Protective effects of edaravone on experimental chronic pancreatitis induced by dibutyltin dichloride in rats

Pancreatology

Volumn 13, Issue 2, 2013, Pages 125-132

  Zhou, Chun Hua ^a   Lin Li, ^a   Zhu, Xiao Yan ^b   Wen Tang, ^a   Hu, Duan Min ^a   Dong, Yun ^a   Li, Ling Yun ^a   Wang, Shao Feng ^a  

^a SOOCHOW UNIVERSITY   (China)

^b The Affiliated Infectious Diseases Hospital of Soochow University   (China)

Author keywords

Antioxidant; Chronic pancreatitis; Dibutyltin dichloride (dbtc); Edaravone; Fibrosis; Radical scavenger

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; DIBUTYLTIN DICHLORIDE; HYDROXYPROLINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; MALONALDEHYDE; NORPHENAZONE; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR RELA; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; BODY WEIGHT; CHRONIC PANCREATITIS; CONFERENCE PAPER; CONTROLLED STUDY; CYSTIC FIBROSIS; DOWN REGULATION; ENZYME ACTIVATION; FOOD INTAKE; GENE EXPRESSION PROFILING; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; OXIDATIVE STRESS; PANCREATIC STELLATE CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCORING SYSTEM; TISSUE LEVEL; TRANSCRIPTION INITIATION; TREATMENT DURATION; WESTERN BLOTTING;

EID: 84878013000     PISSN: 14243903     EISSN: 14243911     Source Type: Journal    
DOI: 10.1016/j.pan.2013.01.007     Document Type: Conference Paper

References (35)

