System for portable nucleic acid testing in low resource settings

Proceedings of SPIE - The International Society for Optical Engineering

Volumn 8615, Issue , 2013, Pages

  Lu, Hsiang Wei ^a   Roskos, Kristina ^a   Hickerson, Anna I ^a   Carey, Thomas ^b   Niemz, Angelika ^a  

^a KECK GRADUATE INSTITUTE   (United States)

^b HARVEY MUDD COLLEGE   (United States)

Author keywords

infectious disease diagnosis; isothermal loop mediated amplification; Mycobacterium tuberculosis; Nucleic acid testing; point of care; sample to answer diagnosis

Indexed keywords

BIOMOLECULES; DISEASES; DNA; ISOTHERMS; PROJECTILES; PUMPS;

DISEASE DIAGNOSIS; INFECTIOUS DISEASE; INFECTIOUS DISEASE DIAGNOSE; ISOTHERMAL LOOP-MEDIATED AMPLIFICATION; LOW-RESOURCE SETTINGS; MYCOBACTERIUM TUBERCULOSIS; NUCLEIC ACID TESTING; POINT OF CARE; SAMPLE PREPARATION; SAMPLE-TO-ANSWER DIAGNOSE;

DIAGNOSIS;

EID: 84878130189     PISSN: 0277786X     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1117/12.2005164     Document Type: Conference Paper

References (24)

