Acute ataxia in children: Approach to clinical presentation and role of additional investigations

Neuropediatrics

Volumn 44, Issue 3, 2013, Pages 127-141

  Poretti, Andrea ^a,b   Benson, Janee ^a   Huisman, Thierrya G M ^a   Boltshauser, Eugen ^b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b University Children's Hospital   (Switzerland)

Author keywords

acute ataxia; acute cerebellitis; cerebellar ataxia; children; differential diagnosis; neuroimaging

Indexed keywords

CYCLOPHOSPHAMIDE; DEXAMETHASONE; IMMUNOGLOBULIN; METHYLPREDNISOLONE; PREDNISOLONE;

ACUTE CEREBELLAR ATAXIA; ACUTE CEREBELLITIS; ACUTE DISSEMINATED ENCEPHALOMYELITIS; ACUTE EPILEPTIC PSEUDOATAXIA; ACUTE POSTINFECTIOUS CEREBELLAR ATAXIA; ACUTE SENSORY ATAXIA; ACUTE TOXIC CEREBELLAR ATAXIA; ACUTE UNILATERAL VESTIBULAR DYSFUNCTION; ARTICLE; ATAXIA; BENIGN PAROXYSMAL VERTIGO OF CHILDHOOD; BRAIN DISEASE; CEREBELLAR ATAXIA; CEREBROVASCULAR ACCIDENT; CLINICAL EXAMINATION; ELECTROENCEPHALOGRAPHY; HUMAN; MEDICAL HISTORY; MIGRAINE RELATED ACUTE VESTIBULAR ATAXIA; MORBIDITY; MORTALITY; MULTIPLE SCLEROSIS; NERVE CONDUCTION; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; OPSOCLONUS MYOCLONUS SYNDROME; PARANEOPLASTIC ACUTE CEREBELLAR ATAXIA; PRIORITY JOURNAL; PROGNOSIS; PSYCHOGENIC ACUTE ATAXIA; TRAUMATIC ACUTE CEREBELLAR ATAXIA; VASCULAR ACUTE CEREBELLAR ATAXIA;

ATAXIA; BRAIN; HUMANS;

EID: 84878115927     PISSN: 0174304X     EISSN: 14391899     Source Type: Journal    
DOI: 10.1055/s-0032-1329909     Document Type: Article

References (139)

1. Ryan M. M., Engle E. C. Acute ataxia in childhood. J Child Neurol: 2003; 18 5 309 316
2. Baxter P. S. Acute ataxia: epidemiology and differential diagnosis. In: Boltshauser E., Schmahmann J. D., eds. Cerebellar Disorders in Children. Oxford Mac Keith Press: 2012; 361 363
3. Poretti A., Boltshauser E. Checklist about acute ataxia (Table 2). In: Boltshauser E., Schmahmann J. D., eds. Cerebellar Disorders in Children. London Mac Keith Press: 2012; 401
4. Desai J., Mitchell W. G. Acute cerebellar ataxia, acute cerebellitis, and opsoclonus-myoclonus syndrome. J Child Neurol: 2012; 27 11 1482 1488
5. Jahn K., Langhagen T., Schroeder A. S., Heinen F. Vertigo and dizziness in childhood-update on diagnosis and treatment. Neuropediatrics: 2011; 42 4 129 134
6. Curthoys I. S. The interpretation of clinical tests of peripheral vestibular function. Laryngoscope: 2012; 122 6 1342 1352
7. Gieron-Korthals M. A., Westberry K. R., Emmanuel P. J. Acute childhood ataxia: 10-year experience. J Child Neurol: 1994; 9 4 381 384
8. Connolly A. M., Dodson W. E., Prensky A. L., Rust R. S. Course and outcome of acute cerebellar ataxia. Ann Neurol: 1994; 35 6 673 679
9. Nussinovitch M., Prais D., Volovitz B., Shapiro R., Amir J. Post-infectious acute cerebellar ataxia in children. Clin Pediatr (Phila): 2003; 42 7 581 584
10. Amlie-Lefond C., Jubelt B. Neurologic manifestations of varicella zoster virus infections. Curr Neurol Neurosci Rep: 2009; 9 6 430 434
11. Sawaishi Y., Takada G. Acute cerebellitis. Cerebellum: 2002; 1 3 223 228
