Investigation of the biotransformation of melarsoprol by electrochemistry coupled to complementary LC/ESI-MS and LC/ICP-MS analysis

Analytical and Bioanalytical Chemistry

Volumn 405, Issue 15, 2013, Pages 5249-5258

  Baumann, Anne ^a,b   Pfeifer, Thorben ^a,c   Melles, Daniel ^a   Karst, Uwe ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b AQura GmbH   (Germany)

^c VOLKSWAGEN AG   (Germany)

Author keywords

Electrochemistry; Mass spectrometry; Phase I metabolism; Sleeping sickness

Indexed keywords

BIOTRANSFORMATION PROCESS; BIOTRANSFORMATION PRODUCT; ELECTROSPRAY IONIZATION MASS SPECTROMETRY; FRAGMENTATION PATTERNS; HUMAN SERUM ALBUMINS; OXIDATIVE BIOTRANSFORMATIONS; SLEEPING SICKNESS; STRUCTURE ELUCIDATION;

ARSENIC; BIOCONVERSION; DISEASES; ELECTROCHEMISTRY; HEMOGLOBIN; INDUCTIVELY COUPLED PLASMA MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITES; PROTEINS;

DRUG PRODUCTS;

ANTITRYPANOSOMAL AGENT; HEMOGLOBIN; MELARSENOXIDE; MELARSOPROL; ORGANOARSENIC DERIVATIVE; SERUM ALBUMIN;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; HUMAN; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; METHODOLOGY; PROTEIN BINDING;

ARSENICALS; CHROMATOGRAPHY, LIQUID; HEMOGLOBINS; HUMANS; MASS SPECTROMETRY; MELARSOPROL; MOLECULAR STRUCTURE; PROTEIN BINDING; SERUM ALBUMIN; TRYPANOCIDAL AGENTS;

EID: 84878276830     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-013-6929-7     Document Type: Article

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