Autoantibodies: Double agents in human disease

Science Translational Medicine

Volumn 5, Issue 186, 2013, Pages

  Acharya, Nimish K ^a   Nagele, Eric P ^a   Han, Min ^a   Nagele, Robert G ^a  

^a UMDNJ School of Osteopathic Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; CALCIUM ION; GRANZYME B; PEPTIDYLARGININE DEIMINASE 3; PEPTIDYLARGININE DEIMINASE 4; PEPTIDYLARGININE DEIMINASE 4 ANTIBODY; PROTEIN ARGININE DEIMINASE; UNCLASSIFIED DRUG;

ANTIBODY PRODUCTION; ANTIBODY TITER; BONE EROSION; CROSS REACTION; DEGENERATIVE DISEASE; DISEASE EXACERBATION; HUMAN; NOTE; PRIORITY JOURNAL; PROTEIN DEGRADATION; RHEUMATOID ARTHRITIS; SYNOVIAL FLUID;

ANTIBODIES; ARTHRITIS, RHEUMATOID; CALCIUM; FEMALE; HUMANS; HYDROLASES; MALE;

EID: 84878310738     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3006288     Document Type: Note

References (10)

1. N. K. Acharya, E. P. Nagele, M. Han, N. J. Coretti, C. DeMarshall, M. C. Kosciuk, P. A. Boulos, R. G. Nagele, Neuronal PAD4 expression and protein citrullination: Possible role in production of autoantibodies associated with neurodegenerative disease. J. Autoimmun. 38, 369-380 (2012).
2. A. Ishigami, T. Ohsawa, M. Hiratsuka, H. Taguchi, S. Kobayashi, Y. Saito, S. Murayama, H. Asaga, T. Toda, N. Kimura, N. Maruyama, Abnormal accumulation of citrullinated proteins catalyzed by peptidylarginine deiminase in hippocampal extracts from patients with Alzheimer's disease. J. Neurosci. Res. 80, 120-128 (2005).
3. C. Foulquier, M. Sebbag, C. Clavel, S. Chapuy-Regaud, R. Al Badine, M. C. Méchin, C. Vincent, R. Nachat, M. Yamada, H. Takahara, M. Simon, M. Guerrin, G. Serre, Peptidyl arginine deiminase type 2 (PAD-2) and PAD-4 but not PAD-1, PAD-3, and PAD-6 are expressed in rheumatoid arthritis synovium in close association with tissue inflammation. Arthritis Rheum. 56, 3541-3553 (2007).
4. E. R. Vossenaar, A. J. Zendman, W. J. van Venrooij, G. J. Pruijn, PAD, a growing family of citrullinating enzymes: Genes, features and involvement in disease. Bioessays 25, 1106-1118 (2003).
5. A. Kinloch, K. Lundberg, R. Wait, N. Wegner, N. H. Lim, A. J. Zendman, T. Saxne, V. Malmström, P. J. Venables, Synovial fluid is a site of citrullination of autoantigens in inflammatory arthritis. Arthritis Rheum. 58, 2287-2295 (2008).
6. E. Darrah, J. T. Giles, M. L. Ols, H. G. Bull, F. Andrade, A. Rosen, Erosive rheumatoid arthritis is associated with antibodies that activate PAD4 by increasing calcium sensitivity. Sci. Transl. Med. 5, 186ra65 (2013).
7. R. G. Nagele, P. M. Clifford, G. Siu, E. C. Levin, N. K. Acharya, M. Han, M. C. Kosciuk, V. Venkataraman, S. Zavareh, S. Zarrabi, K. Kinsler, N. G. Thaker, E. P. Nagele, J. Dash, H. Y. Wang, A. Levitas, Brain-reactive autoantibodies prevalent in human sera increase intraneuronal amyloid-β(1-42) deposition. J. Alzheimers Dis. 25, 605-622 (2011).
8. F. Andrade, E. Darrah, M. Gucek, R. N. Cole, A. Rosen, X. Zhu, Autocitrullination of human peptidyl arginine deiminase type 4 regulates protein citrullination during cell activation. Arthritis Rheum. 62, 1630-1640 (2010).
9. Y. L. Liu, I. C. Tsai, C. W. Chang, Y. F. Liao, G. Y. Liu, H. C. Hung, Functional roles of the non-catalytic calciumbinding sites in the N-terminal domain of human peptidylarginine deiminase 4. PLoS ONE 8, e51660 (2013).
10. E. Nagele, M. Han, C. Demarshall, B. Belinka, R. Nagele, Diagnosis of Alzheimer's disease based on disease-specific autoantibody profiles in human sera. PLoS ONE 6, e23112 (2011).