12. Van Lierde A., Righini A., Tremolati E. Acute cerebellitis with tonsillar herniation and hydrocephalus in Epstein-Barr virus infection. Eur J Pediatr: 2004; 163 11 689 691
13. Takanashi J., Miyamoto T., Ando N., et al. Clinical and radiological features of rotavirus cerebellitis. AJNR Am J Neuroradiol: 2010; 31 9 1591 1595
14. Kato Z., Sasai H., Funato M., Asano T., Kondo N. Acute cerebellitis associated with rotavirus infection. World J Pediatr: 2013; 9 1 87 89
15. Komatsu H., Kuroki S., Shimizu Y., Takada H., Takeuchi Y. Mycoplasma pneumoniae meningoencephalitis and cerebellitis with antiganglioside antibodies. Pediatr Neurol: 1998; 18 2 160 164
16. Gayatri N., Tyagi A., Mahadevan U. Acute hydrocephalus in a child with Mycoplasma cerebellitis. Brain Dev: 2009; 31 8 618 621
17. Matsukuma E., Kato Z., Orii K., et al. Acute mumps cerebellitis with abnormal findings in MRI diffusion-weighted images. Eur J Pediatr: 2008; 167 7 829 830
18. Kato Z., Kozawa R., Teramoto T., Hashimoto K., Shinoda S., Kondo N. Acute cerebellitis in primary human herpesvirus-6 infection. Eur J Pediatr: 2003; 162 11 801 803
19. Montenegro M. A., Santos S. L., Li L. M., Cendes F. Neuroimaging of acute cerebellitis. J Neuroimaging: 2002; 12 1 72 74
20. Soussan V., Husson B., Tardieu M. Description and prognostic value of cerebellar MRI lesions in children with severe acute ataxia. Arch Pediatr: 2003; 10 7 604 607
21. De Bruecker Y., Claus F., Demaerel P., et al. MRI findings in acute cerebellitis. Eur Radiol: 2004; 14 8 1478 1483
22. Kubota T., Suzuki T., Kitase Y., et al. Chronological diffusion-weighted imaging changes and mutism in the course of rotavirus-associated acute cerebellitis/cerebellopathy concurrent with encephalitis/encephalopathy. Brain Dev: 2011; 33 1 21 27
23. de Ribaupierre S., Meagher-Villemure K., Villemure J. G., et al. The role of posterior fossa decompression in acute cerebellitis. Childs Nerv Syst: 2005; 21 11 970 974
24. Hennes E., Zotter S., Dorninger L., et al. Long-term outcome of children with acute cerebellitis. Neuropediatrics: 2012; 43 5 240 248
25. Roulet Perez E., Maeder P., Cotting J., Eskenazy-Cottier A. C., Deonna T. Acute fatal parainfectious cerebellar swelling in two children. A rare or an overlooked situation? Neuropediatrics: 1993; 24 6 346 351
26. Göhlich-Ratmann G., Wallot M., Baethmann M., et al. Acute cerebellitis with near-fatal cerebellar swelling and benign outcome under conservative treatment with high dose steroids. Eur J Paediatr Neurol: 1998; 2 3 157 162
27. Burri S. M., Krauss J. K., Schroth G., Weis J., Steinlin M. Near-fatal cerebellar swelling caused by acute multifocal cerebellar necrosis. Eur J Paediatr Neurol: 2003; 7 3 139 142
28. Kamate M., Chetal V., Hattiholi V. Fulminant cerebellitis: a fatal, clinically isolated syndrome. Pediatr Neurol: 2009; 41 3 220 222
29. Hacohen Y., Niotakis G., Aujla A., et al. Acute life threatening cerebellitis presenting with no apparent cerebellar signs. Clin Neurol Neurosurg: 2011; 113 10 928 930
30. Krupp L. B., Banwell B., Tenembaum S. International Pediatric MS Study Group Consensus definitions proposed for pediatric multiple sclerosis and related disorders. Neurology: 2007; 68 16 02 S7 S12
