Low normal thyroid function enhances plasma cholesteryl ester transfer in Type 2 diabetes mellitus

Atherosclerosis

Volumn 228, Issue 2, 2013, Pages 466-471

  Triolo, Michela ^a   Kwakernaak, Arjan J ^a   Perton, Frank G ^a   de Vries, Rindert ^a   Dallinga Thie, Geesje M ^b   Dullaart, Robin P F ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

Cholesteryl ester transfer; Cholesteryl ester transfer protein; Euthyroidism; Thyroid stimulating hormone; Triglycerides; Type 2 diabetes mellitus

Indexed keywords

CHOLESTEROL ESTER TRANSFER PROTEIN; GLUCOSE; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; THYROTROPIN; THYROXINE; TRIACYLGLYCEROL;

ADULT; ARTICLE; BODY MASS; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; FEMALE; GLUCOSE BLOOD LEVEL; HEMOGLOBIN BLOOD LEVEL; HUMAN; HYPERGLYCEMIA; HYPERTRIGLYCERIDEMIA; IMPAIRED GLUCOSE TOLERANCE; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; THYROID FUNCTION; THYROTROPIN BLOOD LEVEL; THYROXINE BLOOD LEVEL; TRIACYLGLYCEROL BLOOD LEVEL;

AGED; BIOLOGICAL MARKERS; BLOOD GLUCOSE; CASE-CONTROL STUDIES; CHI-SQUARE DISTRIBUTION; CHOLESTEROL ESTER TRANSFER PROTEINS; CROSS-SECTIONAL STUDIES; DIABETES MELLITUS, TYPE 2; FEMALE; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; LINEAR MODELS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PREDICTIVE VALUE OF TESTS; REFERENCE VALUES; THYROID FUNCTION TESTS; THYROID GLAND; THYROTROPIN; THYROXINE; TRIGLYCERIDES; UP-REGULATION;

EID: 84878109585     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2013.03.009     Document Type: Article

References (34)

