Live cell imaging in a micro-array of acoustic traps facilitates quantification of natural killer cell heterogeneity

Integrative Biology (United Kingdom)

Volumn 5, Issue 4, 2013, Pages 712-719

  Christakou, Athanasia E ^a   Ohlin, Mathias ^a   Vanherberghen, Bruno ^a   Khorshidi, Mohammad Ali ^a   Kadri, Nadir ^b   Frisk, Thomas ^a   Wiklund, Martin ^a   Önfelt, Björn ^a,b,c  

^a ALBANOVA UNIVERSITY CENTER   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c SCIENCE FOR LIFE LABORATORY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BIOLOGICAL PHENOMENA AND FUNCTIONS CONCERNING THE ENTIRE ORGANISM; CELL AGGREGATION; CELL HETEROGENEITY; CELL INTERACTION; CELLS; CONTROLLED STUDY; CYTOTOXICITY; FORCE; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; KILLER CELL; MICROARRAY ANALYSIS; MOLECULAR IMAGING; NATURAL KILLER CELL; NATURAL POPULATION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REGULATORY MECHANISM; TIME LAPSE IMAGING; ULTRASOUND; ULTRASOUND SCANNER;

CELL COMMUNICATION; CELL SEPARATION; CELL SURVIVAL; CELLS, CULTURED; EQUIPMENT DESIGN; EQUIPMENT FAILURE ANALYSIS; FLOW CYTOMETRY; HUMANS; KILLER CELLS, NATURAL; NEOPLASMS, EXPERIMENTAL; SONICATION; TISSUE ARRAY ANALYSIS;

EID: 84878096273     PISSN: 17579694     EISSN: 17579708     Source Type: Journal    
DOI: 10.1039/c3ib20253d     Document Type: Article

References (28)

1. P. Höglund P. Brodin Current perspectives of natural killer cell education by MHC class I molecules Nat. Rev. Immunol. 2010 10 724 734
2. H. G. Ljunggren K. J. Malmberg Prospects for the use of NK cells in immunotherapy of human cancer Nat. Rev. Immunol. 2007 7 329 339
3. R. Bhat C. Watzl Serial killing of tumor cells by human natural killer cells-enhancement by therapeutic antibodies PLoS One 2007 2 e326
4. P. Brodin T. Lakshmikanth S. Johansson K. Kärre P. Höglund The strength of inhibitory input during education quantitatively tunes the functional responsiveness of individual natural killer cells Blood 2009 113 2434 2441
5. M. Yawata et al., MHC class I-specific inhibitory receptors and their ligands structure diverse human NK-cell repertoires toward a balance of missing self-response Blood 2008 112 2369 2380
6. P. J. Lee P. J. Hung R. Shaw L. Jan L. P. Lee Microfluidic application-specific integrated device for monitoring direct cell-cell communication via gap junctions between individual cell pairs Appl. Phys. Lett. 2005 86
7. A. M. Skelley O. Kirak H. Suh R. Jaenisch J. Voldman Microfluidic control of cell pairing and fusion Nat. Methods 2009 6 147 152
8. B. Vanherberghen et al., Ultrasound-controlled cell aggregation in a multi-well chip Lab Chip 2010 10 2727 2732
9. E. Forslund et al., Novel Microchip-Based Tools Facilitating Live Cell Imaging and Assessment of Functional Heterogeneity within NK Cell Populations Front. Immunol. 2012 3 300
10. Y. J. Yamanaka et al., Single-cell analysis of the dynamics and functional outcomes of interactions between human natural killer cells and target cells Integr. Biol. 2012 4 1175 1184
11. K. Guldevall et al., Imaging immune surveillance of individual natural killer cells confined in microwell arrays PLoS One 2010 5 e15453
12. N. Varadarajan et al., A high-throughput single-cell analysis of human CD8+ T cell functions reveals discordance for cytokine secretion and cytolysis J. Clin. Invest. 2011 121 4322 4331
13. M. A. Khorshidi et al., Analysis of transient migration behavior of natural killer cells imaged in situ and in vitro Integr. Biol. 2011 3 770 778
14. B. Vanherberghen et al., Classification of human natural killer cells based on migration behavior and cytotoxic response Blood 2013 10.1182/blood-2012-06-439851
15. M. Ohlin A. E. Christakou T. Frisk B. Önfelt M. Wiklund Influence of acoustic streaming on ultrasonic particle manipulation in a 100-well ring-transducer microplate J. Micromech. Microeng. 2013 23
16. T. W. Frisk M. A. Khorshidi K. Guldevall B. Vanherberghen B. Onfelt A silicon-glass microwell platform for high-resolution imaging and high-content screening with single cell resolution Biomed. Microdevices 2011 13 683 693
17. R. G. Miller M. Dunkley Quantitative analysis of the 51Cr release cytotoxicity assay for cytotoxic lymphocytes Cell. Immunol. 1974 14 284 302
18. D. M. Davis et al., The human natural killer cell immune synapse Proc. Natl. Acad. Sci. U. S. A. 1999 96 15062 15067
19. L. M. Carlin K. Eleme F. E. McCann D. M. Davis Intercellular transfer and supramolecular organization of human leukocyte antigen C at inhibitory natural killer cell immune synapses J. Exp. Med. 2001 194 1507 1517
20. S. Isaaz K. Baetz K. Olsen E. Podack G. M. Griffiths Serial killing by cytotoxic T lymphocytes: T cell receptor triggers degranulation, re-filling of the lytic granules and secretion of lytic proteins via a non-granule pathway Eur. J. Immunol. 1995 25 1071 1079
21. E. Martz Multiple target cell killing by the cytolytic T lymphocyte and the mechanism of cytotoxicity Transplantation 1976 21 5 11
22. V. Maruthamuthu B. Sabass U. S. Schwarz M. L. Gardel Cell-ECM traction force modulates endogenous tension at cell-cell contacts Proc. Natl. Acad. Sci. U. S. A. 2011 108 4708 4713
23. M. Wiklund et al., Ultrasonic standing wave manipulation technology integrated into a dielectrophoretic chip Lab Chip 2006 6 1537 1544
24. R. Barnkob P. Augustsson T. Laurell H. Bruus Measuring the local pressure amplitude in microchannel acoustophoresis Lab Chip 2010 10 563 570
25. P. Augustsson R. Barnkob S. T. Wereley H. Bruus T. Laurell Automated and temperature-controlled micro-PIV measurements enabling long-term-stable microchannel acoustophoresis characterization Lab Chip 2011 11 4152 4164
26. R. Barnkob I. Iranmanesh M. Wiklund H. Bruus Measuring acoustic energy density in microchannel acoustophoresis using a simple and rapid light-intensity method Lab Chip 2012 12 2337 2344
27. N. K. Bjorkstrom et al., Expression patterns of NKG2A, KIR, and CD57 define a process of CD56dim NK-cell differentiation uncoupled from NK-cell education Blood 2010 116 3853 3864
28. S. Lopez-Verges et al., CD57 defines a functionally distinct population of mature NK cells in the human CD56dimCD16+ NK-cell subset Blood 2010 116 3865 3874