastasis Rev , vol.25 , Issue.2 , pp. 221-232
    • Leong, S.P.1
  • 6
    • 80051653058 scopus 로고    scopus 로고
    • Lymph node metastases and prognosis in oesophageal carcinoma -A systematic review
    • Kayani B, Zacharakis E, Ahmed K, Hanna GB (2011) Lymph node metastases and prognosis in oesophageal carcinoma -A systematic review. Eur J Surg Oncol 37(9):747-753.
    • (2011) Eur J Surg Oncol , vol.37 , Issue.9 , pp. 747-753
    • Kayani, B.1    Zacharakis, E.2    Ahmed, K.3    Hanna, G.B.4
  • 7
    • 25444485785 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor c (vegf-c) and vegf receptor-3 in human prostate cancer is associated with regional lymph node metastasis
    • Jennbacken K, Vallbo C, Wang W, Damber JE (2005) Expression of vascular endothelial growth factor C (VEGF-C) and VEGF receptor-3 in human prostate cancer is associated with regional lymph node metastasis. Prostate 65(2):110-116.
    • (2005) Prostate , vol.65 , Issue.2 , pp. 110-116
    • Jennbacken, K.1    Vallbo, C.2    Wang, W.3    Damber, J.E.4
  • 8
    • 27344443222 scopus 로고    scopus 로고
    • Tumor lymphangiogenesis predicts melanoma metastasis to sentinel lymph nodes
    • Dadras SS, et al. (2005) Tumor lymphangiogenesis predicts melanoma metastasis to sentinel lymph nodes. Mod Pathol 18(9):1232-1242.
    • (2005) Mod Pathol , vol.18 , Issue.9 , pp. 1232-1242
    • Dadras, S.S.1
  • 9
    • 33645740066 scopus 로고    scopus 로고
    • The association between vascular endothelial growth factor-c, its corresponding receptor, vegfr-3, and prognosis in primary breast cancer: A study with 193 cases
    • Bando H, et al. (2006) The association between vascular endothelial growth factor-C, its corresponding receptor, VEGFR-3, and prognosis in primary breast cancer: a study with 193 cases. Oncol Rep 15(3):653-659.
    • (2006) Oncol Rep , vol.15 , Issue.3 , pp. 653-659
    • Bando, H.1
  • 10
    • 44449155430 scopus 로고    scopus 로고
    • Vegfr-3 expression is restricted to blood and lymphatic vessels in solid tumors
    • Petrova TV, et al. (2008) VEGFR-3 expression is restricted to blood and lymphatic vessels in solid tumors. Cancer Cell 13(6):554-556.
    • (2008) Cancer Cell , vol.13 , Issue.6 , pp. 554-556
    • Petrova, T.V.1
  • 11
    • 25444489567 scopus 로고    scopus 로고
    • Down-regulation of vascular endothelial cell growth factor-c expression using small interfering rna vectors in mammary tumors inhibits tumor lymphangiogenesis and spontaneous metastasis and enhances survival
    • Chen Z, et al. (2005) Down-regulation of vascular endothelial cell growth factor-C expression using small interfering RNA vectors in mammary tumors inhibits tumor lymphangiogenesis and spontaneous metastasis and enhances survival. Cancer Res 65(19):9004-9011.
    • (2005) Cancer Res , vol.65 , Issue.19 , pp. 9004-9011
    • Chen, Z.1
  • 12
    • 21144437844 scopus 로고    scopus 로고
    • Vascular endothelial cell growth factor receptor 3-mediated activation of lymphatic endothelium is crucial for tumor cell entry and spread via lymphatic vessels
    • He Y, et al. (2005) Vascular endothelial cell growth factor receptor 3-mediated activation of lymphatic endothelium is crucial for tumor cell entry and spread via lymphatic vessels. Cancer Res 65(11):4739-4746.
    • (2005) Cancer Res , vol.65 , Issue.11 , pp. 4739-4746
    • He, Y.1
  • 13
    • 77951054237 scopus 로고    scopus 로고
    • Integrin alpha4beta1 signaling is required for lymphangiogenesis and tumor metastasis
    • Garmy-Susini B, et al. (2010) Integrin alpha4beta1 signaling is required for lymphangiogenesis and tumor metastasis. Cancer Res 70(8):3042-3051.
    • (2010) Cancer Res , vol.70 , Issue.8 , pp. 3042-3051
    • Garmy-Susini, B.1
  • 14
    • 77957365795 scopus 로고    scopus 로고
    • Akt/protein kinase b is required for lymphatic network formation, remodeling, and valve development
    • Zhou F, et al. (2010) Akt/Protein kinase B is required for lymphatic network formation, remodeling, and valve development. Am J Pathol 177(4):2124-2133.
