The HER2 amplicon includes several genes required for the growth and survival of HER2 positive breast cancer cells

Molecular Oncology

Volumn 7, Issue 3, 2013, Pages 392-401

  Sahlberg, Kristine Kleivi ^a,b   Hongisto, Vesa ^b   Edgren, Henrik ^c   Mäkelä, Rami ^b   Hellström, Kirsi ^b   Due, Eldri U ^a   Moen Vollan, Hans Kristian ^a,d,e   Sahlberg, Niko ^b   Wolf, Maija ^c   Børresen Dale, Anne Lise ^a,d   Perälä, Merja ^b   Kallioniemi, Olli ^b,c  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

^b VTT TECHNICAL RESEARCH CENTRE OF FINLAND   (Finland)

^c UNIVERSITY OF HELSINKI   (Finland)

^d UNIVERSITY OF OSLO   (Norway)

^e ULLEVÅL UNIVERSITY HOSPITAL   (Norway)

Author keywords

17q12; Breast cancer; Drug resistance; Functional screen; Gene silencing; HER2 positive; HER2 amplicon; Lapatinib; SiRNA; Trastuzumab

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 2; GROWTH FACTOR RECEPTOR BOUND PROTEIN 7; LAPATINIB; OLIGONUCLEOTIDE; TRASTUZUMAB;

AMPLICON; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER GROWTH; CANCER SURVIVAL; CELL VIABILITY; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; DRUG RESPONSE; GENE AMPLIFICATION; GENE EXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; PHENOTYPE; PRIORITY JOURNAL; RNA INTERFERENCE;

EID: 84878106712     PISSN: 15747891     EISSN: 18780261     Source Type: Journal    
DOI: 10.1016/j.molonc.2012.10.012     Document Type: Article

References (33)

