Pharmacokinetics of intravenous fluticasone propionate in healthy subjects

British Journal of Clinical Pharmacology

Volumn 41, Issue 6, 1996, Pages 539-542

  Mackie, A E ^a   Ventresca, G P ^a   Fuller, R W ^a   Bye, A ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

fluticasone propionate; glucocorticosteroid; healthy subjects; intravenous; pharmacokinetics

Indexed keywords

FLUTICASONE PROPIONATE;

ADULT; AREA UNDER THE CURVE; ARTICLE; ASTHMA; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG HALF LIFE; HUMAN; HUMAN EXPERIMENT; INTRAVENOUS DRUG ADMINISTRATION; MALE; NORMAL HUMAN; PRIORITY JOURNAL;

EID: 0029929091     PISSN: 03065251     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2125.1996.36110.x     Document Type: Article

References (7)

1. Phillipps GH. Structure-activity relationships of topically active steroids: the selection of fluticasone propionate. Resp Med 1990; 84 (Supplement A): 19-23.
2. Holliday SM, Faulds D, Sorkin EM. Inhaled fluticasone propionate. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in asthma. Drugs 1994; 47 (2): 318-331.
3. Ventresca GP, Mackie AE, Moss JA, McDowell JE, Bye A. Absorption of oral fluticasone propionate in healthy subjects. Am J Resp Med 1994; 149: A214.
4. Harding SM. The human pharmacology of fluticasone propionate. Resp Med 1990; 84 (Supplement A): 25-29.
5. Bain BM, Harrison G, Jenkins KD, et al. A sensitive radioimmunoassay, incorporating solid-phase extraction, for fluticasone 17-propionate in plasma. J Pharm Biomed Analysis 1993; 11: 557-561.
6. Gibaldi M. Biopharmaceutics and Clinical Pharmacokinetics (4th Edition). Lea and Febiger London (1991): Chapter 2.
7. Cartwright AC. Drug Informat J 1991; 25: 471-482.