-
1
-
-
3042777392
-
Systemic treatment and liver transplantation for hepatocellular carcinoma: two ends of the therapeutic spectrum
-
Burroughs A., Hochhauser D., Meyer T. Systemic treatment and liver transplantation for hepatocellular carcinoma: two ends of the therapeutic spectrum. Lancet Oncol. 2004, 5:409-418.
-
(2004)
Lancet Oncol.
, vol.5
, pp. 409-418
-
-
Burroughs, A.1
Hochhauser, D.2
Meyer, T.3
-
2
-
-
79952277108
-
The challenge of prognosis and staging for hepatocellular carcinoma
-
Marrero J.A., Kudo M., Bronowicki J.-P. The challenge of prognosis and staging for hepatocellular carcinoma. Oncologist 2010, 15:23-33.
-
(2010)
Oncologist
, vol.15
, pp. 23-33
-
-
Marrero, J.A.1
Kudo, M.2
Bronowicki, J.-P.3
-
3
-
-
34250308322
-
Apoptosis: a review of programmed cell death
-
Elmore S. Apoptosis: a review of programmed cell death. Toxicol. Pathol. 2007, 35:495-516.
-
(2007)
Toxicol. Pathol.
, vol.35
, pp. 495-516
-
-
Elmore, S.1
-
4
-
-
0027479977
-
Apoptosis: the biochemistry and molecular biology of programmed cell death
-
Schwartzman R.A., Cidlowski J.A. Apoptosis: the biochemistry and molecular biology of programmed cell death. Endocr. Rev. 1993, 14:133-151.
-
(1993)
Endocr. Rev.
, vol.14
, pp. 133-151
-
-
Schwartzman, R.A.1
Cidlowski, J.A.2
-
5
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan D., Weinberg R.A. The hallmarks of cancer. Cell 2000, 100:57-70.
-
(2000)
Cell
, vol.100
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
6
-
-
3943071150
-
Cytochromec-mediatedapoptosis
-
Jiang X., Wang X. Cytochromec-mediatedapoptosis. Annu. Rev. Biochem. 2004, 73:87-106.
-
(2004)
Annu. Rev. Biochem.
, vol.73
, pp. 87-106
-
-
Jiang, X.1
Wang, X.2
-
7
-
-
78649700978
-
BID, BIM, and PUMA are essential for activation of the BAX- and BAK-dependent cell death program
-
Ren D., Tu H.C., Kim H., Wang G.X., Bean G.R., Takeuchi O., Jeffers J.R., Zambetti G.P., Hsieh J.J.D., Cheng E.H.Y. BID, BIM, and PUMA are essential for activation of the BAX- and BAK-dependent cell death program. Science 2010, 330:1390-1393.
-
(2010)
Science
, vol.330
, pp. 1390-1393
-
-
Ren, D.1
Tu, H.C.2
Kim, H.3
Wang, G.X.4
Bean, G.R.5
Takeuchi, O.6
Jeffers, J.R.7
Zambetti, G.P.8
Hsieh, J.J.D.9
Cheng, E.H.Y.10
-
8
-
-
0142117313
-
The Bcl-2 family: roles in cell survival and oncogenesis
-
Cory S., Huang D.C., Adams J.M. The Bcl-2 family: roles in cell survival and oncogenesis. Oncogene 2003, 22:8590-8607.
-
(2003)
Oncogene
, vol.22
, pp. 8590-8607
-
-
Cory, S.1
Huang, D.C.2
Adams, J.M.3
-
9
-
-
67349136004
-
Mcl-1 is a potential therapeutic target in multiple types of cancer
-
Akgul C. Mcl-1 is a potential therapeutic target in multiple types of cancer. Cell. Mol. Life Sci. 2009, 66:1326-1336.
-
(2009)
Cell. Mol. Life Sci.
, vol.66
, pp. 1326-1336
-
-
Akgul, C.1
-
10
-
-
8844244644
-
Therapeutic potential of antisense Bcl-2 as a chemosensitizer for cancer therapy
-
Kim R., Emi M., Tanabe K., Toge T. Therapeutic potential of antisense Bcl-2 as a chemosensitizer for cancer therapy. Cancer 2004, 101:2491-2502.
