Increased red blood cell transfusions are associated with worsening outcomes in pediatric heart transplant patients

Anesthesia and Analgesia

Volumn 116, Issue 6, 2013, Pages 1295-1308

  Howard Quijano, Kimberly ^a   Schwarzenberger, Johanna C ^a   Scovotti, Jennifer C ^a   Alejos, Alexandra ^a   Ngo, Jason ^a   Gornbein, Jeffrey ^a   Mahajan, Aman ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; CHILD; COLD ISCHEMIA; DIALYSIS; ENDOTRACHEAL INTUBATION; ERYTHROCYTE TRANSFUSION; EXTRACORPOREAL OXYGENATION; FEMALE; GRAFT FAILURE; HEART GRAFT; HEART TRANSPLANTATION; HEMATOCRIT; HUMAN; INFANT; INTENSIVE CARE UNIT; ISCHEMIA; MAJOR CLINICAL STUDY; MALE; MORTALITY; OUTCOME ASSESSMENT; PRESCHOOL CHILD; PRIORITY JOURNAL; REOPERATION; RISK FACTOR; SCHOOL CHILD; SEPSIS; SPEECH ANALYSIS; STERNOTOMY; TREATMENT OUTCOME;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; ERYTHROCYTE TRANSFUSION; FEMALE; HEART TRANSPLANTATION; HUMANS; INFANT; INTENSIVE CARE UNITS; LENGTH OF STAY; MALE; OUTCOME ASSESSMENT (HEALTH CARE);

EID: 84878377850     PISSN: 00032999     EISSN: 15267598     Source Type: Journal    
DOI: 10.1213/ANE.0b013e31828d64ac     Document Type: Article

References (30)

