Detection of fluticasone propionate in horse plasma and urine following inhaled administration

Drug Testing and Analysis

Volumn 5, Issue 5, 2013, Pages 306-314

  Gray, Bobby P ^a   Biddle, Simon ^a   Pearce, Clive M ^a   Hillyer, Lynn ^b  

^a LGC   (United Kingdom)

^b BRITISH HORSERACING AUTHORITY   (United Kingdom)

Author keywords

Fluticasone propionate; Horse; Inhaled; Plasma; Urine

Indexed keywords

BODY FLUIDS; DISEASES; DRUG PRODUCTS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

ACID METABOLITES; ANTI-INFLAMMATORY AGENTS; FLUTICASONE PROPIONATE; HORSE; HORSE URINE; INHALED; LIQUID CHROMATOGRAPHY COUPLED TO TANDEM MASS SPECTROMETRY; ULTRA-HIGH PERFORMANCE LIQUID CHROMATOGRAPHIES; UPLC-MS/MS; URINE;

MASS SPECTROMETRY;

CARBOXYLIC ACID; FLUTICASONE PROPIONATE;

ARTICLE; CONCENTRATION (PARAMETERS); DRUG DETERMINATION; HORSE; NONHUMAN; PRIORITY JOURNAL; SPIKE; TANDEM MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; URINALYSIS;

EID: 84878239092     PISSN: 19427603     EISSN: 19427611     Source Type: Journal    
DOI: 10.1002/dta.1329     Document Type: Article

References (17)

1. H. Funch-Nielson, C.A. Roberts, J.S. Weekes, C.M. Deaton, D.J. Marlin. Evaluation of a new spacer device for delivery of drugs into the equine respiratory tract. Available at: http://equinehaler.com/34-:%20product%20info.htm [1 July 2011].
2. R.A. Willoughby, G.L. Ecker, S.L. McKee, L.J. Riddolls. Use of scintigraphy for the determination of mucociliary clearance rates in normal, sedated, diseased and exercised horses. Can. J. Vet. Res. 1991, 55, 315.
3. P.T. Daley-Yates, R.C. Baker. Systemic bioavailability of fluticasone propionate administered as nasal drops and aqueous nasal spray formulations. J. Clin. Pharmacol. 2001, 51, 103.
4. A.E. Mackie, J.E. McDowall, P. Ventresca, A. Bye, C. Falcoz, P.T. Daley-Yates. Systemic exposure to fluticasone propionate administered via metered-dose inhaler containing chlorofluorocarbon or hydrofluoroalkane propellant. Clin. Pharmacokinet. 2000, 39, 17.
5. A.E. Mackie, J.E. McDowall, P. Ventresca, A. Bye, C. Falcoz, P.T. Daley-Yates. Pharmacokinetics of fluticasone propionate inhaled via the Diskhaler® and Diskus® powder devices in healthy volunteers. Clin. Pharmacokinet. 2000, 39, 23.
6. C. Brindley, C. Falcoz, A.E. Mackie, A. Bye. Absorption kinetics after inhalation of fluticasone propionate via the Diskhaler®, Diskus®, and metered-dose inhaler in healthy volunteers. Clin. Pharmacokinet. 2000, 39, 1.
7. N. Esmailpour, P. Högger, K.F. Rabe, U. Heitmann, M. Nakashima, P. Rohdewald. Distribution of inhaled fluticasone propionate between human lung tissue and serum in vivo. Eur. Respir. J. 1997, 10, 1496.
8. T.C. Carvalho, J.I. Peters, R.O. Williams III. Influence of particle size on regional lung deposition - What evidence is there? Int. J. Pharm. 2011, 406, 1.
9. A. Tal, H. Golan, N. Grauer, M. Aviram, D. Albin, M.R. Quastel. Deposition pattern of radiolabeled salbutamol inhaled from a metered-dose inhaler by means of a spacer with mask in young children with airway obstruction. J. Pediatr. 1996, 128, 479.
10. C. Falcoz, R. Oliver, J.E. McDowall, P. Ventresca, A. Bye, P.T. Daley-Yates. Bioavailability of orally administered micronised fluticasone propionate. Clin. Pharmacokinet. 2000, 39, 9.
11. A.E. Mackie, G.P. Ventresca, R.W. Fuller, A. Bye. Pharmacokinetics of intravenous fluticasone propionate in healthy subjects. Brit. J. Clin. Pharmaco. 1996, 41, 539.
12. N.L. Korpi-Steiner, B.C. Netzel, J.C. Seegmiller, J.B. Hagan, R.J. Singh. Liquid chromatography-tandem mass spectrometry analysis of urinary fluticasone propionate-17beta-carboxylic acid for monitoring compliance with inhaled-fluticasone propionate therapy. Steroids 2010, 75, 77.
13. rd Cologne workshop on dope analysis, 27 February to 4 March 2005, Recent advances in doping analysis (13), Sportverlag Strauβ. 2005, pp 29-37.
14. N.H. Yu, E.N.M. Ho, F.P.W. Tang, T.S.M. Wan, A.S.Y. Wong. Comprehensive screening of acidic and neutral drugs in equine plasma by liquid chromatography-tandem mass spectrometry. J. Chromatogr. A 2008, 1189, 426.
15. Y. Moulard, L. Bailly-Chouriberry, S. Boyer, P. Garcia, M.A. Popot, Y. Bonnaire. Use of benchtop exactive high resolution and high mass accuracy Orbitrap mass spectrometer for screening in horse doping control. Anal. Chim. Acta 2011, 700, 126.
16. B.P. Gray, P. Teale, C.M. Pearce. Analysis of methyloxime derivatives of intact esters of testosterone and boldenone in equine plasma using ultra high performance liquid chromatography tandem mass spectrometry. Drug Test. Analysis 2011, 3, 206.
17. J.P. Scarth, P. Teale, T. Kuuranne. Drug metabolism in the horse: A review. Drug Test. Analysis 2011, 3, 19.