31. Tenembaum S., Chitnis T., Ness J., Hahn J. S. International Pediatric MS Study Group Acute disseminated encephalomyelitis. Neurology: 2007; 68 16 02 S23 S36
32. Parrish J. B., Yeh E. A. Acuted disseminated encephalomyelitis. Adv Exp Med Biol: 2012; 724 1 14
33. Hynson J. L., Kornberg A. J., Coleman L. T., Shield L., Harvey A. S., Kean M. J. Clinical and neuroradiologic features of acute disseminated encephalomyelitis in children. Neurology: 2001; 56 10 1308 1312
34. Tenembaum S., Chamoles N., Fejerman N. Acute disseminated encephalomyelitis: a long-term follow-up study of 84 pediatric patients. Neurology: 2002; 59 8 1224 1231
35. Mikaeloff Y., Suissa S., Vallée L., et al. KIDMUS Study Group First episode of acute CNS inflammatory demyelination in childhood: prognostic factors for multiple sclerosis and disability. J Pediatr: 2004; 144 2 246 252
36. Pavone P., Pettoello-Mantovano M., Le Pira A., et al. Acute disseminated encephalomyelitis: a long-term prospective study and meta-analysis. Neuropediatrics: 2010; 41 6 246 255
37. Rossi A. Imaging of acute disseminated encephalomyelitis. Neuroimaging Clin North Am: 2008; 18 1 149 161, ix
38. Callen D. J., Shroff M. M., Branson H. M., et al. Role of MRI in the differentiation of ADEM from MS in children. Neurology: 2009; 72 11 968 973
39. Hahn C. D., Miles B. S., MacGregor D. L., Blaser S. I., Banwell B. L., Hetherington C. R. Neurocognitive outcome after acute disseminated encephalomyelitis. Pediatr Neurol: 2003; 29 2 117 123
40. Mikaeloff Y., Caridade G., Husson B., Suissa S., Tardieu M. Neuropediatric KIDSEP Study Group of the French Neuropediatric Society Acute disseminated encephalomyelitis cohort study: prognostic factors for relapse. Eur J Paediatr Neurol: 2007; 11 2 90 95
41. Huppke P., Gärtner J. A practical guide to pediatric multiple sclerosis. Neuropediatrics: 2010; 41 4 157 162
42. Banwell B., Ghezzi A., Bar-Or A., Mikaeloff Y., Tardieu M. Multiple sclerosis in children: clinical diagnosis, therapeutic strategies, and future directions. Lancet Neurol: 2007; 6 10 887 902
43. Sadaka Y., Verhey L. H., Shroff M. M., et al. on behalf of the Canadian Pediatric Demyelinating Disease Network 2010 McDonald criteria for diagnosing pediatric multiple sclerosis. Ann Neurol: 2012; 72 2 211 223
44. Banwell B., Shroff M., Ness J. M., Jeffery D., Schwid S., Weinstock-Guttman B. International Pediatric MS Study Group MRI features of pediatric multiple sclerosis. Neurology: 2007; 68 16 02 S46 S53
45. Martínez-González M. J., Martínez-González S., García-Ribes A., Mintegi-Raso S., Benito-Fernández J., Prats-Viñas J. M. Acute onset ataxia in infancy: its aetiology, treatment and follow-up. Rev Neurol: 2006; 42 6 321 324
46. Bridge T. A., Norton R. L., Robertson W. O. Pediatric carbamazepine overdoses. Pediatr Emerg Care: 1994; 10 5 260 263
47. Lifshitz M., Gavrilov V., Sofer S. Signs and symptoms of carbamazepine overdose in young children. Pediatr Emerg Care: 2000; 16 1 26 27
48. Shroff R., Houston B. Unusual cerebellar ataxia: "worm wobbleo" revisited. Arch Dis Child: 2002; 87 4 333 334