1. Yager, P., G. J. Domingo, and J. Gerdes, "Point-of-care diagnostics for global health," Annual Review of Biomedical Engineering 10, 107-144 (2008).
2. Urdea, M., L. A. Penny, S. S. Olmsted, M. Y. Giovanni, P. Kaspar, A. Shepherd, P. Wilson, C. A. Dahl, S. Buchsbaum, G. Moeller, and D. C. Hay Burgess, "Requirements for high impact diagnostics in the developing world," Nature 444 Suppl 1, 73-79 (2006).
3. Niemz, A., T. M. Ferguson, and D. S. Boyle, "Point-of-care nucleic acid testing for infectious diseases," Trends Biotechnol. 29(5), 240-250 (2011).
4. Ince, J. and A. McNally, "Development of rapid, automated diagnostics for infectious disease: advances and challenges," Expert Review of Medical Devices 6(6), 641-651 (2009).
5. Holland, C. A. and F. L. Kiechle, "Point-of-care molecular diagnostic systems - past, present and future," Curr. Opin. Microbiol. 8(5), 504-509 (2005).
6. Niemz, A. and D. Boyle, "Nucleic acid testing for tuberculosis at the point-of-care in high-burden countries," Expert Review of Molecular Diagnostics 12(7), 687-701 (2012).
7. Balasingham, S. V., T. Davidsen, I. Szpinda, S. A. Frye, and T. Tonjuin, "Molecular Diagnostics in Tuberculosis Basis and Implications for Therapy," Molecular Diagnosis & Therapy 13(3), 137-151 (2009).
8. McNerney, R. and P. Daley, "Towards a point-of-care test for active tuberculosis: obstacles and opportunities," Nature Reviews Microbiology 9(3), 204-213 (2011).
9. Boehme, C. C., P. Nabeta, D. Hillemann, M. P. Nicol, S. Shenai, F. Krapp, J. Allen, R. Tahirli, R. Blakemore, R. Rustomjee, A. Milovic, M. Jones, S. M. O'Brien, D. H. Persing, S. Ruesch-Gerdes, E. Gotuzzo, C. Rodrigues, D. Alland, and M. D. Perkins, "Rapid molecular detection of tuberculosis and rifampin resistance," N. Engl. J. Med. 363(11), 1005-1015 (2010).
10. Lawn, S. D. and M. P. Nicol, "Xpert (R) MTB/RIF assay: development, evaluation and implementation of a new rapid molecular diagnostic for tuberculosis and rifampicin resistance," Future Microbiology 6(9), 1067-1082 (2011).
11. Chen, D. F., M. Mauk, X. B. Qiu, C. C. Liu, J. T. Kim, S. Ramprasad, S. Ongagna, W. R. Abrams, D. Malamud, P. L. A. M. Corstjens, and H. H. Bau, "An integrated, self-contained microfluidic cassette for isolation, amplification, and detection of nucleic acids," Biomedical Microdevices 12(4), 705-719 (2010).
12. Easley, C. J., J. M. Karlinsey, J. M. Bienvenue, L. A. Legendre, M. G. Roper, S. H. Feldman, M. A. Hughes, E. L. Hewlett, T. J. Merkel, J. P. Ferrance, and J. P. Landers, "A fully integrated microfluidic genetic analysis system with sample-in-answer-out capability," Proc. Natl. Acad. Sci. U. S. A. 103(51), 19272-19277 (2006).
13. Pal, R., M. Yang, R. Lin, B. N. Johnson, N. Srivastava, S. Z. Razzacki, K. J. Chomistek, D. C. Heldsinger, R. M. Haque, V. M. Ugaz, P. K. Thwar, Z. Chen, K. Alfano, M. B. Yim, M. Krishnan, A. O. Fuller, R. G. Larson, D. T. Burke, and M. A. Burns, "An integrated microfluidic device for influenza and other genetic analyses," Lab on A Chip 5(10), 1024-1032 (2005).
14. Wang, J., Z. Y. Chen, P. L. A. M. Corstjens, M. G. Mauk, and H. H. Bau, "A disposable microfluidic cassette for DNA amplification and detection," Lab on A Chip 6(1), 46-53 (2006).
15. Liu, R. H., J. N. Yang, R. Lenigk, J. Bonanno, and P. Grodzinski, "Self-contained, fully integrated biochip for sample preparation, polymerase chain reaction amplification, and DNA microarray detection," Anal. Chem. 76(7), 1824-1831 (2004).
16. Asiello, P. J. and A. J. Baeumner, "Miniaturized isothermal nucleic acid amplification, a review," Lab on A Chip 11(8), 1420-1430 (2011).
17. Mitarai, S., M. Okumura, E. Toyota, T. Yoshiyama, A. Aono, A. Sejimo, Y. Azuma, K. Sugahara, T. Nagasawa, N. Nagayamaet al., "Evaluation of a simple loop-mediated isothermal amplification test kit for the diagnosis of tuberculosis," Int. J Tuberc. Lung Dis. 15(9), 1211-1217 (2011).
18. Fang, R. D., X. Li, L. Hu, Q. M. You, J. Li, J. Wu, P. Xu, H. Y. Zhong, Y. Luo, J. Mei, and Q. Gao, "Cross-Priming Amplification for Rapid Detection of Mycobacterium tuberculosis in Sputum Specimens," J. Clin. Microbiol. 47(3), 845-847 (2009).
19. Iwamoto, T., T. Sonobe, and K. Hayashi, "Loop-mediated isothermal amplification for direct detection of Mycobacterium tuberculosis complex, M-avium, and M-intracellulare in sputum samples," J. Clin. Microbiol. 41(6), 2616-2622 (2003).
20. Böhm, S., W. Olthuis, and P. Bergveld, "An Integrated Micromachined Electrochemical Pump and Dosing System," Biomedical Microdevices 1(2), 121-130 (1999).
21. Liu, R. H., M. J. Lodes, T. Nguyen, T. Siuda, M. Slota, H. S. Fuji, and A. McShea, "Validation of a fully integrated microfluidic array device for influenza A subtype identification and sequencing," Anal. Chem. 78(12), 4184-4193 (2006).
22. Liu, R. H., T. Nguyen, K. Schwarzkopf, H. S. Fuji, A. Petrova, T. Siuda, K. Peyvan, M. Bizak, D. Danley, and A. McShea, "Fully integrated miniature device for automated gene expression DNA microarray processing," Anal. Chem. 78(6), 1980-1986 (2006).
23. Vandeventer, P. E., K. M. Weigel, J. Salazar, B. Erwin, B. Irvine, R. Doebler, A. Nadim, G. A. Cangelosi, and A. Niemz, "Mechanical Disruption of Lysis-Resistant Bacterial Cells by Use of a Miniature, Low-Power, Disposable Device," J. Clin. Microbiol. 49(7), 2533-2539 (2011).
24. Vandeventer, P. E., J. S. Lin, T. J. Zwang, A. Nadim, M. S. Johal, and A. Niemz, "Multiphasic DNA Adsorption to Silica Surfaces under Varying Buffer, pH, and Ionic Strength Conditions," Journal of Physical Chemistry B 116(19), 5661-5670 (2012).