Reduced adult endothelial cell EphB4 function promotes venous remodeling

American Journal of Physiology - Cell Physiology

Volumn 304, Issue 7, 2013, Pages

  Jadlowiec, Caroline C ^a,b   Feige, Amanda ^a   Yang, Chenzi ^a,c   Feinstein, Aaron J ^a   Kim, Susun T ^a   Collins, Michael J ^a   Kondo, Yuka ^a,d   Muto, Akihito ^a,d   Dardik, Alan ^a,e  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CONNECTICUT   (United States)

^c CENTRAL SOUTH UNIVERSITY   (China)

^d MIE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^e VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

Author keywords

EphB4; Vein graft remodeling; Venous endothelial cells

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; EPHB4 PROTEIN; MESSENGER RNA; NITRIC OXIDE; PLATELET DERIVED GROWTH FACTOR BB; PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; VASCULOTROPIN A; EPHB4 PROTEIN, MOUSE; EPHRIN RECEPTOR B4; VASCULAR ENDOTHELIAL GROWTH FACTOR A, MOUSE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL ISOLATION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; CULTURE MEDIUM; CYTOKINE PRODUCTION; ENDOTHELIUM CELL; GENETIC ENGINEERING; MOUSE; NEOINTIMA; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; TISSUE REGENERATION; VEIN GRAFT; ANIMAL; C57BL MOUSE; CELL MOTION; CYTOLOGY; GENE EXPRESSION REGULATION; GENETICS; INFERIOR CAVA VEIN; LUNG; METABOLISM; MUTATION; PHOSPHORYLATION; PHYSIOLOGY; THORACIC AORTA; TRANSPLANTATION; VASCULAR SMOOTH MUSCLE;

MUS;

ANIMALS; AORTA, THORACIC; CELL MOVEMENT; CELL PROLIFERATION; ENDOTHELIAL CELLS; GENE EXPRESSION REGULATION; LUNG; MICE; MICE, INBRED C57BL; MUSCLE, SMOOTH, VASCULAR; MUTATION; PHOSPHORYLATION; RECEPTOR, EPHB4; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VENA CAVA, INFERIOR;

MLCS; MLOWN;

EID: 84878216824     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00333.2012     Document Type: Article

References (29)

