Aryl uracil inhibitors of hepatitis C virus NS5B polymerase: Synthesis and characterization of analogs with a fused 5,6-bicyclic ring motif

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 12, 2013, Pages 3487-3490

  Krueger, A Chris ^a   Randolph, John T ^a   Degoey, David A ^a   Donner, Pamela L ^a   Flentge, Charles A ^b   Hutchinson, Douglas K ^c   Liu, Dachun ^a   Motter, Christopher E ^d   Rockway, Todd W ^e   Wagner, Rolf ^a   Beno, David W A ^f   Koev, Gennadiy ^a   Lim, Hock B ^a   Beyer, Jill M ^a   Mondal, Rubina ^f   Liu, Yaya ^a   Kati, Warren M ^a   Longenecker, Kenton L ^a   Molla, Akhteruzzaman ^a   Stewart, Kent D ^a   Maring, Clarence J ^a   more..

^a ABBVIE INC   (United States)

^b SAB: Knopp Biosciences LLC   (United States)

^c Bedoukian Research Inc   (United States)

^d UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^e McHenry County College   (United States)

^f ABBOTT LABORATORIES   (United States)

Author keywords

Aryl uracil; Hepatitis C; NS5B polymerase inhibitors

Indexed keywords

ANTIVIRUS AGENT; ARYL URACIL INHIBITOR; NONSTRUCTURAL PROTEIN 5B; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CELL CULTURE; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HEPATITIS C; IC 50; NONHUMAN; STRUCTURE ACTIVITY RELATION; SUZUKI REACTION; VIRUS REPLICATION;

ANIMALS; BICYCLO COMPOUNDS; ENZYME INHIBITORS; HEPACIVIRUS; RATS; RNA REPLICASE; STRUCTURE-ACTIVITY RELATIONSHIP; URACIL; VIRAL NONSTRUCTURAL PROTEINS;

HEPATITIS C VIRUS; RATTUS;

EID: 84878114760     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.04.057     Document Type: Article

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