Alterations of penicillin-binding proteins in pneumococci with stepwise increase in β-lactam resistance

Pathogens and Disease

Volumn 67, Issue 1, 2013, Pages 84-88

  Hsieh, Yu Chia ^a,b   Su, Lin Hui ^a,b   Hsu, Mei Hua ^b   Chiu, Cheng Hsun ^a,b  

^a CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^b CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

Author keywords

lactam resistance; Penicillin binding protein; Streptococcus pneumoniae

Indexed keywords

BETA LACTAM ANTIBIOTIC; CEFTRIAXONE; PENICILLIN BINDING PROTEIN; PENICILLIN BINDING PROTEIN 1A; PENICILLIN BINDING PROTEIN 2B; PENICILLIN BINDING PROTEIN 2X; PENICILLIN DERIVATIVE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL MUTATION; BACTERIUM ISOLATE; CONTROLLED STUDY; HUMAN; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PENICILLIN RESISTANCE; PRIORITY JOURNAL; STREPTOCOCCUS PNEUMONIAE;

AMINO ACID SUBSTITUTION; ANTI-BACTERIAL AGENTS; BETA-LACTAM RESISTANCE; BETA-LACTAMS; CEFTRIAXONE; DNA MUTATIONAL ANALYSIS; DNA, BACTERIAL; HUMANS; PENICILLIN-BINDING PROTEINS; PENICILLINS; STREPTOCOCCUS PNEUMONIAE;

EID: 84878151040     PISSN: None     EISSN: 2049632X     Source Type: Journal    
DOI: 10.1111/2049-632x.12018     Document Type: Article

References (23)

1. Albarracin Orio AG, Pinas GE, Cortes PR, Cian MB & Echenique J (2011) Compensatory evolution of pbp mutations restores the fitness cost imposed by beta-lactam resistance in Streptococcus pneumoniae. PLoS Pathog 7: e1002000.
2. Asahi Y, Takeuchi Y & Ubukata K (1999) Diversity of substitutions within or adjacent to conserved amino acid motifs of penicillin-binding protein 2X in cephalosporin-resistant Streptococcus pneumoniae isolates. Antimicrob Agents Chemother 43: 1252-1255.
3. Beall BW, Gertz RE, Hulkower RL, Whitney CG, Moore MR & Brueggemann AB (2011) Shifting genetic structure of invasive serotype 19A pneumococci in the United States. J Infect Dis 203: 1360-1368.
4. Cafini F, del Campo R, Alou L, Sevillano D, Morosini MI, Baquero F, Prieto J & Spanish Pneumococcal Network (G03/103) (2006) Alterations of the penicillin-binding proteins and murM alleles of clinical Streptococcus pneumoniae isolates with high-level resistance to amoxicillin in Spain. J Antimicrob Chemother 57: 224-229.
5. Clinical and Laboratory Standards Institute (2006) Performance Standards for Antimicrobial Susceptibility Testing, 16th Informational Supplement. Document M100-S16. CLSI, Wayne, PA.
6. Dowson CG, Hutchison A, Brannigan JA, George RC, Hansman D, Linares J, Tomasz A, Smith JM & Spratt BG (1989) Horizontal transfer of penicillin-binding protein genes in penicillin-resistant clinical isolates of Streptococcus pneumoniae. Proc Natl Acad Sci USA 86: 8842-8846.
7. Granger D, Boily-Larouche G, Turgeon P, Weiss K & Roger M (2005) Genetic analysis of pbp2x in clinical Streptococcus pneumoniae isolates in Quebec, Canada. J Antimicrob Chemother 55: 832-839.
8. Granger D, Boily-Larouche G, Turgeon P, Weiss K & Roger M (2006) Molecular characteristics of pbp1a and pbp2b in clinical Streptococcus pneumoniae isolates in Quebec, Canada. J Antimicrob Chemother 57: 61-70.
9. Grebe T & Hakenbeck R (1996) Penicillin-binding proteins 2b and 2x of Streptococcus pneumoniae are primary resistance determinants for different classes of β-lactam antibiotics. Antimicrob Agents Chemother 40: 829-834.
10. Hakenbeck R, Tarpay M & Tomasz A (1980) Multiple changes of penicillin-binding proteins in penicillin-resistant clinical isolates of Streptococcus pneumoniae. Antimicrob Agents Chemother 17: 364-371.
11. Laible G, Spratt BG & Hakenbeck R (1991) Interspecies recombinational events during the evolution of altered PBP 2x genes in penicillin-resistant clinical isolates of Streptococcus pneumoniae. Mol Microbiol 5: 1993-2002.
12. Lefevre JC, Faucon G, Sicard AM & Gasc AM (1993) DNA fingerprinting of Streptococcus pneumoniae strains by pulsed-field gel electrophoresis. J Clin Microbiol 31: 2724-2728.
13. Munoz R, Dowson CG, Daniels M, Coffey TJ, Martin C, Hakenbeck R & Spratt BG (1992) Genetics of resistance to third-generation cephalosporins in clinical isolates of Streptococcus pneumoniae. Mol Microbiol 6: 2461-2465.
14. Munoz-Almagro C, Jordan I, Gene A, Latorre C, Garcia-Garcia JJ & Pallares R (2008) Emergence of invasive pneumococcal disease caused by nonvaccine serotypes in the era of 7-valent conjugate vaccine. Clin Infect Dis 46: 174-182.
15. Nichol KA, Zhanel GG & Hoban DJ (2002) Penicillin-ginding protein 1A, 2B, and 2X alterations in Canadian isolates of penicillin-resistant Streptococcus pneumoniae. Antimicrob Agents Chemother 46: 3261-3264.
16. Reichmann P, Konig A, Marton A & Hakenbeck R (1996) Penicillin-binding proteins as resistance determinants in clinical isolates of Streptococcus pneumoniae. Microb Drug Resist 2: 177-181.
17. Ruoff KL (1995) Streptococcus. Manual of Clinical Microbiology, 6th edn (Murray PR, Baron EJ, Pfaller MA, Tenover FC & Yolken RH, eds), pp. 299-307. ASM Press, Washington, DC.
18. Sibold C, Henrichsen J, Konig A, Martin C, Chalkley L & Hakenbeck R (1994) Mosaic pbpX genes of major clones of penicillin-resistant Streptococcus pneumoniae have evolved from pbpX genes of a penicillin-sensitive Streptococcus oralis. Mol Microbiol 12: 1013-1023.
19. Smith AM & Klugman KP (1998) Alterations in PBP 1A essential-for high-level penicillin resistance in Streptococcus pneumoniae. Antimicrob Agents Chemother 42: 1329-1333.
20. Sorensen UB (1993) Typing of pneumococci by using 12 pooled antisera. J Clin Microbiol 31: 2097-2100.
21. Stephens DS, Zughaier SM, Whitney CG, Baughman WS, Barker L, Gay K, Jackson D, Orenstein WA, Arnold K, Schuchat A, Farley MM, & Georgia Emerging Infections Program (2005) Incidence of macrolide resistance in Streptococcus pneumoniae after introduction of the pneumococcal conjugate vaccine: population-based assessment. Lancet 365: 855-863.
22. Tleyjeh IM, Tlaygeh HM, Hejal R, Montori VM & Baddour LM (2006) The impact of penicillin resistance on short-term mortality in hospitalized adults with pneumococcal pneumonia: a systematic review and meta-analysis. Clin Infect Dis 42: 788-797.
23. Zapun A, Contreras-Martel C & Vernet T (2008) Penicillin-binding proteins and beta-lactam resistance. FEMS Microbiol Rev 32: 361-385.