Chimera of IL-2 linked to light chain of anti-IL-2 mAb mimics IL-2/anti-IL-2 mAb complexes both structurally and functionally

ACS Chemical Biology

Volumn 8, Issue 5, 2013, Pages 871-876

  Tomala, Jakub ^a   Kovarova, Jirina ^a   Kabesova, Martina ^a   Votavova, Petra ^a   Chmelova, Helena ^a   Dvorakova, Barbora ^a   Rihova, Blanka ^a   Kovar, Marek ^a  

^a INSTITUTE OF MICROBIOLOGY   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYFLUORESCEIN DIACETATE SUCCINIMIDYL ESTER; INTERLEUKIN 2; EPITOPE; IMMUNOGLOBULIN FC FRAGMENT; MONOCLONAL ANTIBODY; OVA-8; OVALBUMIN; PEPTIDE FRAGMENT; RECOMBINANT PROTEIN;

ANIMAL CELL; ANTIGEN ANTIBODY COMPLEX; ARTICLE; BINDING AFFINITY; BINDING SITE; BIOLOGICAL ACTIVITY; CD8+ T LYMPHOCYTE; CELL ACTIVATION; CELL ACTIVITY; CELL PROLIFERATION; CHIMERA; CONTROLLED STUDY; DISSOCIATION; GENETIC TRANSFECTION; IN VITRO STUDY; LIGHT CHAIN; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PURIFICATION; TRANSIENT EXPRESSION; ANIMAL; C57BL MOUSE; CELL CULTURE; CHEMISTRY; CHO CELL LINE; CRICETULUS; DOSE RESPONSE; DRUG EFFECTS; GENETICS; HAMSTER; IMMUNOLOGY; METABOLISM; MOLECULAR GENETICS; MOLECULAR MIMICRY; NUCLEOTIDE SEQUENCE; PROTEIN ENGINEERING; TRANSGENIC MOUSE;

ANIMALS; ANTIBODIES, MONOCLONAL; BASE SEQUENCE; BINDING SITES; CD8-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; CELLS, CULTURED; CHO CELLS; CRICETINAE; CRICETULUS; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITOPES; IMMUNOGLOBULIN FC FRAGMENTS; INTERLEUKIN-2; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MOLECULAR MIMICRY; MOLECULAR SEQUENCE DATA; OVALBUMIN; PEPTIDE FRAGMENTS; PROTEIN ENGINEERING; RECOMBINANT PROTEINS;

EID: 84878033053     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb3007242     Document Type: Article

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