Atherosclerotic disease in type 2 diabetes is associated with an increase in sclerostin levels

Diabetes Care

Volumn 36, Issue 6, 2013, Pages 1667-1674

  Morales Santana, Sonia ^a,b   García Fontana, Beatriz ^a   García Martín, Antonia ^a   Rozas Moreno, Pedro ^c   García Salcedo, José Antonio ^a   Reyes García, Rebeca ^a   Muñoz Torres, Manuel ^a  

^a HOSPITAL UNIVERSITARIO SAN CECILIO   (Spain)

^b Fundacion Para la Investigacion Biosanitaria de Andalucia Oriental Alejandro Otero   (Spain)

^c HOSPITAL GENERAL UNIVERSITARIO DE CIUDAD REAL   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

HOMOCYSTEINE; SCLEROSTIN;

ADULT; AGED; ARTERIAL WALL THICKNESS; ARTERY CALCIFICATION; ARTICLE; ATHEROSCLEROSIS; CAROTID ATHEROSCLEROSIS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION ANALYSIS; CROSS-SECTIONAL STUDY; DIAGNOSTIC TEST ACCURACY STUDY; DISEASE ASSOCIATION; FEMALE; GENDER; HUMAN; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PROTEIN BLOOD LEVEL; RECEIVER OPERATING CHARACTERISTIC; RISK ASSESSMENT; SENSITIVITY AND SPECIFICITY;

ATHEROSCLEROSIS; BONE MORPHOGENETIC PROTEINS; CROSS-SECTIONAL STUDIES; DIABETES MELLITUS, TYPE 2; FEMALE; GENETIC MARKERS; HUMANS; LOGISTIC MODELS; MALE; MIDDLE AGED;

EID: 84878236120     PISSN: 01495992     EISSN: 19355548     Source Type: Journal    
DOI: 10.2337/dc12-1691     Document Type: Article

References (36)