49. Kaleyias J., Faerber E., Kothare S. V. Tacrolimus induced subacute cerebellar ataxia. Eur J Paediatr Neurol: 2006; 10 2 86 89
50. Lin G., Lawrence R. Pediatric case report of topiramate toxicity. Clin Toxicol (Phila): 2006; 44 1 67 69
51. Daana M., Nevo Y., Tenenbaum A., Taustein I., Berger I. Lamotrigine overdose in a child. J Child Neurol: 2007; 22 5 642 644
52. O'Brien M. M., Lacayo N. J., Lum B. L., et al. Phase I study of valspodar (PSC-833) with mitoxantrone and etoposide in refractory and relapsed pediatric acute leukemia: a report from the Children's Oncology Group. Pediatr Blood Cancer: 2010; 54 5 694 702
53. Bonkowsky J. L., Sarco D., Pomeroy S. L. Ataxia and shaking in a 2-year-old girl: acute marijuana intoxication presenting as seizure. Pediatr Emerg Care: 2005; 21 8 527 528
54. Mills F., MacLennan S. C., Devile C. J., Saunders D. E. Severe cerebellitis following methadone poisoning. Pediatr Radiol: 2008; 38 2 227 229
55. Kohli U., Kuttiat V. S., Lodha R., Kabra S. K. Profile of childhood poisoning at a tertiary care centre in North India. Indian J Pediatr: 2008; 75 8 791 794
56. Topcu M., Gucuyener K., Topaloglu H., Renda Y., Akyuz C., Kale G. Paraneoplastic syndrome manifesting as chronic cerebellar ataxia in a child with Hodgkin disease. J Pediatr: 1992; 120 2 Pt 1 275 277
57. Hahn A., Claviez A., Brinkmann G., Altermatt H. J., Schneppenheim R., Stephani U. Paraneoplastic cerebellar degeneration in pediatric Hodgkin disease. Neuropediatrics: 2000; 31 1 42 44
58. Gorman M. P. Update on diagnosis, treatment, and prognosis in opsoclonus-myoclonus-ataxia syndrome. Curr Opin Pediatr: 2010; 22 6 745 750
59. Pang K. K., de Sousa C., Lang B., Pike M. G. A prospective study of the presentation and management of dancing eye syndrome/opsoclonus-myoclonus syndrome in the United Kingdom. Eur J Paediatr Neurol: 2010; 14 2 156 161
60. McCarthy V. P., Zimmerman A. W., Miller C. A. Central nervous system manifestations of parainfluenza virus type 3 infections in childhood. Pediatr Neurol: 1990; 6 3 197 201
61. Pranzatelli M. R. The neurobiology of the opsoclonus-myoclonus syndrome. Clin Neuropharmacol: 1992; 15 3 186 228
62. Ichiba N., Miyake Y., Sato K., Oda M., Kimoto H. Mumps-induced opsoclonus-myoclonus and ataxia. Pediatr Neurol: 1988; 4 4 224 227
63. Crawford J. R., Kadom N., Santi M. R., Mariani B., Lavenstein B. L. Human herpesvirus 6 rhombencephalitis in immunocompetent children. J Child Neurol: 2007; 22 11 1260 1268
64. Huber B. M., Strozzi S., Steinlin M., Aebi C., Fluri S. Mycoplasma pneumoniae associated opsoclonus-myoclonus syndrome in three cases. Eur J Pediatr: 2010; 169 4 441 445
65. Krug P., Schleiermacher G., Michon J., et al. Opsoclonus-myoclonus in children associated or not with neuroblastoma. Eur J Paediatr Neurol: 2010; 14 5 400 409
66. Raffaghello L., Conte M., De Grandis E., Pistoia V. Immunological mechanisms in opsoclonus-myoclonus associated neuroblastoma. Eur J Paediatr Neurol: 2009; 13 3 219 223
67. Matthay K. K., Blaes F., Hero B., et al. Opsoclonus myoclonus syndrome in neuroblastoma a report from a workshop on the dancing eyes syndrome at the advances in neuroblastoma meeting in Genoa, Italy, 2004. Cancer Lett: 2005; 228 1-2 275 282
