메뉴 건너뛰기




Volumn 1, Issue 1, 2013, Pages 38-42

Pharmacoresistant epilepsy: Definition and explanation

Author keywords

Anticonvulsants; Drug resistance; Epilepsy drug therapy; Epilepsy surgery; Treatment failure

Indexed keywords

ANTICONVULSIVE AGENT; BIOLOGICAL MARKER; MULTIDRUG RESISTANCE PROTEIN; VOLTAGE GATED SODIUM CHANNEL BETA 1 SUBUNIT;

EID: 84878358742     PISSN: 22128220     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.epilep.2013.01.001     Document Type: Article
Times cited : (23)

References (50)
  • 1
    • 85052608913 scopus 로고    scopus 로고
    • Electrical stimulation and gene-based neuromodulation for control of medically-refractory epilepsy
    • Acta Neurochir Suppl 2007
    • Alexopoulos AV, Gonugunta V, Yang J, Boulis NM. Electrical stimulation and gene-based neuromodulation for control of medically-refractory epilepsy. Acta Neurochir Suppl 2007; (97) 2007; Pt 2:293-309.
    • (2007) , Issue.97 PART 2 , pp. 293-309
    • Alexopoulos, A.V.1    Gonugunta, V.2    Yang, J.3    Boulis, N.M.4
  • 2
    • 84878368410 scopus 로고    scopus 로고
    • Antiepileptogenesis, Plasticity of AED targets, drug resistance, and targeting the immature brain
    • National Center for Biotechnology Information (US), Bethesda, MD, J.L. Noebels, M. Avoli, M.A. Rogawski, R.W. Olsen, A.V. Delgado-Escueta (Eds.)
    • Beck H., Yaari Y. Antiepileptogenesis, Plasticity of AED targets, drug resistance, and targeting the immature brain. Jasper's Basic Mechanisms of the Epilepsies 2012, National Center for Biotechnology Information (US), Bethesda, MD. 4th ed. J.L. Noebels, M. Avoli, M.A. Rogawski, R.W. Olsen, A.V. Delgado-Escueta (Eds.).
    • (2012) Jasper's Basic Mechanisms of the Epilepsies
    • Beck, H.1    Yaari, Y.2
  • 3
    • 1642542531 scopus 로고    scopus 로고
    • Understanding the delay before epilepsy surgery: who develops intractable focal epilepsy and when?
    • Berg A.T. Understanding the delay before epilepsy surgery: who develops intractable focal epilepsy and when?. CNS Spectrum 2004, 9(2):136-144.
    • (2004) CNS Spectrum , vol.9 , Issue.2 , pp. 136-144
    • Berg, A.T.1
  • 6
    • 33745686119 scopus 로고    scopus 로고
    • How long does it take for epilepsy to become intractable? A prospective investigation
    • Berg A.T., Vickrey B.G., Testa F.M., Levy S.R., Shinnar S., DiMario F., et al. How long does it take for epilepsy to become intractable? A prospective investigation. Ann Neurol 2006, 60(1):73-79.
    • (2006) Ann Neurol , vol.60 , Issue.1 , pp. 73-79
    • Berg, A.T.1    Vickrey, B.G.2    Testa, F.M.3    Levy, S.R.4    Shinnar, S.5    DiMario, F.6
  • 7
    • 36148983791 scopus 로고    scopus 로고
    • Likelihood of seizure remission in an adult population with refractory epilepsy
    • Callaghan B.C., Anand K., Hesdorffer D., Hauser W.A., French J.A. Likelihood of seizure remission in an adult population with refractory epilepsy. Ann Neurol 2007, 62(4):382-389.
    • (2007) Ann Neurol , vol.62 , Issue.4 , pp. 382-389
    • Callaghan, B.C.1    Anand, K.2    Hesdorffer, D.3    Hauser, W.A.4    French, J.A.5
  • 10
    • 54549086060 scopus 로고    scopus 로고
    • Antiepileptogenesis Therapy with Levetiracetam: Data from Kindling versus Status Epilepticus Models
    • Dudek F.E., Bertram E.H., Staley K.J. Antiepileptogenesis Therapy with Levetiracetam: Data from Kindling versus Status Epilepticus Models. Epilepsy Curr 2008, 8(1):28-30.
