Low urine vascular endothelial growth factor levels are associated with mechanical ventilation, bronchopulmonary dysplasia and retinopathy of prematurity

Neonatology

Volumn 104, Issue 1, 2013, Pages 56-64

  Levesque, Bernadette M ^a,b,g   Kalish, Leslie A ^a,g   Winston, Abigail B ^a   Parad, Richard B ^a,c,g   Hernandez Diaz, Sonia ^d   Phillips, Michele ^a,c   Zolit, Amy ^c   Morey, Joann ^a,c   Gupta, Munish ^a,e,g   Mammoto, Akiko ^a,g   Ingber, Donald E ^a,f,g   Van Marter, Linda J ^a,c,g  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b ST ELIZABETH'S MEDICAL CENTER   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^e BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^f HARVARD UNIVERSITY   (United States)

^g HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Biomarker; Bronchopulmonary dysplasia; Enzyme linked immunosorbent assay; Fraction of inspired oxygen; Mechanical ventilation; Retinopathy of prematurity; Vascular endothelial growth factor

Indexed keywords

MAGNESIUM SULFATE; OXYGEN; PROTEIN; VASCULOTROPIN;

ARTICLE; ARTIFICIAL VENTILATION; ASSISTED VENTILATION; CLINICAL ASSESSMENT; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GESTATIONAL AGE; HISTOPATHOLOGY; HUMAN; INFANT; LUNG DYSPLASIA; MAJOR CLINICAL STUDY; MALE; MATERNAL HYPERTENSION; NEWBORN SEPSIS; PATIENT SELECTION; PEAK INSPIRATORY FLOW; PERINATAL PERIOD; POSITIVE END EXPIRATORY PRESSURE; PRIORITY JOURNAL; PROTEIN URINE LEVEL; RETROLENTAL FIBROPLASIA; SURVIVAL RATE; URINALYSIS; CONTROLLED STUDY; DATA BASE; DIAGNOSTIC VALUE; EARLY DIAGNOSIS; ELISA KIT; OUTCOME ASSESSMENT; OXYGEN BREATHING; PREMATURITY; SEPSIS; SEX DIFFERENCE; SURVIVAL;

BRONCHOPULMONARY DYSPLASIA; FEMALE; GESTATIONAL AGE; HUMANS; INFANT, NEWBORN; INFANT, PREMATURE; INFANT, PREMATURE, DISEASES; MALE; RESPIRATION, ARTIFICIAL; RETINOPATHY OF PREMATURITY; SEPSIS; SEX FACTORS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84878038265     PISSN: 16617800     EISSN: 16617819     Source Type: Journal    
DOI: 10.1159/000351040     Document Type: Article

References (24)

