Biocatalytic synthesis of chiral intermediate of pregabalin with high substrate loading by a newly isolated Morgarella morganii ZJB-09203

Applied Microbiology and Biotechnology

Volumn 97, Issue 11, 2013, Pages 4839-4847

  Zheng, Ren Chao ^a   Wang, Tian Zhen ^a   Fu, De Jin ^a   Li, Ai Peng ^a   Li, Xiao Jun ^a   Zheng, Yu Guo ^a  

^a ZHEJIANG UNIVERSITY OF TECHNOLOGY   (China)

Author keywords

(3S) 2 carboxyethyl 3 cyano 5 methylhexanoic acid; Anion exchange resin; Enantioselective hydrolysis; High substrate loading; In situ product removal; Morgarella morganii esterase

Indexed keywords

ANION EXCHANGE RESINS; ENANTIOSELECTIVE HYDROLYSIS; MORGARELLA MORGANII ESTERASE; SITU PRODUCT REMOVAL; SUBSTRATE LOADING;

ENANTIOSELECTIVITY; ENZYMATIC HYDROLYSIS; ESTERS; ION EXCHANGE RESINS;

LOADING;

AGAR; ANION EXCHANGE RESIN; DNA 16S; ESTERASE; HYDROLASE; INDICATOR; PREGABALIN;

ACID; AGAR; ENZYME ACTIVITY; ESTER; HYDROLYSIS; INHIBITION; ION EXCHANGE; PH; SOIL; SUBSTRATE;

ARTICLE; BACTERIAL STRAIN; BACTERIUM CULTURE; BACTERIUM ISOLATION; BIOCATALYSIS; CHIRALITY; ENANTIOSELECTIVITY; ENZYME SPECIFICITY; GRAM NEGATIVE BACTERIUM; MORGARELLA MORGANII; NEGATIVE FEEDBACK; NONHUMAN; SOIL;

DNA, BACTERIAL; DNA, RIBOSOMAL; ENTEROBACTERIACEAE; ESTERASES; GAMMA-AMINOBUTYRIC ACID; MOLECULAR SEQUENCE DATA; RNA, RIBOSOMAL, 16S; SEQUENCE ANALYSIS, DNA; SOIL MICROBIOLOGY;

EID: 84878012172     PISSN: 01757598     EISSN: 14320614     Source Type: Journal    
DOI: 10.1007/s00253-013-4810-4     Document Type: Article

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