Preventive effect of varenicline on impairment of endothelial function in cerebral vessels induced by acute smoking in rats

Journal of Anesthesia

Volumn 26, Issue 6, 2012, Pages 928-931

  Iida, Mami ^a,c   Iida, Hiroki ^b   Takenaka, Motoyasu ^b   Tanabe, Kumiko ^b   Iwata, Kenji ^b  

^a GIFU UNIVERSITY   (Japan)

^b GIFU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c GIFU PREFECTURAL GIFU HOSPITAL   (Japan)

Author keywords

Cerebral circulation; Endothelial function; Smoking; Varenicline

Indexed keywords

8 ISOPROSTANE; CIGARETTE SMOKE; GLUCOSE; VARENICLINE; ACETYLCHOLINE; BENZAZEPINE DERIVATIVE; NICOTINIC AGENT; QUINOXALINE DERIVATIVE; VASODILATOR AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIOLE; ARTICLE; BRAIN BLOOD VESSEL; CONTROLLED STUDY; DRUG SAFETY; GLUCOSE BLOOD LEVEL; MALE; NONHUMAN; RAT; SMOKING; SMOKING CESSATION; VASODILATATION; ANIMAL; BRAIN ARTERY; BRAIN CIRCULATION; BRAIN VEIN; DOSE RESPONSE; DRUG EFFECT; HEMODYNAMICS; PATHOPHYSIOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT; VASCULAR ENDOTHELIUM;

ACETYLCHOLINE; ANIMALS; ARTERIOLES; BENZAZEPINES; CEREBRAL ARTERIES; CEREBRAL VEINS; CEREBROVASCULAR CIRCULATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; HEMODYNAMICS; MALE; NICOTINIC AGONISTS; QUINOXALINES; RATS; RATS, SPRAGUE-DAWLEY; SMOKING; VASODILATION; VASODILATOR AGENTS;

EID: 84878363965     PISSN: 09138668     EISSN: 14388359     Source Type: Journal    
DOI: 10.1007/s00540-012-1433-3     Document Type: Article

References (12)

1. Celermajer DS, Sorensen KE, Georgakopoulos D. Cigarette smoking is associated with dose-related and potentially reversible impairment of endothelium-dependent dilation in healthy young adults. Circulation. 1993;88:2149-55.
2. Iida M, Iida H, Dohi S, Takenaka M, Fujiwara H. Mechanisms underlying cerebrovascular effects of cigarette smoking in rats in vivo. Stroke. 1998;29:1656-65.
3. Iida H, Iida M, Takenaka M, Fujiwara H, Dohi S. Angiotensin II type 1(AT1)-receptor blocker prevents impairment of endothelium-dependent cerebral vasodilation by acute cigarette smoking in rat. Life Sci. 2006;78:1310-6.
4. Iida H, Iida M, Takenaka M, Fukuoka N, Dohi S. Rho-kinase inhibitor and nicotinamide adenine dinucleotide phosphate oxidase inhibitor prevent impairment of endothelium-dependent cerebral vasodilation by acute cigarette smoking in rats. J Renin Angiotensin Aldosterone Syst. 2008;9:89-94.
5. Iida H, Iida M, Takenaka M, Fukuoka N, Dohi S. Comparative effects of cilostazol and aspirin on the impairment of endothelium-dependent cerebral vasodilation caused by acute cigarette smoking in rats. J Thromb Thrombolysis. 2009;29:483-8.
6. Critchley JA, Capewell S. Mortality risk reduction associated with smoking cessation in patients with coronary heart disease. A systematic review. JAMA. 2003;290:86-97.
7. Warner DO. Perioperative abstinence from cigarette. Anesthesiology. 2006;104:356-67.
8. Cahill K, Stead LF, Lancaster T. Nicotine receptor partial agonists for smoking cessation. Cochrane Database Syst Rev. 2011;16(2):CD006103.
9. Coe JW, Brooks PR, Vetelino MG, Wirtz MC, Arnold EP, Huang J, Sands SB, Davis TI, Lebel LA, Fox CB, Shrikhande A, Heym JH, Schaeffer E, Rollema H, Lu Y, Mansbach RS, Chambers LK, Rovetti CC, Schulz DW, Tingley FD III, O'Neill BT. Varenicline: an α4β2 nicotinic receptor partial agonist for smoking cessation. J Med Chem. 2005;48:3474-7.
10. Benowitz NL, Gourlay SG. Cardiovascular toxicity of nicotine: implications for nicotine replacement therapy. J Am Coll Cardiol. 1997;29:1422-31.
11. Joseph AM, Norman SM, Ferry LH, Prochazka AV, Westman EC, Steele BG, Sherman SE, Cleveland M, Anthonnucio DO, Hartman N, McGovern PG. The safety of transdermal nicotine as an aid to smoking cessation in patients with cardiac disease. N Engl J Med. 1996;335:1792-8.
12. Di Angelantonio S, Matteoni C, Fabbretti E, Nistri A. Molecular biology and electrophysiology of neuronal nicotinic receptors of rat chromaffin cells. Eur J Neurosci. 2003;17:2313-22.