Mediation analysis reveals a sex-dependent association between ABO gene variants and TG/HDL-C ratio that is suppressed by sE-selectin level

Atherosclerosis

Volumn 228, Issue 2, 2013, Pages 406-412

  Teng, Ming Sheng ^a,b   Hsu, Lung An ^c   Wu, Semon ^b,d   Chou, Hsin Hua ^b   Chang, Chi Jen ^c   Sun, Yu Zen ^e   Juan, Shu Hui ^a   Ko, Yu Lin ^b,f  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b BUDDHIST TZU CHI GENERAL HOSPITAL   (Taiwan)

^c CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^d CHINESE CULTURE UNIVERSITY   (Taiwan)

^e CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^f TZU CHI UNIVERSITY   (Taiwan)

Author keywords

ABO gene variants; Genetic association study; Inflammatory markers; Lipid profiles; Suppression effect; TG HDL C ratio

Indexed keywords

BIOLOGICAL MARKER; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; GENOMIC DNA; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INTERLEUKIN 6; INTERSTITIAL COLLAGENASE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MONOCYTE CHEMOTACTIC PROTEIN 1; TRIACYLGLYCEROL;

ADULT; ARTICLE; BLOOD GROUP A; BLOOD GROUP ABO SYSTEM; CHOLESTEROL BLOOD LEVEL; DNA POLYMORPHISM; FEMALE; GENE LOCUS; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPING TECHNIQUE; HUMAN; LIPID ANALYSIS; MALE; PRIORITY JOURNAL;

ABO BLOOD-GROUP SYSTEM; ADULT; ASIAN CONTINENTAL ANCESTRY GROUP; ATHEROSCLEROSIS; BIOLOGICAL MARKERS; CHOLESTEROL, HDL; CROSS-SECTIONAL STUDIES; DOWN-REGULATION; E-SELECTIN; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INFLAMMATION MEDIATORS; MALE; MIDDLE AGED; PHENOTYPE; POLYMORPHISM, GENETIC; RISK ASSESSMENT; RISK FACTORS; SEX FACTORS; TAIWAN; TRIGLYCERIDES;

EID: 84878112876     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2013.03.032     Document Type: Article

References (35)