    • (2010) Am J Pathol , vol.177 , Issue.4 , pp. 2124-2133
    • Zhou, F.1
  • 15
    • 81155126038 scopus 로고    scopus 로고
    • Decreased lymphangiogenesis and lymph node metastasis by mtor inhibition in head and neck cancer
    • Patel V, et al. (2011) Decreased lymphangiogenesis and lymph node metastasis by mTOR inhibition in head and neck cancer. Cancer Res 71(22):7103-7112.
    • (2011) Cancer Res , vol.71 , Issue.22 , pp. 7103-7112
    • Patel, V.1
  • 16
    • 17144402207 scopus 로고    scopus 로고
    • Vegf-A induces tumor and sentinel lymph node lymphangiogenesis and promotes lymphatic metastasis
    • Hirakawa S, et al. (2005) VEGF-A induces tumor and sentinel lymph node lymphangiogenesis and promotes lymphatic metastasis. J Exp Med 201(7):1089-1099.
    • (2005) J Exp Med , vol.201 , Issue.7 , pp. 1089-1099
    • Hirakawa, S.1
  • 17
    • 33846857321 scopus 로고    scopus 로고
    • Vegf-c-induced lymphangiogenesis in sentinel lymph nodes promotes tumor metastasis to distant sites
    • Hirakawa S, et al. (2007) VEGF-C-induced lymphangiogenesis in sentinel lymph nodes promotes tumor metastasis to distant sites. Blood 109(3):1010-1017.
    • (2007) Blood , vol.109 , Issue.3 , pp. 1010-1017
    • Hirakawa, S.1
  • 18
    • 33947494918 scopus 로고    scopus 로고
    • Tumor-induced sentinel lymph node lymphangiogenesis and increased lymph flow precede melanoma metastasis
    • Harrell MI, Iritani BM, Ruddell A (2007) Tumor-induced sentinel lymph node lymphangiogenesis and increased lymph flow precede melanoma metastasis. Am J Pathol 170(2):774-786.
    • (2007) Am J Pathol , vol.170 , Issue.2 , pp. 774-786
    • Harrell, M.I.1    Iritani, B.M.2    Ruddell, A.3
  • 19
    • 0033593793 scopus 로고    scopus 로고
    • Lyve-1, a new homologue of the cd44 glycoprotein, is a lymph-specific receptor for hyaluronan
    • Banerji S, et al. (1999) LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specific receptor for hyaluronan. J Cell Biol 144(4):789-801.
    • (1999) J Cell Biol , vol.144 , Issue.4 , pp. 789-801
    • Banerji, S.1
  • 20
    • 0033578853 scopus 로고    scopus 로고
    • Prox1 function is required for the development of the murine lymphatic system
    • Wigle JT, Oliver G (1999) Prox1 function is required for the development of the murine lymphatic system. Cell 98(6):769-778.
    • (1999) Cell , vol.98 , Issue.6 , pp. 769-778
    • Wigle, J.T.1    Oliver, G.2
  • 21
    • 44449138380 scopus 로고    scopus 로고
    • Markers for microscopic imaging of lymphangiogenesis and angiogenesis
    • Baluk P, McDonald DM (2008) Markers for microscopic imaging of lymphangiogenesis and angiogenesis. Ann N Y Acad Sci 1131:1-12.
    • (2008) Ann N Y Acad Sci , vol.1131 , pp. 1-12
    • Baluk, P.1    McDonald, D.M.2
  • 22
    • 0026587657 scopus 로고
    • Induction of mammary tumors by expression of polyomavirus middle t oncogene: A transgenic mouse model for metastatic disease
    • Guy CT, Cardiff RD, Muller WJ (1992) Induction of mammary tumors by expression of polyomavirus middle T oncogene: A transgenic mouse model for metastatic disease. Mol Cell Biol 12(3):954-961.
    • (1992) Mol Cell Biol , vol.12 , Issue.3 , pp. 954-961
    • Guy, C.T.1    Cardiff, R.D.2    Muller, W.J.3
  • 23
    • 0025161990 scopus 로고
    • Vcam-1 on activated endothelium interacts with the leukocyte integrin vla-4 at a site distinct from the vla-4/fibronectin binding site
    • Elices MJ, et al. (1990) VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site. Cell 60(4): 577-584.
    • (1990) Cell , vol.60 , Issue.4 , pp. 577-584
    • Elices, M.J.1
  • 24
    • 0025124607 scopus 로고
    • Lymphoid cells recognize an alternatively spliced segment of fibronectin via the integrin receptor alpha 4 beta 1
    • Guan JL, Hynes RO (1990) Lymphoid cells recognize an alternatively spliced segment of fibronectin via the integrin receptor alpha 4 beta 1. Cell 60(1):53-61.