1. Baselga J., Bradbury I., Eidtmann H., Di Cosimo S., de Azambuja E., Aura C., Gomez H., Dinh P., Fauria K., Van Dooren V., Aktan G., Goldhirsch A., Chang T.W., Horvath Z., Coccia-Portugal M., Domont J., Tseng L.M., Kunz G., Sohn J.H., Semiglazov V., Lerzo G., Palacova M., Probachai V., Pusztai L., Untch M., Gelber R.D., Piccart-Gebhart M. Lancet 2012, 379:633-640.
2. Bates M., Sperinde J., Kostler W.J., Ali S.M., Leitzel K., Fuchs E.M., Paquet A., Lie Y., Sherwood T., Horvat R., Singer C.F., Winslow J., Weidler J.M., Huang W., Lipton A. Ann. Oncol. 2011.
3. Baumbusch L.O., Aaroe J., Johansen F.E., Hicks J., Sun H., Bruhn L., Gunderson K., Naume B., Kristensen V.N., Liestol K., Borresen-Dale A.L., Lingjaerde O.C. BMC Genomics 2008, 9(379):379.
4. Belkhiri A., Dar A.A., Peng D.F., Razvi M.H., Rinehart C., Arteaga C.L., El-Rifai W. Clin. Cancer Res. 2008, 14:4564-4571.
5. Berns K., Horlings H.M., Hennessy B.T., Madiredjo M., Hijmans E.M., Beelen K., Linn S.C., Gonzalez-Angulo A.M., Stemke-Hale K., Hauptmann M., Beijersbergen R.L., Mills G.B., van de V., Bernards R. Cancer Cell. 2007, 12:395-402.
6. Campone M., Juin P., Andre F., Bachelot T. Crit. Rev. Oncol. Hematol. 2011, 78:195-205.
7. Edgren H., Murumagi A., Kangaspeska S., Nicorici D., Hongisto V., Kleivi K., Rye I.H., Nyberg S., Wolf M., Borresen-Dale A.L., Kallioniemi O. Genome Biol. 2011, 12:R6.
8. Gennari R., Menard S., Fagnoni F., Ponchio L., Scelsi M., Tagliabue E., Castiglioni F., Villani L., Magalotti C., Gibelli N., Oliviero B., Ballardini B., Da Prada G., Zambelli A., Costa A. Clin. Cancer Res. 2004, 10:5650-5655.
9. Hamel S., Bouchard A., Ferrario C., Hassan S., Guilar-Mahecha A., Buchanan M., Quenneville L., Miller W., Basik M. Breast Cancer Res. Treat. 2010, 120:47-57.
10. Hynes N.E., Lane H.A. Nat. Rev. Cancer 2005, 5:341-354.
11. Jarvinen T.A., Kononen J., Pelto-Huikko M., Isola J. Am. J. Pathol. 1996, 148:2073-2082.
12. Junttila T.T., Akita R.W., Parsons K., Fields C., Lewis Phillips G.D., Friedman L.S., Sampath D., Sliwkowski M.X. Cancer Cell. 2009, 15:429-440.
13. Kao J., Pollack J.R. Genes Chromosomes Cancer 2006, 45:761-769.
14. Kauraniemi P., Kallioniemi A. Endocr. Relat. Cancer 2006, 13:39-49.
15. Kauraniemi P., Kuukasjarvi T., Sauter G., Kallioniemi A. Am. J. Pathol. 2003, 163:1979-1984.
16. Kourtidis A., Jain R., Carkner R.D., Eifert C., Brosnan M.J., Conklin D.S. Cancer Res. 2010, 70:1783-1792.
17. Langerod A., Zhao H., Borgan O., Nesland J.M., Bukholm I.R., Ikdahl T., Karesen R., Borresen-Dale A.L., Jeffrey S.S. Breast Cancer Res. 2007, 9:R30.
18. Leivonen S.K., Makela R., Ostling P., Kohonen P., Haapa-Paananen S., Kleivi K., Enerly E., Aakula A., Hellstrom K., Sahlberg N., Kristensen V.N., Borresen-Dale A.L., Saviranta P., Perala M., Kallioniemi O. Oncogene 2009, 28:3926-3936.
19. Luo J., Solimini N.L., Elledge S.J. Cell 2009, 136:823-837.
20. Miller T.W., Forbes J.T., Shah C., Wyatt S.K., Manning H.C., Olivares M.G., Sanchez V., Dugger T.C., de Matos Granja N., Narasanna A., Cook R.S., Kennedy J.P., Lindsley C.W., Arteaga C.L. Clin. Cancer Res. 2009, 15:7266-7276.
21. Nahta R., O'Regan R.M. Clin. Breast Cancer 2010, 10(Suppl. 3):S72-S78.
22. O'Brien N.A., Browne B.C., Chow L., Wang Y., Ginther C., Arboleda J., Duffy M.J., Crown J., O'Donovan N., Slamon D.J. Mol. Cancer Ther. 2010, 9:1489-1502.
23. Perou C.M., Sorlie T., Eisen M.B., van de Rijn M., Jeffrey S.S., Rees C.A., Pollack J.R., Ross D.T., Johnsen H., Akslen L.A., Fluge O., Pergamenschikov A., Williams C., Zhu S.X., Lonning P.E., Borresen-Dale A.L., Brown P.O., Botstein D. Nature 2000, 406:747-752.
24. Ramsey B., Bai T., Hanlon Newell A., Troxell M., Park B., Olson S., Keenan E., Luoh S.W. Breast Cancer Res. Treat. 2010.
25. Russnes H.G., Vollan H.K., Lingjaerde O.C., Krasnitz A., Lundin P., Naume B., Sorlie T., Borgen E., Rye I.H., Langerod A., Chin S.F., Teschendorff A.E., Stephens P.J., Maner S., Schlichting E., Baumbusch L.O., Karesen R., Stratton M.P., Wigler M., Caldas C., Zetterberg A., Hicks J., Borresen-Dale A.L. Sci. Transl. Med. 2010, 2:38ra47.
26. Sircoulomb F., Bekhouche I., Finetti P., Adelaide J., Ben Hamida A., Bonansea J., Raynaud S., Innocenti C., Charafe-Jauffret E., Tarpin C., Ben Ayed F., Viens P., Jacquemier J., Bertucci F., Birnbaum D., Chaffanet M. BMC Cancer 2010, 10:539.
27. Sorlie T., Perou C.M., Tibshirani R., Aas T., Geisler S., Johnsen H., Hastie T., Eisen M.B., van de Rijn M., Jeffrey S.S., Thorsen T., Quist H., Matese J.C., Brown P.O., Botstein D., Eystein Lonning P., Borresen-Dale A.L. Proc. Natl. Acad. Sci. U S A 2001, 98:10869-10874.
28. Staaf J., Jonsson G., Ringner M., Vallon-Christersson J., Grabau D., Arason A., Gunnarsson H., Agnarsson B.A., Malmstrom P.O., Johannsson O.T., Loman N., Barkardottir R.B., Borg A. Breast Cancer Res. 2010, 12:R25.
29. Stemke-Hale K., Gonzalez-Angulo A.M., Lluch A., Neve R.M., Kuo W.L., Davies M., Carey M., Hu Z., Guan Y., Sahin A., Symmans W.F., Pusztai L., Nolden L.K., Horlings H., Berns K., Hung M.C., van de V., Valero V., Gray J.W., Bernards R., Mills G.B., Hennessy B.T. Cancer Res. 2008, 68:6084-6091.
30. Weigelt B., Warne P.H., Downward J. Oncogene 2011.
31. Wolff A.C., Hammond M.E., Schwartz J.N., Hagerty K.L., Allred D.C., Cote R.J., Dowsett M., Fitzgibbons P.L., Hanna W.M., Langer A., McShane L.M., Paik S., Pegram M.D., Perez E.A., Press M.F., Rhodes A., Sturgeon C., Taube S.E., Tubbs R., Vance G.H., van de V., Wheeler T.M., Hayes D.F. Arch. Pathol. Lab. Med. 2007, 131:18-43.
32. Yang Z.Q., Streicher K.L., Ray M.E., Abrams J., Ethier S.P. Cancer Res. 2006, 66:11632-11643.
33. Zender L., Spector M.S., Xue W., Flemming P., Cordon-Cardo C., Silke J., Fan S.T., Luk J.M., Wigler M., Hannon G.J., Mu D., Lucito R., Powers S., Lowe S.W. Cell 2006, 125:1253-1267.