1. Yamamoto F., Clausen H., White T., Marken J., Hakomori S. Molecular genetic basis of the histo-blood group ABO system. Nature 1990, 345:229-233.
2. Eastlund T. The histo-blood group ABO system and tissue transplantation. Transfusion 1998, 38:975-988.
3. Wu O., Bayoumi N., Vickers M.A., Clark P. ABO(H) blood groups and vascular disease: a systematic review and meta-analysis. JThromb Haemost 2008, 6:62-69.
4. Trégouët D.A., Heath S., Saut N., et al. Common susceptibility alleles are unlikely to contribute as strongly as the FV and ABO loci to VTE risk: results from a GWAS approach. Blood 2009, 113:5298-5303.
5. Schunkert H., König I.R., Kathiresan S., et al. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet 2011, 43:333-338.
6. Blann A.D., Daly R.J., Amiral J. The influence of age, gender and ABO blood group on soluble endothelial cell markers and adhesion molecules. Br J Haematol 1996, 92:498-500.
7. O'Donnell J., Laffan M.A. The relationship between ABO histo-blood group, factor VIII and von Willebrand factor. Transfus Med 2001, 11:343-351.
8. Jenkins P.V., O'Donnell J.S. ABO blood group determines plasma von Willebrand factor levels: a biologic function after all?. Transfusion 2006, 46:1836-1844.
9. Paterson A.D., Lopes-Virella M.F., Waggott D., et al. Genome-wide association identifies the ABO blood group as a major locus associated with serum levels of soluble E-selectin. Arterioscler Thromb Vasc Biol 2009, 29:1958-1967.
10. Qi L., Cornelis M.C., Kraft P., et al. Genetic variants in ABO blood group region, plasma soluble E-selectin levels and risk of type 2 diabetes. Hum Mol Genet 2010, 19:1856-1862.
11. Barbalic M., Dupuis J., Dehghan A., et al. Large-scale genomic studies reveal central role of ABO in sP-selectin and sICAM-1 levels. Hum Mol Genet 2010, 19:1863-1872.
12. Gillum R.F. Blood groups, serum cholesterol, serum uric acid, blood pressure, and obesity in adolescents. JNatl Med Assoc 1991, 83:682-688.
13. Wu S., Hsu L.A., Cheng C.F., et al. Effect of obesity on the association between ATF3 gene haplotypes and C-reactive protein level in Taiwanese. Clin Chim Acta 2011, 412(11-12):1026-1031.
14. Souto J.C., Almasy L., Muñiz-Diaz E., et al. Functional effects of the ABO locus polymorphism on plasma levels of von Willebrand factor, factor VIII, and activated partial thromboplastin time. Arterioscler Thromb Vasc Biol 2000, 20:2024-2028.
15. O'Donnell J.S., McKinnon T.A., Crawley J.T., Lane D.A., Laffan M.A. Bombay phenotype is associated with reduced plasma-VWF levels and an increased susceptibility to ADAMTS13 proteolysis. Blood 2005, 106:1988-1991.
16. Mohlke K.L., Purkayastha A.A., Westrick R.J., et al. Mvwf, a dominant modifier of murine von Willebrand facto results from altered lineage-specific expression of a glycosyltransferase. Cell 1999, 96:111-120.
17. Martinez M., Joffraud M., Giraud S., et al. Regulation of PSGL-1 interactions with L-selectin, P-selectin, and E-selectin: role of human fucosyltransferase-IV and -VII. JBiol Chem 2005, 280:5378-5390.
18. Martín M.J., Feizi T., Leteux C., Pavlovic D., Piskarev V.E., Chai W. An investigation of the interactions of E-selectin with fuco-oligosaccharides of the blood group family. Glycobiology 2002, 12:829-835.
19. Kingsley D.M., Kozarsky K.F., Hobbie L., Krieger M. Reversible defects in O-linked glycosylation and LDL receptor expression in a UDP-Gal/UDP-GalNAc 4-epimerase deficient mutant. Cell 1986, 44:749-759.
20. Magrané J., Casaroli-Marano R.P., Reina M., Gåfvels M., Vilaró S. The role of O-linked sugars in determining the very low density lipoprotein receptor stability or release from the cell. FEBS Lett 1999, 451:56-62.
21. Schjoldager K.T., Vester-Christensen M.B., Bennett E.P., et al. O-glycosylation modulates proprotein convertase activation of angiopoietin-like protein 3: possible role of polypeptide GalNAc-transferase-2 in regulation of concentrations of plasma lipids. JBiol Chem 2010, 285:36293-36303.
22. Kathiresan S., Melander O., Guiducci C., et al. Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. Nat Genet 2008, 40:189-197.
23. Garrison R.J., Havlik R.J., Harris R.B., Feinleib M., Kannel W.B., Padgett S.J. ABO blood group and cardiovascular disease: the Framingham study. Atherosclerosis 1976, 25:311-318.
24. Platt D., Muhlberg W., Kiehl L., Schmitt-Ruth R. ABO blood group system, age, sex, risk factors and cardiac infarction. Arch Gerontol Geriatr 1985, 4:241-249.
25. Whincup P.H., Cook D.G., Phillips A.N., Shaper A.G. ABO blood group and ischaemic heart disease in British men. Brit Med J 1980, 300:1679-1682.
26. Paré G., Chasman D.I., Kellogg M., et al. Novel association of ABO histo-blood group antigen with soluble ICAM-1: results of a genome-wide association study of 6578 women. PLoS Genet 2008, 4(7):e1000118.
27. MacKinnon D., Krull J.L., Lockwood C.M. Equivalence of the mediation, confounding and suppression effect. Prev Sci 2000, 1:173-181.
28. Aiello A.E., Nguyen H.O., Haan M.N. C-reactive protein mediates the effect of apolipoprotein E on cytomegalovirus infection. JInfect Dis 2008, 197:34-41.
29. Connelly P.W., Petrasovits A., Stachenko S., et al. Prevalence of high plasma triglyceride combined with low HDL-C levels and its association with smoking, hypertension, obesity, diabetes, sedentariness and LDL-C levels in the Canadian population. Can J Cardiol 1999, 15:428-433.
30. Cordero A., Andres E., Ordoñez B., et al. Usefulness of triglycerides-to-high density lipoprotein cholesterol ratio for predicting the first coronary event in men. Am J Cardiol 2009, 104:1393-1397.
31. Maggio A.B., Farpour-Lambert N.J., Montecucco F., et al. Elevated E-selectin and diastolic blood pressure in diabetic children. Eur J Clin Invest 2012, 42:303-309.
32. Alina S., Barbara R., Krzysztof G., et al. Elevation of sE-selectin levels from2-24 months following gestational diabetes is associated with early cardiometabolic risk in non-diabetic women. JDiabetes Metab 2011, 2011(2):138.
33. Khampanon K., Chanprakop T., Sriwanitchrak P., Setthakarn M., Oota S., Nathalang O. The characteristics of ABO antibodies in group O Thai blood donors. JClin Lab Anal 2012, 26:223-226.
34. Hirschhorn J.N., Lohmueller K., Byrne E., Hirschhorn K. Acomprehensive review of genetic association studies. Genet Med 2002, 4(2):45-61.
35. Zhu F., Tao S., Xu X., et al. Distribution of ABO blood group allele and identification of three novel alleles in the Chinese Han population. Vox Sang 2010, 98:554-559.