-
(2004)
Cancer
, vol.101
, pp. 2491-2502
-
-
Kim, R.1
Emi, M.2
Tanabe, K.3
Toge, T.4
-
11
-
-
44849112219
-
ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor
-
Tse C., Shoemaker A.R., Adickes J., Anderson M.G., Chen J., Jin S., Johnson E.F., Marsh K.C., Mitten M.J., Nimmer P., Roberts L., Tahir S.K., Xiao Y., Yang X., Zhang H., Fesik S., Rosenberg S.H., Elmore S.W. ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor. Cancer Res. 2008, 68:3421-3428.
-
(2008)
Cancer Res.
, vol.68
, pp. 3421-3428
-
-
Tse, C.1
Shoemaker, A.R.2
Adickes, J.3
Anderson, M.G.4
Chen, J.5
Jin, S.6
Johnson, E.F.7
Marsh, K.C.8
Mitten, M.J.9
Nimmer, P.10
Roberts, L.11
Tahir, S.K.12
Xiao, Y.13
Yang, X.14
Zhang, H.15
Fesik, S.16
Rosenberg, S.H.17
Elmore, S.W.18
-
12
-
-
65849378710
-
Unleashing the power of inhibitors of oncogenic kinases through BH3 mimetics
-
Cragg M.S., Harris C., Strasser A., Scott C.L. Unleashing the power of inhibitors of oncogenic kinases through BH3 mimetics. Nat. Rev. Cancer 2009, 9:321-326.
-
(2009)
Nat. Rev. Cancer
, vol.9
, pp. 321-326
-
-
Cragg, M.S.1
Harris, C.2
Strasser, A.3
Scott, C.L.4
-
13
-
-
83055173306
-
Overcoming blocks in apoptosis with BH3-mimetic therapy in haematological malignancies
-
Khaw S.L., Huang D.C., Roberts A.W. Overcoming blocks in apoptosis with BH3-mimetic therapy in haematological malignancies. Pathol. J. RCPA 2011, 43:525-535.
-
(2011)
Pathol. J. RCPA
, vol.43
, pp. 525-535
-
-
Khaw, S.L.1
Huang, D.C.2
Roberts, A.W.3
-
14
-
-
0036318268
-
Butyrate and aspirin in combination have an enhanced effect on apoptosis in human colorectal cancer cells
-
Menzel T., Schauber J., Kreth F., Kudlich T., Melcher R., Gostner A., Scheppach W., Lührs H. Butyrate and aspirin in combination have an enhanced effect on apoptosis in human colorectal cancer cells. Eur. J. Cancer Prev. 2002, 11:271-281.
-
(2002)
Eur. J. Cancer Prev.
, vol.11
, pp. 271-281
-
-
Menzel, T.1
Schauber, J.2
Kreth, F.3
Kudlich, T.4
Melcher, R.5
Gostner, A.6
Scheppach, W.7
Lührs, H.8
-
15
-
-
50349098706
-
Activity of the Bcl-2 family inhibitor ABT-263 in a panel of small cell lung cancer xenograft models
-
Shoemaker A.R., Mitten M.J., Adickes J., Ackler S., Refici M., Ferguson D., Oleksijew A., O'Connor J.M., Wang B., Frost D.J., Bauch J., Marsh K., Tahir S.K., Yang X., Tse C., Fesik S.W., Rosenberg S.H., Elmore S.W. Activity of the Bcl-2 family inhibitor ABT-263 in a panel of small cell lung cancer xenograft models. Clin. Cancer Res. 2008, 14:3268-3277.
-
(2008)
Clin. Cancer Res.
, vol.14
, pp. 3268-3277
-
-
Shoemaker, A.R.1
Mitten, M.J.2
Adickes, J.3
Ackler, S.4
Refici, M.5
Ferguson, D.6
Oleksijew, A.7
O'Connor, J.M.8
Wang, B.9
Frost, D.J.10
Bauch, J.11
Marsh, K.12
Tahir, S.K.13
Yang, X.14
Tse, C.15
Fesik, S.W.16
Rosenberg, S.H.17
Elmore, S.W.18
-
16
-
-
79952291173
-
Phase I study of Navitoclax (ABT-263), a novel Bcl-2 family inhibitor, in patients with small-cell lung cancer and other solid tumors
-
Gandhi L., Camidge D.R., Ribeiro de Oliveira M., Bonomi P., Gandara D., Khaira D., Hann C.L., McKeegan E.M., Litvinovich E., Hemken P.M., Dive C., Enschede S.H., Nolan C., Chiu Y.L., Busman T., Xiong H., Krivoshik A.P., Humerickhouse R., Shapiro G.I., Rudin C.M. Phase I study of Navitoclax (ABT-263), a novel Bcl-2 family inhibitor, in patients with small-cell lung cancer and other solid tumors. J. Clin. Oncol. 2011, 29:909-916.