1. Duntas L.H., Wartofsky L. Cardiovascular risk and subclinical hypothyroidism: focus on lipids and new emerging risk factors. What is the evidence?. Thyroid 2007, 17:1075-1084.
2. Hak A.E., Pols H.A., Visser T.J., Drexhage H.A., Hofman A., Witteman J.C. Subclinical hypothyroidism is an independent risk factor for atherosclerosis and myocardial infarction in elderly women: the Rotterdam Study. Ann Intern Med 2000, 132:270-278.
3. Cappola A.R., Fried L.P., Arnold A.M., et al. Thyroid status, cardiovascular risk, and mortality in older adults. JAm Med Assoc 2006, 295:1033-1041.
4. Ochs N., Auer R., Bauer D.C., et al. Meta-analysis: subclinical thyroid dysfunction and the risk for coronary heart disease and mortality. Ann Intern Med 2008, 148:832-845.
5. Rodondi N., den Elzen W.P., Bauer D.C., et al. Subclinical hypothyroidism and the risk of coronary heart disease and mortality. JAm Med Assoc 2010, 304:1365-1374.
6. Asvold B.O., Bjøro T., Platou C., Vatten L.J. Thyroid function and the risk of coronary heart disease: 12-year follow-up of the HUNT Study in Norway. Clin Endocrinol (Oxf) 2012, 77:911-917.
7. Dullaart R.P.F., de Vries R., Roozendaal C., Kobold A.C., Sluiter W.J. Carotid artery intima media thickness is inversely related to serum free thyroxine in euthyroid subjects. Clin Endocrinol (Oxf) 2007, 67:668-673.
8. Takamura N., Akilzhanova A., Hayashida N., et al. Thyroid function is associated with carotid intima-media thickness in euthyroid subjects. Atherosclerosis 2009, 204:e77-e81.
9. Asvold B.O., Vatten L.J., Nilsen T.I., Bjøro T. The association between TSH within the reference range and serum lipid concentrations in a population-based study. The HUNT Study. Eur J Endocrinol 2007, 156:181-186.
10. Garduño-Garcia J de Jesus, Alvirde-Garcia U., López-Carrasco G., et al. TSH and free thyroxine concentrations are associated with differing metabolic markers in euthyroid subjects. Eur J Endocrinol 2010, 163:273-278.
11. Wang F., Tan Y., Wang C., et al. Thyroid-stimulating hormone levels within the reference range are associated with serum lipid profiles independent of thyroid hormones. JClin Endocrinol Metab 2012, 97:2724-2731.
12. Ittermann T., Baumeister S.E., Völzke H., et al. Are serum TSH levels associated with oxidized low-density lipoprotein? Results from the Study of Health in Pomerania. Clin Endocrinol (Oxf) 2012, 76:526-532.
13. Dallinga-Thie G.M., Dullaart R.P.F., van Tol A. Concerted actions of cholesteryl ester transfer protein and phospholipid transfer protein in type 2 diabetes: effects of apolipoproteins. Curr Opin Lipidol 2007, 18:251-257.
14. de Vries R., Perton F.G., Dallinga-Thie G.M., et al. Plasma cholesteryl ester transfer is a determinant of intima-media thickness in type 2 diabetic and nondiabetic subjects: role of CETP and triglycerides. Diabetes 2005, 54:3554-3559.
15. Kappelle P.J.W.H., Perton F., Hillege H.L., Dallinga-Thie G.M., Dullaart R.P.F. High plasma cholesteryl ester transfer but not CETP mass predicts incident cardiovascular disease: a nested case-control study. Atherosclerosis 2011, 217:249-252.
16. Zeller M., Masson D., Farnier M., et al. High serum cholesteryl ester transfer rates and small high-density lipoproteins are associated with young age in patients with acute myocardial infarction. JAm Coll Cardiol 2007, 50:1948-1955.
17. Pearce E.N. Update in lipid alterations in subclinical hypothyroidism. JClin Endocrinol Metab 2012, 97:326-333.
18. Ritter M.C., Kannan C.R., Bagdade J.D. The effects of hypothyroidism and replacement therapy on cholesteryl ester transfer. JClin Endocrinol Metab 1996, 81:797-800.
19. Dullaart R.P.F., Hoogenberg K., Groener J.E., Dikkeschei L.D., Erkelens D.W., Doorenbos H. The activity of cholesteryl ester transfer protein is decreased in hypothyroidism: a possible contribution to alterations in high-density lipoproteins. Eur J Clin Invest 1990, 20:581-587.
20. Bagdade J.D., Lane J.T., Subbaiah P.V., Otto M.E., Ritter M.C. Accelerated cholesterylester transfer in noninsulin-dependent diabetes mellitus. Atherosclerosis 1993, 104:69-77.
21. Riemens S., van Tol A., Sluiter W., Dullaart R.P.F. Elevated plasma cholesteryl ester transfer in NIDDM: relationships with apolipoprotein B-containing lipoproteins and phospholipid transfer protein. Atherosclerosis 1998, 140:71-79.
22. Sutherland W.H., Walker R.J., Lewis-Barned N.J., et al. Plasma cholesteryl ester transfer in patients with non-insulin dependent diabetes mellitus. Clin Chim Acta 1994, 231:29-38.
23. Grundy S.M., Cleeman J.I., Daniels S.R., et al. Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation 2005, 112:2735-2752.
24. van Venrooij F.V., Stolk R.P., Banga J.D., et al. Common cholesteryl ester transfer protein gene polymorphisms and the effect of atorvastatin therapy in type 2 diabetes. Diabetes Care 2003, 26:1216-1223.
25. Dullaart R.P.F., de Vries R., Scheek L., et al. Type 2 diabetes mellitus is associated with differential effects on plasma cholesteryl ester transfer protein and phospholipid transfer protein activities and concentrations. Scand J Clin Lab Invest 2004, 64:205-215.
26. Lu M., Lyden P.D., Brott T.G., Hamilton S., Broderick J.P., Grotta J.C. Beyond subgroup analysis: improving the clinical interpretation of treatment effects in stroke research. JNeurosci Methods 2005, 143:209-216.
27. Kabadi U.M. Impaired pituitary thyrotroph function in uncontrolled type II diabetes mellitus: normalization on recovery. JClin Endocrinol Metab 1984, 59:521-525.
28. Lambadiari V., Mitrou P., Maratou E., et al. Thyroid hormones are positively associated with insulin resistance early in the development of type 2 diabetes. Endocrine 2011, 39:28-32.
29. Passarelli M., Catanozi S., Nakandakare E.R., et al. Plasma lipoproteins from patients with poorly controlled diabetes mellitus and "invitro" glycation of lipoproteins enhance the transfer rate of cholesteryl ester from HDL to apo-B-containing lipoproteins. Diabetologia 1997, 40:1085-1093.
30. Ceriello A. Controlling oxidative stress as a novel molecular approach to protecting the vascular wall in diabetes. Curr Opin Lipidol 2006, 17:510-518.
31. Lagrost L. Regulation of cholesteryl ester transfer protein (CETP) activity: review of invitro and invivo studies. Biochim Biophys Acta 1994, 1215:209-226.
32. Dullaart R.P.F., Constantinides A., Perton F.G., et al. Plasma cholesteryl ester transfer, but not cholesterol esterification, is related to lipoprotein-associated phospholipase A2: possible contribution to an atherogenic lipoprotein profile. JClin Endocrinol Metab 2011, 96:1077-1084.
33. Diekman M.J., Anghelescu N., Endert E., Bakker O., Wiersinga W.M. Changes in plasma low-density lipoprotein (LDL)- and high-density lipoprotein cholesterol in hypo- and hyperthyroid patients are related to changes in free thyroxine, not to polymorphisms in LDL receptor or cholesterol ester transfer protein genes. JClin Endocrinol Metab 2000, 85:1857-1862.
34. de Vries R., Dikkeschei B.D., Sluiter W.J., Dallinga-Thie G.M., van Tol A., Dullaart R.P.F. Statin and fibrate combination does not additionally lower plasma cholesteryl ester transfer in type 2 diabetes mellitus. Clin Lab 2012, 58:1231-1239.