    • (2008) Epilepsy Curr , vol.8 , Issue.1 , pp. 28-30
    • Dudek, F.E.1    Bertram, E.H.2    Staley, K.J.3
  • 11
    • 33644827072 scopus 로고    scopus 로고
    • Treatment of refractory primary generalized epilepsy
    • Faught E. Treatment of refractory primary generalized epilepsy. Rev Neurol Dis 2004, 1(Suppl 1):S34-S43.
    • (2004) Rev Neurol Dis , vol.1 , Issue.SUPPL 1
    • Faught, E.1
  • 12
    • 78751616855 scopus 로고    scopus 로고
    • Quality improvement in neurology: AAN epilepsy quality measures: Report of the Quality Measurement and Reporting Subcommittee of the American Academy of Neurology
    • Fountain NB, Van Ness PC, Swain-Eng R, Tonn S., Bever Jr CT. Quality improvement in neurology: AAN epilepsy quality measures: Report of the Quality Measurement and Reporting Subcommittee of the American Academy of Neurology. Neurology; Jan 4 2011;76(1):94-9.
    • (2011) Neurology , vol.76 , Issue.1 , pp. 94-9
    • Fountain, N.B.1    Van Ness, P.C.2    Swain-Eng, R.3    Tonn, S.4    Bever, C.T.5
  • 13
    • 84878370235 scopus 로고    scopus 로고
    • Drug resistance
    • National Center for Biotechnology Information (US), Bethesda, MD, J.L. Noebels, M. Avoli, M.A. Rogawski, R.W. Olsen, A.V. Delgado-Escueta (Eds.)
    • Gorter J.A., Potschka H. Drug resistance. Jasper's Basic Mechanisms of the Epilepsies 2012, National Center for Biotechnology Information (US), Bethesda, MD. 4th ed. J.L. Noebels, M. Avoli, M.A. Rogawski, R.W. Olsen, A.V. Delgado-Escueta (Eds.).
    • (2012) Jasper's Basic Mechanisms of the Epilepsies
    • Gorter, J.A.1    Potschka, H.2
  • 15
    • 33845633371 scopus 로고    scopus 로고
    • Direct and indirect costs of refractory epilepsy in a tertiary epilepsy center in Germany
    • Hamer H.M., Spottke A., Aletsee C., Knake S., Reis J., Strzelczyk A., et al. Direct and indirect costs of refractory epilepsy in a tertiary epilepsy center in Germany. Epilepsia 2006, 47(12):2165-2172.
    • (2006) Epilepsia , vol.47 , Issue.12 , pp. 2165-2172
    • Hamer, H.M.1    Spottke, A.2    Aletsee, C.3    Knake, S.4    Reis, J.5    Strzelczyk, A.6
  • 17
    • 0031849534 scopus 로고    scopus 로고
    • Uptake and costs of care for epilepsy: findings from a U.K. regional study
    • Jacoby A., Buck D., Baker G., McNamee P., Graham-Jones S., Chadwick D. Uptake and costs of care for epilepsy: findings from a U.K. regional study. Epilepsia 1998, 39(7):776-786.
    • (1998) Epilepsia , vol.39 , Issue.7 , pp. 776-786
    • Jacoby, A.1    Buck, D.2    Baker, G.3    McNamee, P.4    Graham-Jones, S.5    Chadwick, D.6
  • 18
    • 0032972287 scopus 로고    scopus 로고
    • EEG and clinical predictors of medically intractable childhood epilepsy
    • Ko T.S., Holmes G.L. EEG and clinical predictors of medically intractable childhood epilepsy. Clin Neurophysiol 1999, 110(7):1245-1251.
    • (1999) Clin Neurophysiol , vol.110 , Issue.7 , pp. 1245-1251
    • Ko, T.S.1    Holmes, G.L.2
  • 19
    • 0034598762 scopus 로고    scopus 로고
    • Early identification of refractory epilepsy
    • Kwan P., Brodie M.J. Early identification of refractory epilepsy. N Engl J Med 2000, 342(5):314-319.
    • (2000) N Engl J Med , vol.342 , Issue.5 , pp. 314-319
    • Kwan, P.1    Brodie, M.J.2
  • 20
    • 0036265042 scopus 로고    scopus 로고
    • Refractory epilepsy: a progressive, intractable but preventable condition?