-
(2011)
J. Clin. Oncol.
, vol.29
, pp. 909-916
-
-
Gandhi, L.1
Camidge, D.R.2
Ribeiro de Oliveira, M.3
Bonomi, P.4
Gandara, D.5
Khaira, D.6
Hann, C.L.7
McKeegan, E.M.8
Litvinovich, E.9
Hemken, P.M.10
Dive, C.11
Enschede, S.H.12
Nolan, C.13
Chiu, Y.L.14
Busman, T.15
Xiong, H.16
Krivoshik, A.P.17
Humerickhouse, R.18
Shapiro, G.I.19
Rudin, C.M.20
more..
-
17
-
-
77957954881
-
The Bcl-xL inhibitor, ABT-737, efficiently induces apoptosis and suppresses growth of hepatoma cells in combination with sorafenib
-
Hikita H., Takehara T., Shimizu S., Kodama T., Shigekawa M., Iwase K., Hayashi N. The Bcl-xL inhibitor, ABT-737, efficiently induces apoptosis and suppresses growth of hepatoma cells in combination with sorafenib. Hepatology 2010, 52:1310-1321.
-
(2010)
Hepatology
, vol.52
, pp. 1310-1321
-
-
Hikita, H.1
Takehara, T.2
Shimizu, S.3
Kodama, T.4
Shigekawa, M.5
Iwase, K.6
Hayashi, N.7
-
18
-
-
77956225330
-
The Bcl-2 inhibitor ABT-263 enhances the response of multiple chemotherapeutic regimens in hematologic tumors in vivo
-
Ackler S., Mitten M.J., Foster K., Oleksijew A., Refici M., Tahir S.K., Xiao Y., Tse C., Frost D.J., Fesik S.W. The Bcl-2 inhibitor ABT-263 enhances the response of multiple chemotherapeutic regimens in hematologic tumors in vivo. Cancer Chemother. Pharmacol. 2010, 66:869-880.
-
(2010)
Cancer Chemother. Pharmacol.
, vol.66
, pp. 869-880
-
-
Ackler, S.1
Mitten, M.J.2
Foster, K.3
Oleksijew, A.4
Refici, M.5
Tahir, S.K.6
Xiao, Y.7
Tse, C.8
Frost, D.J.9
Fesik, S.W.10
-
19
-
-
84859772732
-
ABT-263 sensitizes TRAIL-resistant hepatocarcinoma cells by downregulating the Bcl-2 family of anti-apoptotic protein
-
Wang G., Zhan Y., Wang H., Li W. ABT-263 sensitizes TRAIL-resistant hepatocarcinoma cells by downregulating the Bcl-2 family of anti-apoptotic protein. Cancer Chemother. Pharmacol. 2012, 69:799-805.
-
(2012)
Cancer Chemother. Pharmacol.
, vol.69
, pp. 799-805
-
-
Wang, G.1
Zhan, Y.2
Wang, H.3
Li, W.4
-
20
-
-
84862638645
-
Norcantharidin enhances ABT-737-induced apoptosis in hepatocellular carcinoma cells by transcriptional repression of Mcl-1
-
Zhang S., Li G., Ma X., Wang Y., Liu G., Feng L., Zhao Y., Zhang G., Wu Y., Ye X., Qin B., Lu J. Norcantharidin enhances ABT-737-induced apoptosis in hepatocellular carcinoma cells by transcriptional repression of Mcl-1. Cell. Signal. 2012, 24:1803-1809.
-
(2012)
Cell. Signal.
, vol.24
, pp. 1803-1809
-
-
Zhang, S.1
Li, G.2
Ma, X.3
Wang, Y.4
Liu, G.5
Feng, L.6
Zhao, Y.7
Zhang, G.8
Wu, Y.9
Ye, X.10
Qin, B.11
Lu, J.12
-
21
-
-
33750834023
-
The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized
-
van Delft M.F., Wei A.H., Mason K.D., Vandenberg C.J., Chen L., Czabotar P.E., Willis S.N., Scott C.L., Day C.L., Cory S., Adams J.M., Roberts A.W., Huang D.C. The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized. Cancer Cell 2006, 10:389-399.