68. Haden S. V., McShane M. A., Holt C. M. Opsoclonus myoclonus: a non-epileptic movement disorder that may present as status epilepticus. Arch Dis Child: 2009; 94 11 897 899
69. Klein A., Schmitt B., Boltshauser E. Long-term outcome of ten children with opsoclonus-myoclonus syndrome. Eur J Pediatr: 2007; 166 4 359 363
70. De Grandis E., Parodi S., Conte M., et al. Long-term follow-up of neuroblastoma-associated opsoclonus-myoclonus-ataxia syndrome. Neuropediatrics: 2009; 40 3 103 111
71. Brunklaus A., Pohl K., Zuberi S. M., de Sousa C. Outcome and prognostic features in opsoclonus-myoclonus syndrome from infancy to adult life. Pediatrics: 2011; 128 2 e388 e394
72. Tate E. D., Allison T. J., Pranzatelli M. R., Verhulst S. J. Neuroepidemiologic trends in 105 US cases of pediatric opsoclonus-myoclonus syndrome. J Pediatr Oncol Nurs: 2005; 22 1 8 19
73. Rostásy K., Wilken B., Baumann M., et al. High dose pulsatile dexamethasone therapy in children with opsoclonus-myoclonus syndrome. Neuropediatrics: 2006; 37 5 291 295
74. Ertle F., Behnisch W., Al Mulla N. A., et al. Treatment of neuroblastoma-related opsoclonus-myoclonus-ataxia syndrome with high-dose dexamethasone pulses. Pediatr Blood Cancer: 2008; 50 3 683 687
75. Wilken B., Baumann M., Bien C. G., Hero B., Rostasy K., Hanefeld F. Chronic relapsing opsoclonus-myoclonus syndrome: combination of cyclophosphamide and dexamethasone pulses. Eur J Paediatr Neurol: 2008; 12 1 51 55
76. Pranzatelli M. R., Tate E. D., Travelstead A. L., et al. Rituximab (anti-CD20) adjunctive therapy for opsoclonus-myoclonus syndrome. J Pediatr Hematol Oncol: 2006; 28 9 585 593
77. Bell J., Moran C., Blatt J. Response to rituximab in a child with neuroblastoma and opsoclonus-myoclonus. Pediatr Blood Cancer: 2008; 50 2 370 371
78. Corapcioglu F., Mutlu H., Kara B., et al. Response to rituximab and prednisolone for opsoclonus-myoclonus-ataxia syndrome in a child with ganglioneuroblastoma. Pediatr Hematol Oncol: 2008; 25 8 756 761
79. Leen W. G., Weemaes C. M., Verbeek M. M., Willemsen M. A., Rotteveel J. J. Rituximab and intravenous immunoglobulins for relapsing postinfectious opsoclonus-myoclonus syndrome. Pediatr Neurol: 2008; 39 3 213 217
80. Battaglia T., De Grandis E., Mirabelli-Badenier M., et al. Response to rituximab in 3 children with opsoclonus-myoclonus syndrome resistant to conventional treatments. Eur J Paediatr Neurol: 2012; 16 2 192 195
81. Gohil J. R., Munshi S. S. Post concussion ataxia following minor head injury. Indian Pediatr: 2006; 43 9 829
82. Yeoh H. K., Lind C. R., Law A. J. Acute transient cerebellar dysfunction and stuttering following mild closed head injury. Childs Nerv Syst: 2006; 22 3 310 313
83. Lückhoff C., Starr M. Minor head injuries in children-an approach to management. Aust Fam Physician: 2010; 39 5 284 287
84. Adaletli I., Sirikci A., Ulus S., Yilmaz M. H., Kervancioglu S., Kurugoglu S. Traumatic bilateral vertebral artery dissection at the dural entry point site in a 10-year-old boy. Pediatr Surg Int: 2006; 22 5 468 470