    • Kwan P., Brodie M.J. Refractory epilepsy: a progressive, intractable but preventable condition?. Seizure 2002, 11(2):77-84.
    • (2002) Seizure , vol.11 , Issue.2 , pp. 77-84
    • Kwan, P.1    Brodie, M.J.2
  • 21
    • 77954625557 scopus 로고    scopus 로고
    • Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies
    • Kwan P., Arzimanoglou A., Berg A.T., Brodie M.J., Allen Hauser W., Mathern G., et al. Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies. Epilepsia 2010, 51(6):1069-1077.
    • (2010) Epilepsia , vol.51 , Issue.6 , pp. 1069-1077
    • Kwan, P.1    Arzimanoglou, A.2    Berg, A.T.3    Brodie, M.J.4    Allen Hauser, W.5    Mathern, G.6
  • 23
    • 16844378420 scopus 로고    scopus 로고
    • Case-control study of SUDEP
    • Langan Y., Nashef L., Sander J.W. Case-control study of SUDEP. Neurology 2005, 64(7):1131-1133.
    • (2005) Neurology , vol.64 , Issue.7 , pp. 1131-1133
    • Langan, Y.1    Nashef, L.2    Sander, J.W.3
  • 24
    • 33644771230 scopus 로고    scopus 로고
    • Cause-specific mortality in epilepsy
    • Lhatoo S.D., Sander J.W. Cause-specific mortality in epilepsy. Epilepsia 2005, 46(Suppl 11):36-39.
    • (2005) Epilepsia , vol.46 , Issue.SUPPL 11 , pp. 36-39
    • Lhatoo, S.D.1    Sander, J.W.2
  • 25
    • 78650118698 scopus 로고    scopus 로고
    • Prevention or modification of epileptogenesis after brain insults: experimental approaches and translational research
    • Löscher W., Brandt C. Prevention or modification of epileptogenesis after brain insults: experimental approaches and translational research. Pharmacol Rev 2010, 62(4):668-700.
    • (2010) Pharmacol Rev , vol.62 , Issue.4 , pp. 668-700
    • Löscher, W.1    Brandt, C.2
  • 26
    • 23044500398 scopus 로고    scopus 로고
    • Drug resistance in brain diseases and the role of drug efflux transporters
    • Löscher W., Potschka H. Drug resistance in brain diseases and the role of drug efflux transporters. Nat Rev Neurosci 2005, 6(8):591-602.
    • (2005) Nat Rev Neurosci , vol.6 , Issue.8 , pp. 591-602
    • Löscher, W.1    Potschka, H.2
  • 27
    • 33746887419 scopus 로고    scopus 로고
    • Experimental and clinical evidence for loss of effect (tolerance) during prolonged treatment with antiepileptic drugs
    • Löscher W., Schmidt D. Experimental and clinical evidence for loss of effect (tolerance) during prolonged treatment with antiepileptic drugs. Epilepsia 2006, 47(8):1253-1284.
    • (2006) Epilepsia , vol.47 , Issue.8 , pp. 1253-1284
    • Löscher, W.1    Schmidt, D.2
  • 28
    • 84878366681 scopus 로고    scopus 로고
    • Mechanisms of tolerance and drug resistance
    • Wiley-Blackwell, Oxford, UK, p. 156-165, S. Shorvon, E. Perucca, J. Engel (Eds.)
    • Löscher W., Schmidt D. Mechanisms of tolerance and drug resistance. The Treatment of Epilepsy 2009, Wiley-Blackwell, Oxford, UK, p. 156-165. 3rd ed. S. Shorvon, E. Perucca, J. Engel (Eds.).
    • (2009) The Treatment of Epilepsy
    • Löscher, W.1    Schmidt, D.2
  • 29
    • 20744457438 scopus 로고    scopus 로고
    • An epilepsy mutation in the beta1 subunit of the voltage-gated sodium channel results in reduced channel sensitivity to phenytoin
    • Lucas P.T., Meadows L.S., Nicholls J., Ragsdale D.S. An epilepsy mutation in the beta1 subunit of the voltage-gated sodium channel results in reduced channel sensitivity to phenytoin. Epilepsy Res 2005, 64(3):77-84.