1. Guzzetta NA. Benefits and risks of red blood cell transfusion in pediatric patients undergoing cardiac surgery. Pediatr Anesth 2010;21:504-11
2. Lavoie J. Blood Transfusion risks and alternative strategies in pediatric patients. Pediatr Anesth 2011;21:14-24
3. Corwin HL, Gettinger A, Pearl RG, Fink MP, Levy MM, Abraham E, MacIntyre NR, Shabot MM, Duh MS, Shapiro MJ. The CRIT study: anemia and blood transfusion in the critically ill -current clinical practice in the United States. Crit Care Med 2004;32:39-52 (Pubitemid 38125561)
4. Hebert PC, Blajchman MA, Cook DJ, Yetisir E, Wells G, Marshall J, Schweitzer I. Transfusion Requirements in Critical Care Investigators for the Canadian Critical Care Trials Group. Do blood transfusions improve outcomes related to mechanical ventilation? Chest 2001;119:1850-7 (Pubitemid 32744945)
5. Vincent JL, Baron JF, Reinhart K, Gattinoni L, Thijs L, Webb A, Meier-Hellmann A, Nollet G, Peres-Bota D. ABC (Anemia and Blood Transfusion in Critical Care) Investigators. Anemia and blood transfusion in critically ill patients. JAMA 2002;288:1499-507
6. Vincent JL, Sakr Y, Sprung C, Harboe S, Damas P; Sepsis Occurrence in Acutely Ill Patients (SOAP) Investigators. Are blood transfusions associated with greater mortality rates? Results of the Sepsis Occurrence in Acutely Ill Patients study. Anesthesiology 2008;108:31-9
7. Kipps AK, Wypij D, Thiagarajan RR, Bacha EA, Newburger JW. Blood transfusion is associated with prolonged duration of mechanical ventilation in infants undergoing reparative cardiac surgery. Pediatr Crit Care Med 2002;3:269-74
8. Salvin JW, Scheurer MA, Laussen PC, Wypij D, Polito A, Bacha EA, McGowan FX, Costello JM, Thiagarajan RR. Blood transfusion after Pediatric Cardiac Surgery is associated with prolonged hospital stay. Ann Thorac Surg 2011;91:204-11
9. Kneyber MC, Hersi MI, Twisk JW, Markhorst DG, Plotz FB. Red blood cell transfusion in critically ill children is associated with increased mortality. Intensive Care Med 2007;33:1414-22 (Pubitemid 47101723)
10. Szekely A, Cserep Z, Sapi E, Breuer T, Nagy CA, Vargha P, Hartyanszky I, Szatmari A, Treszel A. Risks and predictors of blood transfusion in pediatric patients undergoing open heart operations. Ann Thorac Surg 2009;87:187-97
11. Willems A, Harrington K, Lacroix J, Biarent D, Joffe AR, Wensley D, Ducruet T, Hébert PC, Tucci M. TRIPICU investigators; Canadian Critical Care Trials Group; Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Comparison of two red-cell transfusion strategies after pediatric cardiac surgery: a subgroup analysis. Crit Care Med 2010;38:649-56
12. Kilic A, Allen J G, Arnaoutakis, George TJ, Cameron DE, Vricella LA, Weiss ES. Adult-derived Index for Mortality Prediction After Cardiac Transplantation (IMPACT) risk score predicts short-term mortality after pediatric heart transplantation. Ann Thorac Surg 2012;93:1228-34
13. Wernovsky G Wypij D Jonas RA Mayer JE Jr Hanley FL Hickey PR Walsh AZ Chang AC Castañeda AR Newburger JW Wessel DL. Postoperative course hemodynamic profile after the arterial switch operation in neonates infants a Comparison Of Low Profile Cardiopulmonary Bypass Circulatory Arrest. Circulation 1998;922226-35
14. Gaies MG, Gurney JG, Yen AH, Napoli ML, Gajarski RJ, Ohye RG, Charpie JR, Hirsch JC. Vasoactive-inotropic score as a predictor of morbidity and mortality in infants after cardiopulmonary bypass. Pediatr Crit Care Med 2010;11:234-38
15. Ledolter J, Dexter F, Epstein RH. Analysis of variance of communication latencies in anesthesia: comparing means of multiple log-normal distributions. Anesth Analg 2011;113:888-96
16. Iyer H, Patterson D. A Recipe for Constructing Generalized Pivotal Quantities and Generalized Confidence Intervals. Technical Report 2-10. Fort Collins, CO: Colorado State University, 2002
17. Chen Y-H, Zhou X-H. Interval estimates for the ratio and the difference of two log-normal means. Stat Med 2006;25:4099-113 (Pubitemid 44823877)
18. Murphy GJ, Reeves BC, Rogers CA, Rizvi SI, Culliford L, Angelini GD. Increased mortality, postoperative morbidity, and cost after red blood cell transfusion in patients having cardiac surgery. Circulation 2007;116:2544-52 (Pubitemid 350179219)
19. Bateman ST, Lacroix J, Boven K, Forbes P, Barton R, Thomas NJ, Jacobs B, Markovitz B, Goldstein B, Hanson JH, Li HA, Randolph AG. Pediatric Acute Lung Injury and Sepsis Investigators Network. Pediatric Acute Lung Injury and Sepsis Investigators Network. Anemia, blood loss and blood transfusions in North American Children in the intensive care unit. Am J Respir Crit Care Med 2008:178:26-33 (Pubitemid 351919190)
20. Hebert PC, Wells G, Blajchman MA, Marshall J, Martin C, Pagliarello G, Tweeddale M, Schweitzer I, Yetisir E. A multicenter randomized, controlled trial of transfusion requirements in critical care. Transfusions Requirements in Critical Care Investigators, Canadian Critical Care Trials Group. Crit Care Med 1998:26:482-7
21. Newburger JW, Jonas RA, Soul J, Kussman BD, Bellinger DC, Laussen PC, Robertson R, Mayer JE Jr, del Nido PJ, Bacha EA, Forbess JM, Pigula F, Roth SJ, Visconti KJ, du Plessis AJ, Farrell DM, McGrath E, Rappaport LA, Wypij D. Randomized trial of hematocrit 25% vs 35% during hypothermic cardiopulmonary bypass in infant heart surgery. J Thorac Cardiovasc Surg 2008;135:347-54
22. Cholette JM, Henrichs KF, Alfieris GM, Powers KS, Phipps R, Spinelli SL, Swartz M, Gensini F, Daugherty LE, Nazarian E, Rubenstein JS, Sweeney D, Eaton M, Lerner NB, Blumberg N. Washing red blood cells and platelets transfused in cardiac surgery reduces postoperative inflammation and number of transfusions: Results of a prospective, randomized, controlled clinical trial. Pediatr Crit Care Med 2012;13:290-9
23. Karkouti K, Wijeysundera DN, Yau TM, Beattie WS, Abdelnaem E, McCluskey SA, Ghannam M, Yeo E, Djaiani G, Karski J. The independent association of massive blood loss with mortality in cardiac surgery. Transfusion 2004;44:1453-62 (Pubitemid 39318980)
24. Hill GE, Frawley WH, Griffith KE, Forestner JE, Minel JP. Allogenic blood transfusion increases the risk of postoperative bacterial infection: a meta-analysis. J Trauma 2003;54:908-14 (Pubitemid 36758801)
25. Costello JM, Graham DA, Morrow DF, Morrow J, Potter-Bynoe G, Sandora TJ, Pigula FA, Laussen PC. Risk factors for surgical site infection after cardiac surgery in children. Ann Thorac Surg 2010;89:1833-42
26. van de Watering LM, Hermans J, Houbiers JG, van den Broek PJ, Bouter H, Boer F, Harvey MS, Huysmans HA, Brand A. Beneficial effects of leukocyte depletion of transfused blood on postoperative complications in patients undergoing cardiac surgery: a randomized clinical trial. Circulation 1998;97:562-8 (Pubitemid 28090685)
27. Fergusson D, Hebert PC, Lee SK, Walker CR, Barrington KJ, Joseph L, Blajchman MA, Shapiro S. Clinical outcomes following institution of universal leukoreduction of blood transfusions for premature infants. JAMA 2003;298:1950-6 (Pubitemid 37430226)
28. Glance LG, Dick AW, Mukamel DB, Fleming FJ, Zollo RA, Wissler R, Salloum R, Meredith UW, Osler TM. Association between intraoperative blood transfusion and mortality and morbidity in patients undergoing noncardiac surgery. Anesthesiology 2011;114:283-92
29. Koch CG, Li L, Sessler DI, Figueroa P, Hoeltge GA, Mihaljevic T, Blackstone EH. Duration of red blood cell storage and complications after cardiac surgery. N Engl J Med 2008;358:1229-39 (Pubitemid 351439224)
30. Karem O, Tucci M, Bateman ST, Ducruet T, Spinella PC, Randolph AG, Lacroix J. Association between length of storage of red blood cell unit and outcome of critically ill children: a prospective observational study. Crit Care 2010;14:R57