Impact of P-glycoprotein and breast cancer resistance protein on the brain distribution of antiepileptic drugs in knockout mouse models

European Journal of Pharmacology

Volumn 710, Issue 1-3, 2013, Pages 20-28

  Nakanishi, Haruka ^a   Yonezawa, Atsushi ^b   Matsubara, Kazuo ^b   Yano, Ikuko ^a  

^a KYOTO UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY HOSPITAL   (Japan)

Author keywords

Abcb1; Abcg2; Antiepileptic drug; Blood brain barrier; Knockout mice; Pharmacokinetics

Indexed keywords

ANTICONVULSIVE AGENT; BREAST CANCER RESISTANCE PROTEIN; CARBAMAZEPINE; CLOBAZAM; ETHOSUXIMIDE; ETIRACETAM; GABAPENTIN; LAMOTRIGINE; MULTIDRUG RESISTANCE PROTEIN; PHENOBARBITAL; PHENYTOIN; TIAGABINE; TOPIRAMATE; VALPROIC ACID; ZONISAMIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN; BRAIN TO PLASMA CONCENTRATION RATIO; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG STRUCTURE; KIDNEY TO PLASMA CONCENTRATION RATIO; KNOCKOUT MOUSE; LIVER TO PLASMA CONCENTRATION RATIO; MALE; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PHARMACOLOGICAL PARAMETERS; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

ANIMALS; ANTICONVULSANTS; ATP-BINDING CASSETTE TRANSPORTERS; BRAIN; MALE; MICE; MICE, KNOCKOUT; P-GLYCOPROTEINS;

EID: 84878257778     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2013.03.049     Document Type: Article

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