    • (2005) Epilepsy Res , vol.64 , Issue.3 , pp. 77-84
    • Lucas, P.T.1    Meadows, L.S.2    Nicholls, J.3    Ragsdale, D.S.4
  • 30
    • 13844299003 scopus 로고    scopus 로고
    • Significance of MDR1 and multiple drug resistance in refractory human epileptic brain
    • Marchi N., Hallene K.L., Kight K.M., Cucullo L., Moddel G., Bingaman W., et al. Significance of MDR1 and multiple drug resistance in refractory human epileptic brain. BMC Med 2004, 2:37.
    • (2004) BMC Med , vol.2 , pp. 37
    • Marchi, N.1    Hallene, K.L.2    Kight, K.M.3    Cucullo, L.4    Moddel, G.5    Bingaman, W.6
  • 31
    • 84860182383 scopus 로고    scopus 로고
    • The blood-brain barrier hypothesis in drug resistant epilepsy
    • Marchi N., Granata T., Alexopoulos A., Janigro D. The blood-brain barrier hypothesis in drug resistant epilepsy. Brain 2012, 135(Pt 4):e211.
    • (2012) Brain , vol.135 , Issue.PART 4
    • Marchi, N.1    Granata, T.2    Alexopoulos, A.3    Janigro, D.4
  • 32
    • 0034566942 scopus 로고    scopus 로고
    • Perinatal brain damage, cortical reorganization (acquired cortical dysplasias), and epilepsy
    • Marín-Padilla M. Perinatal brain damage, cortical reorganization (acquired cortical dysplasias), and epilepsy. Adv Neurol 2000, 84:153-172.
    • (2000) Adv Neurol , vol.84 , pp. 153-172
    • Marín-Padilla, M.1
  • 34
    • 33645305420 scopus 로고    scopus 로고
    • Diagnosing refractory epilepsy: response to sequential treatment schedules
    • Mohanraj R., Brodie M.J. Diagnosing refractory epilepsy: response to sequential treatment schedules. Eur J Neurol 2006, 13(3):277-282.
    • (2006) Eur J Neurol , vol.13 , Issue.3 , pp. 277-282
    • Mohanraj, R.1    Brodie, M.J.2
  • 35
    • 0029865520 scopus 로고    scopus 로고
    • Cost of refractory epilepsy in adults in the USA
    • Murray M.I., Halpern M.T., Leppik I.E. Cost of refractory epilepsy in adults in the USA. Epilepsy Res 1996, 23(2):139-148.
    • (1996) Epilepsy Res , vol.23 , Issue.2 , pp. 139-148
    • Murray, M.I.1    Halpern, M.T.2    Leppik, I.E.3
  • 36
    • 77954668304 scopus 로고    scopus 로고
    • Pharmacoresistant epilepsy: from pathogenesis to current and emerging therapies
    • Pati S., Alexopoulos A.V. Pharmacoresistant epilepsy: from pathogenesis to current and emerging therapies. Cleve Clin J Med 2010, 77(7):457-467.
    • (2010) Cleve Clin J Med , vol.77 , Issue.7 , pp. 457-467
    • Pati, S.1    Alexopoulos, A.V.2
  • 37
    • 0036283744 scopus 로고    scopus 로고
    • A comparison of surgical and medical costs for refractory epilepsy
    • Platt M., Sperling M.R. A comparison of surgical and medical costs for refractory epilepsy. Epilepsia 2002, 43(Suppl 4):25-31.
    • (2002) Epilepsia , vol.43 , Issue.SUPPL 4 , pp. 25-31
    • Platt, M.1    Sperling, M.R.2
  • 38
    • 78149319882 scopus 로고    scopus 로고
    • Transporter hypothesis of drug-resistant epilepsy: challenges for pharmacogenetic approaches
    • Potschka H. Transporter hypothesis of drug-resistant epilepsy: challenges for pharmacogenetic approaches. Pharmacogenomics 2010, 11(10):1427-1438.
    • (2010) Pharmacogenomics , vol.11 , Issue.10 , pp. 1427-1438
    • Potschka, H.1
  • 39
    • 0032918385 scopus 로고    scopus 로고
    • Clinical aspects and biological bases of drug-resistant epilepsies
    • Regesta G., Tanganelli P. Clinical aspects and biological bases of drug-resistant epilepsies. Epilepsy Res 1999, 34(2-3):109-122.
