Competition for Gβγ dimers mediates a specific cross-talk between stimulatory and inhibitory G protein α subunits of the adenylyl cyclase in cardiomyocytes

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 386, Issue 6, 2013, Pages 459-469

  Hippe, Hans Jörg ^a   Lüdde, Mark ^a   Schnoes, Katrin ^b   Novakovic, Ana ^c,d   Lutz, Susanne ^e   Katus, Hugo A ^b   Niroomand, Feraydoon ^b   Nürnberg, Bernd ^c,d   Frey, Norbert ^a   Wieland, Thomas ^b  

^a UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c UNIVERSITY OF TÜBINGEN   (Germany)

^d Interfaculty Center of Pharmacogenomic and Drug Research   (Germany)

^e UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

adrenoceptor stimulation; Adenylyl cyclase; Cardiomyocytes; G protein coupled receptors; Heterotrimeric G proteins; Plasma membrane

Indexed keywords

ADENYLATE CYCLASE; DIMER; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN GAMMA SUBUNIT; MESSENGER RNA;

ADENOVIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; HEART MUSCLE CELL; IMMUNOPRECIPITATION; MOLECULAR INTERACTION; MOUSE; NEWBORN; NONHUMAN; PROTEIN CONTENT; PROTEIN EXPRESSION; PROTEIN PROCESSING; RAT;

ADENOVIRIDAE; ADENYLATE CYCLASE; ANIMALS; CELL MEMBRANE; GENE EXPRESSION REGULATION; GTP-BINDING PROTEIN ALPHA SUBUNIT, GI2; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; GTP-BINDING PROTEIN BETA SUBUNITS; GTP-BINDING PROTEIN GAMMA SUBUNITS; MICE; MICE, KNOCKOUT; MYOCYTES, CARDIAC; PROTEIN ISOFORMS; RATS; RECEPTOR CROSS-TALK; RNA, MESSENGER; SIGNAL TRANSDUCTION;

EID: 84878013267     PISSN: 00281298     EISSN: 14321912     Source Type: Journal    
DOI: 10.1007/s00210-013-0876-x     Document Type: Article

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