    • (1990) Cell , vol.60 , Issue.1 , pp. 53-61
    • Guan, J.L.1    Hynes, R.O.2
  • 25
    • 0032937233 scopus 로고    scopus 로고
    • Angiosarcomas express mixed endothelial phenotypes of blood and lymphatic capillaries: Podoplanin as a specific marker for lymphatic endothelium
    • Breiteneder-Geleff S, et al. (1999) Angiosarcomas express mixed endothelial phenotypes of blood and lymphatic capillaries: Podoplanin as a specific marker for lymphatic endothelium. Am J Pathol 154(2):385-394.
    • (1999) Am J Pathol , vol.154 , Issue.2 , pp. 385-394
    • Breiteneder-Geleff, S.1
  • 26
    • 49649090640 scopus 로고    scopus 로고
    • Circulating lymphangiogenic growth factors in gastrointestinal solid tumors, could they be of any clinical significance?
    • Tsirlis TD, et al. (2008) Circulating lymphangiogenic growth factors in gastrointestinal solid tumors, could they be of any clinical significance? World J Gastroenterol 14(17):2691-2701.
    • (2008) World J Gastroenterol , vol.14 , Issue.17 , pp. 2691-2701
    • Tsirlis, T.D.1
  • 27
    • 44349119736 scopus 로고    scopus 로고
    • Angiogenesis selectively requires the p110alpha isoform of pi3k to control endothelial cell migration
    • Graupera M, et al. (2008) Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration. Nature 453(7195):662-666.
    • (2008) Nature , vol.453 , Issue.7195 , pp. 662-666
    • Graupera, M.1
  • 28
    • 79958696667 scopus 로고    scopus 로고
    • Receptor tyrosine kinases and tlr/il1rs unexpectedly activate myeloid cell pi3k?, a single convergent point promoting tumor inflammation and progression
    • Schmid MC, et al. (2011) Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3k?, a single convergent point promoting tumor inflammation and progression. Cancer Cell 19(6):715-727.
    • (2011) Cancer Cell , vol.19 , Issue.6 , pp. 715-727
    • Schmid, M.C.1
  • 29
    • 77949862490 scopus 로고    scopus 로고
    • The final steps of integrin activation: The end game
    • Shattil SJ, Kim C, Ginsberg MH (2010) The final steps of integrin activation: The end game. Nat Rev Mol Cell Biol 11(4):288-300.
    • (2010) Nat Rev Mol Cell Biol , vol.11 , Issue.4 , pp. 288-300
    • Shattil, S.J.1    Kim, C.2    Ginsberg, M.H.3
  • 30
    • 33644651159 scopus 로고    scopus 로고
    • Blocking the alpha 4 integrin-paxillin interaction selectively impairs mononuclear leukocyte recruitment to an inflammatory site
    • Féral CC, et al. (2006) Blocking the alpha 4 integrin-paxillin interaction selectively impairs mononuclear leukocyte recruitment to an inflammatory site. J Clin Invest 116(3):715-723.
    • (2006) J Clin Invest , vol.116 , Issue.3 , pp. 715-723
    • Féral, C.C.1
  • 31
    • 23144461051 scopus 로고    scopus 로고
    • Genes that mediate breast cancer metastasis to lung
    • Minn AJ, et al. (2005) Genes that mediate breast cancer metastasis to lung. Nature 436(7050):518-524.
    • (2005) Nature , vol.436 , Issue.7050 , pp. 518-524
    • Minn, A.J.1
  • 32
    • 80054725681 scopus 로고    scopus 로고
    • Macrophage binding to receptor vcam-1 transmits survival signals in breast cancer cells that invade the lungs
    • Chen Q, Zhang XH, Massagué J (2011) Macrophage binding to receptor VCAM-1 transmits survival signals in breast cancer cells that invade the lungs. Cancer Cell 20(4): 538-549.
    • (2011) Cancer Cell , vol.20 , Issue.4 , pp. 538-549
    • Chen, Q.1    Zhang, X.H.2    Massagué, J.3
  • 33
    • 0037036136 scopus 로고    scopus 로고
    • Lymphatic metastasis in the absence of functional intratumor lymphatics
    • Padera TP, et al. (2002) Lymphatic metastasis in the absence of functional intratumor lymphatics. Science 296(5574):1883-1886.
    • (2002) Science , vol.296 , Issue.5574 , pp. 1883-1886
    • Padera, T.P.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.