    • (1999) Epilepsy Res , vol.34 , Issue.2-3 , pp. 109-122
    • Regesta, G.1    Tanganelli, P.2
  • 40
    • 30344467212 scopus 로고    scopus 로고
    • Molecular and cellular mechanisms of pharmacoresistance in epilepsy
    • Remy S., Beck H. Molecular and cellular mechanisms of pharmacoresistance in epilepsy. Brain 2006, 129(Pt 1):18-35.
    • (2006) Brain , vol.129 , Issue.PART 1 , pp. 18-35
    • Remy, S.1    Beck, H.2
  • 41
    • 67649966426 scopus 로고    scopus 로고
    • Intrinsic severity as a determinant of antiepileptic drug refractoriness
    • Rogawski M.A., Johnson M.R. Intrinsic severity as a determinant of antiepileptic drug refractoriness. Epilepsy Curr 2008, 8(5):127-130.
    • (2008) Epilepsy Curr , vol.8 , Issue.5 , pp. 127-130
    • Rogawski, M.A.1    Johnson, M.R.2
  • 43
    • 0031744007 scopus 로고    scopus 로고
    • Is the underlying cause of epilepsy a major prognostic factor for recurrence?
    • Semah F., Picot M.C., Adam C., Broglin D., Arzimanoglou A., Bazin B., et al. Is the underlying cause of epilepsy a major prognostic factor for recurrence?. Neurology 1998, 51(5):1256-1262.
    • (1998) Neurology , vol.51 , Issue.5 , pp. 1256-1262
    • Semah, F.1    Picot, M.C.2    Adam, C.3    Broglin, D.4    Arzimanoglou, A.5    Bazin, B.6
  • 44
    • 0037431040 scopus 로고    scopus 로고
    • Association of multidrug resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1
    • Siddiqui A., Kerb R., Weale M.E., Brinkmann U., Smith A., Goldstein D.B., et al. Association of multidrug resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1. N Engl J Med 2003, 348(15):1442-1448.
    • (2003) N Engl J Med , vol.348 , Issue.15 , pp. 1442-1448
    • Siddiqui, A.1    Kerb, R.2    Weale, M.E.3    Brinkmann, U.4    Smith, A.5    Goldstein, D.B.6
  • 45
    • 0027364405 scopus 로고
    • Remission of seizures and predictors of intractability in long-term follow-up
    • Sillanpaa M. Remission of seizures and predictors of intractability in long-term follow-up. Epilepsia 1993, 34(5):930-936.
    • (1993) Epilepsia , vol.34 , Issue.5 , pp. 930-936
    • Sillanpaa, M.1
  • 46
    • 0032508055 scopus 로고    scopus 로고
    • Long-term prognosis of seizures with onset in childhood
    • Sillanpaa M., Jalava M., Kaleva O., Shinnar S. Long-term prognosis of seizures with onset in childhood. N Engl J Med 1998, 338(24):1715-1722.
    • (1998) N Engl J Med , vol.338 , Issue.24 , pp. 1715-1722
    • Sillanpaa, M.1    Jalava, M.2    Kaleva, O.3    Shinnar, S.4
  • 47
    • 0032942120 scopus 로고    scopus 로고
    • The misdiagnosis of epilepsy and the management of refractory epilepsy in a specialist clinic
    • Smith D., Defalla B.A., Chadwick D.W. The misdiagnosis of epilepsy and the management of refractory epilepsy in a specialist clinic. Q J Med 1999, 92(1):15-23.
    • (1999) Q J Med , vol.92 , Issue.1 , pp. 15-23
    • Smith, D.1    Defalla, B.A.2    Chadwick, D.W.3
  • 50
    • 53649103661 scopus 로고    scopus 로고
    • Sudden unexpected death in epilepsy: current knowledge and future directions
    • Tomson T., Nashef L., Ryvlin P. Sudden unexpected death in epilepsy: current knowledge and future directions. Lancet Neurol 2008, 7(11):1021-1031.
    • (2008) Lancet Neurol , vol.7 , Issue.11 , pp. 1021-1031
    • Tomson, T.1    Nashef, L.2    Ryvlin, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.