85. Mortazavi M. M., Verma K., Tubbs R. S., Harrigan M. Pediatric traumatic carotid, vertebral and cerebral artery dissections: a review. Childs Nerv Syst: 2011; 27 12 2045 2056
86. Kristoffersen S., Vetti N., Morild I. Traumatic dissection of the vertebral artery in a toddler following a short fall. Forensic Sci Int: 2012; 221 1-3 e34 e38 [Epub ahead of print]
87. Fullerton H. J., Johnston S. C., Smith W. S. Arterial dissection and stroke in children. Neurology: 2001; 57 7 1155 1160
88. Hasan I., Wapnick S., Tenner M. S., Couldwell W. T. Vertebral artery dissection in children: a comprehensive review. Pediatr Neurosurg: 2002; 37 4 168 177
89. van der Knaap M. S., Pronk J. C., Scheper G. C. Vanishing white matter disease. Lancet Neurol: 2006; 5 5 413 423
90. Jen J. C., Graves T. D., Hess E. J., Hanna M. G., Griggs R. C., Baloh R. W. CINCH investigators Primary episodic ataxias: diagnosis, pathogenesis and treatment. Brain: 2007; 130 Pt 10 2484 2493
91. Ganesan V., Chong W. K., Cox T. C., Chawda S. J., Prengler M., Kirkham F. J. Posterior circulation stroke in childhood: risk factors and recurrence. Neurology: 2002; 59 10 1552 1556
92. Mackay M. T., Prabhu S. P., Coleman L. Childhood posterior circulation arterial ischemic stroke. Stroke: 2010; 41 10 2201 2209
93. Edlow J. A., Newman-Toker D. E., Savitz S. I. Diagnosis and initial management of cerebellar infarction. Lancet Neurol: 2008; 7 10 951 964
94. Poretti A., Boltshauser E. Checklist about intermittent ataxia (Table 3). In: Boltshauser E., Schmahmann J. D., eds. Cerebellar Disorders in Children. London Mac Keith Press: 2012; 402
95. Simon E., Flaschker N., Schadewaldt P., Langenbeck U., Wendel U. Variant maple syrup urine disease (MSUD)-the entire spectrum. J Inherit Metab Dis: 2006; 29 6 716 724
96. Jan W., Zimmerman R. A., Wang Z. J., Berry G. T., Kaplan P. B., Kaye E. M. MR diffusion imaging and MR spectroscopy of maple syrup urine disease during acute metabolic decompensation. Neuroradiology: 2003; 45 6 393 399
97. Di Rocco M., Biancheri R., Rossi A., Allegri A. E., Vecchi V., Tortori-Donati P. MRI in acute intermittent maple syrup urine disease. Neurology: 2004; 63 6 1078
98. Barnerias C., Saudubray J. M., Touati G., et al. Pyruvate dehydrogenase complex deficiency: four neurological phenotypes with differing pathogenesis. Dev Med Child Neurol: 2010; 52 2 e1 e9
99. Strassburg H. M., Koch J., Mayr J., Sperl W., Boltshauser E. Acute flaccid paralysis as initial symptom in 4 patients with novel E1alpha mutations of the pyruvate dehydrogenase complex. Neuropediatrics: 2006; 37 3 137 141
100. Debray F. G., Lambert M., Gagne R., et al. Pyruvate dehydrogenase deficiency presenting as intermittent isolated acute ataxia. Neuropediatrics: 2008; 39 1 20 23
101. Brockmann K. The expanding phenotype of GLUT1-deficiency syndrome. Brain Dev: 2009; 31 7 545 552
102. Leen W. G., Klepper J., Verbeek M. M., et al. Glucose transporter-1 deficiency syndrome: the expanding clinical and genetic spectrum of a treatable disorder. Brain: 2010; 133 Pt 3 655 670
