In vivo optical activation of astrocytes as a potential therapeutic strategy for neurodegenerative diseases

Progress in Biomedical Optics and Imaging - Proceedings of SPIE

Volumn 8565, Issue , 2013, Pages

  Chen, Yuanxin ^a   Mancuso, James ^a   Zhao, Zhen ^a,b   Li, Xuping ^a   Xue, Zhong ^a   Wong, Stephen T C ^a  

^a HOUSTON METHODIST RESEARCH INSTITUTE   (United States)

^b SOUTHEAST UNIVERSITY   (China)

Author keywords

Astrocytes vasculature; Calcium uncaging; Endfoot; Femtosecond laser; Intravital 2 photon microscopy

Indexed keywords

ASTROCYTES-VASCULATURE; ENDFOOT; FLUORESCENT LABELING; NEURONAL DYSFUNCTION; OPTICAL IMAGING TECHNIQUE; QUANTITATIVE RESULT; SPATIAL AND TEMPORAL RESOLUTIONS; THERAPEUTIC STRATEGY;

BRAIN; CALCIUM; HEMODYNAMICS; IMAGING TECHNIQUES; NEURONS; PHOTONS; ULTRASHORT PULSES;

NEURODEGENERATIVE DISEASES;

EID: 84878199541     PISSN: 16057422     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1117/12.2004712     Document Type: Conference Paper

References (26)

1. Jalbert, J. J., Daiello, L. A. and Lapane, K. L., "Dementia of the Alzheimer Type," Epidemiol Rev 30(1), 15-34 (2008)
2. Mayeux, R. and Hyslop, P. S. G., "Alzheimer's disease: advances in trafficking," Lancet Neurol 7(1), 2-3 (2008)
3. de la Torre, J. C., "Alzheimer disease as a vascular disorder -Nosological evidence," Stroke 33(4), 1152-1162 (2002)
4. He, Y., Wang, L., Zang, Y., Tian, L., Zhang, X., Li, K. and Jiang, T., "Regional coherence changes in the early stages of Alzheimer's disease: a combined structural and resting-state functional MRI study," Neuroimage 35(2), 488-500 (2007)
5. Lu, T., Pan, Y., Kao, S. Y., Li, C., Kohane, I., Chan, J. and Yankner, B. A., "Gene regulation and DNA damage in the ageing human brain," Nature 429(6994), 883-891 (2004)
6. Zlokovic, B. V., Yamada, S., Holtzman, D., Ghiso, J. and Frangione, B., "Clearance of amyloid beta-peptide from brain: transport or metabolism?," Nat Med 6(7), 718 (2000)
7. Deane, R., Du Yan, S., Submamaryan, R. K., LaRue, B., Jovanovic, S., Hogg, E., Welch, D., Manness, L., Lin, C., Yu, J., Zhu, H., Ghiso, J., Frangione, B., Stern, A., Schmidt, A. M., Armstrong, D. L., Arnold, B., Liliensiek, B., Nawroth, P., Hofman, F., Kindy, M., Stern, D. and Zlokovic, B., "RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain," Nat Med 9(7), 907-913 (2003)
8. Thomas, T., Thomas, G., McLendon, C., Sutton, T. and Mullan, M., "beta-Amyloid-mediated vasoactivity and vascular endothelial damage," Nature 380(6570), 168-171 (1996)
9. Bell, R. D. and Zlokovic, B. V., "Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease," Acta Neuropathol 118(1), 103-113 (2009)
10. Iadecola, C., "Neurovascular regulation in the normal brain and in Alzheimer's disease," Nat Rev Neurosci 5(5), 347-360 (2004)
11. Zlokovic, B. V., "Neurovascular mechanisms of Alzheimer's neurodegeneration," Trends Neurosci 28(4), 202-208 (2005)
12. Deane, R., Bell, R. D., Sagare, A. and Zlokovic, B. V., "Clearance of amyloid-beta peptide across the bloodbrain barrier: implication for therapies in Alzheimer's disease," CNS Neurol Disord Drug Targets 8(1), 16-30 (2009)
13. Ransom, B., Behar, T. and Nedergaard, M., "New roles for astrocytes (stars at last)," Trends Neurosci 26(10), 520-522 (2003)
14. Zonta, M., Angulo, M. C., Gobbo, S., Rosengarten, B., Hossmann, K. A., Pozzan, T. and Carmignoto, G., "Neuron-to-astrocyte signaling is central to the dynamic control of brain microcirculation," Nat Neurosci 6(1), 43-50 (2003)
15. Takano, T., Tian, G. F., Peng, W., Lou, N., Libionka, W., Han, X. and Nedergaard, M., "Astrocyte-mediated control of cerebral blood flow," Nat Neurosci 9(2), 260-267 (2006)
16. Wang, X., Lou, N., Xu, Q., Tian, G. F., Peng, W. G., Han, X., Kang, J., Takano, T. and Nedergaard, M., "Astrocytic Ca2+ signaling evoked by sensory stimulation in vivo," Nat Neurosci 9(6), 816-823 (2006)
17. Hamby, M. E. and Sofroniew, M. V., "Reactive Astrocytes As Therapeutic Targets for CNS Disorders," Neurotherapeutics 7(4), 494-506 (2010)
18. Kraft, A. W., Hu, X., Yoon, H., Yan, P., Xiao, Q., Wang, Y., Gil, S. C., Brown, J., Wilhelmsson, U., Restivo, J. L., Cirrito, J. R., Holtzman, D. M., Kim, J., Pekny, M. and Lee, J. M., "Attenuating astrocyte activation accelerates plaque pathogenesis in APP/PS1 mice," FASEB J (2012)
19. Stosiek, C., Garaschuk, O., Holthoff, K. and Konnerth, A., "In vivo two-photon calcium imaging of neuronal networks," Proc Natl Acad Sci U S A 100(12), 7319-7324 (2003)
20. Schummers, J., Yu, H. B. and Sur, M., "Tuned responses of astrocytes and their influence on hemodynamic signals in the visual cortex," Science 320(5883), 1638-1643 (2008)
21. Zhao, Y., Zhang, Y., Liu, X., Lv, X., Zhou, W., Luo, Q. and Zeng, S., "Photostimulation of astrocytes with femtosecond laser pulses," Optics Express 17(3), 1291-1298 (2009)
22. Brown, E. B., Shear, J. B., Adams, S. R., Tsien, R. Y. and Webb, W. W., "Photolysis of caged calcium in femtoliter volumes using two-photon excitation," Biophysical Journal 76(1), 489-499 (1999)
23. Choi, M., Yoon, J., Ku, T., Choi, K. and Choi, C., "Label-free optical activation of astrocyte in vivo," J Biomed Opt 16(7), 075003 (2011)
24. Denk, W., "Two-photon scanning photochemical microscopy: mapping ligand-gated ion channel distributions," Proc Natl Acad Sci U S A 91(14), 6629-6633 (1994)
25. Watanabe, W., Matsunaga, S., Higashi, T., Fukui, K. and Itoh, K., "In vivo manipulation of fluorescently labeled organelles in living cells by multiphoton excitation," J Biomed Opt 13(3), 031213 (2008)
26. Tirlapur, U. K. and Konig, K., "Targeted transfection by femtosecond laser," Nature 418(6895), 290-291 (2002)