1. Madonna R, De Caterina R. Cellular and molecular mechanisms of vascular injury in diabetes - part I: pathways of vascular disease in diabetes. Vascul Pharmacol 2011;54:68-74
2. Couffinhal T, Dufourcq P, Duplàa C. Beta-catenin nuclear activation: common pathway between Wnt and growth factor signaling in vascular smooth muscle cell proliferation? Circ Res 2006;99:1287-1289 (Pubitemid 44949663)
3. Tsaousi A, Williams H, Lyon CA, et al. Wnt4/β-catenin signaling induces VSMC proliferation and is associated with intimal thickening. Circ Res 2011;108:427-436
4. Wang X, Xiao Y, Mou Y, Zhao Y, Blankesteijn WM, Hall JL. A role for the β-catenin/T-cell factor signaling cascade in vascular remodeling. Circ Res 2002;90:340-347 (Pubitemid 34633936)
5. Mani A, Radhakrishnan J, Wang H, et al. LRP6 mutation in a family with early coronary disease and metabolic risk factors. Science 2007;315:1278-1282 (Pubitemid 46364265)
6. Chafey P, Finzi L, Boisgard R, et al. Proteomic analysis of β-catenin activation in mouse liver by DIGE analysis identifies glucose metabolism as a new target of the Wnt pathway. Proteomics 2009;9:3889-3900
7. Jin T. The WNT signalling pathway and diabetes mellitus. Diabetologia 2008;51:1771-1780
8. Manolagas SC, Almeida M. Gone with the Wnts: β-catenin, T-cell factor, forkhead box O, and oxidative stress in age-dependent diseases of bone, lipid, and glucose metabolism. Mol Endocrinol 2007;21:2605-2614 (Pubitemid 350035144)
9. Ueland T, Otterdal K, Lekva T, et al. Dickkopf-1 enhances inflammatory interaction between platelets and endothelial cells and shows increased expression in atherosclerosis. Arterioscler Thromb Vasc Biol 2009;29:1228-1234
10. Rao TP, Kühl M. An updated overview on Wnt signaling pathways: a prelude for more. Circ Res 2010;106:1798-1806
11. Barandon L, Couffinhal T, Ezan J, et al. Reduction of infarct size and prevention of cardiac rupture in transgenic mice overexpressing FrzA. Circulation 2003;108:2282-2289 (Pubitemid 37363048)
12. Mastroiacovo F, Busceti CL, Biagioni F, et al. Induction of the Wnt antagonist, Dickkopf-1, contributes to the development of neuronal death in models of brain focal ischemia. J Cereb Blood Flow Metab 2009;29:264-276
13. Román-García P, Carrillo-López N, Fernández-Martín JL, Naves-Díaz M, Ruiz-Torres MP, Cannata-Andía JB. High phosphorus diet induces vascular calcification, a related decrease in bone mass and changes in the aortic gene expression. Bone 2010;46:121-128
14. Goliasch G, Wiesbauer F, Kastl SP, et al. Premature myocardial infarction is associated with low serum levels of Wnt-1. Atherosclerosis 2012;222:251-256
15. Poole KE, van Bezooijen RL, Loveridge N, et al. Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation. FASEB J 2005;19:1842-1844 (Pubitemid 41598769)
16. van Bezooijen RL, ten Dijke P, Papapoulos SE, Löwik CW. SOST/sclerostin, an osteocyte-derived negative regulator of bone formation. Cytokine Growth Factor Rev 2005;16:319-327 (Pubitemid 40910321)
17. García-Martín A, Rozas-Moreno P, Reyes-García R, et al. Circulating levels of sclerostin are increased in patients with type 2 diabetes mellitus. J Clin Endocrinol Metab 2012;97:234-241
18. Shao JS, Cheng SL, Pingsterhaus JM, Charlton-Kachigian N, Loewy AP, Towler DA. Msx2 promotes cardiovascular calcification by activating paracrine Wnt signals. J Clin Invest 2005;115:1210-1220 (Pubitemid 40629039)
19. Didangelos A, Yin X, Mandal K, Baumert M, Jahangiri M, Mayr M. Proteomics characterization of extracellular space components in the human aorta. Mol Cell Proteomics 2010;9:2048-2062
20. Zhu D, Mackenzie NC, Millán JL, Farquharson C, MacRae VE. The appearance and modulation of osteocyte marker expression during calcification of vascular smooth muscle cells. PLoS ONE 2011;6:e19595
21. Junyent M, Gilabert R, Núñez I, et al. [Carotid ultrasound in the assessment of preclinical atherosclerosis. Distribution of intima-media thickness values and plaque frequency in a Spanish community cohort]. Med Clin (Barc) 2005;125:770-774
22. Kauppila LI, Polak JF, Cupples LA, Hannan MT, Kiel DP,Wilson PW. New indices to classify location, severity and progression of calcific lesions in the abdominal aorta: a 25-year follow-up study. Atherosclerosis 1997;132:245-250 (Pubitemid 27311017)
23. Malekar P, Hagenmueller M, Anyanwu A, et al. Wnt signaling is critical for maladaptive cardiac hypertrophy and accelerates myocardial remodeling. Hypertension 2010;55:939-945
24. Thambiah S, Roplekar R, Manghat P, et al. Circulating sclerostin and Dickkopf-1 (DKK1) in predialysis chronic kidney disease (CKD): relationship with bone density and arterial stiffness. Calcif Tissue Int 2012;90:473-480
25. Mödder UI, Hoey KA, Amin S, et al. Relation of age, gender, and bone mass to circulating sclerostin levels in women and men. J Bone Miner Res 2011;26:373-379
26. Cejka D, Jäger-Lansky A, Kieweg H, et al. Sclerostin serumlevels correlate positively with bone mineral density and microarchitecture in haemodialysis patients. Nephrol Dial Transplant 2012;27:226-230
27. Mödder UI, Clowes JA, Hoey K, et al. Regulation of circulating sclerostin levels by sex steroids in women and in men. J Bone Miner Res 2011;26:27-34
28. Braunwald E. Shattuck lecture - cardiovascular medicine at the turn of the millennium: triumphs, concerns, and opportunities. N Engl J Med 1997;337:1360-1369 (Pubitemid 27467771)
29. Manolio TA, Pearson TA, Wenger NK, Barrett-Connor E, Payne GH, Harlan WR. Cholesterol and heart disease in older persons and women. Review of an NHLBI workshop. Ann Epidemiol 1992;2:161-176
30. Rimm EB, Stampfer MJ, Ascherio A, Giovannucci E, Colditz GA, Willett WC. Vitamin E consumption and the risk of coronary heart disease in men. N Engl J Med 1993;328:1450-1456 (Pubitemid 23143847)
31. Stampfer MJ, Hennekens CH, Manson JE, Colditz GA, Rosner B,WillettWC. Vitamin E consumption and the risk of coronary disease in women. N Engl JMed 1993;328:1444-1449 (Pubitemid 23143846)
32. Cefalu WT. Glycemic control and cardiovascular disease - should we reassess clinical goals? N Engl J Med 2005;353:2707-2709 (Pubitemid 41817721)
33. You H, Yang H, Zhu Q, et al. Advanced oxidation protein products induce vascular calcification by promoting osteoblastic trans-differentiation of smooth muscle cells via oxidative stress and ERK pathway. Ren Fail 2009;31:313-319
34. Petramala L, Acca M, Francucci CM, D'Erasmo E. Hyperhomocysteinemia: a biochemical link between bone and cardiovascular system diseases? J Endocrinol Invest 2009;32(Suppl. 4):10-14
35. Urano T, Shiraki M, Ouchi Y, Inoue S. Association of circulating sclerostin levels with fat mass and metabolic disease-related markers in Japanese postmenopausal women. J Clin Endocrinol Metab 2012 [Epub ahead of print]
36. Lorenz MW, Markus HS, Bots ML, Rosvall M, Sitzer M. Prediction of clinical cardiovascular events with carotid intima-media thickness: a systematic review and meta-analysis. Circulation 2007;115:459-467 (Pubitemid 46184197)