An improved synthesis of substituted benzo[b]thiophenes using microwave irradiation

Tetrahedron Letters

Volumn 45, Issue 52, 2004, Pages 9645-9647

  Allen, Daniel ^a   Callaghan, Owen ^a   Cordier, Frederic L ^a   Dobson, David R ^a   Harris, John R ^a   Hotten, Terry M ^a   Owton, W Martin ^a   Rathmell, Richard E ^a   Wood, Virginia A ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

Benzothiophenes; Cyclisation; Decarboxylation; Microwave irradiation

Indexed keywords

BENZOTHIOPHENE DERIVATIVE;

ARTICLE; CYCLIZATION; DECARBOXYLATION; HEATING; HIGH TEMPERATURE; MICROWAVE IRRADIATION; RADIATION ENERGY; SUBSTITUTION REACTION; SYNTHESIS;

EID: 9644277049     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2004.11.005     Document Type: Article

References (12)

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8. 3, 300 MHz): δ 8.2 (1H, s), 7.9 (1H, d, J = 8.3 Hz), 7.7 (1H, d, J = 5.65 Hz), 7.6 (1H, dd, J = 1.01 and 7.28 Hz), 7.4 (1H, d, J = 5.65 Hz)
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10. 11 Note: Readers should be aware that this reaction develops pressure due to release of carbon dioxide, and this should be taken into account when performing this transformation
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