Determination of cocaine, cocaine metabolites and cannabinoids in single hairs by MALDI Fourier transform mass spectrometry - preliminary results

Drug Testing and Analysis

Volumn 5, Issue 5, 2013, Pages 361-365

  Musshoff, Frank ^a   Arrey, Tabiwang ^b   Strupat, Kerstin ^b  

^a UNIVERSITY HOSPITAL BONN   (Germany)

^b THERMO FISHER SCIENTIFIC   (Germany)

Author keywords

Cannabinoids; Cocaine; Hair testing; MALDI; Mass spectrometry

Indexed keywords

DRUG PRODUCTS; METABOLITES;

ADHESIVE TAPES; CANNABINOIDS; COCAINE; CYANO-4-HYDROXYCINNAMIC ACIDS; DOUBLE SIDED; FOURIER TRANSFORM MASS SPECTROMETRY; HAIR TESTING; MALDI; MATRIX; Z RATIO;

MASS SPECTROMETRY;

CANNABINOID; COCAINE; DRUG METABOLITE;

ARTICLE; DRUG ABUSE; DRUG DETERMINATION; FORENSIC TOXICOLOGY; FOURIER TRANSFORM MASS SPECTROMETRY; HAIR ANALYSIS; HAIR ROOT; HUMAN; PRIORITY JOURNAL;

EID: 84878227887     PISSN: 19427603     EISSN: 19427611     Source Type: Journal    
DOI: 10.1002/dta.1453     Document Type: Article

References (14)

1. A. Walch, S. Rauser, S.O. Deininger, H. Hofler. MALDI imaging mass spectrometry for direct tissue analysis: A new frontier for molecular histology. Histochem. Cell Biol. 2008, 130, 421.
2. R.F. Reich, K. Cudzilo, J.A. Levisky, R.A. Yost. Quantitative MALDI-MS(n) analysis of cocaine in the autopsied brain of a human cocaine user employing a wide isolation window and internal standards. J. Am. Soc. Mass Spectrom. 2010, 21, 564.
3. T. Porta, E. Varesio, G. Hopfgartner, T. Kraemer. MALDI mass spectrometric imaging in tissue sections as a new tool in forensic toxicology. Toxichem. Krimtech. 2010, 77, 188.
4. F. Musshoff, B. Madea. New trends in hair analysis and scientific demands on validation and technical notes. Forensic Sci. Int. 2007, 165, 204.
5. F. Musshoff, B. Madea. Analytical pitfalls in hair testing. Anal. Bioanal. Chem. 2007, 388, 1475.
6. F. Pragst, M.A. Balikova. State of the art in hair analysis for detection of drug and alcohol abuse. Clin. Chim. Acta 2006, 370, 17.
7. F. Musshoff, K. Lachenmeier, J. Trafkowski, B. Madea, F. Nauck, U. Stamer. Determination of opioid analgesics in hair samples using liquid chromatography/tandem mass spectrometry and application to patients under palliative care. Ther. Drug Monit. 2007, 29, 655.
8. S. Vogliardi, D. Favretto, G. Frison, S.D. Ferrara, R. Seraglia, P. Traldi. A fast screening MALDI method for the detection of cocaine and its metabolites in hair. J. Mass Spectrom. 2009, 44, 18.
9. S. Vogliardi, D. Favretto, G. Frison, S. Maietti, G. Viel, R. Seraglia, et al. Validation of a fast screening method for the detection of cocaine in hair by MALDI-MS. Anal. Bioanal. Chem. 2010, 396, 2435.
10. T. Porta, C. Grivet, T. Kraemer, E. Varesio, G. Hopfgartner. Single hair cocaine consumption monitoring by mass spectrometric imaging. Anal. Chem. 2011, 83, 4266.
11. A. Miki, M. Katagi, T. Kamata, K. Zaitsu, M. Tatsuno, T. Nakanishi, et al. MALDI-TOF and MALDI-FTICR imaging mass spectrometry of methamphetamine incorporated into hair. J. Mass Spectrom. 2011, 46, 411.
12. P.J. Trim, S. Francese, M.R. Clench. Imaging mass spectrometry for the assessment of drugs and metabolites in tissue. Bioanalysis 2009, 1, 309.
13. D.S. Cornett, S.L. Frappier, R.M. Caprioli. MALDI-FTICR imaging mass spectrometry of drugs and metabolites in tissue. Anal. Chem. 2008, 80, 5648.
14. K. Lachenmeier, F. Musshoff, B. Madea. Determination of opiates and cocaine in hair using automated enzyme immunoassay screening methodologies followed by gas chromatographic-mass spectrometric (GC-MS) confirmation. Forensic Sci. Int. 2006, 159, 189.