1. Braganza JM, Lee SH, McCloy RF, McMahon MJ. Chronic pancreatitis. Lancet 2011;377(9772):1184-97.
2. Spanier BW, Dijkgraaf MG, Bruno MJ. Trends and forecasts of hospital admissions for acute and chronic pancreatitis in the Netherlands. Eur J Gastroenterol Hepatol 2008;20(7):653-8.
3. Apte MV, Wilson JS. Mechanisms of pancreatic fibrosis. Dig Dis 2004;22(3): 273-9. (Pubitemid 40467602)
4. Mas MR, Isik AT, Yamanel L, Inal V, Tasci I, Deveci S, et al. Antioxidant treatment with taurine ameliorates chronic pancreatitis in an experimental rat model. Pancreas 2006;33(1):77-81. (Pubitemid 43995343)
5. Yasar M, Mas MR, Comert B, Akay C, Deveci S, Yilmaz MI, et al. Has the oxidative stress a role in late phase of experimental acute necrotizing pancreatitis? Hepatogastroenterology 2002;49(48):1692-5. (Pubitemid 35277359)
6. Yoo BM, Oh TY, Kim YB, Yeo M, Lee JS, Surh YJ, et al. Novel antioxidant ameliorates the fibrosis and inflammation of cerulein-induced chronic pancreatitis in a mouse model. Pancreatology 2005;5(2-3):165-76. (Pubitemid 40754733)
7. Altavilla D, Famulari C, Passaniti M, Galeano M, Macri A, Seminara P, et al. Attenuated cerulein-induced pancreatitis in nuclear factor-kappaB-deficient mice. Lab Invest 2003;83(12):1723-32. (Pubitemid 38018535)
8. Casini A, Galli A, Pignalosa P, Frulloni L, Grappone C, Milani S, et al. Collagen type I synthesized by pancreatic periacinar stellate cells (PSC) co-localizes with lipid peroxidation-derived aldehydes in chronic alcoholic pancreatitis. J Pathol 2000;192(1):81-9.
9. Kirk GR, White JS, McKie L, Stevenson M, Young I, Clements WD, et al. Combined antioxidant therapy reduces pain and improves quality of life in chronic pancreatitis. J Gastrointest Surg 2006;10(4):499-503. (Pubitemid 43696992)
10. Watanabe T, Egawa M. Effects of an antistroke agent MCl-186 on cerebral arachidonate cascade. J Pharmacol Exp Ther 1994;271(3):1624-9. (Pubitemid 24382679)
11. Watanabe T, Tahara M, Todo S. The novel antioxidant edaravone: from bench to bedside. Cardiovasc Ther 2008;26(2):101-14. (Pubitemid 351952827)
12. Watanabe T, Yuki S, Egawa M, Nishi H. Protective effects of MCI-186 on cerebral ischemia: possible involvement of free radical scavenging and antioxidant actions. J Pharmacol Exp Ther 1994;268(3):1597-604. (Pubitemid 24100383)
13. Effect of a novel free radical scavenger, edaravone (MCI-186), on acute brain infarction. Randomized, placebo-controlled, double-blind study at multicenters. Cerebrovasc Dis 2003;15(3):222-9.
14. Ito K, Ozasa H, Horikawa S. Edaravone protects against lung injury induced by intestinal ischemia/reperfusion in rat. Free Radic Biol Med 2005;38(3): 369-74. (Pubitemid 40075578)
15. Minhaz U, Tanaka M, Tsukamoto H, Watanabe K, Koide S, Shohtsu A, et al. Effect of MCI-186 on postischemic reperfusion injury in isolated rat heart. Free Radic Res 1996;24(5):361-7. (Pubitemid 26181778)
16. Nishi H, Watanabe T, Sakurai H., Yuki SIshibashi A. Effect of MCI-186 on brain edema in rats. Stroke 1989;20(9):1236-40. (Pubitemid 19226920)
17. Sueishi K, Mishima K, Makino K, Itoh Y, Tsuruya K, Hirakata H, et al. Protection by a radical scavenger edaravone against cisplatin-induced nephrotoxicity in rats. Eur J Pharmacol 2002;451(2):203-8. (Pubitemid 35253961)
18. Araki Y, Andoh A, Yokono T, Asano N, Yoshikawa K, Bamba S, et al. The free radical scavenger edaravone suppresses experimental closed duodenal loopinduced acute pancreatitis in rats. Int J Mol Med 2003;12(1):121-4.
19. Yang T, Mao YF, Liu SQ, Hou J, Cai ZY, Hu JY, et al. Protective effects of the free radical scavenger edaravone on acute pancreatitis-associated lung injury. Eur J Pharmacol 2010;630(1-3):152-7.
20. Tanaka H, Ueda H, Fukuchi H, Ichinose M. Antifibrotic effect of edaravone in rat liver cirrhosis induced by dimethylnitrosamine. Clin Exp Med 2009; 9(3):229-33.
21. Inoue M, Ino Y, Gibo J, Ito T, Hisano T, Arita Y, et al. The role of monocyte chemoattractant protein-1 in experimental chronic pancreatitis model induced by dibutyltin dichloride in rats. Pancreas 2002;25(4):e64-e70.
22. Sparmann G, Merkord J, Jaschke A, Nizze H, Jonas L, Lohr M, et al. Pancreatic fibrosis in experimental pancreatitis induced by dibutyltin dichloride. Gastroenterology 1997;112(5):1664-72. (Pubitemid 27181392)
23. Kaku T, Oono T, Zhao H, Gibo J, Kawabe K, Ito T, et al. IS-741 attenuates local migration of monocytes and subsequent pancreatic fibrosis in experimental chronic pancreatitis induced by dibutyltin dichloride in rats. Pancreas 2007; 34(3):299-309. (Pubitemid 46588255)
24. Mathew P, Wyllie R, Van Lente F, Steffen RM, Kay MH. Antioxidants in hereditary pancreatitis. Am J Gastroenterol 1996;91(8):1558-62. (Pubitemid 26269170)
25. Van Gossum A, Closset P, Noel E, Cremer M, Neve J. Deficiency in antioxidant factors in patients with alcohol-related chronic pancreatitis. Dig Dis Sci 1996; 41(6):1225-31. (Pubitemid 26227897)
26. Steinle AU, Weidenbach H, Wagner M, Adler G, Schmid RM. NF-kappaB/Rel activation in cerulein pancreatitis. Gastroenterology 1999;116(2):420-30.
27. Masamune A, Watanabe T, Kikuta K, Shimosegawa T. Roles of pancreatic stellate cells in pancreatic inflammation and fibrosis. Clin Gastroenterol Hepatol 2009;7(11 Suppl):S48-54.
28. Masamune AShimosegawa T. Signal transduction in pancreatic stellate cells. J Gastroenterol 2009;44(4):249-60.
29. Arii K, Kumon Y, Sugahara K, Nakatani K, Ikeda Y, Suehiro T, et al. Edaravone inhibits collagen-induced arthritis possibly through suppression of nuclear factor-kappa B. Mol Immunol 2008;45(2):463-9. (Pubitemid 47332633)
30. Yagi K, Kitazato KT, Uno M, Tada Y, Kinouchi T, Shimada K, et al. Edaravone, a free radical scavenger, inhibits MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator. Stroke 2009;40(2):626-31.
31. Han SJ, Ko HM, Choi JH, Seo KH, Lee HS, Choi EK, et al. Molecular mechanisms for lipopolysaccharide-induced biphasic activation of nuclear factor-kappa B (NF-kappa B). J Biol Chem 2002;277(47):44715-21. (Pubitemid 36159062)
32. Satoh A, Shimosegawa T, Fujita M, Kimura K, Masamune A, Koizumi M, et al. Inhibition of nuclear factor-kappaB activation improves the survival of rats with taurocholate pancreatitis. Gut 1999;44(2):253-8. (Pubitemid 29119370)
33. Treiber M, Neuhofer P, Anetsberger E, Einwachter H, Lesina M, Rickmann M, et al. Myeloid, but not pancreatic, RelA/p65 is required for fibrosis in a mouse model of chronic pancreatitis. Gastroenterology 2011;141(4):1473-85. 1485. e1471-7.
34. Ito K, Ozasa H, Noda Y, Arii S, Horikawa S. Effects of free radical scavenger on acute liver injury induced by d-galactosamine and lipopolysaccharide in rats. Hepatol Res 2008;38(2):194-201.
35. Kono H, Asakawa M, Fujii H, Maki A, Amemiya H, Yamamoto M, et al. Edaravone, a novel free radical scavenger, prevents liver injury and mortality in rats administered endotoxin. J Pharmacol Exp Ther 2003;307(1):74-82. (Pubitemid 37151893)