1. Adams RH, Wilkinson GA, Weiss C, Diella F, Gale NW, Deutsch U, Risau W, Klein R. Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vas-cular morphogenesis, and sprouting angiogenesis. Genes Dev 13: 295-306, 1999.
2. Allen KE, Varty K, Jones L, Sayers RD, Bell PR, London NJ. Human venous endothelium can promote intimal hyperplasia in a paracrine man-ner. J Vasc Surg 19: 577-584, 1994.
3. Cayatte AJ, Palacino JJ, Horten K, Cohen RA. Chronic inhibition of nitric oxide production accelerates neointima formation and impairs en-dothelial function in hypercholesterolemic rabbits. Arterioscler Thromb 14: 753-759, 1994.
4. Dimmeler S, Fleming I, Fisslthaler B, Hermann C, Busse R, Zeiher AM. Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature 399: 601-605, 1999.
5. Fernández-Hernando C, József L, Jenkins D, Di Lorenzo A, Sessa WC. Absence of Akt1 reduces vascular smooth muscle cell migration and survival and induces features of plaque vulnerability and cardiac dysfunc-tion during atherosclerosis. Arterioscler Thromb Vasc Biol 29: 2033-2040, 2009.
6. Fernández-Hernando C, Fukata M, Bernatchez PN, Fukata Y, Lin MI, Bredt DS, Sessa WC. Identification of Golgi-localized acyl trans-ferases that palmitoylate and regulate endothelial nitric oxide synthase. J Cell Biol 174: 369-377, 2006.
7. Gerber HP, McMurtrey A, Kowalski J, Yan M, Keyt BA, Dixit V, Ferrara N. Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3=-kinase/Akt signal transduc-tion pathway. Requirement for Flk-1/KDR activation. J Biol Chem 273: 30336-30343, 1998.
8. Gerety SS, Wang HU, Chen ZF, Anderson DJ. Symmetrical mutant phenotypes of the receptor EphB4 and its specific transmembrane ligand ephrin-B2 in cardiovascular development. Mol Cell 4: 403-414, 1999.
9. Hata JA, Petrofski JA, Schroder JN, Williams ML, Timberlake SH, Pippen A, Corwin MT, Solan AK, Jakoi A, Gehrig TR, Kontos CD, Milano CA. Modulation of phosphatidylinositol 3-kinase signaling re-duces intimal hyperplasia in aortocoronary saphenous vein grafts. J Thorac Cardiovasc Surg 129: 1405-1413, 2005.
10. Hamdan AD, Aiello LP, Misare BD, Contreras MA, King GL, LoGerfo FW, Quist WC. Vascular endothelial growth factor expression in canine peripheral vein bypass grafts. J Vasc Surg 26: 79-86, 1997.
11. Janssens S, Flaherty D, Nong Z, Varenne O, van Pelt N, Haustermans C, Zoldhelyi P, Gerard R, Collen D. Human endothelial nitric oxide synthase gene transfer inhibits vascular smooth muscle cell proliferation and neointima formation after balloon injury in rats. Circulation 97: 1274-1281, 1998.
12. Kudo FA, Muto A, Maloney SP, Pimiento JM, Bergaya S, Fitzgerald TN, Westvik TS, Frattini JC, Breuer CK, Cha CH, Nishibe T, Tellides G, Sessa WC, Dardik A. Venous identity is lost but arterial identity is not gained during vein graft adaptation. Arterioscler Thromb Vasc Biol 27: 1562-1571, 2007.
13. Lal BK, Varma S, Pappas PJ, Hobson RW 2nd, Durán WN. VEGF increases permeability of the endothelial cell monolayer by activation of PKB/akt, endothelial nitric-oxide synthase, and MAP kinase pathways. Microvasc Res 62: 252-262, 2001.
14. Lee JH, Johnson PR, Roth M, Hunt NH, Black JL. ERK activation and mitogenesis in human airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 280: L1019-L1029, 2001.
15. Li YS, Haga JH, Chien S. Molecular basis of the effects of shear stress on vascular endothelial cells. J Biomech 38: 1949-1971, 2005.
16. Luo Z, Asahara T, Tsurumi Y, Isner JM, Symes JF. Reduction of vein graft intimal hyperplasia and preservation of endothelium-dependent re-laxation by topical vascular endothelial growth factor. J Vasc Surg 27: 167-173, 1998.
17. Morales-Ruiz M, Fulton D, Sowa G, Languino LR, Fujio Y, Walsh K, Sessa WC. Vascular endothelial growth factor-stimulated actin reorganization and migration of endothelial cells is regulated via the serine/threonine kinase Akt. Circ Res 86: 892-896, 2000.
18. Muto A, Yi T, Harrison KD, Dávalos A, Fancher TT, Ziegler KR, Feigel A, Kondo Y, Nishibe T, Sessa WC, Dardik A. Eph-B4 prevents venous adaptive remodeling in the adult arterial environment. J Exp Med 208: 561-575, 2011.
19. Niu XF, Smith CW, Kubes P. Intracellular oxidative stress induced by nitric oxide synthesis inhibition increases endothelial cell adhesion to neutrophils. Circ Res 74: 1133-1140, 1994.
20. Owens CD, Wake N, Jacot JG, Gerhard-Herman M, Gaccione P, Belkin M, Creager MA, Conte Owens CD MS, Wake N, Jacot JG, Gerhard-Herman M, Gaccione P, Belkin M, Creager MA, Conte MS. Early biomechanical changes in lower extremity vein grafts-distinct temporal phases of remodeling and wall stiffness. J Vasc Surg 44: 740-746, 2006.
21. Owens CD, Rybicki FJ, Wake N, Schanzer A, Mitsouras D, Gerhard-Herman MD, Conte MS. Early remodeling of lower extremity vein grafts: inflammation influences biomechanical adaptation. J Vasc Surg 47: 1235-1242, 2008.
22. Owens CD. Adaptive changes in autogenous vein grafts for arterial reconstruction: clinical implications. J Vasc Surg 51: 736-746, 2010.
23. Shah DM, Darling RC 3rd, Chang BB, Fitzgerald KM, Paty PS, Leather RP. Long-term results of in situ saphenous vein bypass. Analysis of 2058 cases. Ann Surg 222: 438-446, 1995.
24. Srinivasan R, Zabuawala T, Huang H, Zhang J, Gulati P, Fernandez S, Karlo JC, Landreth GE, Leone G, Ostrowski MC. Erk1 and Erk2 regulate endothelial cell proliferation and migration during mouse embryonic angiogenesis. PLos One 4: e8283, 2009.
25. Steinle JJ, Meininger CJ, Forough R, Wu G, Wu MH, Granger HJ. Eph B4 receptor signaling mediates endothelial cell migration and prolif-eration via the phosphatidylinositol 3-kinase pathway. J Biol Chem 277: 43830-43835, 2002.
26. van der Zee R, Murohara T, Luo Z, Zollmann F, Passeri J, Lekutat C, Isner JM. Vascular endothelial growth factor/vascular permeability actor augments nitric oxide release from quiescent rabbit and human vascular endothelium. Circulation 95: 1030-1037, 1997.
27. Wang HU, Chen ZF, Anderson DJ. Molecular distinction and angio-genic interaction between embryonic arteries and veins revealed by eph-rin-B2 and its receptor Eph-B4. Cell 93: 741-753, 1998.
28. Westerband A, Gentile AT, Hunter GC, Gooden MA, Aguirre ML, Berman SS, Mills JL. Intimal growth and neovascularization in human stenotic vein grafts. J Am Coll Surg 191: 264-271, 2000.
29. Yamashita A, Hanna AK, Hirata S, Dardik A, Sumpio BE. Antisense basic fibroblast growth factor alters the time course of mitogen-activated protein kinase in arterialized vein graft remodeling. J Vasc Surg 37: 866-873, 2003.