103. Pons R., Collins A., Rotstein M., Engelstad K., De Vivo D. C. The spectrum of movement disorders in Glut-1 deficiency. Mov Disord: 2010; 25 3 275 281
104. Verrotti A., D'Egidio C., Agostinelli S., Gobbi G. Glut1 deficiency: when to suspect and how to diagnose? Eur J Paediatr Neurol: 2012; 16 1 3 9
105. Freeman J. M., Kossoff E. H., Hartman A. L. The ketogenic diet: one decade later. Pediatrics: 2007; 119 3 535 543
106. Livingstone I. R., Gardner-Medwin D., Pennington R. J. Familial intermittent ataxia with possible X-linked recessive inheritance. Two patients with abnormal pyruvate metabolism and a response to acetazolamide. J Neurol Sci: 1984; 64 1 89 97
107. Smith W., Kishnani P. S., Lee B., et al. Urea cycle disorders: clinical presentation outside the newborn period. Crit Care Clin: 2005; 21 4 (Suppl): S9 S17
108. Swango K. L., Demirkol M., Hüner G., et al. Partial biotinidase deficiency is usually due to the D444H mutation in the biotinidase gene. Hum Genet: 1998; 102 5 571 575
109. Tanaka K. Isovaleric acidemia: personal history, clinical survey and study of the molecular basis. Prog Clin Biol Res: 1990; 321 273 290
110. Deodato F., Boenzi S., Santorelli F. M., Dionisi-Vici C. Methylmalonic and propionic aciduria. Am J Med Genet C Semin Med Genet: 2006; 142C 2 104 112
111. Poretti A., Boltshauser E. Checklist about episodic ataxia (Table 4). In: Boltshauser E., Schmahmann J. D., eds. Cerebellar Disorders in Children. London Mac Keith Press: 2012; 403
112. Zuberi S. M., Eunson L. H., Spauschus A., et al. A novel mutation in the human voltage-gated potassium channel gene (Kv1.1) associates with episodic ataxia type 1 and sometimes with partial epilepsy. Brain: 1999; 122 Pt 5 817 825
113. Jen J., Kim G. W., Baloh R. W. Clinical spectrum of episodic ataxia type 2. Neurology: 2004; 62 1 17 22
114. Bertholon P., Chabrier S., Riant F., Tournier-Lasserve E., Peyron R. Episodic ataxia type 2: unusual aspects in clinical and genetic presentation. Special emphasis in childhood. J Neurol Neurosurg Psychiatry: 2009; 80 11 1289 1292
115. Jen J. C., Baloh R. W. Familial episodic ataxia: a model for migrainous vertigo. Ann N Y Acad Sci: 2009; 1164 252 256
116. Miyahara M., Hirayama M., Yuta A., Takeuchi K., Inoki T. Too young to talk of vertigo? Lancet: 2009; 373 9662 516
117. Balatsouras D. G., Kaberos A., Assimakopoulos D., Katotomichelakis M., Economou N. C., Korres S. G. Etiology of vertigo in children. Int J Pediatr Otorhinolaryngol: 2007; 71 3 487 494
118. Humphriss R. L., Hall A. J. Dizziness in 10 year old children: an epidemiological study. Int J Pediatr Otorhinolaryngol: 2011; 75 3 395 400
119. Lewis D., Ashwal S., Hershey A., Hirtz D., Yonker M., Silberstein S. American Academy of Neurology Quality Standards Subcommittee; Practice Committee of the Child Neurology Society Practice parameter: pharmacological treatment of migraine headache in children and adolescents. Report of the American Academy of Neurology Quality Standards Subcommittee and the Practice Committee of the Child Neurology Society. Neurology: 2004; 63 12 2215 2224
120. Ralli G., Atturo F., de Filippis C. Idiopathic benign paroxysmal vertigo in children, a migraine precursor. Int J Pediatr Otorhinolaryngol: 2009; 73 01 S16 S18