-
(2006)
Cancer Cell
, vol.10
, pp. 389-399
-
-
van Delft, M.F.1
Wei, A.H.2
Mason, K.D.3
Vandenberg, C.J.4
Chen, L.5
Czabotar, P.E.6
Willis, S.N.7
Scott, C.L.8
Day, C.L.9
Cory, S.10
Adams, J.M.11
Roberts, A.W.12
Huang, D.C.13
-
22
-
-
77649185149
-
Aspirin induces apoptosis in YD-8 human oral squamous carcinoma cells through activation of caspases, down-regulation of Mcl-1, and inactivation of ERK-1/2 and AKT
-
Park I.-S., Jo J.-R., Hong H., Nam K.-Y., Kim J.-B., Hwang S.-H., Choi M.-S., Ryu N.-H., Jang H.-J., Lee S.-H., Kim C.-S., Kwon T.-G., Park G.-Y., Park J.-W., Jang B.-C. Aspirin induces apoptosis in YD-8 human oral squamous carcinoma cells through activation of caspases, down-regulation of Mcl-1, and inactivation of ERK-1/2 and AKT. Toxicol. In Vitro 2010, 24:713-720.
-
(2010)
Toxicol. In Vitro
, vol.24
, pp. 713-720
-
-
Park, I.-S.1
Jo, J.-R.2
Hong, H.3
Nam, K.-Y.4
Kim, J.-B.5
Hwang, S.-H.6
Choi, M.-S.7
Ryu, N.-H.8
Jang, H.-J.9
Lee, S.-H.10
Kim, C.-S.11
Kwon, T.-G.12
Park, G.-Y.13
Park, J.-W.14
Jang, B.-C.15
-
23
-
-
84864083713
-
Aspirin enhances TRAIL-induced apoptosis via regulation of ERK1/2 activation in human cervical cancer cells
-
Im S.-R., Jang Y.-J. Aspirin enhances TRAIL-induced apoptosis via regulation of ERK1/2 activation in human cervical cancer cells. Biochem. Biophys. Res. Commun. 2012, 424:65-70.
-
(2012)
Biochem. Biophys. Res. Commun.
, vol.424
, pp. 65-70
-
-
Im, S.-R.1
Jang, Y.-J.2
-
24
-
-
77749298186
-
Aspirin induces apoptosis in human leukemia cells independently of NF-κB and MAPKs through alteration of the Mcl-1/Noxa balance
-
Iglesias-Serret D., Piqué M., Barragán M., Cosialls A.M., Santidrián A.F., González-Gironès D.M., Coll-Mulet L., Frias M., Pons G., Gil J. Aspirin induces apoptosis in human leukemia cells independently of NF-κB and MAPKs through alteration of the Mcl-1/Noxa balance. Apoptosis 2009, 15:219-229.
-
(2009)
Apoptosis
, vol.15
, pp. 219-229
-
-
Iglesias-Serret, D.1
Piqué, M.2
Barragán, M.3
Cosialls, A.M.4
Santidrián, A.F.5
González-Gironès, D.M.6
Coll-Mulet, L.7
Frias, M.8
Pons, G.9
Gil, J.10
-
25
-
-
84855408911
-
Pim kinase inhibitors sensitize prostate cancer cells to apoptosis triggered by Bcl-2 family inhibitor ABT-737
-
Song J.H., Kraft A.S. Pim kinase inhibitors sensitize prostate cancer cells to apoptosis triggered by Bcl-2 family inhibitor ABT-737. Cancer Res. 2011, 72:294-303.
-
(2011)
Cancer Res.
, vol.72
, pp. 294-303
-
-
Song, J.H.1
Kraft, A.S.2
-
26
-
-
34247639408
-
A large cohort study of long-term daily use of adult-strength aspirin and cancer incidence
-
Jacobs E.J., Thun M.J., Bain E.B., Rodriguez C., Henley S.J., Calle E.E. A large cohort study of long-term daily use of adult-strength aspirin and cancer incidence. JNCI 2007, 99:608-615.