1. Coalson JJ: Pathology of bronchopulmonary dysplasia. Semin Perinatol 2006; 30: 179-184.
2. Stoll BJ, Hansen NI, Bell EF, Shankaran S, Laptook AR, Walsh MC, et al: Neonatal outcomes of extremely preterm infants from the NICHD Neonatal Research Network. Pediatrics 2010; 126: 443-456.
3. Acarregui MJ, Penisten ST, Goss KL, Ramirez K, Snyder JM: Vascular endothelial growth factor gene expression in human fetal lung in vitro. Am J Respir Cell Mol Biol 1999; 20: 14-23.
4. Lassus P, Turanlahti M, Heikkila P, Andersson LC, Nupponen I, Sarnesto A, et al: Pulmonary vascular endothelial growth factor and Flt-1 in fetuses, in acute and chronic lung disease, and in persistent pulmonary hypertension of the newborn. Am J Respir Crit Care Med 2001; 164: 1981-1987.
5. Bhatt AJ, Pryhuber GS, Huyck H, Watkins RH, Metlay LA, Maniscalco WM: Disrupted pulmonary vasculature and decreased vascular endothelial growth factor, Flt-1, and TIE-2 in human infants dying with bronchopulmonary dysplasia. Am J Respir Crit Care Med 2001; 164: 1971-1980.
6. Asikainen TM, Chang LY, Coalson JJ, Schneider BK, Waleh NS, Ikegami M, et al: Improved lung growth and function through hypoxia-inducible factor in primate chronic lung disease of prematurity. FASEB J 2006; 20: 1698-1700.
7. Kunig AM, Balasubramaniam V, Markham NE, Morgan D, Montgomery G, Grover TR, et al: Recombinant human VEGF treatment enhances alveolarization after hyperoxic lung injury in neonatal rats. Am J Physiol Lung Cell Mol Physiol 2005; 289:L529-L535.
8. Thebaud B, Ladha F, Michelakis ED, Sawicka M, Thurston G, Eaton F, et al: Vascular endothelial growth factor gene therapy increases survival, promotes lung angiogenesis, and prevents alveolar damage in hyperoxia-induced lung injury: evidence that angiogenesis participates in alveolarization. Circulation 2005; 112: 2477-2486.
9. Smith LE: Through the eyes of a child: understanding retinopathy through ROP the Friedenwald lecture. Invest Ophthalmol Vis Sci 2008; 49: 5177-5182.
10. Alon T, Hemo I, Itin A, Pe'er J, Stone J, Keshet E: Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity. Nat Med 1995; 1: 1024-1028.
11. Mintz-Hittner HA, Kennedy KA, Chuang AZ: Efficacy of intravitreal bevacizumab for stage 3+ retinopathy of prematurity. N Engl J Med 2011; 364: 603-615.
12. Sears JE, Hoppe G, Ebrahem Q, Anand-Apte B: Prolyl hydroxylase inhibition during hyperoxia prevents oxygen-induced retinopathy. Proc Natl Acad Sci USA 2008; 105: 19898-19903.
13. Kronquist KE, Crandall BF, Tabsh KM: Characterization of fetal urinary proteins at midgestation and term. Biol Neonate 1984; 46: 267-275.
14. Liu Y, Cox SR, Morita T, Kourembanas S: Hypoxia regulates vascular endothelial growth factor gene expression in endothelial cells. Identification of a 5 ? ? enhancer. Circ Res 1995; 77: 638-643.
15. Moore KA, Polte T, Huang S, Shi B, Alsberg E, Sunday ME, et al: Control of basement membrane remodeling and epithelial branching morphogenesis in embryonic lung by rho and cytoskeletal tension. Dev Dyn 2005; 232: 268-281.
16. Wirtz HR, Dobbs LG: Calcium mobilization and exocytosis after one mechanical stretch of lung epithelial cells. Science 1990; 250: 1266-1269.
17. Harding R, Hooper SB: Regulation of lung expansion and lung growth before birth. J Appl Physiol 1996; 81: 209-224.
18. Bose CL, Dammann CE, Laughon MM: Bronchopulmonary dysplasia and inflammatory biomarkers in the premature neonate. Arch Dis Child Fetal Neonatal Ed 2008; 93:F455-F461.
19. Muratore CS, Nguyen HT, Ziegler MM, Wilson JM: Stretch-induced upregulation of VEGF gene expression in murine pulmonary culture: a role for angiogenesis in lung development. J Pediatr Surg 2000; 35: 906-913.
20. Levesque BM, Mammoto A, Ingber D: Vascular endothelial growth factor is mechanically regulated in lung epithelial cells. Am J Respir Crit Care Med 2006; 173:A2835.
21. Hara A, Chapin CJ, Ertsey R, Kitterman JA: Changes in fetal lung distension alter expression of vascular endothelial growth factor and its isoforms in developing rat lung. Pediatr Res 2005; 58: 30-37.
22. Bland RD, Mokres LM, Ertsey R, Jacobson BE, Jiang S, Rabinovitch M, et al: Mechanical ventilation with 40% oxygen reduces pulmonary expression of genes that regulate lung development and impairs alveolar septation in newborn mice. Am J Physiol Lung Cell Mol Physiol 2007; 293:L1099-L1110.
23. Park JE, Keller GA, Ferrara N: The vascular endothelial growth factor isoforms: differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound vascular endothelial growth factor. Mol Biol Cell 1993; 4: 1317-1326.
24. Okamoto Y, Nagai T, Nakajo I, Seta K, Gotoh Y, Fujita N, et al: Determination of age-related changes in human vascular endothelial growth factor in the serum and urine of healthy subjects. Clin Lab 2008; 54: 173-177.