121. Krams B., Echenne B., Leydet J., Rivier F., Roubertie A. Benign paroxysmal vertigo of childhood: long-term outcome. Cephalalgia: 2011; 31 4 439 443
122. Fernandez-Alvarez E. Transient movement disorders in children. J Neurol: 1998; 245 1 1 5
123. Ryan M. M. Guillain-Barré syndrome in childhood. J Paediatr Child Health: 2005; 41 5-6 237 241
124. Incecik F., Ozlem Hergüner M., Altunbasak S. Guillain-Barré syndrome in children. Neurol Sci: 2011; 32 3 381 385
125. Delanoe C., Sebire G., Landrieu P., Huault G., Metral S. Acute inflammatory demyelinating polyradiculopathy in children: clinical and electrodiagnostic studies. Ann Neurol: 1998; 44 3 350 356
126. Lee J. H., Sung I. Y., Rew I. S. Clinical presentation and prognosis of childhood Guillain-Barré syndrome. J Paediatr Child Health: 2008; 44 7-8 449 454
127. Hicks C. W., Kay B., Worley S. E., Moodley M. A clinical picture of Guillain-Barré syndrome in children in the United States. J Child Neurol: 2010; 25 12 1504 1510
128. Nachamkin I. Campylobacter enteritis and the Guillain-Barré syndrome. Curr Infect Dis Rep: 2001; 3 2 116 122
129. Kalra V., Chaudhry R., Dua T., Dhawan B., Sahu J. K., Mridula B. Association of Campylobacter jejuni infection with childhood Guillain-Barré syndrome: a case-control study. J Child Neurol: 2009; 24 6 664 668
130. Nachamkin I., Barbosa P. A., Ung H., et al. Patterns of Guillain- Barré syndrome in children: results from a Mexican population. Neurology: 2007; 69 17 1665 1671
131. Ito M., Matsuno K., Sakumoto Y., Hirata K., Yuki N. Ataxic Guillain-Barré syndrome and acute sensory ataxic neuropathy form a continuous spectrum. J Neurol Neurosurg Psychiatry: 2011; 82 3 294 299
132. Zuccoli G., Panigrahy A., Bailey A., Fitz C. Redefining the Guillain-Barré spectrum in children: neuroimaging findings of cranial nerve involvement. AJNR Am J Neuroradiol: 2011; 32 4 639 642
133. Patwa H. S., Chaudhry V., Katzberg H., Rae-Grant A. D., So Y. T. Evidence-based guideline: intravenous immunoglobulin in the treatment of neuromuscular disorders. Report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology. Neurology: 2012; 78 13 1009 1015
134. Bennett H. S., Selman J. E., Rapin I., Rose A. Nonconvulsive epileptiform activity appearing as ataxia. Am J Dis Child: 1982; 136 1 30 32
135. Bisht J., Sankhyan N., Kaushal R. K., Sharma R. C., Grover N. Clinical profile of pediatric somatoform disorders. Indian Pediatr: 2008; 45 2 111 115
136. Ahmed M. A., Martinez A., Yee A., Cahill D., Besag F. M. Psychogenic and organic movement disorders in children. Dev Med Child Neurol: 2008; 50 4 300 304
137. Ferrara J., Jankovic J. Psychogenic movement disorders in children. Mov Disord: 2008; 23 13 1875 1881
138. Schwingenschuh P., Pont-Sunyer C., Surtees R., Edwards M. J., Bhatia K. P. Psychogenic movement disorders in children: a report of 15 cases and a review of the literature. Mov Disord: 2008; 23 13 1882 1888
139. Edwards M. J., Bhatia K. P. Functional (psychogenic) movement disorders: merging mind and brain. Lancet Neurol: 2012; 11 3 250 260