-
(2007)
JNCI
, vol.99
, pp. 608-615
-
-
Jacobs, E.J.1
Thun, M.J.2
Bain, E.B.3
Rodriguez, C.4
Henley, S.J.5
Calle, E.E.6
-
27
-
-
22344439728
-
Aspirin, ibuprofen, and other non-steroidal anti-inflammatory drugs in cancer prevention: a critical review of non-selective COX-2 blockade (review)
-
Harris R., Beebe-Donk J., Doss H. Aspirin, ibuprofen, and other non-steroidal anti-inflammatory drugs in cancer prevention: a critical review of non-selective COX-2 blockade (review). Oncol. Rep. 2005, 13:559.
-
(2005)
Oncol. Rep.
, vol.13
, pp. 559
-
-
Harris, R.1
Beebe-Donk, J.2
Doss, H.3
-
28
-
-
49649095644
-
Aspirin sensitizes cancer cells to TRAIL-induced apoptosis by reducing survivin levels
-
Lu M., Strohecker A., Chen F., Kwan T., Bosman J., Jordan V.C., Cryns V.L. Aspirin sensitizes cancer cells to TRAIL-induced apoptosis by reducing survivin levels. Clin. Cancer Res. 2008, 14:3168-3176.
-
(2008)
Clin. Cancer Res.
, vol.14
, pp. 3168-3176
-
-
Lu, M.1
Strohecker, A.2
Chen, F.3
Kwan, T.4
Bosman, J.5
Jordan, V.C.6
Cryns, V.L.7
-
29
-
-
36348999296
-
Aspirin enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in hormone-refractory prostate cancer cells through survivin down-regulation
-
Yoo J., Lee Y. Aspirin enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in hormone-refractory prostate cancer cells through survivin down-regulation. Mol. Pharmacol. 2007, 72:1586-1592.
-
(2007)
Mol. Pharmacol.
, vol.72
, pp. 1586-1592
-
-
Yoo, J.1
Lee, Y.2
-
30
-
-
64049106907
-
Aspirin, salicylates, and cancer
-
Elwood P.C., Gallagher A.M., Duthie G.G., Mur L.A., Morgan G. Aspirin, salicylates, and cancer. Lancet (London, England) 2009, 373:1301-1309.
-
(2009)
Lancet (London, England)
, vol.373
, pp. 1301-1309
-
-
Elwood, P.C.1
Gallagher, A.M.2
Duthie, G.G.3
Mur, L.A.4
Morgan, G.5
-
31
-
-
83155182434
-
Mcl-1 levels need not be lowered for cells to be sensitized for ABT-263/737-induced apoptosis
-
Yamaguchi R., Perkins G. Mcl-1 levels need not be lowered for cells to be sensitized for ABT-263/737-induced apoptosis. Cell Death Dis. 2011, 2:e227.
-
(2011)
Cell Death Dis.
, vol.2
-
-
Yamaguchi, R.1
Perkins, G.2
-
32
-
-
68949099384
-
RNA silencing of Mcl-1 enhances ABT-737-mediated apoptosis in melanoma: role for a caspase-8-dependent pathway
-
Keuling A., Parker A. RNA silencing of Mcl-1 enhances ABT-737-mediated apoptosis in melanoma: role for a caspase-8-dependent pathway. PLoS ONE. 2009, 4:e6651.
-
(2009)
PLoS ONE.
, vol.4
-
-
Keuling, A.1
Parker, A.2
-
33
-
-
79960146856
-
Synergistic antitumor activity of gemcitabine and ABT-737 in vitro and in vivo through disrupting the interaction of USP9X and Mcl-1
-
Zhang C., Cai T.Y., Zhu H., Yang L.Q., Jiang H., Dong X.W., Hu Y.Z., Lin N.M., He Q.J., Yang B. Synergistic antitumor activity of gemcitabine and ABT-737 in vitro and in vivo through disrupting the interaction of USP9X and Mcl-1. Mol. Cancer Ther. 2011, 10:1264-1275.
-
(2011)
Mol. Cancer Ther.
, vol.10
, pp. 1264-1275
-
-
Zhang, C.1
Cai, T.Y.2
Zhu, H.3
Yang, L.Q.4
Jiang, H.5
Dong, X.W.6
Hu, Y.Z.7
Lin, N.M.8
He, Q.J.9
Yang, B.10
|